{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:19:11Z","timestamp":1770999551651,"version":"3.50.1"},"reference-count":264,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neurobiology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.pneurobio.2011.04.007","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T11:51:10Z","timestamp":1303213870000},"page":"670-685","source":"Crossref","is-referenced-by-count":44,"title":["Development of biomarkers for multiple sclerosis as a neurodegenerative disorder"],"prefix":"10.1016","volume":"95","author":[{"given":"Ulf","family":"Ziemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Hattingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pneurobio.2011.04.007_bib0005","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1093\/brain\/awl208","article-title":"Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis","volume":"129","author":"Agosta","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tins.2009.12.002","article-title":"Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis","volume":"33","author":"Aktas","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0015","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00415-007-0538-3","article-title":"Optical coherence tomography measures axonal loss in multiple sclerosis independently of optic neuritis","volume":"254","author":"Albrecht","year":"2007","journal-title":"J. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0020","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/sj.jcbfm.9600122","article-title":"Altered functional connectivity related to white matter changes inside the working memory network at the very early stage of MS","volume":"25","author":"Au Duong","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.neuroimage.2004.08.038","article-title":"Modulation of effective connectivity inside the working memory network in patients at the earliest stage of multiple sclerosis","volume":"24","author":"Au Duong","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0030","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/hbm.20083","article-title":"Magnetic resonance study of the influence of tissue damage and cortical reorganization on PASAT performance at the earliest stage of multiple sclerosis","volume":"24","author":"Audoin","year":"2005","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0035","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1177\/1352458508089360","article-title":"Efficiency of cognitive control recruitment in the very early stage of multiple sclerosis: a one-year fMRI follow-up study","volume":"14","author":"Audoin","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0040","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/1522-2594(200010)44:4<583::AID-MRM12>3.0.CO;2-O","article-title":"Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis","volume":"44","author":"Bammer","year":"2000","journal-title":"Magn. Reson. Med."},{"issue":"Pt 11","key":"10.1016\/j.pneurobio.2011.04.007_bib0045","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/brain\/123.11.2321","article-title":"The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity","volume":"123","author":"Banati","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0050","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1001\/archneur.60.8.1073","article-title":"Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance","volume":"60","author":"Barkhof","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrneurol.2009.41","article-title":"Imaging outcomes for neuroprotection and repair in multiple sclerosis trials","volume":"5","author":"Barkhof","year":"2009","journal-title":"Nat. Rev. Neurol."},{"issue":"Pt 11","key":"10.1016\/j.pneurobio.2011.04.007_bib0060","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/brain\/120.11.2059","article-title":"Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis","volume":"120","author":"Barkhof","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1212\/WNL.42.1.63","article-title":"A correlative triad of gadolinium-DTPA MRI EDSS, and CSF-MBP in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone","volume":"42","author":"Barkhof","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0070","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/brain\/124.7.1396","article-title":"T(1) hypointense lesions in secondary progressive multiple sclerosis: effect of interferon beta-1b treatment","volume":"124","author":"Barkhof","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0075","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1098\/rstb.1999.0511","article-title":"Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance","volume":"354","author":"Barkhof","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0080","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ana.20016","article-title":"Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion","volume":"55","author":"Barnett","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jmrb.1996.0086","article-title":"Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI","volume":"111","author":"Basser","year":"1996","journal-title":"J. Magn. Reson. B"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0090","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system\u2014a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0095","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/WNF.0b013e3181880359","article-title":"Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: therapeutic implications","volume":"32","author":"Bennett","year":"2009","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2006.05.070","article-title":"Multiple sclerosis: disease biomarkers as indicated by pathophysiology","volume":"259","author":"Berger","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJMoa022328","article-title":"Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event","volume":"349","author":"Berger","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0110","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2217\/14796708.1.1.57","article-title":"The emergence of antibodies as biomarkers in multiple sclerosis","volume":"1","author":"Berger","year":"2006","journal-title":"Future Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0115","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1212\/01.WNL.0000036566.00866.26","article-title":"Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions","volume":"59","author":"Bergers","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0120","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S1474-4422(06)70349-0","article-title":"The measurement and clinical relevance of brain atrophy in multiple sclerosis","volume":"5","author":"Bermel","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0125","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/brain\/awh176","article-title":"Development of biomarkers in multiple sclerosis","volume":"127","author":"Bielekova","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0130","first-page":"214","article-title":"Current and future treatments for relapsing-remitting multiple sclerosis","volume":"13","author":"Birnbaum","year":"2010","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0135","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ana.1053","article-title":"A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions","volume":"49","author":"Bitsch","year":"2001","journal-title":"Ann. Neurol."