{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:25:08Z","timestamp":1770999908780,"version":"3.50.1"},"reference-count":355,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL059658"],"award-info":[{"award-number":["R01 HL059658"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 NS077408"],"award-info":[{"award-number":["R01 NS077408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 NS087550"],"award-info":[{"award-number":["R21 NS087550"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 NS082876"],"award-info":[{"award-number":["R01 NS082876"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 NS083639"],"award-info":[{"award-number":["R21 NS083639"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 NS085757"],"award-info":[{"award-number":["R21 NS085757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neurobiology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.pneurobio.2015.12.002","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T04:54:45Z","timestamp":1450846485000},"page":"89-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Challenges in the development of therapeutics for narcolepsy"],"prefix":"10.1016","volume":"152","author":[{"given":"Sarah Wurts","family":"Black","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Kilduff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pneurobio.2015.12.002_bib0005","doi-asserted-by":"publisher","first-page":"13404","DOI":"10.1073\/pnas.1204376109","article-title":"alpha4betadelta GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB)","volume":"109","author":"Absalom","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0010","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2014.01.033","article-title":"Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants","volume":"50","author":"Ahmed","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0015","doi-asserted-by":"publisher","first-page":"294ra105","DOI":"10.1126\/scitranslmed.aab2354","article-title":"Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2","volume":"7","author":"Ahmed","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0020","first-page":"704","article-title":"Pharmacotherapy in narcolepsy","volume":"21","author":"Akimoto","year":"1960","journal-title":"Dis. Nerv. Syst."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0025","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1111\/bph.12445","article-title":"The Concise Guide to PHARMACOLOGY 2013\/14: G protein-coupled receptors","volume":"170","author":"Alexander","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0030","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.5665\/sleep.2080","article-title":"Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy","volume":"35","author":"Andlauer","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0035","first-page":"77","article-title":"Validation of a cataplexy questionnaire in 983 sleep-disorders patients","volume":"22","author":"Anic-Labat","year":"1999","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0040","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","author":"Aran","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0045","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.phrs.2014.10.005","article-title":"Is narcolepsy a classical autoimmune disease?","volume":"92","author":"Arango","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0050","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1126\/science.118.3062.273","article-title":"Regularly occurring periods of eye motility, and concomitant phenomena, during sleep","volume":"118","author":"Aserinsky","year":"1953","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0055","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.01-08-00876.1981","article-title":"Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle","volume":"1","author":"Aston-Jones","year":"1981","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0060","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0091-3057(76)90298-7","article-title":"Effects of imipramine, chlorimipramine, and fluoxetine on cataplexy in dogs","volume":"5","author":"Babcock","year":"1976","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0065","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.sleep.2011.06.015","article-title":"Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy","volume":"12","author":"Baier","year":"2011","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0070","series-title":"Brain Mechanisms of Sleep","first-page":"199","article-title":"Canine narcolepsy-cataplexy syndrome: evidence for an inherited monoaminergic-cholinergic imbalance","author":"Baker","year":"1985"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0075","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/sleep\/9.1.232","article-title":"Comparative polysomnographic study of narcolepsy and idiopathic central nervous system hypersomnia","volume":"9","author":"Baker","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0080","doi-asserted-by":"publisher","first-page":"d5956","DOI":"10.1136\/bmj.d5956","article-title":"Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden","volume":"343","author":"Bardage","year":"2011","journal-title":"Br. Med. J."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0085","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0733-8619(05)70273-5","volume":"14","author":"Bassetti","year":"1996","journal-title":"Narcolepsy Neurol. Clin."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0090","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1365-2869.2011.00945.x","article-title":"High-amplitude theta wave bursts during REM sleep and cataplexy in hypocretin-deficient narcoleptic mice","volume":"21","author":"Bastianini","year":"2012","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0095","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0278-5846(88)90014-0","article-title":"Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil","volume":"12","author":"Bastuji","year":"1988","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0100","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.5665\/sleep.3756","article-title":"Challenges in diagnosing narcolepsy without cataplexy: a consensus statement","volume":"37","author":"Baumann","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0105","doi-asserted-by":"publisher","first-page":"231","DOI":"10.5665\/sleep.1628","article-title":"Glucose tolerance in patients with narcolepsy","volume":"35","author":"Beitinger","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0110","doi-asserted-by":"publisher","first-page":"E3735","DOI":"10.1073\/pnas.1412189111","article-title":"Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns","volume":"111","author":"Bergman","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0115","doi-asserted-by":"publisher","first-page":"152 ra127","DOI":"10.1126\/scitranslmed.3004214","article-title":"Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial","volume":"4","author":"Berry-Kravis","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0120","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1093\/sleep\/17.suppl_8.S29","article-title":"Homeostasis and narcolepsy","volume":"17","author":"Besset","year":"1994","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0125","doi-asserted-by":"publisher","first-page":"4469","DOI":"10.1523\/JNEUROSCI.5560-03.2004","article-title":"Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat","volume":"24","author":"Beuckmann","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0130","doi-asserted-by":"crossref","first-page":"596","DOI":"10.5664\/jcsm.27994","article-title":"The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy","volume":"6","author":"Black","year":"2010","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0140","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.biopsych.2005.04.026","article-title":"Studies of humoral immunity to preprohypocretin in human leukocyte antigen DQB1*0602-positive narcoleptic subjects with cataplexy","volume":"58","author":"Black","year":"2005","journal-title":"Biol Psychiatry"},{"issue":"Supp. 1","key":"10.1016\/j.pneurobio.2015.12.002_bib1780","first-page":"S32","article-title":"Oral JZP-110 (ADX-N05) for the treatment of excessive daytime sleepiness in adults with narcolepsy: results of a randomised, double-blind, placebo-controlled trial","volume":"23","author":"Black","year":"2014","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0145","doi-asserted-by":"publisher","first-page":"6485","DOI":"10.1523\/JNEUROSCI.0080-14.2014","article-title":"GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy","volume":"34","author":"Black","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0150","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5665\/sleep.2442","article-title":"Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy","volume":"36","author":"Black","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0155","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5665\/sleep.2296","article-title":"Effects of orexin gene transfer in the dorsolateral pons in orexin knockout mice","volume":"36","author":"Blanco-Centurion","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0160","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1212\/01.wnl.0000175219.01544.c8","article-title":"Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy","volume":"65","author":"Blouin","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0165","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/0024-3205(84)90675-1","article-title":"Narcolepsy: cholinergic receptor changes in an animal model","volume":"34","author":"Boehme","year":"1984","journal-title":"Life Sci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0170","first-page":"A257","article-title":"A double-blind, placebo-controlled, randomized, cross-over study of the efficacy and safety of ADX-N05 for the treatment of excessive daytime sleepiness in adult subjects with narcolepsy","volume":"36","author":"Bogan","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0175","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1046\/j.1460-9568.2003.02861.x","article-title":"Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset","volume":"18","author":"Boissard","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0180","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1046\/j.1460-9568.2002.02257.x","article-title":"The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study","volume":"16","author":"Boissard","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0185","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0166-4328(84)90186-4","article-title":"Effect of sleep deprivation on sleep and EEG power spectra in the rat","volume":"14","author":"Borbely","year":"1984","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0190","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1177\/0269881111421975","article-title":"Reconsidering GHB: orphan drug or new model antidepressant?","volume":"26","author":"Bosch","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0195","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.smrv.2011.09.001","article-title":"Narcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trials","volume":"16","author":"Boscolo-Berto","year":"2012","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0200","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/0006-8993(87)91045-6","article-title":"Brain dopamine receptor