{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:28:40Z","timestamp":1772461720299,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T00:00:00Z","timestamp":1246320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if self\u2010reported levels of physical activity and fatigue are related to peak oxygen uptake (VO<jats:sub>2peak<\/jats:sub>) and whether these relationships differ among the patient groups (rheumatoid arthritis [RA], polymyositis [PM], and chronic fatigue syndrome [CFS]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Correlational investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two ambulatory research clinics at the National Institutes of Health, Clinical Center, Bethesda, MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>There were 9 patients with PM, 10 with RA, and 10 with CFS. All patients met case criteria for their respective diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Main Outcome Measurements<\/jats:title><jats:p>VO<jats:sub>2peak<\/jats:sub> during bicycle ergometry and self\u2010reported fatigability, fatigue, and physical activity. VO<jats:sub>2peak<\/jats:sub> was used as the criterion measurement of physiological fatigue with which the self\u2010reported variables were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Pearson r revealed that self\u2010reported physical activity correlated with VO<jats:sub>2peak<\/jats:sub> (<jats:italic>r<\/jats:italic> = 61, <jats:italic>P<\/jats:italic> = .01). However, fatigability and fatigue did not correlate with VO<jats:sub>2peak<\/jats:sub>. Linear regression analysis was performed to assess the effects of diagnosis group, self\u2010reported activity level or fatigue, and their interaction. A trend in the data showed a distinctive relationship between fatigue\/fatigability within the 3 groups. In addition, when controlling for group status, self\u2010reported activity predicted aerobic capacity as measured by VO<jats:sub>2peak<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms that patients with chronic, but stable RA, PM, or CFS are fatigued and have significantly decreased aerobic capacity. Self\u2010reports of physical activity predicted VO<jats:sub>2peak<\/jats:sub>, and may be used as an indicator of activity\u2010based aerobic capacity. Self\u2010reports of fatigue, however, did not correlate with VO<jats:sub>2peak<\/jats:sub> and hence are assessing something other than an index of aerobic capacity, and provide additional information about patients' perceptions, which will require further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2009.04.007","type":"journal-article","created":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T08:17:12Z","timestamp":1246436232000},"page":"620-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Exploratory Analysis of the Relationships between Aerobic Capacity and Self\u2010Reported Fatigue in Patients with Rheumatoid Arthritis, Polymyositis, and Chronic Fatigue Syndrome"],"prefix":"10.1002","volume":"1","author":[{"given":"Ali A.","family":"Weinstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart M.","family":"Drinkard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Furst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet K.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Straus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn H.","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-618X.1996.tb00293.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.1999.00168.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968308315046"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1111\/j.1753-4887.2006.tb00256.x","article-title":"Mental energy: Assessing the mood dimension","volume":"64","author":"O'Connor P.J.","year":"2008","journal-title":"Nutrit Rev"},{"issue":"1","key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1093\/clinids\/13.Supplement_1.S94","article-title":"Definition and measurement of fatigue","volume":"13","author":"Barofsky I.","year":"1991","journal-title":"Rev Infect Dis"},{"key":"e_1_2_5_7_2","first-page":"12","volume-title":"A Model of Human Occupation: Theory and Application","author":"Kielhofner G.","year":"1985"},{"issue":"11","key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1097\/00002060-200211001-00011","article-title":"Role of fatigue in limiting physical activities in humans with neuromuscular diseases","volume":"81","author":"Miller R.G.","year":"2002","journal-title":"Am J Phys Med Rehabil"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2007.02082.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.06.013"},{"key":"e_1_2_5_11_2","first-page":"1450","article-title":"A study of fatigue in systemic lupus erythematosus","volume":"17","author":"Krupp L.B.","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.7.633"},{"key":"e_1_2_5_13_2","first-page":"2453","article-title":"Fatigue in systemic lupus erythematosus: Contributions of disordered sleep, sleepiness, and depression","volume":"33","author":"Iaboni A.","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-197912000-00005"},{"key":"e_1_2_5_15_2","first-page":"23","article-title":"Fatigue and the cancer experience: the state of the knowledge","volume":"21","author":"Winningham M.L.","year":"1994","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0466-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2008.0036"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770010402"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-200804000-00005"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.121129"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00009"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1359105305049774"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90099-X"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2139"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22903"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0185"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31816a8dbc"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-3-19"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(97)00039-3"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.07.001"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000204628.73273.23"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.12.012"},{"key":"e_1_2_5_33_2","first-page":"458","article-title":"Measurement of exercise tolerance in patients with rheumatoid arthritis and osteoarthritis","volume":"12","author":"Beals C.A.","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23255"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199621010-00004"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.4.779"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00041-1"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(00)90212-0"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22996"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21185"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280106"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-199303000-00006"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.Supplement_1.S79"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(99)00138-4"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7117.2008.07275.x"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh010"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1891\/rtnp.20.1.49"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_5_52_2","volume-title":"ACSM's Resource Manual for Guidelines for Exercise Testing and Prescription","author":"American College of Sports Medicine","year":"1993"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"e_1_2_5_54_2","volume-title":"Principles of Exercise Testing and Prescription","author":"Wasserman K.","year":"1999"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00280-5"},{"key":"e_1_2_5_56_2","volume-title":"Manual for the Profile of Mood States","author":"McNair D.M.","year":"1992"},{"key":"e_1_2_5_57_2","volume-title":"Human Activity Profile Professional Manual","author":"Fix A.J.","year":"1988"},{"key":"e_1_2_5_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10926"},{"key":"e_1_2_5_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7095.1647"},{"key":"e_1_2_5_60_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199509000-00009"},{"key":"e_1_2_5_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-006-0252-3"},{"key":"e_1_2_5_62_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199301000-00011"},{"issue":"9","key":"e_1_2_5_63_2","doi-asserted-by":"crossref","first-page":"S498","DOI":"10.1097\/00005768-200009001-00009","article-title":"Compendium of physical activities: An update of activity codes and MET intensities","volume":"32","author":"Ainsworth B.E.","year":"2000","journal-title":"Med Sci Sports Exerc"}],"container-title":["PM&amp;R"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.pmrj.2009.04.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148209004365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148209004365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.pmrj.2009.04.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:48:26Z","timestamp":1694666906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.pmrj.2009.04.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,30]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1016\/j.pmrj.2009.04.007"],"URL":"https:\/\/doi.org\/10.1016\/j.pmrj.2009.04.007","archive":["Portico"],"relation":{},"ISSN":["1934-1482","1934-1563"],"issn-type":[{"value":"1934-1482","type":"print"},{"value":"1934-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,30]]},"assertion":[{"value":"2008-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}