},{"issue":"Pt 6","key":"10.1016\/j.pneurobio.2011.04.007_bib0140","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/brain\/123.6.1174","article-title":"Acute axonal injury in multiple sclerosis correlation with demyelination and inflammation","volume":"123","author":"Bitsch","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0145","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/1531-8249(200012)48:6<893::AID-ANA10>3.0.CO;2-B","article-title":"Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients","volume":"48","author":"Bjartmar","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0150","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1212\/01.wnl.0000242885.71725.76","article-title":"fMRI study of episodic memory in relapsing-remitting MS: correlation with T2 lesion volume","volume":"67","author":"Bobholz","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pneurobio.2009.06.004","article-title":"Assessing neuronal networks: understanding Alzheimer's disease","volume":"89","author":"Bokde","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroimage.2008.08.015","article-title":"Structural connectivity influences brain activation during PVSAT in multiple sclerosis","volume":"44","author":"Bonzano","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0165","first-page":"985","article-title":"Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging","volume":"23","author":"Bozzali","year":"2002","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0170","doi-asserted-by":"crossref","first-page":"e11986","DOI":"10.1371\/journal.pone.0011986","article-title":"The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)","volume":"5","author":"Brettschneider","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0175","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jneuroim.2009.07.017","article-title":"Serum anti-GAGA4 IgM antibodies differentiate relapsing remitting and secondary progressive multiple sclerosis from primary progressive multiple sclerosis and other neurological diseases","volume":"217","author":"Brettschneider","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0180","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1191\/135248506ms1263oa","article-title":"Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis","volume":"12","author":"Brettschneider","year":"2006","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0185","doi-asserted-by":"crossref","first-page":"e7638","DOI":"10.1371\/journal.pone.0007638","article-title":"IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome","volume":"4","author":"Brettschneider","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0190","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMoa011341","article-title":"A longitudinal study of abnormalities on MRI and disability from multiple sclerosis","volume":"346","author":"Brex","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0195","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/jnnp.68.5.627","article-title":"Lesion heterogeneity in multiple sclerosis: a study of the relations between appearances on T1 weighted images T1 relaxation times, and metabolite concentrations","volume":"68","author":"Brex","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0200","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/ana.21916","article-title":"Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease","volume":"66","author":"Brilot","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0205","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ana.410420515","article-title":"Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology","volume":"42","author":"Br\u00fcck","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0210","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/brain\/124.3.468","article-title":"Long-term remyelination after optic neuritis: a 2-year visual evoked potential and psychophysical serial study","volume":"124","author":"Brusa","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0215","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S1388-2457(01)00506-5","article-title":"The triple stimulation technique to study central motor conduction to the lower limbs","volume":"112","author":"B\u00fchler","year":"2001","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0220","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrneurol.2010.93","article-title":"Cortical lesions in multiple sclerosis","volume":"6","author":"Calabrese","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0225","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/ana.410370404","article-title":"The adhesion molecule and cytokine profile of multiple sclerosis lesions","volume":"37","author":"Cannella","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0230","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1093\/brain\/awh640","article-title":"1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review","volume":"128","author":"Caramanos","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0235","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jnnp.70.3.311","article-title":"Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis","volume":"70","author":"Cercignani","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0240","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1212\/WNL.54.5.1139","article-title":"Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI","volume":"54","author":"Cercignani","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0245","first-page":"952","article-title":"Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis","volume":"22","author":"Cercignani","year":"2001","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0250","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/archneur.65.9.1218","article-title":"Reproducibility of optical coherence tomography in multiple sclerosis","volume":"65","author":"Cettomai","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0255","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1093\/brain\/awf240","article-title":"Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis","volume":"125","author":"Chard","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0260","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ana.21302","article-title":"Magnetization transfer ratio evolution with demyelination and remyelination in multiple sclerosis lesions","volume":"63","author":"Chen","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0265","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.clinph.2007.10.014","article-title":"The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee","volume":"119","author":"Chen","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0270","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","article-title":"Cognitive impairment in multiple sclerosis","volume":"7","author":"Chiaravalloti","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0275","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1212\/WNL.56.7.926","article-title":"Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations","volume":"56","author":"Ciccarelli","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0280","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ana.410080104","article-title":"A diagnostic index of active demyelination: myelin basic protein in cerebrospinal fluid","volume":"8","author":"Cohen","year":"1980","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0285","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0290","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.20851","article-title":"Quantifying axonal loss after optic neuritis with optical coherence tomography","volume":"59","author":"Costello","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0295","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/1352458508091367","article-title":"Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography","volume":"14","author":"Costello","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0300","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuroimage.2005.08.048","article-title":"Multiple sclerosis patients show a highly significant decrease in alpha band interhemispheric synchronization measured using MEG","volume":"29","author":"Cover","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0305","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/brain\/awh126","article-title":"Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes","volume":"127","author":"Dalton","year":"2004","journal-title":"Brain"},{"issue":"Suppl. 1","key":"10.1016\/j.pneurobio.2011.04.007_bib0310","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1111\/j.1552-6569.2007.00134.x","article-title":"MR spectroscopy in multiple sclerosis","volume":"17","author":"De Stefano","year":"2007","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0315","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1212\/WNL.0b013e3181e24136","article-title":"Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes","volume":"74","author":"De Stefano","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0320","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/brain\/awh118","article-title":"Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts","volume":"127","author":"DeLuca","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0325","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/brain\/awl074","article-title":"The contribution of demyelination to axonal loss in multiple sclerosis","volume":"129","author":"DeLuca","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0330","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/brain\/awn275","article-title":"Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis","volume":"132","author":"Dineen","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0335","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ana.410370111","article-title":"Circulating, soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: correlation with clinical activity","volume":"37","author":"Dore-Duffy","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0340","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0730-725X(99)00011-9","article-title":"Comparison of multiple sclerosis clinical subgroups using navigated spin echo diffusion-weighted imaging","volume":"17","author":"Droogan","year":"1999","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0345","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.it.2005.07.004","article-title":"The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms","volume":"26","author":"Engelhardt","year":"2005","journal-title":"Trends Immunol."