levels elevated in canine narcolepsy","volume":"402","author":"Bowersox","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0205","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/sleep\/9.1.111","article-title":"Brain benzodiazepine receptor characteristics in canine narcolepsy","volume":"9","author":"Bowersox","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0210","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1523\/JNEUROSCI.5023-07.2008","article-title":"Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia","volume":"28","author":"Brooks","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0215","doi-asserted-by":"publisher","first-page":"9785","DOI":"10.1523\/JNEUROSCI.0482-12.2012","article-title":"Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis","volume":"32","author":"Brooks","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0220","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/0013-4694(88)90145-9","article-title":"Ambulatory 24hour sleep-wake monitoring in narcolepsy-cataplexy compared to matched controls","volume":"70","author":"Broughton","year":"1988","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0225","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1017\/S0317167100044723","article-title":"Life effects of narcolepsy: relationships to geographic origin (North American Asian or European) and to other patient and illness variables","volume":"10","author":"Broughton","year":"1983","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0230","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/sleep\/9.1.205","article-title":"Excessive daytime sleepiness and the pathophysiology of narcolepsy-cataplexy: a laboratory perspective","volume":"9","author":"Broughton","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0235","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.2174\/138161211796197098","article-title":"A review of sodium oxybate and baclofen in the treatment of sleep disorders","volume":"17","author":"Brown","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0240","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1152\/physrev.00032.2011","article-title":"Control of sleep and wakefulness","volume":"92","author":"Brown","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0245","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.neuroscience.2006.08.045","article-title":"Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins","volume":"143","author":"Brown","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0250","doi-asserted-by":"publisher","first-page":"9734","DOI":"10.1523\/JNEUROSCI.5632-12.2013","article-title":"Amygdala lesions reduce cataplexy in orexin knock-out mice","volume":"33","author":"Burgess","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0255","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.cub.2013.07.014","article-title":"A noradrenergic mechanism functions to couple motor behavior with arousal state","volume":"23","author":"Burgess","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0260","doi-asserted-by":"publisher","first-page":"12305","DOI":"10.1523\/JNEUROSCI.2630-12.2012","article-title":"Narcolepsy: neural mechanisms of sleepiness and cataplexy","volume":"32","author":"Burgess","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0265","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1093\/sleep\/33.10.1295","article-title":"Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy","volume":"33","author":"Burgess","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0270","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1523\/JNEUROSCI.22-07-02862.2002","article-title":"Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin\/Orexin peptides: implications for wakefulness and narcolepsy","volume":"22","author":"Burlet","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0275","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1016\/j.vaccine.2013.05.007","article-title":"The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect","volume":"31","author":"Calabro","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0280","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.5664\/jcsm.4040","article-title":"Dual cases of type 1 narcolepsy with schizophrenia and other psychotic disorders","volume":"10","author":"Canellas","year":"2014","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0285","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0987-7053(05)80279-5","article-title":"Autoimmune hypothesis in narcolepsy","volume":"23","author":"Carlander","year":"1993","journal-title":"Neurophysiol. Clin."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0290","series-title":"The Voice of the Patient: Narcolepsy","first-page":"1","author":"CDER","year":"2013"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0295","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchemneu.2015.03.002","article-title":"Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: a characterisation of OX1R-eGFP mice","volume":"66\u201367V\u2013","author":"Ch\u2019ng","year":"2015","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0300","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1093\/sleep\/30.10.1267","article-title":"Eating disorder and metabolism in narcoleptic patients","volume":"30","author":"Chabas","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0305","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1089\/cap.2014.0084","article-title":"Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference","volume":"25","author":"Chang","year":"2015","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0310","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.09-03-00743.1989","article-title":"Evidence that glycine mediates the postsynaptic potentials that inhibit lumbar motoneurons during the atonia of active sleep","volume":"9","author":"Chase","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0315","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0320","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.neuroscience.2009.04.007","article-title":"Feeding-elicited cataplexy in orexin knockout mice","volume":"161","author":"Clark","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0325","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1111\/j.1460-9568.2006.04995.x","article-title":"A potent non-monoaminergic paradoxical sleep inhibitory system: a reverse microdialysis and single-unit recording study","volume":"24","author":"Crochet","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0330","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1212\/01.WNL.0000168173.71940.ab","article-title":"Concomitant loss of dynorphin NARP, and orexin in narcolepsy","volume":"65","author":"Crocker","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0335","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nn1181","article-title":"Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system","volume":"7","author":"Cruz","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0340","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1172\/JCI41366","article-title":"Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients","volume":"120","author":"Cvetkovic-Lopes","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0345","first-page":"R161","article-title":"Timing of human sleep: recovery process gated by a circadian pacemaker","volume":"246","author":"Daan","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0350","first-page":"257","article-title":"Prevalence of eating disorders and eating attacks in narcolepsy","volume":"4","author":"Dahmen","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0355","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s004060170057","article-title":"Increased prevalence of obesity in narcoleptic patients and relatives","volume":"251","author":"Dahmen","year":"2001","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0360","first-page":"962","article-title":"Basal metabolic rate in narcoleptic patients","volume":"32","author":"Dahmen","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0365","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/0013-4694(94)90110-4","article-title":"Circadian rhythms in narcolepsy: studies on a 90min day","volume":"90","author":"Dantz","year":"1994","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0370","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.neuroscience.2014.08.027","article-title":"Distribution of orexin-1 receptor-green fluorescent protein- (OX1-GFP) expressing neurons in the mouse brain stem and pons: co-localization with tyrosine hydroxylase and neuronal nitric oxide synthase","volume":"278","author":"Darwinkel","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0375","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1073\/pnas.96.2.748","article-title":"Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems","volume":"96","author":"Date","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0380","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1212\/WNL.0b013e3181bd1344","article-title":"Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment","volume":"73","author":"Dauvilliers","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0385","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1093\/brain\/awt187","article-title":"a Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France","volume":"136","author":"Dauvilliers","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0390","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/S1474-4422(13)70225-4","article-title":"Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial","volume":"12","author":"Dauvilliers","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0395","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/ana.20339","article-title":"Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset","volume":"56","author":"Dauvilliers","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0400","doi-asserted-by":"publisher","first-page":"e38977","DOI":"10.1371\/journal.pone.0038977","article-title":"Non-dipping blood pressure profile in narcolepsy with cataplexy","volume":"7","author":"Dauvilliers","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0410","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1212\/WNL.57.11.2029","article-title":"Age at onset of narcolepsy in two large populations of patients in France and Quebec","volume":"57","author":"Dauvilliers","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1785","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.bbi.2013.12.019","article-title":"Cerebrospinal fluid and serum cytokine profiles in narcolepsy with cataplexy: a case-control study","volume":"37","author":"Dauvilliers","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.pneurobio.2015.12.002_bib0415","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/nrneurol.2014.97","article-title":"Cataplexy-clinical aspects, pathophysiology and management strategy","volume":"10","author":"Dauvilliers","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0420","doi-asserted-by":"publisher","first-page":"216ra176","DOI":"10.1126\/scitranslmed.3007762","article-title":"CD4+ T cell autoimmunity to hypocretin\/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy","volume":"5","author":"De la Herran-Arita","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0425","doi-asserted-by":"publisher","first-page":"247rt241","DOI":"10.1126\/scitranslmed.3009995","article-title":"Retraction of the research