{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T20:49:38Z","timestamp":1747169378870,"version":"3.40.5"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neurobiology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.pneurobio.2016.01.004","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T01:45:41Z","timestamp":1454636741000},"page":"149-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Neurofibromatosis as a gateway to better treatment for a variety of malignancies"],"prefix":"10.1016","volume":"152","author":[{"given":"Annette C.","family":"Bakker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"La Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-6551","authenticated-orcid":false,"given":"Larry S.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-7550","authenticated-orcid":false,"given":"Pamela","family":"Knight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyerim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0405-9993","authenticated-orcid":false,"given":"Patrice","family":"Pancza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Nievo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pneurobio.2016.01.004_bib0005","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s11910-996-0036-5","article-title":"Neurofibromatosis type 1: new insights into neurocognitive issues","volume":"6","author":"Acosta","year":"2006","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0010","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1479-7364-6-12","article-title":"Genotype\u2013phenotype associations in neurofibromatosis type 1 (NF1): an increased risk of tumor complications in patients with NF1 splice-site mutations?","volume":"6","author":"Alkindy","year":"2012","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0015","doi-asserted-by":"publisher","first-page":"5236","DOI":"10.1158\/0008-5472.CAN-07-5849","article-title":"Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma","volume":"68","author":"Ammoun","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0020","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/WNO.0b013e31822aef82","article-title":"Optic pathway gliomas","volume":"31","author":"Avery","year":"2011","journal-title":"J. Neuroophthalmol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0025","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10048-009-0204-2","article-title":"Schwannomatosis associated with multiple meningiomas due to a familial SMARCB1 mutation","volume":"11","author":"Bacci","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0030","first-page":"8573","article-title":"Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity","volume":"63","author":"Bajenaru","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0035","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.1523\/JNEUROSCI.22-23-10399.2002","article-title":"Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons","volume":"22","author":"Balkowiec","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0040","doi-asserted-by":"publisher","first-page":"873","DOI":"10.2217\/bmm.14.52","article-title":"The National Biomarker Development Alliance accelerating the translation of biomarkers to the clinic","volume":"8","author":"Barker","year":"2014","journal-title":"Biomark. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0045","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1017\/S0012162204000921","article-title":"Social skills of children with neurofibromatosis type 1","volume":"46","author":"Barton","year":"2004","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0050","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1054\/bjoc.1999.1030","article-title":"Neurofibromatosis 2, radiosurgery and malignant nervous system tumours","volume":"82","author":"Baser","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0055","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1136\/jmg.2004.029504","article-title":"The location of constitutional neurofibromatosis 2 (NF2) splice site mutations is associated with the severity of NF2","volume":"42","author":"Baser","year":"2005","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0060","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0165-5728(91)90094-N","article-title":"Rat Schwann cells produce interleukin-1","volume":"34","author":"Bergsteinsdottir","year":"1991","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0065","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1038\/onc.2010.20","article-title":"NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation","volume":"29","author":"Bosco","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0070","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/ajh.23403","article-title":"Neurofibromatosis-1 gene deletions and mutations in de novo adult acute myeloid leukemia","volume":"88","author":"Boudry-Labis","year":"2013","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0075","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/ph5020114","article-title":"TRPV1 antagonists and chronic pain: beyond thermal perception","volume":"5","author":"Brandt","year":"2012","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0080","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1158\/0008-5472.CAN-12-1888","article-title":"Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth","volume":"73","author":"Burns","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0085","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/j.1460-9568.2006.04606.x","article-title":"Erythropoietin reduces Schwann cell TNF-alpha Wallerian degeneration and pain-related behaviors after peripheral nerve injury","volume":"23","author":"Campana","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0090","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.bbi.2006.12.008","article-title":"Schwann cells: activated peripheral glia and their role in neuropathic pain","volume":"21","author":"Campana","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0095","doi-asserted-by":"publisher","first-page":"8422","DOI":"10.1200\/JCO.2005.01.4886","article-title":"Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group","volume":"23","author":"Carli","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0100","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1172\/JCI63193","article-title":"Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice","volume":"123","author":"Chang","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0105","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ccell.2014.09.009","article-title":"Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma","volume":"26","author":"Chen","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0110","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1136\/jmg.2010.082420","article-title":"Germline SMARCB1 mutation and somatic NF2 mutations in familial multiple meningiomas","volume":"48","author":"Christiaans","year":"2011","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0115","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1126\/science.286.5447.2172","article-title":"Mouse models of tumor development in neurofibromatosis type 1","volume":"286","author":"Cichowski","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0120","first-page":"145","article-title":"Rationale for combining biotherapy in the treatment of advanced colon cancer","volume":"2","author":"Cohen","year":"2008","journal-title":"Gastrointest. Cancer Res."