},{"issue":"Pt 3","key":"10.1016\/j.pneurobio.2011.04.007_bib0350","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/brain\/120.3.393","article-title":"Axonal damage in acute multiple sclerosis lesions","volume":"120","author":"Ferguson","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0355","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/awh153","article-title":"Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis","volume":"127","author":"Fernando","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0360","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1034\/j.1600-0404.2002.1o369.x","article-title":"A transcranial magnetic stimulation study evaluating methylprednisolone treatment in multiple sclerosis","volume":"105","author":"Fierro","year":"2002","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0365","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1212\/WNL.56.3.304","article-title":"Diffusion tensor magnetic resonance imaging in multiple sclerosis","volume":"56","author":"Filippi","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0370","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/ana.410430616","article-title":"Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis","volume":"43","author":"Filippi","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0375","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hbm.10160","article-title":"Simple and complex movement-associated functional MRI changes in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis","volume":"21","author":"Filippi","year":"2004","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0380","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0730-725X(99)00049-1","article-title":"Short-term evolution of individual enhancing MS lesions studied with magnetization transfer imaging","volume":"17","author":"Filippi","year":"1999","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0385","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S0140-6736(04)17271-1","article-title":"Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial","volume":"364","author":"Filippi","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0390","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1212\/WNL.57.4.731","article-title":"Glatiramer acetate reduces the proportion of new MS lesions evolving into \u201cblack holes\u201d","volume":"57","author":"Filippi","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0395","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ana.21436","article-title":"Gray matter atrophy in multiple sclerosis: a longitudinal study","volume":"64","author":"Fisher","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0400","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1212\/01.WNL.0000036271.49066.06","article-title":"Eight-year follow-up study of brain atrophy in patients with MS","volume":"59","author":"Fisher","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0405","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/01.STR.0000138730.03264.ac","article-title":"Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion","volume":"35","author":"Foerch","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0410","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/hbm.20284","article-title":"Compensatory activations in patients with multiple sclerosis during preserved performance on the auditory N-back task","volume":"28","author":"Forn","year":"2007","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0415","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S1474-4422(08)70192-3","article-title":"B cells and multiple sclerosis","volume":"7","author":"Franciotta","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0420","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1001\/archneur.62.6.865","article-title":"Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement","volume":"62","author":"Freedman","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0425","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awp070","article-title":"The relation between inflammation and neurodegeneration in multiple sclerosis brains","author":"Frischer","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0430","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/hbm.460010108","article-title":"Time-dependent changes in effective connectivity measured with PET","volume":"1","author":"Friston","year":"1993","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0435","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/jcbfm.1993.4","article-title":"Functional connectivity: the principal-component analysis of large (PET) data sets","volume":"13","author":"Friston","year":"1993","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0440","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrneurol.2010.13","article-title":"Multiple sclerosis: can retinal imaging accurately detect optic neuritis?","volume":"6s","author":"Frohman","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0445","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1474-4422(05)00992-0","article-title":"The neuro-ophthalmology of multiple sclerosis","volume":"4","author":"Frohman","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0450","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/ncpneuro0950","article-title":"Optical coherence tomography: a window into the mechanisms of multiple sclerosis","volume":"4","author":"Frohman","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0455","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1093\/brain\/124.11.2162","article-title":"Visual and motor evoked potentials in the course of multiple sclerosis","volume":"124","author":"Fuhr","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0460","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1177\/1352458508093617","article-title":"Magnetic resonance imaging measures of brain and spinal cord atrophy correlate with clinical impairment in secondary progressive multiple sclerosis","volume":"14","author":"Furby","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmri.20083","article-title":"Preferential occult injury of corpus callosum in multiple sclerosis measured by diffusion tensor imaging","volume":"20","author":"Ge","year":"2004","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0470","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1177\/1352458510377333","article-title":"Cortical functional reorganization and its relationship with brain structural damage in patients with benign multiple sclerosis","volume":"16","author":"Giorgio","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0475","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1155\/2006\/509476","article-title":"Multiple sclerosis cerebrospinal fluid biomarkers","volume":"22","author":"Giovannoni","year":"2006","journal-title":"Dis. Markers"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0480","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/01.wnl.0000295995.46586.ae","article-title":"Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis","volume":"69","author":"Gordon-Lipkin","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0485","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jns.2007.10.020","article-title":"Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis","volume":"268","author":"Grazioli","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0490","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1067\/mcp.2001.113989","article-title":"Biomarkers and surrogate endpoints: preferred definitions and conceptual framework","volume":"69","author":"Group","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0495","article-title":"Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab","author":"Gunnarsson","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0500","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.0105-2896.2005.00240.x","article-title":"Multiple sclerosis","volume":"204","author":"Hafler","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0505","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0140-6736(72)91155-5","article-title":"Delayed visual evoked response in optic neuritis","volume":"1","author":"Halliday","year":"1972","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.pneurobio.2011.04.007_bib0510","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.pneurobio.2010.11.005","article-title":"Biomarkers for Alzheimer's disease therapeutic trials","volume":"95","author":"Hampel","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0515","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1212\/01.WNL.0000149516.30155.B8","article-title":"Rate of brain atrophy in relapsing MS decreases during treatment with IFNbeta-1a","volume":"64","author":"Hardmeier","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0520","article-title":"Combined (1)H and (31)P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis","author":"Hattingen","year":"2010","journal-title":"NMR Biomed."