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Although patients with advanced disease have well\u2010documented and profound functional limitations, less is known about the determinants of function in early to mid\u2010stage disease where interventions may be more likely to benefit and preserve function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the current study was to identify motor, cognitive, and gait determinants of physical functional performance in patients with early to mid\u2010stage PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a secondary analysis of cross\u2010sectional baseline data from a randomized clinical trial of exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The study was performed at a tertiary academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The study included 121 patients with early to mid\u2010stage PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our functional performance outcomes included the following: the Continuous Scale Physical Functional Performance Test (CS\u2010PFP; primary outcome); the Timed Up and Go test (TUG); and Section 2 (Activities of Daily Living) of the Unified Parkinson's Disease Rating Scale (UPDRS). Explanatory variables included measures of disease severity, motor function, cognitive function, balance, and gait. Stepwise linear regression models were used to determine correlations between explanatory variables and outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our regression models, the CS\u2010PFP significantly correlated with walking endurance (Six\u2010Minute Walk Test; r<jats:sup>2<\/jats:sup> = 0.12, <jats:italic>P<\/jats:italic> &lt; .0001), turning ability (360\u00b0 Turn Test; r<jats:sup>2<\/jats:sup> = 0.03, <jats:italic>P<\/jats:italic> = .002), attention (Brief Test of Attention; r<jats:sup>2<\/jats:sup> = 0.01, <jats:italic>P<\/jats:italic> = .03), overall cognitive status (Mini\u2013Mental State Examination; r<jats:sup>2<\/jats:sup> = 0.01, <jats:italic>P<\/jats:italic> = .04), and bradykinesia (timed tapping; r<jats:sup>2<\/jats:sup> = 0.02, <jats:italic>P<\/jats:italic> = .02). The TUG significantly correlated with walking speed (5\u2010Meter Walk Test; r<jats:sup>2<\/jats:sup> = 0.33, <jats:italic>P<\/jats:italic> &lt; .0001), stride length (r<jats:sup>2<\/jats:sup> = 0.25, <jats:italic>P<\/jats:italic> &lt; .0001), turning ability (360\u00b0 turn, r<jats:sup>2<\/jats:sup> = 0.05, <jats:italic>P<\/jats:italic> = .0003), and attention (r<jats:sup>2<\/jats:sup> = 0.016, <jats:italic>P<\/jats:italic> = .03). Section 2 of the UPDRS was significantly correlated with endurance (r<jats:sup>2<\/jats:sup> = 0.09, <jats:italic>P<\/jats:italic> &lt; .0001), turning ability (r<jats:sup>2<\/jats:sup> = 0.03, <jats:italic>P<\/jats:italic> = .001), and attention (r<jats:sup>2<\/jats:sup> = 0.01, <jats:italic>P<\/jats:italic> = .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gait, motor, and cognitive function all contribute to objectively measured global functional ability in mild to moderate PD. Subjectively measured functional activity outcomes may underestimate the impact of both motor and nonmotor symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2014.05.013","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T08:30:21Z","timestamp":1401265821000},"page":"992-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Determinants of Objectively Measured Physical Functional Performance in Early to Mid\u2010stage Parkinson Disease"],"prefix":"10.1002","volume":"6","author":[{"given":"Benzi M.","family":"Kluger","sequence":"first","affiliation":[{"name":"Department of Neurology Academic Office 1 Mailstop B185, PO Box 6511 Aurora CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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