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Such treatments include the use of nonsteroidal anti\u2010inflammatory drugs (NSAIDs), therapeutic modalities (eg, thermal and manual therapies), and corticosteroid injections in conjunction with specific rehabilitation exercises. Although NSAIDs, modalities, and corticosteroids may be helpful for short\u2010term pain reduction and early recovery of function, they do not typically reverse the structural changes associated with degenerative conditions and may contribute to worse long\u2010term outcomes by potentially interfering with tissue healing. Regenerative interventions, including platelet\u2010rich plasma and mesenchymal stem cells, recently have been used to treat refractory painful conditions such as chronic tendinopathies because of the potential of these interventions to facilitate tissue healing. The future development of these regenerative techniques will require a variety of conditions to be met, including determining the most appropriate procedures based on the disease being treated; establishing the optimal preparations of these regenerative techniques; and providing clinicians, patients, and regulatory agencies with high\u2010quality evidence demonstrating the safety, effectiveness, and long\u2010term results of these treatments. Clarification of current regulatory uncertainty, improved access for all patients, proper training for clinicians who incorporate these techniques into their practice, and determination of the most appropriate postinjection protocols will allow physical medicine and rehabilitation specialists to play a unique role in the long\u2010term management of patients with musculoskeletal and sports injuries. This article will also address the role physiatrists<jats:italic>should<\/jats:italic>have in the inevitable growth of regenerative medicine applications.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2015.01.004","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T02:20:32Z","timestamp":1428632432000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Physiatry in Regenerative Medicine: The Past, The Present, and Future Challenges"],"prefix":"10.1002","volume":"7","author":[{"given":"Fernando","family":"Sep\u00falveda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Baerga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Micheo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Bresnahan M Turner B. 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