{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:06Z","timestamp":1761895806483},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:label \/><jats:p>SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome includes a variety of musculoskeletal disorders and associated skin conditions. Diagnosis can be difficult but should be considered in the differential in patients with lytic, sclerotic, or hyperostotic bone lesions and pain. Appropriate and prompt treatment, including use of nonsteroidal medications such as ibuprofen or naproxen, colchicine, corticosteroids, and bisphosphonates, and use of disease\u2010modifying agents such as methotrexate, sulfasalazine and infliximab, can produce improvement of symptoms. Multidisciplinary care, including the disciplines of rheumatology and dermatology, should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2013.08.610","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T14:19:16Z","timestamp":1389795556000},"page":"92-95","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of Pain in SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) Syndrome"],"prefix":"10.1002","volume":"6","author":[{"given":"Chong H.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Division of Pain Management West Virginia University School of Medicine Morgantown WV 26505"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Kadhim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West Virginia University Morgantown WV"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Julien","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West Virginia University Morgantown WV"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"187","article-title":"Acne\u2010pustulosis\u2010hyperostosis\u2010osteitis syndrome. 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