},{"issue":"Suppl. 1","key":"10.1016\/j.pneurobio.2016.01.004_bib0125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2165\/00003495-200868001-00001","article-title":"The evolution of immunosuppressant therapy in renal transplantation","volume":"68","author":"Cole","year":"2008","journal-title":"Drugs"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0130","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4161\/sgtp.1.1.12178","article-title":"Ras history: the saga continues","volume":"1","author":"Cox","year":"2010","journal-title":"Small GTPases"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0135","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/0002-9149(93)90715-O","article-title":"Efficacy and tolerability of lovastatin in hypercholesterolemia in patients with systemic hypertension","volume":"71","author":"D\u2019Agostino","year":"1993","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0140","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1158\/0008-5472.236.65.1","article-title":"Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes","volume":"65","author":"Dasgupta","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0145","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.ccr.2011.08.014","article-title":"Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors","volume":"20","author":"De Raedt","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0150","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00403-006-0644-6","article-title":"Caf\u00e9-au-lait spots in neurofibromatosis type 1 and in healthy control individuals: hyperpigmentation of a different kind?","volume":"297","author":"De Schepper","year":"2006","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0155","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/sj.jid.5701095","article-title":"Somatic mutation analysis in NF1 Caf\u00e9 au lait spots reveals two NF1 hits in the melanocytes","volume":"128","author":"De Schepper","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0165","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11060-009-0049-4","article-title":"Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model","volume":"98","author":"Demestre","year":"2010","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0170","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/BF03033260","article-title":"BDNF is involved in sympathetic sprouting in the dorsal root ganglia following peripheral nerve injury in rats","volume":"1","author":"Deng","year":"2000","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0175","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/ana.24093","article-title":"Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1","volume":"75","author":"Diggs-Andrews","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0180","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.bcp.2006.04.010","article-title":"Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1","volume":"72","author":"Dilworth","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0185","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature07423","article-title":"Somatic mutations affect key pathways in lung adenocarcinoma","volume":"455","author":"Ding","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0190","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrc969","article-title":"Targeting RAS signalling pathways in cancer therapy","volume":"3","author":"Downward","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0195","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1111\/cas.12697","article-title":"Cooperatively transcriptional and epigenetic regulation of sonic hedgehog overexpression drives malignant potential of breast cancer","volume":"106","author":"Duan","year":"2015","journal-title":"Cancer Sci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0200","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1124\/jpet.109.159079","article-title":"Multipotent neurotrophin antagonist targets brain-derived neurotrophic factor and nerve growth factor","volume":"332","author":"Eibl","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0205","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.bone.2012.07.011","article-title":"Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia","volume":"51","author":"El Khassawna","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0210","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/jbmr.528","article-title":"A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells","volume":"27","author":"El-Hoss","year":"2012","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0215","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00401-011-0800-8","article-title":"Medulloblastoma: clinicopathological correlates of SHH WNT, and non-SHH\/WNT molecular subgroups","volume":"121","author":"Ellison","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0220","doi-asserted-by":"publisher","first-page":"532","DOI":"10.7326\/0003-4819-146-7-200704030-00011","article-title":"Trials that matter: two faces of progress in the treatment of age-related macular degeneration","volume":"146","author":"Epstein","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0225","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1136\/jmg.29.12.841","article-title":"A genetic study of type 2 neurofibromatosis in the United Kingdom: I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity","volume":"29","author":"Evans","year":"1992","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0230","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/jmg.2006.045906","article-title":"Guidelines for the diagnosis and management of individuals with neurofibromatosis 1","volume":"44","author":"Ferner","year":"2007","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0235","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1136\/jnnp.2010.206532","article-title":"The