article: \u201cCD4(+) T cell autoimmunity to hypocretin\/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy\u201d","volume":"6","author":"De la Herran-Arita","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0430","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neuroscience.2011.03.029","article-title":"Aspects of the narcolepsy-cataplexy syndrome in O\/E3-null mutant mice","volume":"183","author":"De La Herran-Arita","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0435","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0440","doi-asserted-by":"publisher","first-page":"14239","DOI":"10.1523\/JNEUROSCI.3878-07.2007","article-title":"Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates","volume":"27","author":"Deadwyler","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0445","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0198-8859(89)90067-0","article-title":"Narcolepsy without unique MHC class II antigen association: studies in the canine model","volume":"25","author":"Dean","year":"1989","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0450","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/0014-4886(79)90218-8","article-title":"Cholinergic mechanisms and cataplexy in dogs","volume":"66","author":"Delashaw","year":"1979","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0455","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1037\/h0048189","article-title":"The relation of eye movements during sleep to dream activity: an objective method for the study of dreaming","volume":"53","author":"Dement","year":"1957","journal-title":"J. Exp. Psychol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0460","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1212\/WNL.16.1.18","article-title":"The nature of the narcoleptic sleep attack","volume":"16","author":"Dement","year":"1966","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0465","series-title":"Narcolepsy and Hypersomnia","first-page":"1","article-title":"Historical aspects of narcolepsy","author":"Dement","year":"2007"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0470","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1002\/jps.21604","article-title":"2nd Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system","volume":"98","author":"Dhuria","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0475","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1212\/WNL.0000000000000793","article-title":"Lower wake resting sympathetic and cardiovascular activities in narcolepsy with cataplexy","volume":"83","author":"Donadio","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0480","doi-asserted-by":"publisher","first-page":"795","DOI":"10.5665\/sleep.3592","article-title":"Glucose and fat metabolism in narcolepsy and the effect of sodium oxybate: a hyperinsulinemic-euglycemic clamp study","volume":"37","author":"Donjacour","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0485","doi-asserted-by":"crossref","first-page":"797","DOI":"10.5664\/jcsm.2924","article-title":"Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: basal concentrations and response to sodium oxybate","volume":"9","author":"Donjacour","year":"2013","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0490","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1001\/jama.1932.02730330024006","article-title":"Narcolepsy: results of treatment with ephedrine sulphate","volume":"98","author":"Doyle","year":"1932","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0495","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2460\/javma.1984.184.02.131","article-title":"Narcolepsy in a horse","volume":"184","author":"Dreifuss","year":"1984","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0500","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1212\/WNL.0000000000000987","article-title":"Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States","volume":"83","author":"Duffy","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0505","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1523\/JNEUROSCI.13-03-01065.1993","article-title":"Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation","volume":"13","author":"Edgar","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0510","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0022-3565(24)37050-8","article-title":"Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat","volume":"283","author":"Edgar","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0515","series-title":"International Classification of Sleep Disorders","author":"Eichler","year":"2014"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0520","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1093\/sleep\/30.11.1417","article-title":"Running promotes wakefulness and increases cataplexy in orexin knockout mice","volume":"30","author":"Espana","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0525","doi-asserted-by":"publisher","first-page":"e1003270","DOI":"10.1371\/journal.pgen.1003270","article-title":"ImmunoChip study implicates antigen presentation to T cells in narcolepsy","volume":"9","author":"Faraco","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0530","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0006-8993(82)90503-0","article-title":"Monoamine metabolite concentrations in the cerebrospinal fluid of normal and narcoleptic dogs","volume":"242","author":"Faull","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0535","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/sleep\/9.1.107","article-title":"Biogenic amine concentrations in the brains of normal and narcoleptic canines: current status","volume":"9","author":"Faull","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0540","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s004150050080","article-title":"Autonomic function in narcolepsy: power spectrum analysis of heart rate variability","volume":"244","author":"Ferini-Strambi","year":"1997","journal-title":"J. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0545","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/sleep\/31.3.335","article-title":"High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study","volume":"31","author":"Fortuyn","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0550","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/sleep\/1.4.413","article-title":"Genetic factors in canine narcolepsy","volume":"1","author":"Foutz","year":"1979","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0555","doi-asserted-by":"crossref","first-page":"805","DOI":"10.5664\/jcsm.2926","article-title":"Delayed diagnosis, range of severity, and multiple sleep comorbidities: a clinical and polysomnographic analysis of 100 patients of the innsbruck narcolepsy cohort","volume":"9","author":"Frauscher","year":"2013","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0560","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1093\/sleep\/29.11.1444","article-title":"Altered skin-temperature regulation in narcolepsy relates to sleep propensity","volume":"29","author":"Fronczek","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0565","doi-asserted-by":"crossref","first-page":"248","DOI":"10.5664\/jcsm.27188","article-title":"Increased heart rate variability but normal resting metabolic rate in hypocretin\/orexin-deficient human narcolepsy","volume":"4","author":"Fronczek","year":"2008","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0570","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1136\/jnnp.2008.143610","article-title":"Manipulation of skin temperature improves nocturnal sleep in narcolepsy","volume":"79","author":"Fronczek","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0575","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.expneurol.2009.01.015","article-title":"Specificity of direct transition from wake to REM sleep in orexin\/ataxin-3 transgenic narcoleptic mice","volume":"217","author":"Fujiki","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0580","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.cmet.2008.10.010","article-title":"Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity","volume":"9","author":"Funato","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0585","first-page":"535","article-title":"De la Narcolepsie","volume":"53","author":"G\u00e9lineau","year":"1880","journal-title":"Gaz Hop (Paris)"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0590","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/S0014-4886(03)00388-1","article-title":"Relationship between CSF hypocretin levels and hypocretin neuronal loss","volume":"184","author":"Gerashchenko","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0595","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0006-8993(01)02792-5","article-title":"Effects of hypocretin-saporin injections into the medial septum on sleep and hippocampal theta","volume":"913","author":"Gerashchenko","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0600","first-page":"Ra177","article-title":"Modafinil for narcolepsy: systematic review and meta-analysis","volume":"16","author":"Golicki","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0605","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00415-009-5431-9","article-title":"Antibodies and neuronal autoimmune disorders of the CNS","volume":"257","author":"Graus","year":"2010","journal-title":"J. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0610","doi-asserted-by":"publisher","first-page":"D1079","DOI":"10.1093\/nar\/gku1071","article-title":"2015 Genenames.org: the HGNC resources in","volume":"43","author":"Gray","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0615","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.3109\/07420528.2010.504907","article-title":"a Hypocretin deficiency in narcolepsy with cataplexy is associated with a normal body core temperature modulation","volume":"27","author":"Grimaldi","year":"2010","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1790","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.clinph.2010.01.028","article-title":"b Spectral analysis of heart rate variability reveals an enhanced sympathetic activity in narcolepsy with cataplexy","volume":"121","author":"Grimaldi","year":"2010","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0620","doi-asserted-by":"publisher","first-page":"519","DOI":"10.5665\/sleep.1738","article-title":"Abnormal sleep-cardiovascular system interaction in narcolepsy with cataplexy: effects of hypocretin deficiency in humans","volume":"35","author":"Grimaldi","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0630","series-title":"Principles and Practice of Sleep Medicine","first-page":"957","article-title":"Narcolepsy: Diagnosis and management","author":"Guilleminault","year":"2011"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0635","series-title":"Narcolepsy and Hypersomnia","first-page":"49","article-title":"Cataplexy","author":"Guilleminault","year":"2007"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0640","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0306-4522(02)00089-1","article-title":"Cataplexy-related neurons in the amygdala of the narcoleptic dog","volume":"112","author":"Gulyani","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0645","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy is strongly associated with the T-cell receptor alpha