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This treatment paradigm has shifted because recent literature has supported the attempt to preserve or repair the meniscus whenever possible given its importance for the structural integrity of the knee joint and the risk of early osteoarthritis associated after meniscus excision. Choosing an appropriate management strategy depends on multiple factors such as patient demographics and location of the tear. Physical therapy remains a first\u2010line treatment for knee pain secondary to meniscus tear and should be pursued in the setting of acute and chronic knee pain. Furthermore, there is a growing amount of evidence showing that elderly patients with complex meniscus tears in the setting of degenerative arthritis should not undergo arthroscopic surgery. Direct meniscus repair remains an option in ideal patients who are young, healthy, and have tears near the more vascular periphery of the meniscus but it is not suitable for all patients. Use of orthobiologics such as platelet\u2010rich plasma and mesenchymal stem cells have shown promise in augmenting surgical repairs or as standalone treatments, although research for their use in meniscal tear management is limited.<\/jats:p>","DOI":"10.1016\/j.pmrj.2018.08.384","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T08:11:13Z","timestamp":1536307873000},"page":"292-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Treatment of Knee Meniscus Pathology: Rehabilitation, Surgery, and Orthobiologics"],"prefix":"10.1002","volume":"11","author":[{"given":"Paul S.","family":"Chirichella","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, New Jersey Medical School Rutgers University Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Jow","sequence":"additional","affiliation":[{"name":"Saba University School of Medicine The Bottom Saba Dutch Caribbean"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Iacono","sequence":"additional","affiliation":[{"name":"New Jersey Medical School Rutgers University Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Wey","sequence":"additional","affiliation":[{"name":"New Jersey Medical School Rutgers University Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard A.","family":"Malanga","sequence":"additional","affiliation":[{"name":"New Jersey Regenerative Institute LLC, 197 Ridgedale Avenue, #210 Cedar Knolls NJ 07927"},{"name":"Department of Physical Medicine and Rehabilitation, New Jersey Medical School Rutgers University Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.1.111"},{"key":"e_1_2_10_3_1","first-page":"279","article-title":"Load\u2010bearing in the knee joint","volume":"131","author":"Shrive NG","year":"1978","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0278-5919(20)30704-3","article-title":"Anatomy and biomechanics of the menisci","volume":"9","author":"Renstrom P","year":"1990","journal-title":"Clin Sports Med"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800777"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.01.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-47.1.67"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-015-3814-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506293700"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22456"},{"key":"e_1_2_10_11_1","volume-title":"Their Nature and Morphology","author":"Bland\u2010Sutton J.","year":"1897"},{"key":"e_1_2_10_12_1","first-page":"33","article-title":"Principles and decision making in meniscal surgery","volume":"9","author":"Newman AP","year":"1993","journal-title":"Art Ther"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1982"},{"key":"e_1_2_10_14_1","first-page":"161","article-title":"The menisci of the knee joint","volume":"193","author":"Messner K","year":"1998","journal-title":"Anatomical and functional characteristics, and a rationale for clinical treatment. 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