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0525","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fnhum.2010.00219","article-title":"Functional brain network changes associated with maintenance of cognitive function in multiple sclerosis","volume":"4","author":"Helekar","year":"2010","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0530","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.expneurol.2009.11.019","article-title":"Neurodegeneration in autoimmune CNS inflammation","volume":"225","author":"Herz","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0535","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/ana.410220611","article-title":"Magnetic brain stimulation: central motor conduction studies in multiple sclerosis","volume":"22","author":"Hess","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0540","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1191\/1352458502ms809oa","article-title":"Continuing optic nerve atrophy following optic neuritis: a serial MRI study","volume":"8","author":"Hickman","year":"2002","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0545","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/mrm.1910360310","article-title":"Apparent diffusion coefficients in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance","volume":"36","author":"Horsfield","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0550","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0555","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/S1388-2457(03)00231-1","article-title":"Central motor conduction differs between acute relapsing-remitting and chronic progressive multiple sclerosis","volume":"114","author":"Humm","year":"2003","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0560","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/jnnp.2005.065284","article-title":"Quantification of central motor conduction deficits in multiple sclerosis patients before and after treatment of acute exacerbation by methylprednisolone","volume":"77","author":"Humm","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0565","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/mrm.10481","article-title":"Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis","volume":"50","author":"Inglese","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0570","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/1352458507085758","article-title":"Multimodal evoked potentials measure and predict disability progression in early relapsing-remitting multiple sclerosis","volume":"14","author":"Jung","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0575","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1191\/135248506ms1244oa","article-title":"Early abnormalities of evoked potentials and future disability in patients with multiple sclerosis","volume":"12","author":"Kallmann","year":"2006","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0580","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1191\/1352458502ms822oa","article-title":"Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis","volume":"8","author":"Kapeller","year":"2002","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0585","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2174\/187152709789824598","article-title":"Disease-modifying agents in the treatment of multiple sclerosis: a review of long-term outcomes","volume":"8","author":"Katrych","year":"2009","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0590","article-title":"Corpus callosal diffusivity predicts motor impairment in relapsing-remitting multiple sclerosis: a TBSS and tractography study","author":"Kern","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0595","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/brain\/122.1.17","article-title":"Cortical lesions in multiple sclerosis","volume":"122","author":"Kidd","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0600","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1468-1331.2010.03154.x","article-title":"Positron emission tomography imaging in multiple sclerosis-current status and future applications","volume":"18","author":"Kiferle","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0605","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1136\/jnnp.2009.176263","article-title":"MR spectroscopy indicates diffuse multiple sclerosis activity during remission","volume":"80","author":"Kirov","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0610","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0404.1983.tb04547.x","article-title":"Evoked potentials. With special reference to the diagnostic value in multiple sclerosis","volume":"67","author":"Kjaer","year":"1983","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0615","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ana.21474","article-title":"Axonal loss and myelin in early ON loss in postacute optic neuritis","volume":"64","author":"Klistorner","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0620","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroimage.2011.02.041","article-title":"Magnetisation transfer ratio in optic neuritis is associated with axonal loss, but not with demyelination","volume":"56","author":"Klistorner","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0625","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1474-4422(10)70064-8","article-title":"The changing demographic pattern of multiple sclerosis epidemiology","volume":"9","author":"Koch-Henriksen","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0630","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/brain\/awh680","article-title":"Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment","volume":"129","author":"Krumbholz","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0635","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1056\/NEJMoa063602","article-title":"Lack of association between antimyelin antibodies and progression to multiple sclerosis","volume":"356","author":"Kuhle","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0640","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/brain\/awf235","article-title":"Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time","volume":"125","author":"Kuhlmann","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0645","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/brain\/awh641","article-title":"Cortical demyelination and diffuse white matter injury in multiple sclerosis","volume":"128","author":"Kutzelnigg","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0650","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/135245859800400306","article-title":"Myelin basic protein in CSF as indicator of disease activity in multiple sclerosis","volume":"4","author":"Lamers","year":"1998","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0655","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-0404.1995.tb01696.x","article-title":"Cerebrospinal neuron-specific enolase S-100 and myelin basic protein in neurological disorders","volume":"92","author":"Lamers","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0660","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/1352458509359782","article-title":"Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients","volume":"16","author":"Laron","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0665","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.expneurol.2009.10.009","article-title":"Axonal and neuronal pathology in multiple sclerosis: what have we learnt from animal models","volume":"225","author":"Lassmann","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0670","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrn1119","article-title":"Looking into the functional architecture of the brain with diffusion MRI","volume":"4","author":"Le Bihan","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0675","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jmri.1076","article-title":"Diffusion