locus","volume":"41","author":"Hallmayer","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0650","doi-asserted-by":"publisher","first-page":"e1003880","DOI":"10.1371\/journal.pgen.1003880","article-title":"Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic","volume":"9","author":"Han","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0655","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/ana.23799","article-title":"Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic","volume":"73","author":"Han","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0660","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China","volume":"70","author":"Han","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0665","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0896-6273(01)00293-8","article-title":"Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity","volume":"30","author":"Hara","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0670","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.neulet.2005.01.046","article-title":"Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions","volume":"380","author":"Hara","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0675","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1046\/j.1365-2869.2000.00217.x","article-title":"Night-time sleep and daytime sleepiness in narcolepsy","volume":"9","author":"Harsh","year":"2000","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0680","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1172\/JCI71017","article-title":"Orexin neurons suppress narcolepsy via 2 distinct efferent pathways","volume":"124","author":"Hasegawa","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0685","doi-asserted-by":"crossref","first-page":"653","DOI":"10.5664\/jcsm.1474","article-title":"Cerebrospinal fluid hypocretin 1 deficiency, overweight, and metabolic dysregulation in patients with narcolepsy","volume":"7","author":"Heier","year":"2011","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0690","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1093\/sleep\/32.9.1135","article-title":"Cholinergic modulation of GABAergic and glutamatergic transmission in the dorsal subcoeruleus: mechanisms for REM sleep control","volume":"32","author":"Heister","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0695","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0022-510X(66)90001-3","article-title":"Treatment of narcolepsy with imipramine (tofranil) and desmethylimipramine (pertofran)","volume":"3","author":"Hishikawa","year":"1966","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0700","series-title":"Narcolepsy and Hypersomnia","first-page":"25","article-title":"Historical aspects of the treatment for narcolepsy","author":"Hishikawa","year":"2007"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0705","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1126\/science.1094539","article-title":"Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups","volume":"189","author":"Hobson","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0710","first-page":"191","article-title":"Census of narcolepsy, cataplexy and sleep life among teenagers in Fujisawa City","volume":"8","author":"Honda","year":"1979","journal-title":"Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0715","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/sleep\/9.1.254","article-title":"Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients","volume":"9","author":"Honda","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0720","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pediatrneurol.2009.02.008","article-title":"Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate","volume":"41","author":"Huang","year":"2009","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0725","doi-asserted-by":"publisher","first-page":"9965","DOI":"10.1073\/pnas.181330998","article-title":"Arousal effect of orexin A depends on activation of the histaminergic system","volume":"98","author":"Huang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0730","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1212\/WNL.44.11.2095","article-title":"Selegiline in the treatment of narcolepsy","volume":"44","author":"Hublin","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0735","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/bmj.4.5778.15","article-title":"Baclofen in the treatment of spasticity","volume":"4","author":"Hudgson","year":"1971","journal-title":"Br. Med. J."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0740","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1101\/gr.GR-1610R","article-title":"Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines","volume":"11","author":"Hungs","year":"2001","journal-title":"Genome Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0745","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.bbi.2014.11.004","article-title":"Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development","volume":"47","author":"Jacob","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0750","doi-asserted-by":"crossref","first-page":"835","DOI":"10.5665\/sleep.2706","article-title":"Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study","volume":"36","author":"Jennum","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0755","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/cercor\/11.5.424","article-title":"GHB depresses fast excitatory and inhibitory synaptic transmission via GABA(B) receptors in mouse neocortical neurons","volume":"11","author":"Jensen","year":"2001","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0760","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1002\/ana.23968","article-title":"Greatly increased numbers of histamine cells in human narcolepsy with cataplexy","volume":"74","author":"John","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0765","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0896-6273(04)00247-8","article-title":"Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior","volume":"42","author":"John","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0770","first-page":"1024","article-title":"[On a stage of rapid cerebral electrical activity in the course of physiological sleep]","volume":"153","author":"Jouvet","year":"1959","journal-title":"C R Seances Soc. Biol. Fil"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0775","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.sleep.2010.07.022","article-title":"Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants","volume":"12","author":"Ju","year":"2011","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0780","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/j.1399-0039.1984.tb02144.x","article-title":"HLA antigens in Japanese patients with narcolepsy: all the patients were DR2 positive","volume":"24","author":"Juji","year":"1984","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0785","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0013-4694(86)90078-7","article-title":"Evidence for excessive sleepiness in canine narcoleptics","volume":"64","author":"Kaitin","year":"1986","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0790","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/sleep\/9.1.116","article-title":"Sleep fragmentation in canine narcolepsy","volume":"9","author":"Kaitin","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0795","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1460-9568.2010.07259.x","article-title":"Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons","volume":"32","author":"Kalogiannis","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0800","doi-asserted-by":"publisher","first-page":"e18697","DOI":"10.1371\/journal.pone.0018697","article-title":"Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice","volume":"6","author":"Kalogiannis","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0805","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.5665\/sleep.2870","article-title":"Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice","volume":"36","author":"Kantor","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0810","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1111\/j.1460-9568.2003.03013.x","article-title":"Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice","volume":"18","author":"Kaupmann","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0815","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1093\/sleep\/9.1.102","article-title":"Muscarinic cholinergic receptors and the canine model of narcolepsy","volume":"9","author":"Kilduff","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0820","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0166-2236(00)01594-0","article-title":"The hypocretin\/orexin ligand-receptor system: Implications for sleep and sleep disorders","volume":"23","author":"Kilduff","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0825","first-page":"565","article-title":"Solution structure of human orexin-A: regulator of appetite and wakefulness","volume":"37","author":"Kim","year":"2004","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0830","first-page":"A22","article-title":"Behavioral and polysomnographic characterization of orexin-1 receptor and orexin-2 receptor double knockout mice","volume":"24","author":"Kisanuki","year":"2001","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0835","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1212\/WNL.0b013e31825dce03","article-title":"Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency","volume":"79","author":"Knudsen","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0840","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1055\/s-0030-1267993","article-title":"Intravenous immunoglobulin treatment and screening for hypocretin neuron-specific autoantibodies in recent onset childhood narcolepsy with cataplexy","volume":"41","author":"Knudsen","year":"2010","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0845","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1365-2869.2009.00756.x","article-title":"Medical exposures in youth and the frequency of narcolepsy with cataplexy: a population-based case-control study in genetically predisposed people","volume":"19","author":"Koepsell","year":"2010","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0850","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1210\/jcem.87.2.8246","article-title":"Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans","volume":"87","author":"Kok","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0855","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/oby.2003.156","article-title":"Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity","volume":"11","author":"Kok","year":"2003","journal-title":"Obes. Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0860","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.conb.2011.09.003","article-title":"Narcolepsy with hypocretin\/orexin deficiency, infections and autoimmunity of the brain","volume":"21","author":"Kornum","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0865","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/ng.734","article-title":"Common variants in P2RY11 are associated with narcolepsy","volume":"43","author":"Kornum","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0870","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbi.2015.03.004","article-title":"Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset","volume":"49","author":"Kornum","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0875","doi-asserted-by":"publisher","first-page":"e24998","DOI":"10.1371\/journal.pone.0024998","article-title":"Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia","volume":"6","author":"Krenzer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0880","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0013-4694(85)91073-9","article-title":"Electroencephalographic correlates of cataplectic attacks in narcoleptic canines","volume":"61","author":"Kushida","year":"1985","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0885","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/sleep\/19.1.75","article-title":"Spontaneous food choice in narcolepsy","volume":"19","author":"Lammers","year":"1996","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0890","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/sleep\/9.2.371","article-title":"Fluoxetine in the treatment of cataplexy","volume":"9","author":"Langdon","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0895","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5664\/jcsm.1478","article-title":"Psychosis in the context of sodium oxybate therapy","volume":"7","author":"Langford","year":"2011","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0900","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/sleep\/10.6.608","article-title":"Narcolepsy is a rare disease in Israel","volume":"10","author":"Lavie","year":"1987","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0905","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1046\/j.1432-1327.1999.00911.x","article-title":"Solution structure of a new hypothalamic neuropeptide, human hypocretin-2\/orexin-B","volume":"266","author":"Lee","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0910","doi-asserted-by":"crossref","unstructured":"Legrand, 1888 Narcolepsy. Lancet, 131.","DOI":"10.1016\/S0140-6736(02)25450-1"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0915","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/hup.579","article-title":"Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects","volume":"19","author":"Leonard","year":"2004","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0920","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1471-4159.2011.07335.x","article-title":"Dopamine release mediated by the dopamine transporter, facts and consequences","volume":"118","author":"Leviel","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0925","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1006\/geno.1999.5772","article-title":"Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library","volume":"58","author":"Li","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0930","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S1474-4422(14)70218-2","article-title":"Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy","volume":"14","author":"Liblau","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0935","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","article-title":"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene","volume":"98","author":"Lin","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0940","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0945","doi-asserted-by":"publisher","first-page":"6028","DOI":"10.1523\/JNEUROSCI.6069-10.2011","article-title":"Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice","volume":"31","author":"Liu","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0950","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1111\/j.1460-9568.2008.06446.x","article-title":"Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice","volume":"28","author":"Liu","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0955","first-page":"1041","article-title":"\u00dcber narkolepsie","volume":"49","author":"L\u00f6wenfeld","year":"1902","journal-title":"M\u00fcnch Med Wochenschr"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0960","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nature04767","article-title":"A putative flip-flop switch for control of REM sleep","volume":"441","author":"Lu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0965","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/jsr.12044","article-title":"Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study","volume":"22","author":"Luca","year":"2013","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0970","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/0031-9384(79)90168-9","article-title":"Sleep cycle organization in narcoleptic and normal dogs","volume":"23","author":"Lucas","year":"1979","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0975","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/01652176.2012.714089","article-title":"Familial narcolepsy in the Lipizzaner horse: a report of three fillies born to the same sire","volume":"32","author":"Ludvikova","year":"2012","journal-title":"Vet. Q."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0980","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.2042-3306.1993.tb02998.x","article-title":"Familial occurrence of narcolepsy in miniature horses","volume":"25","author":"Lunn","year":"1993","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0985","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.smrv.2010.08.002","article-title":"The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder","volume":"15","author":"Luppi","year":"2011","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0990","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1748-1716.2009.02068.x","article-title":"Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin\/hypocretin","volume":"198","author":"Makela","year":"2010","journal-title":"Acta Physiol. (Oxf)"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib0995","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.pneurobio.2009.07.004","article-title":"Narcolepsy and depression and the neurobiology of gammahydroxybutyrate","volume":"89","author":"Mamelak","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1000","series-title":"Narcolepsy and Hypersomnia","first-page":"243","article-title":"Vigilance tests in narcolepsy","author":"Mathis","year":"2007"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1005","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/0140-6736(92)90571-J","article-title":"DQ (rather than DR) gene marks susceptibility to narcolepsy","volume":"339","author":"Matsuki","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1010","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1365-2869.1993.tb00078.x","article-title":"Motor dyscontrol in sleep of narcoleptic patients (a lifelong development?)","volume":"2","author":"Mayer","year":"1993","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1015","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/0006-8993(76)90480-7","article-title":"Dorsal raphe neurons: depression of firing during sleep in cats","volume":"101","author":"McGinty","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1020","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/sleep\/27.5.899","article-title":"Effects of gamma-hydroxybutyrate (GHB) on vigilance states and EEG in mice","volume":"27","author":"Meerlo","year":"2004","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1025","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1126\/science.6188216","article-title":"Narcolepsy: biogenic amine deficits in an animal model","volume":"220","author":"Mefford","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1030","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1242\/dev.117978","article-title":"Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells","volume":"142","author":"Merkle","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1035","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S1474-4422(14)70053-5","article-title":"Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial","volume":"13","author":"Michelson","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1040","doi-asserted-by":"publisher","first-page":"6518","DOI":"10.1523\/JNEUROSCI.6506-10.2011","article-title":"Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep","volume":"31","author":"Mieda","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1045","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1073\/pnas.0400590101","article-title":"Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice","volume":"101","author":"Mieda","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1050","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1086\/515487","article-title":"Genetics of narcolepsy and other sleep disorders","volume":"60","author":"Mignot","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1055","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1212\/WNL.50.2_Suppl_1.S16","article-title":"Genetic and familial aspects of narcolepsy","volume":"50","author":"Mignot","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1060","first-page":"207","article-title":"A hundred years of narcolepsy research","volume":"139","author":"Mignot","year":"2001","journal-title":"Arch. Ital. Biol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1065","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/0006-8993(88)90927-4","article-title":"Effect of alpha 1-adrenoceptors blockade with prazosin in canine narcolepsy","volume":"444","author":"Mignot","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1070","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1172\/JCI113694","article-title":"Role of central alpha-1 adrenoceptors in canine narcolepsy","volume":"82","author":"Mignot","year":"1988","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1075","first-page":"1012","article-title":"HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients","volume":"20","author":"Mignot","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1080","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1001\/archneur.59.10.1553","article-title":"The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias","volume":"59","author":"Mignot","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1085","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups","volume":"68","author":"Mignot","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1095","series-title":"Narcolepsy and Hypersomnia","first-page":"641","article-title":"Perspectives for new treatments: an update","author":"Mignot","year":"2007"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1795","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1093\/sleep\/17.suppl_8.S60","article-title":"a DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans","volume":"17","author":"Mignot","year":"1994","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1100","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/sleep\/17.5.436","article-title":"Modafinil binds to the dopamine uptake carrier site with low affinity","volume":"17","author":"Mignot","year":"1994","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1105","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/BF02244337","article-title":"Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers","volume":"113","author":"Mignot","year":"1993","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1110","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s13311-012-0150-9","article-title":"A practical guide to the therapy of narcolepsy and hypersomnia syndromes","volume":"9","author":"Mignot","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1115","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s12026-014-8513-4","article-title":"History of narcolepsy at Stanford University","volume":"58","author":"Mignot","year":"2014","journal-title":"Immunol. Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1120","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.neuron.2005.04.035","article-title":"Behavioral correlates of activity in identified hypocretin\/orexin neurons","volume":"46","author":"Mileykovskiy","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1125","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0006-8993(90)90328-9","article-title":"CNS monoamines and their metabolites in canine narcolepsy: a replication study","volume":"509","author":"Miller","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1130","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1081\/CLT-120004400","article-title":"Trends in illicit drug emergencies: the emerging role of gamma-hydroxybutyrate","volume":"40","author":"Miro","year":"2002","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1135","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/0013-4694(77)90084-0","article-title":"Sleep studies on canine narcolepsy: pattern and cycle comparisons between affected and normal dogs","volume":"43","author":"Mitler","year":"1977","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1140","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.2460\/javma.1976.168.11.1036","article-title":"Narcolepsy in seven dogs","volume":"168","author":"Mitler","year":"1976","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1145","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0013-4694(79)90149-4","article-title":"REM sleep episodes during the Multiple Sleep Latency Test in narcoleptic patients","volume":"46","author":"Mitler","year":"1979","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1150","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1073\/pnas.1012456108","article-title":"Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice","volume":"108","author":"Mochizuki","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1155","doi-asserted-by":"publisher","first-page":"6291","DOI":"10.1523\/JNEUROSCI.0586-04.2004","article-title":"Behavioral state instability in orexin knock-out mice","volume":"24","author":"Mochizuki","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1160","doi-asserted-by":"publisher","first-page":"R533","DOI":"10.1152\/ajpregu.00887.2005","article-title":"Elevated body temperature during sleep in orexin knockout mice","volume":"291","author":"Mochizuki","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1165","doi-asserted-by":"publisher","first-page":"e108489","DOI":"10.1371\/journal.pone.0108489","article-title":"Risk of narcolepsy associated with inactivated adjuvanted (AS03) A\/H1N1 (2009) pandemic influenza vaccine in Quebec","volume":"9","author":"Montplaisir","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1170","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbr.2011.04.005","article-title":"Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors","volume":"222","author":"Morawska","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1175","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.neuropharm.2009.08.009","article-title":"Monoaminergic neuronal changes in orexin deficient mice","volume":"58","author":"Mori","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1180","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/sleep\/6.2.137","article-title":"The 24-hour rhythm of core temperature in narcolepsy","volume":"6","author":"Mosko","year":"1983","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1185","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/BF00395862","article-title":"Restriction fragment length polymorphism in canine narcolepsy","volume":"29","author":"Motoyama","year":"1989","journal-title":"Immunogenetics"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1190","doi-asserted-by":"publisher","first-page":"7159","DOI":"10.1523\/JNEUROSCI.1027-04.2004","article-title":"Serotonergic regulation of the orexin\/hypocretin neurons through the 5-HT1A receptor","volume":"24","author":"Muraki","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1195","doi-asserted-by":"publisher","first-page":"7931","DOI":"10.1021\/acs.jmedchem.5b00988","article-title":"Design and synthesis of non-peptide selective orexin receptor 2 agonists","volume":"58","author":"Nagahara","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1200","doi-asserted-by":"publisher","first-page":"e81059","DOI":"10.1371\/journal.pone.0081059","article-title":"Differences in brain morphological findings between narcolepsy with and without cataplexy","volume":"8","author":"Nakamura","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1205","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.smrv.2008.04.007","article-title":"Narcolepsy in childhood","volume":"13","author":"Nevsimalova","year":"2009","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1210","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neuron.2013.10.061","article-title":"Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle","volume":"81","author":"Niewoehner","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1215","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.sleep.2007.03.008","article-title":"Clinical and neurobiological aspects of narcolepsy","volume":"8","author":"Nishino","year":"2007","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1220","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1523\/JNEUROSCI.11-09-02666.1991","article-title":"Dopamine D2 mechanisms in canine narcolepsy","volume":"11","author":"Nishino","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1225","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0022-3565(25)10116-X","article-title":"Further characterization of the alpha-1 receptor subtype involved in the control of cataplexy in canine narcolepsy","volume":"264","author":"Nishino","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1230","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0022-3565(25)13215-1","article-title":"Effects of central alpha-2 adrenergic compounds on canine narcolepsy, a disorder of rapid eye movement sleep","volume":"253","author":"Nishino","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1235","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0301-0082(96)00070-6","article-title":"Pharmacological aspects of human and canine narcolepsy","volume":"52","author":"Nishino","year":"1997","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1240","series-title":"Principles and Practice of Sleep Medicine","first-page":"510","article-title":"Wake-promoting medications: basic mechanisms and pharmacology","author":"Nishino","year":"2011"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1245","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1073\/pnas.86.7.2483","article-title":"Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy","volume":"86","author":"Nishino","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1250","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"Hypocretin (orexin) deficiency in human narcolepsy","volume":"355","author":"Nishino","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1255","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/ana.1130","article-title":"Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy","volume":"50","author":"Nishino","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1260","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1093\/sleep\/32.2.175","article-title":"Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls","volume":"32","author":"Nishino","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1265","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1523\/JNEUROSCI.15-07-04806.1995","article-title":"Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy","volume":"15","author":"Nishino","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1270","doi-asserted-by":"publisher","first-page":"e33536","DOI":"10.1371\/journal.pone.0033536","article-title":"AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland","volume":"7","author":"Nohynek","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1275","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2807\/1560-7917.ES2014.19.17.20789","article-title":"Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine Ireland April 2009\u2013December 2010","volume":"19","author":"O\u2019Flanagan","year":"2014","journal-title":"EuroSurveillance"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1280","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.sleep.2013.03.002","article-title":"Narcolepsy is complicated by high medical and psychiatric comorbidities: a comparison with the general population","volume":"14","author":"Ohayon","year":"2013","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1285","doi-asserted-by":"publisher","first-page":"439","DOI":"10.5665\/sleep.3470","article-title":"Increased mortality in narcolepsy","volume":"37","author":"Ohayon","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1290","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1212\/WNL.58.12.1826","article-title":"Prevalence of narcolepsy symptomatology and diagnosis in the European general population","volume":"58","author":"Ohayon","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1295","doi-asserted-by":"publisher","first-page":"9743","DOI":"10.1523\/JNEUROSCI.0499-13.2013","article-title":"Role of the medial prefrontal cortex in cataplexy","volume":"33","author":"Oishi","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1300","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.ajhg.2014.12.010","article-title":"HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy","volume":"96","author":"Ollila","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1305","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/jnr.22781","article-title":"Modulation of neurotransmitter release in orexin\/hypocretin-2 receptor knockout mice: a microdialysis study","volume":"90","author":"Ortega","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1310","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jneuroim.2006.02.010","article-title":"Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy","volume":"174","author":"Overeem","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1315","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1124\/jpet.111.183327","article-title":"Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome","volume":"338","author":"Pacey","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1320","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.5665\/SLEEP.1280","article-title":"Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study","volume":"34","author":"Palaia","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1325","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1046\/j.1365-2869.1998.00093.x","article-title":"The clinical diagnosis of the narcoleptic syndrome","volume":"7","author":"Parkes","year":"1998","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1330","doi-asserted-by":"publisher","first-page":"e33723","DOI":"10.1371\/journal.pone.0033723","article-title":"Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland","volume":"7","author":"Partinen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1335","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.pbb.2010.03.006","article-title":"Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents","volume":"95","author":"Paterson","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1340","first-page":"454","article-title":"Control of motoneuron function and muscle tone during REM sleep REM sleep behavior disorder and cataplexy\/narcolepsy","volume":"149","author":"Peever","year":"2011","journal-title":"Arch. Ital. Biol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1345","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1152\/jn.00968.2002","article-title":"Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism","volume":"89","author":"Peever","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1350","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1399-0039.1998.tb02952.x","article-title":"HLA-DQB1*0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups. US Modafinil in Narcolepsy Multicenter Study Group","volume":"51","author":"Pelin","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1355","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"Peyron","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1360","first-page":"2032","article-title":"Distribution of immunoreactive neurons and fibers for a hypothalamic neuropeptide precursor related to secretin","volume":"23","author":"Peyron","year":"1997","journal-title":"Soc. Neurosci. Abs."