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Behav."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib72","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0028-3908(83)90221-6","article-title":"On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds","volume":"22","author":"Foster","year":"1983","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib73","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1471-4159.1985.tb05493.x","article-title":"Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease","volume":"45","author":"Foster","year":"1985","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib74","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0304-3940(84)90050-8","article-title":"Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid","volume":"48","author":"Foster","year":"1984","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib75","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-8993(85)90647-X","article-title":"Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum","volume":"336","author":"Foster","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib76","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1471-4159.1986.tb02826.x","article-title":"Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro","volume":"47","author":"Foster","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib77","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1471-4159.1985.tb05435.x","article-title":"Quinolinic acid phosphoribosyltransferase in rat brain","volume":"44","author":"Foster","year":"1985","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib78","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/j.1471-4159.1991.tb03460.x","article-title":"Blood\u2013brain barrier transport of kynurenines: implications for brain synthesis and metabolism","volume":"56","author":"Fukui","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib79","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00964611","article-title":"l-Kynurenine: its synthesis and possible regulatory function in brain","volume":"5","author":"G\u00e1l","year":"1980","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib80","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0306-4522(86)90164-8","article-title":"Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices","volume":"18","author":"Garthwaite","year":"1986","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib81","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0165-0173(94)00015-H","article-title":"Microglia: intrinsic immuneffector cell of the brain","volume":"20","author":"Gehrmann","year":"1995","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib82","series-title":"Protein Misfolding in Biology and Disease","first-page":"231","article-title":"The kynurenine pathway and microglia: implications for pathology and therapy in Huntington's disease","author":"Giorgini","year":"2008"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib83","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ng1542","article-title":"A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease","volume":"37","author":"Giorgini","year":"2005","journal-title":"Nat. Gen."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib84","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1074\/jbc.M708192200","article-title":"Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment","volume":"283","author":"Giorgini","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib85","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-1-4615-4709-9_50","article-title":"Radical scavenging properties of tryptophan metabolites. Estimation of their radical reactivity","volume":"467","author":"Goda","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib86","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.1021\/bi992997s","article-title":"3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote \u03b1-crystallin cross-linking by metal ion reduction","volume":"39","author":"Goldstein","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0065-2423(07)00007-8","article-title":"Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach","volume":"45","author":"Gonzalez","year":"2008","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib88","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.2858129","article-title":"Alterations in l-glutamate binding in Alzheimer's and Huntington's diseases","volume":"227","author":"Greenamyre","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib89","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1523\/JNEUROSCI.04-08-02133.1984","article-title":"Quantitative autoradiographic distribution of l-[3H]glutamate-binding sites in rat central nervous system","volume":"4","author":"Greenamyre","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib90","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0301-0082(96)00006-8","article-title":"Bioenergetics and glutamate excitotoxicity","volume":"48","author":"Greene","year":"1996","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib91","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2006.02.011","article-title":"Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice","volume":"23","author":"Guidetti","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib92","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1046\/j.1471-4159.1995.65062621.x","article-title":"Metabolism of [5-3H]kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway","volume":"65","author":"Guidetti","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib93","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nbd.2004.07.006","article-title":"Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease","volume":"17","author":"Guidetti","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib94","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0304-3940(00)00956-3","article-title":"Early kynurenergic impairment in Huntington's disease and in a transgenic animal model","volume":"283","author":"Guidetti","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib95","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1046\/j.1460-9568.1999.00806.x","article-title":"3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum","volume":"11","author":"Guidetti","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib96","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1046\/j.1471-4159.2001.00498.x","article-title":"Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection","volume":"78","author":"Guillemin","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib97","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1113\/jphysiol.1979.sp012605","article-title":"The excitation of mammalian central neurones by amino acids","volume":"286","author":"Hall","year":"1979","journal-title":"J. Physiol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib98","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejphar.2008.02.052","article-title":"Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant","volume":"586","author":"Hamann","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib99","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.bjp.0701834","article-title":"Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid","volume":"124","author":"Harris","year":"1998","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib100","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s11064-007-9463-1","article-title":"Glutamate uptake is reduced in prefrontal cortex in Huntington's disease","volume":"33","author":"Hassel","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib101","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1042\/bj3200595","article-title":"Human microglia convert l-tryptophan into the neurotoxin quinolinic acid","volume":"320","author":"Heyes","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib102","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj3260351","article-title":"Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types","volume":"326","author":"Heyes","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib103","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/0024-3205(85)90223-1","article-title":"Normal excretion of quinolinic acid in Huntington's disease","volume":"37","author":"Heyes","year":"1985","journal-title":"Life Sci."