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Res."},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib0585","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.neuroscience.2010.07.039","article-title":"Mechanisms of l-DOPA-induced cytotoxicity in rat adrenal pheochromocytoma cells: implication of oxidative stress-related kinases and cyclic AMP","volume":"170","author":"Jin","year":"2010","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.pneurobio.2011.06.005_bib0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2005.01.014","article-title":"Use of TH-EGFP transgenic mice as a source of identified dopaminergic neurons for physiological studies in postnatal cell culture","volume":"146","author":"Jomphe","year":"2005","journal-title":"J. Neurosci. 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Neurochem."},{"issue":"1","key":"10.1016\/j.pneurobio.2011.06.005_bib0820","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/exnr.2002.8050","article-title":"Altered proteasomal function in sporadic Parkinson's disease","volume":"179","author":"McNaught","year":"2003","journal-title":"Exp. Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.pneurobio.2011.06.005_bib0825","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1002\/ana.410440722","article-title":"Levodopa toxicity and apoptosis","volume":"44","author":"Melamed","year":"1998","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.pneurobio.2011.06.005_bib0830","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/mds.870070105","article-title":"Neurotoxicity of levodopa on catecholamine-rich neurons","volume":"7","author":"Mena","year":"1992","journal-title":"Mov. 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Neurochem."},{"issue":"4","key":"10.1016\/j.pneurobio.2011.06.005_bib0900","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1046\/j.1471-4159.1999.721516.x","article-title":"Role of high-affinity dopamine uptake and impulse activity in the appearance of extracellular dopamine in striatum after administration of exogenous l-DOPA: studies in intact and 6-hydroxydopamine-treated rats","volume":"72","author":"Miller","year":"1999","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.pneurobio.2011.06.005_bib0905","first-page":"141","article-title":"Dopaminergic neuron-specific oxidative stress caused by dopamine itself","volume":"62","author":"Miyazaki","year":"2008","journal-title":"Acta Med. 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Disord."},{"issue":"Suppl. 7","key":"10.1016\/j.pneurobio.2011.06.005_bib0925","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1002\/mds.10581","article-title":"How valid is dopamine transporter imaging as a surrogate marker in research trials in Parkinson's disease?","volume":"18","author":"Morrish","year":"2003","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib0930","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuron.2009.01.033","article-title":"Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons","volume":"62","author":"Mosharov","year":"2009","journal-title":"Neuron"},{"issue":"617472","key":"10.1016\/j.pneurobio.2011.06.005_bib0935","first-page":"1","article-title":"Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection","volume":"2011","author":"Mounsey","year":"2010","journal-title":"Parkinsons Dis."},{"issue":"5","key":"10.1016\/j.pneurobio.2011.06.005_bib0940","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ana.410430504","article-title":"Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions","volume":"43","author":"Murer","year":"1998","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.pneurobio.2011.06.005_bib0945","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2165\/00002018-199921050-00001","article-title":"Levodopa in Parkinson's disease","volume":"21","author":"Murer","year":"1999","journal-title":"Drug Saf."},{"issue":"4","key":"10.1016\/j.pneurobio.2011.06.005_bib0950","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/j.1471-4159.1993.tb13642.x","article-title":"Toxic and protective effects of l-dopa on mesencephalic cell cultures","volume":"61","author":"Mytilineou","year":"1993","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib0955","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1124\/jpet.102.042267","article-title":"Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress","volume":"304","author":"Mytilineou","year":"2003","journal-title":"J. Pharmacol. Exp. 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J."},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib0965","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0006-8993(95)01325-3","article-title":"Dopamine-derived endogenous 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies","volume":"709","author":"Naoi","year":"1996","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.pneurobio.2011.06.005_bib1475","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0892-0362(02)00211-8","article-title":"Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease","volume":"24","author":"Naoi","year":"2002","journal-title":"Neurotoxicol. Teratol."