{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:28:18Z","timestamp":1763620098937},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe and validate a practical technique for sonographically guided anterior cruciate ligament (ACL) injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, cadaveric laboratory investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Procedural skills laboratory in a tertiary medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Ten unembalmed, cadaveric mid\u2013thigh\u2010knee\u2010ankle foot specimens (5 left knees and 5 right knees; 5 male and 5 female) from 10 donors aged 76 to 93 years (mean 85.6 years) with body mass indices of 17.6 to 42.2 kg\/m<jats:sup>2<\/jats:sup> (mean 28.8 kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single, experienced operator used a 22\u2010gauge, 63.5\u2010mm stainless steel needle and a 12\u20103\u2013MHz linear transducer to inject 1.5 mL of diluted colored latex into the ACLs of 10 unembalmed cadaveric specimens via an in\u2010plane, caudad\u2010to\u2010cephalad approach, long axis to the ACL. At a minimum of 24 hours postinjection, specimens were dissected, and the presence and distribution of latex within the ACL assessed by a study co\u2010investigator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome<\/jats:title><jats:p>Presence and distribution of latex within the ACL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 10 injections accurately delivered latex into the proximal (femoral), midsubstance, and distal (tibial) portions of the ACL. No specimens exhibited evidence of needle injury or latex infiltration with respect to the menisci, hyaline cartilage, or posterior cruciate ligament.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sonographically guided intra\u2010ligamentous ACL injections are technically feasible and can be performed with a high degree of accuracy. Sonographically guided ACL injections could be considered for research and clinical purposes to directly deliver injectable agents into the healing ACL postinjury or postreconstruction.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2015.01.014","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T07:38:57Z","timestamp":1422430737000},"page":"736-745","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sonographically Guided Anterior Cruciate Ligament Injection: Technique and Validation"],"prefix":"10.1002","volume":"7","author":[{"given":"Jay","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua G.","family":"Hackel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Pawlina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob L.","family":"Sellon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2010.09.003"},{"key":"e_1_2_8_3_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2106\/JBJS.H.00819","article-title":"A comprehensive review of partial anterior cruciate ligament tears","volume":"91","author":"DeFranco M.","year":"2009","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.10.013"},{"key":"e_1_2_8_5_2","first-page":"160","article-title":"Natural history of partial anterior cruciate ligament tears: A systematic literature review","volume":"98","author":"Pujol N.","year":"2012","journal-title":"Orthop Traumatol"},{"key":"e_1_2_8_6_2","first-page":"92","article-title":"Partial tears of the anterior cruciate ligament: Diagnosis and treatment","volume":"40","author":"Tjoumakaris F.","year":"2011","journal-title":"Am J Orthop"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200005000-00001"},{"key":"e_1_2_8_8_2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1302\/0301-620X.71B5.2584255","article-title":"Partial tears of the anterior cruciate ligament: Progression to complete ligament deficiency","volume":"71","author":"Noyes F.","year":"1989","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2013.12.003"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2007.01.013"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2008.06.016"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-006-0124-8"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-001-0387-y"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546504266979"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200010000-00004"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20367"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100402"},{"key":"e_1_2_8_18_2","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/438125","article-title":"Ligament tissue engineering and its potential role in anterior cruciate ligament reconstruction","author":"Yates E.","year":"2012","journal-title":"Stem Cells Int"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.01.020"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31821d0f65"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2009.08.019"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2009.06.030"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/JSM.0b013e31820758c7","article-title":"Platelet rich plasma treatment for ligament and tendon injuries","volume":"21","author":"Paolini J.","year":"2011","journal-title":"Clin J Sports Med"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1179\/175361409X12472218840924"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0000000000000005"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20073"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0182"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken114"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508327141"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000318597"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-009-0762-8"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-010-1340-2"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(04)00653-X"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2011.06.003"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(98)80323-1"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90019-2"},{"key":"e_1_2_8_37_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s002560100374","article-title":"Ultrasound\u2010guided aspiration of posterior cruciate ligament ganglion cysts","volume":"30","author":"DeFriend D.","year":"2001","journal-title":"Skel Radiol"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(99)00042-7"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2014.07.008"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmu.2013.01.002"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00571059"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2008.09.001"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e31802ca45b"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-007-0417-6"}],"container-title":["PM&amp;R"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.pmrj.2015.01.014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148215000465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934148215000465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.pmrj.2015.01.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:34:06Z","timestamp":1694669646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.pmrj.2015.01.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1016\/j.pmrj.2015.01.014"],"URL":"https:\/\/doi.org\/10.1016\/j.pmrj.2015.01.014","archive":["Portico"],"relation":{},"ISSN":["1934-1482","1934-1563"],"issn-type":[{"value":"1934-1482","type":"print"},{"value":"1934-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]},"assertion":[{"value":"2014-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}