tensor imaging: concepts and applications","volume":"13","author":"Le Bihan","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0680","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1212\/WNL.60.1.44","article-title":"Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial","volume":"60","author":"Leary","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0685","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1001\/archneurol.2009.119","article-title":"Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients","volume":"66","author":"Lebrun","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0690","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-5728(99)00084-3","article-title":"Adhesion molecule expression and regulation on cells of the central nervous system","volume":"98","author":"Lee","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0695","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1136\/jnnp.2005.086280","article-title":"Multimodal evoked potentials to assess the evolution of multiple sclerosis: a longitudinal study","volume":"77","author":"Leocani","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 12","key":"10.1016\/j.pneurobio.2011.04.007_bib0700","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1093\/brain\/121.12.2327","article-title":"Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis","volume":"121","author":"Leppert","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0705","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jns.2005.04.019","article-title":"\u2019Importance sampling\u2019 in MS: use of diffusion tensor tractography to quantify pathology related to specific impairment","volume":"237","author":"Lin","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0710","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1136\/jnnp.74.8.1090","article-title":"Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial","volume":"74","author":"Lin","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0715","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1191\/135245898678909141","article-title":"The cytokine storm in multiple sclerosis","volume":"4","author":"Link","year":"1998","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0720","doi-asserted-by":"crossref","first-page":"10273","DOI":"10.1073\/pnas.0503178102","article-title":"An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis","volume":"102","author":"Lolli","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0725","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nrd2358","article-title":"Novel therapeutic strategies for multiple sclerosis\u2014a multifaceted adversary","volume":"7","author":"Lopez-Diego","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"issue":"Pt 3","key":"10.1016\/j.pneurobio.2011.04.007_bib0730","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/brain\/119.3.701","article-title":"Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression","volume":"119","author":"Losseff","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0735","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/hbm.20576","article-title":"Resting state sensorimotor functional connectivity in multiple sclerosis inversely correlates with transcallosal motor pathway transverse diffusivity","volume":"29","author":"Lowe","year":"2008","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0740","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1136\/jnnp.64.3.402","article-title":"Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis","volume":"64","author":"Lycke","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 4","key":"10.1016\/j.pneurobio.2011.04.007_bib0745","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/brain\/121.4.687","article-title":"Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms","volume":"121","author":"Lycklama a Nijeholt","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0750","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/brain\/122.2.265","article-title":"A clinical study of motor evoked potentials using a triple stimulation technique","volume":"122","author":"Magistris","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0755","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/brain\/121.3.437","article-title":"Transcranial stimulation excites virtually all motor neurons supplying the target muscle. A demonstration and a method improving the study of motor evoked potentials","volume":"121","author":"Magistris","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0760","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neuroimage.2003.10.004","article-title":"fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis","volume":"21","author":"Mainero","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0765","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1212\/01.WNL.0000098880.19793.B6","article-title":"Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS","volume":"61","author":"Malmestr\u00f6m","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0770","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2174\/157488710792007275","article-title":"Emerging therapies in relapsing-remitting multiple sclerosis","volume":"5","author":"Marriott","year":"2010","journal-title":"Rev. Recent Clin. Trials"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0775","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/135245859900500206","article-title":"Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis","volume":"5","author":"Matusevicius","year":"1999","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0780","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis","volume":"50","author":"McDonald","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0785","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ni1507","article-title":"Multiple sclerosis: a complicated picture of autoimmunity","volume":"8","author":"McFarland","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0790","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ana.20890","article-title":"B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation","volume":"59","author":"Meinl","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0795","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jaci.2005.03.023","article-title":"Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis","volume":"116","author":"Menge","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0800","article-title":"Natalizumab restores evoked potential abnormalities in patients with relapsing-remitting multiple sclerosis","author":"Meuth","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0805","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/brain\/awf177","article-title":"Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance","volume":"125","author":"Miller","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0810","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1212\/01.wnl.0000260064.77700.fd","article-title":"MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS","volume":"68","author":"Miller","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0815","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1136\/jnnp.2007.124123","article-title":"Predicting short-term disability progression in early multiple sclerosis: added value of MRI parameters","volume":"79","author":"Minneboo","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0820","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ana.410430311","article-title":"Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis","volume":"43","author":"Molyneux","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0825","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-5728(97)00148-3","article-title":"Cytokine mRNA expression in CSF and peripheral blood mononuclear cells in multiple sclerosis: detection by RT-PCR without in vitro stimulation","volume":"80","author":"Monteyne","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0830","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1212\/WNL.55.10.1506","article-title":"A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain","volume":"55","author":"Moore","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0835","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/npp.2010.187","article-title":"Cognitive and cortical plasticity deficits correlate with altered amyloid-beta CSF levels in multiple sclerosis","volume":"36","author":"Mori","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0840","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1148\/radiology.176.2.2367658","article-title":"Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system","volume":"176","author":"Moseley","year":"1990","journal-title":"Radiology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0845","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1007\/s00330-008-0925-x","article-title":"Reproducibility