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1365","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1370","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1093\/sleep\/33.5.689","article-title":"Restless legs syndrome is frequent in narcolepsy with cataplexy patients","volume":"33","author":"Plazzi","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1375","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.smrv.2010.05.002","article-title":"Autonomic disturbances in narcolepsy","volume":"15","author":"Plazzi","year":"2011","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1380","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1093\/sleep\/32.11.1491","article-title":"Body mass index-independent metabolic alterations in narcolepsy with cataplexy","volume":"32","author":"Poli","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1385","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0091-3057(94)90112-0","article-title":"Core body temperature in narcoleptic and normal subjects living in temporal isolation","volume":"47","author":"Pollak","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1390","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S0006-8993(02)03956-2","article-title":"Rapid eye movement sleep induction by microinjection of the GABA-A antagonist bicuculline into the dorsal subcoeruleus area of the rat","volume":"962","author":"Pollock","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1395","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1001\/jama.1935.02760510023006","article-title":"The use of benzedrine for the treatment of narcolepsy","volume":"105","author":"Prinzmetal","year":"1935","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1400","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0013-4694(63)90032-4","article-title":"Nocturnal sleep of narcoleptics","volume":"15","author":"Rechtschaffen","year":"1963","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1405","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0006-8993(96)00541-0","article-title":"Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine","volume":"733","author":"Reid","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1410","first-page":"424","article-title":"Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors","volume":"17","author":"Reid","year":"1994","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1415","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/0013-4694(78)90162-1","article-title":"Excessive daytime sleepiness in man: multiple sleep latency measurement in narcoleptic and control subjects","volume":"45","author":"Richardson","year":"1978","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1420","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1006\/nbdi.2001.0389","article-title":"Hypocretin levels in sporadic and familial canine narcolepsy","volume":"8","author":"Ripley","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1425","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.sleep.2008.04.004","article-title":"Exacerbation of cataplexy following gradual withdrawal of antidepressants: manifestation of probable protracted rebound cataplexy","volume":"10","author":"Ristanovic","year":"2009","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1430","doi-asserted-by":"crossref","first-page":"955","DOI":"10.5664\/jcsm.3004","article-title":"Disrupted nighttime sleep in narcolepsy","volume":"9","author":"Roth","year":"2013","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1435","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/sleep\/5.3.227","article-title":"Autonomic regulation of cardiopulmonary functions in sleep apnea syndrome and narcolepsy","volume":"5","author":"Sachs","year":"1982","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1440","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nrn3837","article-title":"The role of orexin in motivated behaviours","volume":"15","author":"Sakurai","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1445","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1450","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0166-2236(00)02002-6","article-title":"The sleep switch: hypothalamic control of sleep and wakefulness","volume":"24","author":"Saper","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1455","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.neuron.2010.11.032","article-title":"Sleep state switching","volume":"68","author":"Saper","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1460","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5665\/sleep\/32.1.111","article-title":"A consensus definition of cataplexy in mouse models of narcolepsy","volume":"32","author":"Scammell","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1465","doi-asserted-by":"crossref","first-page":"301","DOI":"10.5664\/jcsm.26804","article-title":"English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gelineau in the late 19th century, with commentary","volume":"3","author":"Schenck","year":"2007","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1470","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S1389-9457(02)00012-6","article-title":"Increased body mass index (BMI) in male narcoleptic patients, but not in HLA-DR2-positive healthy male volunteers","volume":"3","author":"Schuld","year":"2002","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1475","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000054587","article-title":"Reduced leptin levels in human narcolepsy","volume":"72","author":"Schuld","year":"2000","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1480","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/syn.20647","article-title":"Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil","volume":"63","author":"Seeman","year":"2009","journal-title":"Synapse"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1485","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.cmet.2011.08.010","article-title":"Orexin is required for brown adipose tissue development, differentiation, and function","volume":"14","author":"Sellayah","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1490","first-page":"817","article-title":"Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs","volume":"18","author":"Shelton","year":"1995","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1495","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbr.2012.07.039","article-title":"Interactions between modafinil and cocaine during the induction of conditioned place preference and locomotor sensitization in mice: implications for addiction","volume":"235","author":"Shuman","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1500","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1126\/science.1925546","article-title":"Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla","volume":"252","author":"Siegel","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1505","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/sleep\/25.2.197","article-title":"The epidemiology of narcolepsy in Olmsted County Minnesota: a population-based study","volume":"25","author":"Silber","year":"2002","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.pneurobio.2015.12.002_bib1510","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1038\/npp.2015.66","article-title":"GABA receptor agonist R-baclofen reverses social deficits and reduces repetitive behavior in two mouse models of autism","volume":"40","author":"Silverman","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1515","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5665\/sleep.2308","article-title":"Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy","volume":"36","author":"Sorensen","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1520","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2460\/javma.1984.185.05.538","article-title":"Narcolepsy in a Brahman bull","volume":"185","author":"Strain","year":"1984","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1530","first-page":"42","article-title":"A randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy","volume":"25","author":"Study Group U.S.X.M.","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1800","first-page":"31","article-title":"A 12-month, open-label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsy","volume":"26","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1535","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1081\/CLT-120019128","article-title":"The abrupt cessation of therapeutically administered sodium oxybate (GHB) does not cause withdrawal symptoms","volume":"41","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1540","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.sleep.2003.11.002","article-title":"Sodium oxybate demonstrates long-term efficacy for the treatment of cataplexy in patients with narcolepsy","volume":"5","year":"2004","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1545","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.sleep.2005.03.010","article-title":"Further evidence supporting the use of sodium oxybate for the treatment of cataplexy: a double-blind, placebo-controlled study in 228 patients","volume":"6","year":"2005","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1550","first-page":"2032","article-title":"Two novel hypothalamic peptides related to secretin derived from a single neuropeptide precursor","volume":"23","author":"Sutcliffe","year":"1997","journal-title":"Soc. Neurosci. Abs."