neurofibromatoses","volume":"10","author":"Ferner","year":"2010","journal-title":"Pract. Neurol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0240","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0049-0172(99)80028-6","article-title":"Clinical experience with soluble TNF p75 receptor in rheumatoid arthritis","volume":"29","author":"Franklin","year":"1999","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0245","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/B978-0-12-801185-0.00015-5","article-title":"CRISPR\/Cas9-based genome editing in mice by single plasmid injection","volume":"546","author":"Fujihara","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0250","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/ddu414","article-title":"A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation","volume":"24","author":"Gehlhausen","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0255","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2013.06.044","article-title":"CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes","volume":"154","author":"Gilbert","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0260","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","article-title":"Genome-scale CRISPR-mediated control of gene repression and activation","volume":"159","author":"Gilbert","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0265","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1101\/gad.13.8.978","article-title":"Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein","volume":"13","author":"Giovannini","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0270","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1101\/gad.14.13.1617","article-title":"Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2","volume":"14","author":"Giovannini","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0275","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.devcel.2010.10.008","article-title":"The NF2 tumor suppressor Merlin, regulates epidermal development through the establishment of a junctional polarity complex","volume":"19","author":"Gladden","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0280","first-page":"723","article-title":"B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice","volume":"27","author":"Gleiss","year":"2013","journal-title":"In Vivo"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0285","doi-asserted-by":"publisher","first-page":"13979","DOI":"10.3390\/ijms140713979","article-title":"Hedgehog signaling in prostate cancer and its therapeutic implication","volume":"14","author":"Gonnissen","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0290","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3171\/2010.8.JNS091900","article-title":"Schwannomatosis, sporadic schwannomatosis, and familial schwannomatosis: a surgical series with long-term follow-up clinical article","volume":"114","author":"Gonzalvo","year":"2011","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0295","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/stem.170235","article-title":"The molecular perspective: the ras oncogene","volume":"17","author":"Goodsell","year":"1999","journal-title":"Stem Cells"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0300","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s11060-014-1710-0","article-title":"Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas","volume":"122","author":"Goutagny","year":"2015","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0305","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1523\/JNEUROSCI.3686-05.2006","article-title":"Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation","volume":"26","author":"Guo","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0310","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1517\/13543784.2013.772979","article-title":"Optimizing biologically targeted clinical trials for neurofibromatosis","volume":"22","author":"Gutmann","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0315","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1136\/jmg.2007.056499","article-title":"Molecular characterisation of SMARCB1 and NF2 in familial and sporadic schwannomatosis","volume":"45","author":"Hadfield","year":"2008","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0320","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ncb1339","article-title":"The tumour-suppressor genes NF2\/Merlin and expanded act through Hippo signalling to regulate cell proliferation and apoptosis","volume":"8","author":"Hamaratoglu","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0325","doi-asserted-by":"publisher","first-page":"470","DOI":"10.2174\/138920009788897975","article-title":"Tyrosine kinase inhibitors \u2013 a review on pharmacology, metabolism and side effects","volume":"10","author":"Hartmann","year":"2009","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0330","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2174\/187152810792231878","article-title":"Current and future treatment options in idiopathic pulmonary fibrosis","volume":"9","author":"Hauber","year":"2010","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0335","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1158\/0008-5472.CAN-07-5916","article-title":"Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma","volume":"68","author":"Hegedus","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0340","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1136\/jmedgenet-2015-103290","article-title":"Clinical and molecular predictors of mortality in neurofibromatosis 2: a UK national analysis of 1192 patients","volume":"52","author":"Hexter","year":"2015","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0345","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.cell.2010.06.004","article-title":"NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome","volume":"142","author":"H\u00f6lzel","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0350","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1523\/JNEUROSCI.23-19-07269.2003","article-title":"Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor beta3 in myelinating Schwann cells","volume":"23","author":"Huijbregts","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0355","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1086\/513207","article-title":"Germline mutation of INI1\/SMARCB1 in familial schwannomatosis","volume":"80","author":"Hulsebos","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0360","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00401-014-1311-1","article-title":"Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants","volume":"128","author":"Hutter","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0365","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1212\/01.wnl.0000179303.72345.ce","article-title":"The