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib104","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ana.410260215","article-title":"Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome","volume":"26","author":"Heyes","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib105","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1096\/fasebj.6.11.1322853","article-title":"Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain","volume":"6","author":"Heyes","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib106","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/brain\/116.6.1425","article-title":"A mechanism of quinolinic acid formation by brain in inflammatory neurological disease","volume":"116","author":"Heyes","year":"1993","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib107","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0304-3940(91)90874-S","article-title":"Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease","volume":"122","author":"Heyes","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib108","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1523\/JNEUROSCI.21-19-07463.2001","article-title":"The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications","volume":"21","author":"Hilmas","year":"2001","journal-title":"J. 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Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib111","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib112","first-page":"317","article-title":"On chorea","volume":"26","author":"Huntington","year":"1872","journal-title":"Med. Surg. Rep."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib113","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/311458a0","article-title":"Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum","volume":"311","author":"Isacson","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib114","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/j.1471-4159.1982.tb07900.x","article-title":"Cysteine sulfinic acid in the central nervous system: uptake and release of cysteine sulfinic acid by a rat brain preparation","volume":"38","author":"Iwata","year":"1982","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2990.1995.tb01024.x","article-title":"The cortical neuritic pathology of Huntington's disease","volume":"21","author":"Jackson","year":"1995","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib116","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1750-3639.2005.tb00526.x","article-title":"Excitotoxicity in perinatal brain injury","volume":"15","author":"Johnston","year":"2005","journal-title":"Brain Pathol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib117","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0959-4388(94)90098-1","article-title":"Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS","volume":"4","author":"Jonas","year":"1994","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib118","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1474-4422(08)70165-0","article-title":"NMDA receptors in clinical neurology: excitatory times ahead","volume":"7","author":"Kalia","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib119","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/j.1471-4159.1989.tb01881.x","article-title":"A glycine site associated with N-methyl-d-aspartic acid receptors: characterization and identification of a new class of antagonists","volume":"52","author":"Kessler","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib120","first-page":"310","article-title":"Kynurenine pyruvate transaminase and its specific inhibitor in rat intestine","volume":"29","author":"Kido","year":"1975","journal-title":"Acta Vitam. 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Transm."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib123","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1471-4159.2002.00955.x","article-title":"Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the l-kynurenine and quinolinic acid pools in brain","volume":"82","author":"Kita","year":"2002","journal-title":"J. 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Lett."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib126","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF01262727","article-title":"Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice","volume":"42","author":"Lapin","year":"1978","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib127","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s002210100887","article-title":"Immunohistochemical visualization of newly formed quinolinate in the normal and excitotoxically lesioned rat striatum","volume":"141","author":"Lehrmann","year":"2001","journal-title":"Exp. 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Transm."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib158","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00004647-199906000-00001","article-title":"Excitotoxins in neuronal apoptosis and necrosis","volume":"19","author":"Nicotera","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib159","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0959-4388(98)80062-7","article-title":"Molecular mechanisms of glutamate receptor clustering at excitatory synapses","volume":"8","author":"O\u2019Brien","year":"1998","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib160","doi-asserted-by":"crossref","unstructured":"O\u2019Connor, J.C., Lawson, M.A., Andre, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K.W., Dantzer, R., 2008. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol. Psych. (Epub).","DOI":"10.1038\/sj.mp.4002148"},{"key":"10.1016\/j.pneurobio.2009.04.005_bib161","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0003-9861(69)90435-4","article-title":"Solubilization and partial purification of kynurenine hydroxylase from mitochondrial outer membrane and its electron donors","volume":"131","author":"Okamoto","year":"1969","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.pneurobio.2009.04.005_bib162","doi-asserted-by":"crossref","first-page":"12553","DOI":"10.1073\/pnas.93.22.12553","article-title":"Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine","volume":"93","author":"Okuda","year":"1996","journal-title":"Proc. Natl. Acad. Sci. 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