{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:42:15Z","timestamp":1793040135601,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Capsaicin specifically activates, and then gradually exhausts, the transient receptor potential vanilloid type 1 (TRPV1) receptor, a key receptor in neuropathic pain. Activation of the TRPV\u20101 receptor is accompanied by burning pain. A natural substance or medication that can reduce the burning pain resulting from capsaicin application may have therapeutic potential in neuropathic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the pain\u2010relieving effects of a mannitol\u2010containing cream in a capsaicin\u2010based pain model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomized, placebo\u2010controlled, double\u2010blind clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Outpatient pain clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Twenty\u2010five adults with pain\u2010free lips.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Capsaicin .075% cream was applied to both halves of each participant's upper lip, inducing pain via stimulation of the transient receptor potential vanilloid 1 (TRPV1, capsaicin) receptor, then removed after 5 minutes or when participants reported a burning pain of 8\/10, whichever came first. A cream containing mannitol and the same cream without mannitol (control) were then immediately applied, 1 on each side of the lip, in an allocation\u2010masked manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome Measures<\/jats:title><jats:p>Participants self\u2010recorded a numeric rating scale (NRS, 0\u201010) pain score for each side of the lip per minute for 10 minutes. A <jats:italic>t<\/jats:italic>\u2010test was performed to evaluate the pain score change from baseline between each side of the lip at each recording. Area under the curve (AUC) analysis was used to determine the overall difference between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants reached a capsaicin\u2010induced pain level of 7.8 \u00b1 1.0 points in 3.3 \u00b1 1.6 minutes that was equal on both sides of the lip. Both groups reported progressive diminution of pain over the 10\u2010minute study period. However, participants reported significantly reduced pain scores on the mannitol cream half\u2010lip compared to control at 3 through 10 minutes (<jats:italic>P<\/jats:italic> &lt; .05) and in AUC analysis (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mannitol cream reduced self\u2010reported pain scores in a capsaicin pain model more rapidly than a control cream, potentially via a TRPV1 receptor effect.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.pmrj.2015.05.002","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T17:11:54Z","timestamp":1431450714000},"page":"1111-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Topical Mannitol Reduces Capsaicin\u2010Induced Pain: Results of a Pilot\u2010Level, Double\u2010Blind, Randomized Controlled Trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Helene","family":"Bertrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylene","family":"Kyriazis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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