nature and frequency of cognitive deficits in children with neurofibromatosis type 1","volume":"65","author":"Hyman","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0370","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1017\/S0012162206002131","article-title":"Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder","volume":"48","author":"Hyman","year":"2006","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0375","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/ng0794-353","article-title":"Tumour predisposition in mice heterozygous for a targeted mutation in Nf1","volume":"7","author":"Jacks","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0380","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1200\/JCO.2012.46.3653","article-title":"Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers","volume":"31","author":"Jain","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0385","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1128\/MCB.01581-08","article-title":"NF2\/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth","volume":"29","author":"James","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0390","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1172\/JCI60578","article-title":"MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors","volume":"123","author":"Jessen","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0395","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/GIM.0b013e3181bf15e3","article-title":"Clinical and genetic aspects of neurofibromatosis 1","volume":"12","author":"Jett","year":"2010","journal-title":"Genet. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0400","doi-asserted-by":"publisher","first-page":"8573","DOI":"10.1073\/pnas.0503224102","article-title":"The NF1 tumor suppressor critically regulates TSC2 and mTOR","volume":"102","author":"Johannessen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0405","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1158\/1535-7163.MCT-07-2335","article-title":"Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors","volume":"7","author":"Johansson","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0410","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ccr.2008.01.030","article-title":"A conditional mouse model for malignant mesothelioma","volume":"13","author":"Jongsma","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0415","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/hmg\/ddg146","article-title":"Upregulation of the Rac1\/JNK signaling pathway in primary human schwannoma cells","volume":"12","author":"Kaempchen","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0420","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1101\/gad.226302","article-title":"Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse","volume":"16","author":"Kalamarides","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0425","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1038\/onc.2010.609","article-title":"Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes","volume":"30","author":"Kalamarides","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0430","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00401-011-0905-0","article-title":"Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting","volume":"123","author":"Kalamarides","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0435","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/nature09208","article-title":"Diverse somatic mutation patterns and pathway alterations in human cancers","volume":"466","author":"Kan","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0440","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/neuonc\/not150","article-title":"Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas","volume":"16","author":"Karajannis","year":"2014","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0445","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/1098-2779(2000)6:2<117::AID-MRDD5>3.0.CO;2-X","article-title":"Behavioral phenotype of neurofibromatosis, type 1","volume":"6","author":"Kayl","year":"2000","journal-title":"Ment. Retard Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0450","doi-asserted-by":"publisher","first-page":"10657","DOI":"10.3390\/molecules200610657","article-title":"Neurotrophins and neuropathic pain: role in pathobiology","volume":"20","author":"Khan","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0455","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1017\/S1355617713001227","article-title":"Cognitive and psychosocial phenotype of young children with neurofibromatosis-1","volume":"20","author":"Klein-Tasman","year":"2014","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0460","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1093\/hmg\/7.8.1261","article-title":"Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1","volume":"7","author":"Klose","year":"1998","journal-title":"Hum. Mol. Genet."},{"year":"2011","series-title":"Neurofibromatosis: A Handbook for Patients, Families and Health Care Professionals","author":"Korf","key":"10.1016\/j.pneurobio.2016.01.004_bib0465"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0470","series-title":"Translational\/Clinical Studies in Children and Adults With Neurofibromatosis Type 1. Neurofibromatosis Type 1: Molecular and Cellular Biology","first-page":"625","author":"Korf","year":"2012"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0480","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1158\/0008-5472.CAN-07-6867","article-title":"Pten haploinsufficiency accelerates formation of high-grade astrocytomas","volume":"68","author":"Kwon","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0485","doi-asserted-by":"publisher","first-page":"301292","DOI":"10.1155\/2015\/301292","article-title":"Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model","volume":"2015","author":"Lattanzi","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0490","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1182\/blood-2003-08-2650","article-title":"Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder","volume":"103","author":"Le","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0495","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1523\/JNEUROSCI.13-05-02136.1993","article-title":"Nerve growth factor-induced hyperalgesia in the neonatal and adult rat","volume":"13","author":"Lewin","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0500","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1111\/j.1460-9568.1994.tb00581.x","article-title":"Peripheral and central mechanisms of NGF-induced