{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:54:06Z","timestamp":1694753646451},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006370","name":"Small Business Innovation Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the presence of inflammatory cytokines and the fibronectin\u2010aggrecan complex (FAC) in persons undergoing surgical treatment for cervical radiculopathy caused by disk herniation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single\u2010center, prospective, consecutive case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A single large academic institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 11 patients with radiculopathic pain and magnetic resonance imaging findings positive for disk herniation elected to undergo single\u2010level cervical diskectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods or Interventions<\/jats:title><jats:p>Lavage was performed by needle injection and aspiration upon entering the disk space for fluoroscopic localization before diskectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measurements<\/jats:title><jats:p>The lavage fluid was assayed for pH and the FAC, as well as for the cytokines interleukin\u20106 (IL\u20106), interferon\u2010\u03b3, monocyte chemotactic protein (MCP), and macrophage inhibitory protein\u20101\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The subjects were 7 women and 4 men with a mean age of 50.6 years (SE 9.7; range, 36\u201070 years). The mean concentrations (SE; range) in picograms per milliliter were 7.9 (4.4; 0\u201044) for IL\u20106, 25.3 (15.5; 0\u2010159) for interferon\u2010\u03b3, 16.1 (11.9; 0\u2010121) for MCP, and 6.1 (2.8; 0\u201029) for macrophage inhibitory protein\u20101\u03b2. The optical density of the FAC at 450 nm was 0.151 (0.036; 0.1\u20100.32), and the pH was 6.68 (0.1; 6.10\u20107.15). Statistically significant correlations were found between MCP and FAC (<jats:italic>P<\/jats:italic> = .036) and between FAC and pH (<jats:italic>P<\/jats:italic> = .008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biochemical analysis of injured cervical intervertebral disks reveals the presence of inflammatory markers such as MCP, fragments of structural matrix proteins such as FAC, and a correlation with pH. Further evaluation of the FAC as a potential diagnostic biomarker or therapeutic target is warranted in the cervical spine.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2011.07.003","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T13:51:53Z","timestamp":1321969913000},"page":"1030-1034","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is the Fibronectin\u2010Aggrecan Complex Present in Cervical Disk Disease?"],"prefix":"10.1002","volume":"3","author":[{"given":"Varun K.","family":"Gajendran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrill W.","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Raymond","family":"Golish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis S.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano J.","family":"Scuderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199602010-00003"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199511001-00001"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199705150-00003"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.04.069"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00718"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181f40e88"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2006.10.005"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.10.1.133-139.2003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00835"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2010.07.002"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bsd.0000204501.22343.99"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181913872"}],"container-title":["PM&amp;R"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.pmrj.2011.07.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148211004631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148211004631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.pmrj.2011.07.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.pmrj.2011.07.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.pmrj.2011.07.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:47:45Z","timestamp":1694713665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.pmrj.2011.07.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1016\/j.pmrj.2011.07.003"],"URL":"https:\/\/doi.org\/10.1016\/j.pmrj.2011.07.003","archive":["Portico"],"relation":{},"ISSN":["1934-1482","1934-1563"],"issn-type":[{"value":"1934-1482","type":"print"},{"value":"1934-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"2011-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}