over a 1-month period of 1H-MR spectroscopic imaging NAA\/Cr ratios in clinically stable multiple sclerosis patients","volume":"18","author":"Mostert","year":"2008","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0850","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1212\/WNL.0b013e3181aaea32","article-title":"Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis","volume":"73","author":"Naismith","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0855","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12028-007-9019-x","article-title":"S100 as a marker of acute brain ischemia: a systematic review","volume":"8","author":"Nash","year":"2008","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0860","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1074-7613(01)00118-2","article-title":"Chemokines, chemokine receptors, and allograft rejection","volume":"14","author":"Nelson","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0865","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1212\/WNL.54.7.1421","article-title":"Whole-brain diffusion MR histograms differ between MS subtypes","volume":"54","author":"Nusbaum","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0870","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/ana.410440320","article-title":"Evoked potential abnormality scores are a useful measure of disease burden in relapsing-remitting multiple sclerosis","volume":"44","author":"O\u2019Connor","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0875","article-title":"Translocator protein PET imaging for glial activation in multiple sclerosis","author":"Oh","year":"2010","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0880","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1001\/archneur.63.5.736","article-title":"Magnetization transfer magnetic resonance imaging and clinical changes in patients with relapsing-remitting multiple sclerosis","volume":"63","author":"Oreja-Guevara","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0885","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archneur.62.4.578","article-title":"Progressive gray matter damage in patients with relapsing-remitting multiple sclerosis: a longitudinal diffusion tensor magnetic resonance imaging study","volume":"62","author":"Oreja-Guevara","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0890","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neuroimage.2005.01.008","article-title":"A method for obtaining tract-specific diffusion tensor MRI measurements in the presence of disease: application to patients with clinically isolated syndromes suggestive of multiple sclerosis","volume":"26","author":"Pagani","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0895","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases","volume":"443","author":"Palop","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0900","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/brain\/awf164","article-title":"Cortical motor reorganization after a single clinical attack of multiple sclerosis","volume":"125","author":"Pantano","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0905","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1093\/brain\/awg284","article-title":"Potentially adaptive functional changes in cognitive processing for patients with multiple sclerosis and their acute modulation by rivastigmine","volume":"126","author":"Parry","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0910","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/1352458508096684","article-title":"Cognitive impairment in multiple sclerosis","volume":"15","author":"Patti","year":"2009","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0915","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd3078","article-title":"How to improve R&D productivity: the pharmaceutical industry's grand challenge","volume":"9","author":"Paul","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0920","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1056\/NEJMc062467","article-title":"Antimyelin antibodies with no progression to multiple sclerosis","volume":"356","author":"Pelayo","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0925","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1111\/j.1552-6569.2004.tb00274.x","article-title":"Measurement of whole-brain atrophy in multiple sclerosis","volume":"14","author":"Pelletier","year":"2004","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0930","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00415-003-1025-0","article-title":"Analysis of impairment related functional architecture in MS patients during performance of different attention tasks","volume":"250","author":"Penner","year":"2003","journal-title":"J. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0935","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/jnnp.2005.086116","article-title":"Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis","volume":"77","author":"Perini","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0940","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ana.1123","article-title":"Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions","volume":"50","author":"Peterson","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0945","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S1474-4422(10)70168-X","article-title":"Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis","volume":"9","author":"Petzold","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0950","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/brain\/awf165","article-title":"Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations","volume":"125","author":"Petzold","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0955","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiology.201.3.8939209","article-title":"Diffusion tensor MR imaging of the human brain","volume":"201","author":"Pierpaoli","year":"1996","journal-title":"Radiology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0960","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0965","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20703","article-title":"Diagnostic criteria for multiple sclerosis: 2005 revisions to the \u201cMcDonald Criteria\u201d","volume":"58","author":"Polman","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0970","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/archneur.64.8.1163","article-title":"Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study","volume":"64","author":"Pulizzi","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0975","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1191\/1352458503ms938oa","article-title":"MRI\/MRS of corpus callosum in patients with clinically isolated syndrome suggestive of multiple sclerosis","volume":"9","author":"Ranjeva","year":"2003","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0980","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jnnp.2005.068338","article-title":"Increasing cord atrophy in early relapsing-remitting multiple sclerosis: a 3 year study","volume":"77","author":"Rashid","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0985","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1212\/WNL.42.7.1296","article-title":"The diagnostic reliability of magnetically evoked motor potentials in multiple sclerosis","volume":"42","author":"Ravnborg","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0990","first-page":"99","article-title":"Cerebrospinal fluid--physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases","volume":"4","author":"Reiber","year":"1998","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib0995","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/ana.410410307","article-title":"Soluble adhesion molecules (sVCAM-1 and sICAM-1) in cerebrospinal fluid and serum correlate with MRI activity in multiple sclerosis","volume":"41","author":"Rieckmann","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1000","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0165-5728(93)90023-R","article-title":"Soluble intercellular adhesion molecule-1 in cerebrospinal fluid: an indicator for the inflammatory impairment of the blood-cerebrospinal fluid