hyperalgesia","volume":"6","author":"Lewin","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0505","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.cell.2010.01.029","article-title":"Merlin\/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus","volume":"140","author":"Li","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0510","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.ctrv.2014.05.004","article-title":"Systemic therapy in neurofibromatosis type 2","volume":"40","author":"Lim","year":"2014","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0515","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/ana.21107","article-title":"Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations","volume":"61","author":"Listernick","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0520","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0002-9394(14)73984-4","article-title":"Spontaneous visual improvement in chiasmal gliomas","volume":"114","author":"Liu","year":"1992","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0525","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.1128\/MCB.01578-08","article-title":"Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling","volume":"29","author":"L\u00f3pez-Lago","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0530","doi-asserted-by":"publisher","first-page":"5281","DOI":"10.1200\/JCO.2005.14.415","article-title":"Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies","volume":"23","author":"Lorusso","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0540","first-page":"E81","article-title":"The neurofibromatoses: Part 2. NF2 and schwannomatosis","volume":"6","author":"Lu-Emerson","year":"2009","journal-title":"Rev. Neurol. Dis."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0545","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1212\/01.WNL.0000163982.78900.AD","article-title":"Diagnostic criteria for schwannomatosis","volume":"64","author":"MacCollin","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0550","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1002\/humu.20389","article-title":"Comprehensive NF1 screening on cultured Schwann cells from neurofibromas","volume":"27","author":"Maertens","year":"2006","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0555","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1158\/2159-8290.CD-14-0159","article-title":"Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers","volume":"4","author":"Malone","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0560","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1592\/phco.23.12.1281.32697","article-title":"Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations","volume":"23","author":"Markowitz","year":"2003","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0565","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1523\/JNEUROSCI.11-10-03165.1991","article-title":"Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: comparison of Schwann cells with other cell types","volume":"11","author":"Matsuoka","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0570","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1124\/jpet.105.091454","article-title":"The mitogen-activated protein kinase\/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines","volume":"316","author":"Mattingly","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0575","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1017\/S0012162201001876","article-title":"Treatment of ADHD in neurofibromatosis type 1","volume":"44","author":"Mautner","year":"2002","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0580","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1158\/0008-5472.CAN-10-4558","article-title":"Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation","volume":"71","author":"Mayes","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0585","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.tcb.2009.02.006","article-title":"Merlin and the ERM proteins \u2013 regulators of receptor distribution and signaling at the cell cortex","volume":"19","author":"McClatchey","year":"2009","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0590","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000126545","article-title":"NF1 mutational spectrum","volume":"16","author":"Messiaen","year":"2008","journal-title":"Monogr. Hum. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0595","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/j.1532-2149.2012.00202.x","article-title":"Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats","volume":"17","author":"Mills","year":"2013","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0600","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1101\/gad.189601","article-title":"The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44","volume":"15","author":"Morrison","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0605","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s11864-010-0120-6","article-title":"Exciting new targets in lung cancer therapy: ALK, IGF-1R, HDAC, and Hh","volume":"11","author":"Neal","year":"2010","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0610","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1093\/bja\/aeu056","article-title":"Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy","volume":"113","author":"Niesters","year":"2014","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0615","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1212\/WNL.48.4.1121","article-title":"Cognitive function and academic performance in neurofibromatosis 1 consensus statement from the NF1 Cognitive Disorders Task Force","volume":"48","author":"North","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0620","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.1016\/j.amjmed.2009.04.007","article-title":"Treatment of neuropathic pain: an overview of recent guidelines","volume":"122","author":"O\u2019Connor","year":"2009","journal-title":"Am. J. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0625","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1083\/jcb.200503165","article-title":"Merlin\/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane","volume":"171","author":"Okada","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0630","first-page":"442","article-title":"Mechanisms of inactivation of PTCH1 gene in nevoid basal cell carcinoma syndrome: modification of the two-hit hypothesis Clin","volume":"16","author":"Pan","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0635","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1126\/science.1164382","article-title":"An integrated genomic analysis of human glioblastoma multiforme","volume":"321","author":"Parsons","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0640","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/ajmg.a.36338","article-title":"Longitudinal assessment of cognition and T2-hyperintensities in NF1: an 18-year study","volume":"164A","author":"Payne","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0645","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/labinvest.3700675","article-title":"An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation","volume":"87","author":"Perrin","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0650","series-title":"Meningiomas in WHO Classification of Tumours of the Central Nervous System","first-page":"164","author":"Perry","year":"2007"},{"issue":"5","key":"10.1016\/j.pneurobio.2016.01.004_bib0655","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/onc.2015.125","article-title":"Role of Merlin\/NF2 inactivation in tumor biology","volume":"35","author":"Petrilli","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0660","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/ng.2855","article-title":"Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas","volume":"46","author":"Piotrowski","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0665","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0670","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/ajmg.a.35760","article-title":"Update from the 2011 International Schwannomatosis Workshop: from genetics to diagnostic criteria","volume":"161A","author":"Plotkin","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0675","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1056\/NEJMoa0902579","article-title":"Hearing improvement after bevacizumab in patients with neurofibromatosis type 2","volume":"361","author":"Plotkin","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0680","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jpeds.2011.08.051","article-title":"Pediatric plexiform neurofibromas: impact on morbidity and mortality in neurofibromatosis type 1","volume":"160","author":"Prada","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0685","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00401-012-1056-7","article-title":"Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition","volume":"125","author":"Prada","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0690","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nrc3911","article-title":"A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor","volume":"15","author":"Ratner","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0695","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrc1273","article-title":"The SWI\/SNF complex\u2013chromatin and cancer","volume":"4","author":"Roberts","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0700","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0705","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22832","article-title":"High incidence of noonan syndrome features including short stature and pulmonic stenosis in patients carrying NF1 missense mutations affecting p.Arg1809: genotype\u2013phenotype correlation","author":"Rojnueangnit","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0710","doi-asserted-by":"publisher","first-page":"8988","DOI":"10.1523\/JNEUROSCI.2995-05.2005","article-title":"Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain","volume":"25","author":"Romero-Sandoval","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0715","doi-asserted-by":"publisher","first-page":"18200","DOI":"10.1073\/pnas.0405971102","article-title":"Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L","volume":"101","author":"Rong","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0720","doi-asserted-by":"publisher","first-page":"642","DOI":"10.5858\/arpa.2014-0200-OA","article-title":"Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options","volume":"139","author":"Ross","year":"2015","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0725","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11910-003-0064-3","article-title":"Neurocognitive dysfunction in children with neurofibromatosis type 1","volume":"3","author":"Rosser","year":"2003","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0730","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.pain.2009.11.022","article-title":"NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin","volume":"148","author":"Rukwied","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0735","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1002\/humu.22392","article-title":"NF1 molecular characterization and neurofibromatosis type I genotype\u2013phenotype correlation: the French experience","volume":"34","author":"Sabbagh","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0740","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/nrd4281","article-title":"Targeting RAS-ERK signalling in cancer: promises and challenges","volume":"13","author":"Samatar","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0745","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.ejpain.2010.05.005","article-title":"Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain","volume":"14","author":"Schr\u00f6der","year":"2010","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0750","first-page":"263","article-title":"Recent advances in the pharmacological management of acute and chronic pain","volume":"3","author":"Schug","year":"2014","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0755","doi-asserted-by":"publisher","first-page":"10177","DOI":"10.1523\/JNEUROSCI.0840-10.2010","article-title":"Merlin inhibits neurite outgrowth in the CNS","volume":"30","author":"Schulz","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0760","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nn.3348","article-title":"Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy","volume":"16","author":"Schulz","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0765","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s40478-014-0082-1","article-title":"A neuronal function of the tumor suppressor protein merlin","volume":"2","author":"Schulz","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0770","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1399-0004.2009.01315.x","article-title":"Further genotype\u2013phenotype correlations in neurofibromatosis 2","volume":"77","author":"Selvanathan","year":"2010","journal-title":"Clin. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0775","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1093\/hmg\/9.20.3055","article-title":"Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations","volume":"9","author":"Serra","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0780","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s40264-013-0050-x","article-title":"Tyrosine kinase inhibitors: their on-target toxicities as potential indicators of efficacy","volume":"36","author":"Shah","year":"2013","journal-title":"Drug Saf."