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1555","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2460\/javma.1983.183.01.126","article-title":"Narcolepsy in a horse","volume":"183","author":"Sweeney","year":"1983","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1560","doi-asserted-by":"publisher","first-page":"6495","DOI":"10.1523\/JNEUROSCI.0073-14.2014","article-title":"Conditional ablation of orexin\/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function","volume":"34","author":"Tabuchi","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1565","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5665\/sleep.3300","article-title":"DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe","volume":"37","author":"Tafti","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1570","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0013-4694(92)90069-T","article-title":"Sleep deprivation in narcoleptic subjects: effect on sleep stages and EEG power density","volume":"83","author":"Tafti","year":"1992","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1575","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.celrep.2012.06.011","article-title":"Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system","volume":"2","author":"Tanaka","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1580","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/sleep\/29.5.633","article-title":"Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy","volume":"29","author":"Tanaka","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1585","first-page":"228","article-title":"An epidemiological study on prevalence of narcolpsy in Japanese","volume":"1","author":"Tashiro","year":"1992","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1590","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1595","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/sleep\/32.8.993","article-title":"Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy","volume":"32","author":"Thannickal","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1600","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.sleep.2014.10.002","article-title":"Clinical and practical considerations in the pharmacologic management of narcolepsy","volume":"16","author":"Thorpy","year":"2015","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1605","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.sleep.2014.01.015","article-title":"Delayed diagnosis of narcolepsy: characterization and impact","volume":"15","author":"Thorpy","year":"2014","journal-title":"Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1610","doi-asserted-by":"publisher","first-page":"10529","DOI":"10.1523\/JNEUROSCI.0784-11.2011","article-title":"Acute optogenetic silencing of orexin\/hypocretin neurons induces slow-wave sleep in mice","volume":"31","author":"Tsunematsu","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1615","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbr.2013.05.021","article-title":"Long-lasting silencing of orexin\/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice","volume":"255","author":"Tsunematsu","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1620","doi-asserted-by":"publisher","first-page":"15944","DOI":"10.1523\/JNEUROSCI.3909-11.2011","article-title":"An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis","volume":"31","author":"Tupone","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1625","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/ana.24019","article-title":"Increase of histaminergic tuberomammillary neurons in narcolepsy","volume":"74","author":"Valko","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1630","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1007\/s00415-008-0996-2","article-title":"No persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexy","volume":"255","author":"Valko","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1635","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.neubiorev.2012.02.002","article-title":"Possible long-term effects of gamma-hydroxybutyric acid (GHB) due to neurotoxicity and overdose","volume":"36","author":"van Amsterdam","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1640","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1172\/JCI119587","article-title":"Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men","volume":"100","author":"Van Cauter","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1645","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1523\/JNEUROSCI.19-08-03171.1999","article-title":"Hypothalamic hypocretin (orexin): robust innervation of the spinal cord","volume":"19","author":"van den Pol","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1650","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1093\/brain\/awt069","article-title":"Electroencephalogram paroxysmal theta characterizes cataplexy in mice and children","volume":"136","author":"Vassalli","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1655","first-page":"57","article-title":"Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions","volume":"6","author":"Vetrivelan","year":"2014","journal-title":"Nat. Sci. Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1660","doi-asserted-by":"publisher","first-page":"14194","DOI":"10.1523\/JNEUROSCI.3145-10.2010","article-title":"Differential effects of GABAB receptor subtypes {gamma}-hydroxybutyric acid, and baclofen on EEG activity and sleep regulation","volume":"30","author":"Vienne","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1665","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.5665\/sleep.1992","article-title":"Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory","volume":"35","author":"Vienne","year":"2012","journal-title":"Sleep"},{"issue":"Suppl 1","key":"10.1016\/j.pneurobio.2015.12.002_bib1670","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.neuropharm.2008.05.022","article-title":"Imaging dopamine's role in drug abuse and addiction","volume":"56","author":"Volkow","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1675","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1093\/sleep\/33.9.1217","article-title":"Enhancing slow wave sleep with sodium oxybate reduces the behavioral and physiological impact of sleep loss","volume":"33","author":"Walsh","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1680","doi-asserted-by":"crossref","first-page":"715","DOI":"10.5664\/jcsm.2848","article-title":"Status cataplecticus precipitated by abrupt withdrawal of venlafaxine","volume":"9","author":"Wang","year":"2013","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1685","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1172\/JCI79220","article-title":"Differentiation of hypothalamic-like neurons from human pluripotent stem cells","volume":"125","author":"Wang","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1690","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bbr.2013.12.045","article-title":"The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy","volume":"262","author":"Weinhold","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1695","first-page":"631","article-title":"Eigenh\u00fcmliche mit Einschl\u00e4fen verbundene Anf\u00e4lle","volume":"7","author":"Westphal","year":"1877","journal-title":"Arch. Psychiatry"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1700","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S0896-6273(03)00330-1","article-title":"Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes","volume":"38","author":"Willie","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1705","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.neuroscience.2004.10.005","article-title":"Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates","volume":"130","author":"Willie","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1710","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12031-010-9437-7","article-title":"Ectopic overexpression of orexin alters sleep\/wakefulness states and muscle tone regulation during REM sleep in mice","volume":"43","author":"Willie","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1715","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1111\/dmcn.12522","article-title":"Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A\/H1N1 2009 influenza vaccine in England","volume":"56","author":"Winstone","year":"2014","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1720","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fneur.2013.00139","article-title":"Modafinil as a catecholaminergic agent: empirical evidence and unanswered questions","volume":"4","author":"Wisor","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1725","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1523\/JNEUROSCI.21-05-01787.2001","article-title":"Dopaminergic role in stimulant-induced wakefulness","volume":"21","author":"Wisor","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1730","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S0306-4522(98)00600-9","article-title":"Locus coeruleus neurons: cessation of activity during cataplexy","volume":"91","author":"Wu","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1735","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0014-2999(92)90347-7","article-title":"Gamma-hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptors","volume":"212","author":"Xie","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1740","unstructured":"Xyrem\u00ae 2005 Xyrem(R) (sodium oxybate oral solution) Prescribing Information [Package Insert]. Jazz Pharmaceuticals, Inc.: Palo Alto, CA."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1745","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S0006-291X(03)00299-7","article-title":"Regulation of orexin neurons by the monoaminergic and cholinergic systems","volume":"303","author":"Yamanaka","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1750","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1523\/JNEUROSCI.4812-03.2004","article-title":"Hypocretinergic control of spinal cord motoneurons","volume":"24","author":"Yamuy","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1755","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nature14035","article-title":"Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant","volume":"519","author":"Yin","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1760","first-page":"320","article-title":"Criteria for the diagnosis of the narcoleptic syndrome","volume":"32","author":"Yoss","year":"1957","journal-title":"Proc. Staff Meet. Mayo Clin."},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1765","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.biopsych.2009.12.015","article-title":"Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors?","volume":"67","author":"Young","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1770","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuroscience.2007.05.029","article-title":"The development of hypocretin (orexin) deficiency in hypocretin\/ataxin-3 transgenic rats","volume":"148","author":"Zhang","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2015.12.002_bib1775","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1124\/jpet.108.146142","article-title":"Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil","volume":"329","author":"Zolkowska","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Progress in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030100821530023X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030100821530023X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T22:32:29Z","timestamp":1748730749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030100821530023X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":355,"alternative-id":["S030100821530023X"],"URL":"https:\/\/doi.org\/10.1016\/j.pneurobio.2015.12.002","relation":{},"ISSN":["0301-0082"],"issn-type":[{"value":"0301-0082","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Challenges in the development of therapeutics for narcolepsy","name":"articletitle","label":"Article Title"},{"value":"Progress in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pneurobio.2015.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}