},{"issue":"11","key":"10.1016\/j.pneurobio.2011.06.005_bib0970","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1021\/tx990079p","article-title":"New reaction pathways of dopamine under oxidative stress conditions: nonenzymatic iron-assisted conversion to norepinephrine and the neurotoxins 6-hydroxydopamine and 6,7-dihydroxytetrahydroisoquinoline","volume":"12","author":"Napolitano","year":"1999","journal-title":"Chem. Res. 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Neurochem."},{"issue":"4","key":"10.1016\/j.pneurobio.2011.06.005_bib0985","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1046\/j.1471-4159.1995.64041742.x","article-title":"Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin","volume":"64","author":"Newcomer","year":"1995","journal-title":"J. Neurochem."},{"issue":"11","key":"10.1016\/j.pneurobio.2011.06.005_bib0990","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.bbabio.2009.03.010","article-title":"Mitochondrial calcium function and dysfunction in the central nervous system","volume":"1787","author":"Nicholls","year":"2009","journal-title":"Biochim. Biophys. 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Suppl."},{"issue":"4","key":"10.1016\/j.pneurobio.2011.06.005_bib1135","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0306-4522(97)00347-3","article-title":"Differential compartmentalization of brain ascorbate and glutathione between neurons and glia","volume":"82","author":"Rice","year":"1998","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib1140","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1471-4159.1989.tb09150.x","article-title":"Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains","volume":"52","author":"Riederer","year":"1989","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib1145","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/mds.870120204","article-title":"The effects of chronic levodopa treatment on pre- and postsynaptic markers of dopaminergic function in striatum of parkinsonian monkeys","volume":"12","author":"Rioux","year":"1997","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.pneurobio.2011.06.005_bib1150","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1460-9568.2004.03591.x","article-title":"Chronic l-DOPA treatment increases extracellular glutamate levels and GLT1 expression in the basal ganglia in a rat model of Parkinson's disease","volume":"20","author":"Robelet","year":"2004","journal-title":"Eur. J. 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Sci."},{"issue":"12","key":"10.1016\/j.pneurobio.2011.06.005_bib1170","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1021\/bi9018658","article-title":"Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease","volume":"49","author":"Sabens","year":"2010","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib1175","first-page":"169","article-title":"Functional and structural consequences of long-term dietary l-dopa treatment in mice","volume":"4","author":"Sahakian","year":"1980","journal-title":"Commun. 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Disord."},{"issue":"3","key":"10.1016\/j.pneurobio.2011.06.005_bib1190","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ncl.2009.04.004","article-title":"Etiology and pathogenesis of Parkinson disease","volume":"27","author":"Schapira","year":"2009","journal-title":"Neurol. Clin."},{"issue":"Suppl. 4","key":"10.1016\/j.pneurobio.2011.06.005_bib1195","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/S1353-8020(09)70834-X","article-title":"Neuroprotection in Parkinson's disease","volume":"15","author":"Schapira","year":"2009","journal-title":"Parkinsonism Relat. 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Neurochem."},{"issue":"18","key":"10.1016\/j.pneurobio.2011.06.005_bib1245","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1097\/00001756-199412000-00048","article-title":"Reduction of MPP(+)-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase","volume":"5","author":"Smith","year":"1994","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.pneurobio.2011.06.005_bib1250","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1385\/JMN:24:3:425","article-title":"Pathological proteins in Parkinson's disease: focus on the proteasome","volume":"24","author":"Snyder","year":"2004","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.pneurobio.2011.06.005_bib1255","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0024-3205(02)02204-X","article-title":"Levodopa modulating effects of inducible nitric oxide synthase and reactive oxygen species in glioma cells","volume":"72","author":"Soliman","year":"2002","journal-title":"Life Sci."},{"issue":"1\u20133","key":"10.1016\/j.pneurobio.2011.06.005_bib1260","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF01345245","article-title":"Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism","volume":"14","author":"Sonsalla","year":"1998","journal-title":"Amino Acids"},{"issue":"12","key":"10.1016\/j.pneurobio.2011.06.005_bib1265","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1007\/s00259-010-1581-3","article-title":"Levodopa and pramipexole effects on presynaptic dopamine PET markers and estimated dopamine release","volume":"37","author":"Sossi","year":"2010","journal-title":"Eur. 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