barrier","volume":"47","author":"Rieckmann","year":"1993","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1005","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S1474-4422(05)70171-X","article-title":"Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes","volume":"4","author":"Rocca","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1010","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S1053-8119(03)00043-0","article-title":"Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis","volume":"18","author":"Rocca","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1015","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1212\/01.wnl.0000295504.92020.ca","article-title":"Altered functional and structural connectivities in patients with MS: a 3-T study","volume":"69","author":"Rocca","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1020","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1212\/WNL.0b013e3181d9ed91","article-title":"Default-mode network dysfunction and cognitive impairment in progressive MS","volume":"74","author":"Rocca","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1025","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1177\/1073858402238517","article-title":"Matrix metalloproteinases and neuroinflammation in multiple sclerosis","volume":"8","author":"Rosenberg","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1030","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1093\/brain\/awg232","article-title":"Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study","volume":"126","author":"Rovaris","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1035","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1093\/brain\/124.12.2540","article-title":"In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis","volume":"124","author":"Rovaris","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1040","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.neuroimage.2004.10.006","article-title":"Short-term accrual of gray matter pathology in patients with progressive multiple sclerosis: an in vivo study using diffusion tensor MRI","volume":"24","author":"Rovaris","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0022-510X(01)00690-6","article-title":"Cognitive dysfunction in patients with mildly disabling relapsing-remitting multiple sclerosis: an exploratory study with diffusion tensor MR imaging","volume":"195","author":"Rovaris","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000008055","article-title":"Reproducibility of brain MRI lesion volume measurements in multiple sclerosis using a local thresholding technique: effects of formal operator training","volume":"41","author":"Rovaris","year":"1999","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1055","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1212\/WNL.53.8.1698","article-title":"Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group","volume":"53","author":"Rudick","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1060","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S1474-4422(09)70082-1","article-title":"Current approaches to the identification and management of breakthrough disease in patients with multiple sclerosis","volume":"8","author":"Rudick","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0404.2009.01221.x","article-title":"Black holes in multiple sclerosis: definition, evolution, and clinical correlations","volume":"122","author":"Sahraian","year":"2010","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1070","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0022-510X(92)90049-Q","article-title":"Improvement in motor evoked potentials and clinical course post-steroid therapy in multiple sclerosis","volume":"108","author":"Salle","year":"1992","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1075","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1212\/WNL.59.8.1218","article-title":"Correlates of disability in multiple sclerosis detected by transcranial magnetic stimulation","volume":"59","author":"Schmierer","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1080","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ana.20202","article-title":"Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain","volume":"56","author":"Schmierer","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1085","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1468-1331.2007.01871.x","article-title":"Intrathecal IgM-synthesis does not correlate with the risk of relapse in patients with a primary demyelinating event","volume":"14","author":"Schneider","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jns.2005.12.006","article-title":"Serum anti-Glc(alpha1,4)Glc(alpha) antibodies as a biomarker for relapsing-remitting multiple sclerosis","volume":"244","author":"Schwarz","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1095","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1212\/WNL.0b013e3181c5b457","article-title":"Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS","volume":"73","author":"Sellebjerg","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1100","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/135245859800400603","article-title":"Cerebrospinal fluid measures of disease activity in patients with multiple sclerosis","volume":"4","author":"Sellebjerg","year":"1998","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0361-9230(03)00097-2","article-title":"Chemokines and matrix metalloproteinase-9 in leukocyte recruitment to the central nervous system","volume":"61","author":"Sellebjerg","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0165-5728(01)00455-6","article-title":"Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability","volume":"122","author":"Semra","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1115","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1212\/01.wnl.0000260612.51849.ed","article-title":"Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS","volume":"68","author":"Sepulcre","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1120","doi-asserted-by":"crossref","first-page":"e13877","DOI":"10.1371\/journal.pone.0013877","article-title":"Heterogeneous pattern of retinal nerve fiber layer in multiple sclerosis. High resolution optical coherence tomography: potential and limitations","volume":"5","author":"Serbecic","year":"2010","journal-title":"PLoS ONE"},{"issue":"Pt 1A","key":"10.1016\/j.pneurobio.2011.04.007_bib1125","first-page":"181","article-title":"Intrathecal immunoglobulin M synthesis in multiple sclerosis Relationship with clinical and cerebrospinal fluid parameters","volume":"114","author":"Sharief","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00887815","article-title":"Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission","volume":"242","author":"Shaw","year":"1995","journal-title":"J. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1135","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00415-008-0985-5","article-title":"Optical coherence tomography in multiple sclerosis: thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy","volume":"255","author":"Siger","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1140","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1212\/WNL.55.2.185","article-title":"A longitudinal study of T1 hypointense lesions in relapsing MS: MSCRG trial of interferon beta-1a. Multiple Sclerosis Collaborative Research Group","volume":"55","author":"Simon","year":"2000","journal-title":"Neurology"},{"issue":"49\u201365","key":"10.1016\/j.pneurobio.2011.04.007_bib1145","first-page":"111","article-title":"Neuronal synchrony: a versatile code for the definition of relations?","volume":"24","author":"Singer","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1150","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1212\/01.WNL.0000120663.85143.B3","article-title":"Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis","volume":"62","author":"Sormani","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12017-009-8109-7","article-title":"Functional alterations in memory networks in early Alzheimer's disease","volume":"12","author":"Sperling","year":"2010","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1160","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/brain\/awf125","article-title":"Cognitive function and fMRI in patients with multiple sclerosis: evidence for compensatory cortical activation during an attention task","volume":"125","author":"Staffen","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1165","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1212\/01.wnl.0000327341.89587.76","article-title":"Immunologic, clinical, and radiologic status 14 months after cessation of natalizumab therapy","volume":"72","author":"St\u00fcve","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1170","first-page":"148","article-title":"1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS","volume":"6","author":"Suhy","year":"2000","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1175","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/1352458510371640","article-title":"Reproducibility