{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:39:19Z","timestamp":1791329959105,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"5S","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/Association of Academic Physiatrists K-12 Early Career Development","award":["5K12HD001097-15"],"award-info":[{"award-number":["5K12HD001097-15"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Electrophysiology remains an important tool in the evaluation of patients presenting with signs and symptoms of motor neuron disease. The electrodiagnostic study should include peripheral nerve conduction studies and needle electromyography to both exclude treatable disease and gather evidence regarding a diagnosis of amyotrophic lateral sclerosis (ALS). The recent changes in the revised El Escorial criteria, recommended by the Awaji\u2010shima consensus group, have increased the diagnostic significance of fasciculation potentials to equal that of fibrillation and positive sharp\u2010wave potentials in the needle electromyography examination of patients suspected of having ALS. In addition, electrophysiologic evidence is now considered equivalent to clinical signs and symptoms in reaching a diagnostic certainty of ALS. These changes, strategies for the design, and implementation of an effective electrodiagnostic evaluation, in addition to electrophysiologic techniques and their relationship to the evaluation of a patient with ALS, are reviewed and discussed.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2013.03.020","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T08:45:29Z","timestamp":1363855529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Electrodiagnosis in Persons With Amyotrophic Lateral Sclerosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Nanette C.","family":"Joyce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-9651(02)00119-5"},{"key":"e_1_2_9_3_2","first-page":"96","article-title":"El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases\/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial \u201cClinical limits of amyotrophic lateral sclerosis\u201d workshop contributors","volume":"124","author":"Brooks B.R.","year":"1994","journal-title":"J Neurol Sci"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.09.143"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.662689"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.235952"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200010)23:10<1488::AID-MUS4>3.0.CO;2-E"},{"key":"e_1_2_9_8_2","first-page":"57","article-title":"Clinical neurophysiology in ALS","volume":"149","author":"Inghilleri M.","year":"2011","journal-title":"Arch Ital Biol"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.03.002"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200003)23:3<344::AID-MUS5>3.0.CO;2-N"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00148-8"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.61"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00838169"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160208"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308818"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.098533"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2009.41.3.017"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.01.010"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2005000100028"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e318209efc6"},{"key":"e_1_2_9_21_2","first-page":"199","article-title":"Motor nerve conduction velocities calculated by F tacheodispersion in patients with anterior horn diseases","volume":"36","author":"Chroni E.","year":"1996","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/146608202760834139"},{"issue":"1","key":"e_1_2_9_23_2","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1080\/14660820050515539","article-title":"Pathophysiological significance of fasciculations in the early diagnosis of ALS","volume":"1","author":"Carvalho M.","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.7.681"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afj001"},{"key":"e_1_2_9_26_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/14660820050515115","article-title":"Treatable lower motor neuron disease due to vitamin D deficiency and secondary hyperparathyroidism","volume":"1","author":"Whitaker C.H.","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.186833"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq290"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000300559.14806.2a"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl024"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.04.005"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199803)21:3<336::AID-MUS7>3.0.CO;2-B"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.06.032"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21109"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.3171\/2011.1.SPINE10717"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21202"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20659"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.9.10.627"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.897"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21105"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22301"},{"key":"e_1_2_9_42_2","first-page":"1830","article-title":"Single fiber electromyography in 78 patients with amyotrophic lateral sclerosis","volume":"117","author":"Cui L.Y.","year":"2004","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10351"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100008568"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)31017-X"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.8.1171"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22299"},{"key":"e_1_2_9_48_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/mus.23408","article-title":"Does Awaji decrease diagnostic yield in ALS?","volume":"46","author":"Carvalho M.","year":"2012","journal-title":"Muscle Nerve"},{"key":"e_1_2_9_49_2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/mus.21495","article-title":"Sensitivity of electrophysiological tests for upper and lower motor neuron dysfunction in ALS: A six\u2010month longitudinal study","volume":"41","author":"Carvalho M.","year":"2010","journal-title":"Muscle Nerve"}],"container-title":["PM&amp;R"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.pmrj.2013.03.020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148213001299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148213001299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.pmrj.2013.03.020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T19:38:18Z","timestamp":1715110698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.pmrj.2013.03.020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":48,"journal-issue":{"issue":"5S","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1016\/j.pmrj.2013.03.020"],"URL":"https:\/\/doi.org\/10.1016\/j.pmrj.2013.03.020","archive":["Portico"],"relation":{},"ISSN":["1934-1482","1934-1563"],"issn-type":[{"value":"1934-1482","type":"print"},{"value":"1934-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]},"assertion":[{"value":"2013-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}