{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:54:39Z","timestamp":1695560079116},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"U.S. Department of Health and Human Services, National Institutes of Health","award":["5 R01 NS41855-02"],"award-info":[{"award-number":["5 R01 NS41855-02"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe neurophysiologic changes over time in persons with and without spinal complaints and to assess whether paraspinal denervation predicts change in stenosis on magnetic resonance imaging (MRI) and clinical course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, controlled, masked trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University spine program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Persons aged 55 to 80 years, screened for polyneuropathy and determined on clinical examination to have spinal stenosis, mechanical low back pain, or no spinal symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>A comprehensive codified history was obtained and subjects underwent physical examination, ambulation testing, masked electrodiagnostic testing including paraspinal mapping, and MRI, repeated at greater than 18 months. This study presents detailed technical information and additional analyses not reported previously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measurements<\/jats:title><jats:p>Change in electrodiagnostic findings. Among persons with clinical stenosis, relationship of change in paraspinal mapping scores to MRI findings and clinical changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 149 initial subjects, 83 (79.3% of eligible subjects) repeated testing at 20 (\u00b12 SDs) months. No significant change in limb muscle spontaneous activity or motor unit pathology was noted in any group. In 23 persons with initial diagnosis of stenosis, paraspinal mapping electromyography related to change in diagnosis over time (analysis of variance <jats:italic>F<\/jats:italic> = 3.77, <jats:italic>P<\/jats:italic> = .037), but not to most initial magnetic resonance imaging measurements or to change in spinal canal diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical spinal stenosis is neurophysiologically stable in most persons. Paraspinal electromyographic changes reflect large changes in clinical course, but neither neurophysiologic nor clinical changes relate to change in spinal geometry over 20 months.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2008.10.007","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T17:22:55Z","timestamp":1233768175000},"page":"127-136","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Prospective, Masked 18\u2010Month Minimum Follow\u2010up On Neurophysiologic Changes In Persons with Spinal Stenosis, Low Back Pain, and No Symptoms"],"prefix":"10.1002","volume":"1","author":[{"given":"Andrew J.","family":"Haig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.J.","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Parres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Chiodo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.crd.0000126082.86717.12"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000082369"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2005.08.002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072080-00008"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.03.016"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM199407143310201","article-title":"Magnetic resonance imaging of the lumbar spine in people without back pain","volume":"14","author":"Jensen M.C.","year":"1994","journal-title":"N Engl J Med"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1994.tb02675.x"},{"key":"e_1_2_7_9_2","first-page":"68","article-title":"Lumbar stenosis. 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