{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:06:45Z","timestamp":1776362805212,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To systematically analyze the literature on the use of platelet\u2010rich plasma (PRP) for intra\u2010articular injections of the knee and its efficacy in the treatment of knee osteoarthritis (OA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Systematic literature reviews were conducted in PubMed, Embase, and CINAHL (ie, Cumulative Index to Nursing and Allied Health Literature) on October 30, 2013, using the keywords \u201cplatelet\u2010rich plasma\u201d and \u201cknee\u201d and \u201costeoarthritis.\u201d Inclusion criteria included (1) studies with human subjects, (2) prospective clinical studies (including either clinical trials or observational studies), and (3) full\u2010text articles published in English. Exclusion criteria were: (1) animal studies; (2) retrospective studies; (3) patients with previous surgical intervention with total knee arthroplasty or reconstruction of the anterior cruciate ligaments; and (4) articles not published in English<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 319 abstracts and titles were reviewed (60 from PubMed, 250 from Embase, and 9 from CINAHL). A total of 8 relevant journal articles were identified, all of which were published between 2010 and 2013. One\u2010half of the studies were prospective observational studies that included only PRP treatment; the rest were prospective comparative studies including both PRP and controls\u20142 were randomized controlled trials. Of the 4 comparative studies, 3 compared PRP with hyaluronic acid, which was considered as a commonly used effective treatment for knee OA; the other one used saline injection (ie, placebo) as the control. Although most of the analyses suffered from small sample size and was thus inconclusive, the findings consistently indicated that PRP might have better outcomes in patients with a lesser degree of degeneration and in younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PRP intra\u2010articular injections of the knee may be an effective alternative treatment for knee OA. However, current studies are at best inconclusive regarding the efficacy of the PRP treatment. A large, multicenter randomized trial study is needed to further assess the efficacy of PRP treatment for patients with knee OA.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2015.02.003","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T19:14:23Z","timestamp":1424805263000},"page":"637-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Use of Platelet\u2010Rich Plasma in Intra\u2010Articular Knee Injections for Osteoarthritis: A Systematic Review"],"prefix":"10.1002","volume":"7","author":[{"given":"Lawrence P.","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd P.","family":"Stitik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Foye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Georgy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun","family":"Patibanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_7_3_2","unstructured":"Centers for Disease Control and Prevention. Osteoarthritis. Available at:http:\/\/www.cdc.gov\/arthritis\/basics\/osteoarthritis.htm. Accessed November 17 2013."},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.1.8"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-11-201112060-00004"},{"key":"e_1_2_7_6_2","unstructured":"Centers for Disease Control and Prevention. Available at:http:\/\/www.cdc.gov\/arthritis\/data_statistics\/Disabilities\u2010Limitations.htm. Accessed November 29 2013."},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2011.05.011"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3182aab72"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31820758c7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-009-0940-8"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1238-6"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512471299"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-229"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181fc7edf"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1941738111431801"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511419278"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514525593"},{"key":"e_1_2_7_18_2","first-page":"1192","volume-title":"Therapeutic effectiveness of intra\u2010knee\u2010articular injection of platelet\u2010rich plasma on knee articular cartilage degeneration","author":"Li M.","year":"2011"}],"container-title":["PM&amp;R"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.pmrj.2015.02.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193414821500074X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193414821500074X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.pmrj.2015.02.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:32:40Z","timestamp":1694665960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.pmrj.2015.02.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,14]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1016\/j.pmrj.2015.02.003"],"URL":"https:\/\/doi.org\/10.1016\/j.pmrj.2015.02.003","archive":["Portico"],"relation":{},"ISSN":["1934-1482","1934-1563"],"issn-type":[{"value":"1934-1482","type":"print"},{"value":"1934-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,14]]},"assertion":[{"value":"2014-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}