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There was a significant inverse linear trend between quartile of IL\u20106 and %\u2010predicted FEV<jats:sub>1<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; .001) and FVC (<jats:italic>P<\/jats:italic> &lt; .006), unadjusted and adjusted for SCI level and completeness of injury, obstructive lung disease history, smoking, and body mass index (<jats:italic>P<\/jats:italic> = .010\u2010.039). Although not as strong as for IL\u20106, there also were similar trends for %\u2010predicted FEV<jats:sub>1<\/jats:sub> and FVC with CRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In chronic SCI, higher levels of IL\u20106 and CRP were associated with a lower FEV<jats:sub>1<\/jats:sub> and FVC, independent of level and completeness of injury. These results suggest that the reduction of pulmonary function after SCI is related not only to neuromuscular impairment but also to factors that promote systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2011.02.003","type":"journal-article","created":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T23:06:26Z","timestamp":1305932786000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Systemic Inflammation and Reduced Pulmonary Function in Chronic Spinal Cord Injury"],"prefix":"10.1002","volume":"3","author":[{"given":"Eric","family":"Garshick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Stolzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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