of high-resolution optical coherence tomography in multiple sclerosis","volume":"16","author":"Syc","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1180","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1474-4422(04)00964-0","article-title":"Biological markers in CSF and blood for axonal degeneration in multiple sclerosis","volume":"4","author":"Teunissen","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1185","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1212\/WNL.0b013e3181c47cc2","article-title":"A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking","volume":"73","author":"Teunissen","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1190","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/WNP.0b013e3181eaa9e3","article-title":"Improving test\u2013retest variability of visual-evoked responses in multiple sclerosis: implications for trial design","volume":"27","author":"Thomae","year":"2010","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1195","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1212\/01.WNL.0000154526.22878.30","article-title":"Gray and white matter volume changes in early RRMS: a 2-year longitudinal study","volume":"64","author":"Tiberio","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1200","first-page":"702","article-title":"Isolated demyelinating syndromes: comparison of different MR imaging criteria to predict conversion to clinically definite multiple sclerosis","volume":"21","author":"Tintore","year":"2000","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1205","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1212\/01.wnl.0000280576.73609.c6","article-title":"Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?","volume":"70","author":"Tintore","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1210","first-page":"211","article-title":"Clinicopathological study of the visual pathways, eyes, and cerebral hemispheres in 32 cases of disseminated sclerosis","volume":"3","author":"Toussaint","year":"1983","journal-title":"J. Clin. Neuroophthalmol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1215","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.neuro.30.051606.094313","article-title":"Multiple sclerosis: an immune or neurodegenerative disorder?","volume":"31","author":"Trapp","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1220","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM199801293380502","article-title":"Axonal transection in the lesions of multiple sclerosis","volume":"338","author":"Trapp","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1225","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.20575","article-title":"Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis","volume":"58","author":"Trip","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1230","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nbd.2009.04.010","article-title":"Cerebrospinal fluid biomarkers in multiple sclerosis","volume":"35","author":"Tumani","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1235","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0022-510X(97)00272-4","article-title":"Acute optic neuritis: combined immunological markers and magnetic resonance imaging predict subsequent development of multiple sclerosis. The Optic Neuritis Study group","volume":"155","author":"Tumani","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1240","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuron.2006.09.020","article-title":"Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology","volume":"52","author":"Uhlhaas","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1245","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1177\/1352458510364630","article-title":"Lesional magnetization transfer ratio: a feasible outcome for remyelinating treatment trials in multiple sclerosis","volume":"16","author":"van den Elskamp","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1250","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1212\/WNL.50.5.1282","article-title":"Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis","volume":"50","author":"van Walderveen","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1255","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1352458507082046","article-title":"Influence of oligoclonal IgM specificity in multiple sclerosis disease course","volume":"14","author":"Villar","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1260","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ana.10441","article-title":"Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis","volume":"53","author":"Villar","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1265","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/jmri.20564","article-title":"Altered diffusion tensor in multiple sclerosis normal-appearing brain tissue: cortical diffusion changes seem related to clinical deterioration","volume":"23","author":"Vrenken","year":"2006","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1270","doi-asserted-by":"crossref","unstructured":"Wahl, M., H\u00fcbers, A., Lauterbach-Soon, B., Hattingen, E., Jung, P., Cohen, L.G., Ziemann, U., 2011. Motor callosal disconnection in early relapsing-remitting multiple sclerosis. Hum. Brain Mapp., doi:10.1002\/hbm.21071, in press.","DOI":"10.1002\/hbm.21071"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1275","series-title":"The Oxford Handbook of Transcranial Stimulation","author":"Wassermann","year":"2008"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1280","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3174\/ajnr.A0594","article-title":"Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy","volume":"28","author":"Wattjes","year":"2007","journal-title":"Am. J. Neuroradiol."},{"issue":"Pt 8","key":"10.1016\/j.pneurobio.2011.04.007_bib1285","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/brain\/123.8.1667","article-title":"The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: a serial diffusion MRI study","volume":"123","author":"Werring","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1290","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1212\/WNL.52.8.1626","article-title":"Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis","volume":"52","author":"Werring","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1295","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ana.410330104","article-title":"Correlation of myelin basic protein-like material in cerebrospinal fluid of multiple sclerosis patients with their response to glucocorticoid treatment","volume":"33","author":"Whitaker","year":"1993","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1300","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/jnnp.74.2.203","article-title":"Pyramidal tract mapping by diffusion tensor magnetic resonance imaging in multiple sclerosis: improving correlations with disability","volume":"74","author":"Wilson","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1305","doi-asserted-by":"crossref","first-page":"19057","DOI":"10.1073\/pnas.0607242103","article-title":"Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1310","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/1352458506070446","article-title":"Interferon beta-1a slows progression of brain atrophy in relapsing-remitting multiple sclerosis predominantly by reducing gray matter atrophy","volume":"13","author":"Zivadinov","year":"2007","journal-title":"Mult. Scler."},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1315","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1212\/01.wnl.0000316810.01120.05","article-title":"Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis","volume":"71","author":"Zivadinov","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2011.04.007_bib1320","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ncpneuro0832","article-title":"The role of regulatory T cells in multiple sclerosis","volume":"4","author":"Zozulya","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."}],"container-title":["Progress in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030100821100058X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030100821100058X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T04:31:57Z","timestamp":1560141117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030100821100058X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":264,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S030100821100058X"],"URL":"https:\/\/doi.org\/10.1016\/j.pneurobio.2011.04.007","relation":{},"ISSN":["0301-0082"],"issn-type":[{"value":"0301-0082","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}