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0785","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.pcl.2010.07.002","article-title":"The diagnostic and clinical significance of caf\u00e9-au-lait macules","volume":"57","author":"Shah","year":"2010","journal-title":"Pediatr. Clin. N. Am."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0790","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1136\/jmg.2010.081760","article-title":"A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype\u2013phenotype correlations","volume":"48","author":"Sharif","year":"2011","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0795","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S1534-5807(01)00009-0","article-title":"The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling","volume":"1","author":"Shaw","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0800","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-neuro-060909-153215","article-title":"Molecular and cellular mechanisms of learning disabilities: a focus on NF1","volume":"33","author":"Shilyansky","year":"2010","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0805","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/ng0397-281","article-title":"A mouse model for the learning and memory deficits associated with neurofibromatosis type I","volume":"15","author":"Silva","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0810","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.ctrv.2012.05.001","article-title":"Treatment-related mortality with vascular endothelial growth factor receptor tyrosine kinase inhibitor therapy in patients with advanced solid tumors: a meta-analysis","volume":"38","author":"Sivendran","year":"2012","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0820","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1093\/hmg\/dds370","article-title":"Expression of SMARCB1 (INI1) mutations in familial schwannomatosis","volume":"21","author":"Smith","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0825","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s10048-012-0319-8","article-title":"Frequency of SMARCB1 mutations in familial and sporadic schwannomatosis","volume":"13","author":"Smith","year":"2012","journal-title":"Neurogenetics"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0830","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.cancergen.2014.04.001","article-title":"SMARCB1 mutations in schwannomatosis and genotype correlations with rhabdoid tumors","volume":"207","author":"Smith","year":"2014","journal-title":"Cancer Genetics"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0835","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.1200\/JCO.2014.58.2569","article-title":"Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations","volume":"32","author":"Smith","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0840","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/nn.4053","article-title":"Different immune cells mediate mechanical pain hypersensitivity in male and female mice","volume":"18","author":"Sorge","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0845","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1146\/annurev-pathol-011811-132441","article-title":"Pathogenesis of plexiform neurofibroma: tumor-stromal\/hematopoietic interactions in tumor progression","volume":"7","author":"Staser","year":"2012","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0850","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/ajmg.c.30296","article-title":"The musculoskeletal phenotype of the RASopathies","volume":"157C","author":"Stevenson","year":"2011","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0855","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3390\/ijms14011179","article-title":"Hedgehog signaling pathway in ovarian cancer","volume":"14","author":"Szkandera","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0860","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.ejim.2014.04.004","article-title":"Is it time to change the neurofibromatosis 1 diagnostic criteria?","volume":"25","author":"Tadini","year":"2014","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0865","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1167\/iovs.14-16300","article-title":"Merlin regulates epithelial-to-mesenchymal transition of ARPE-19 cells via TAK1-p38MAPK-mediated activation","volume":"56","author":"Takahashi","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0870","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature07385","article-title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"455","author":"The Cancer Genome Atlas Research Network","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0875","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"The Cancer Genome Atlas Research Network","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0880","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0304-3959(94)00271-F","article-title":"Nerve growth factor induces mechanical allodynia associated with novel A fibre-evoked spinal reflex activity and enhanced neurokinin-1 receptor activation in the rat","volume":"62","author":"Thompson","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0885","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/BF02738732","article-title":"Characterization of pheochromocytomas in a mouse strain with a targeted disruptive mutation of the neurofibromatosis gene Nf1","volume":"6","author":"Tischler","year":"1995","journal-title":"Endocr. Pathol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0890","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00586-004-0829-7","article-title":"Spinal deformity in neurofibromatosis type-1: diagnosis and treatment","volume":"14","author":"Tsirikos","year":"2005","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0895","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1212\/01.wnl.0000168830.79997.13","article-title":"Association between benign and malignant peripheral nerve sheath tumors in NF1","volume":"65","author":"Tucker","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0900","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/ajcn\/69.5.842","article-title":"Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety","volume":"69","author":"Vieth","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0905","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1126\/science.286.5447.2176","article-title":"Mouse tumor model for neurofibromatosis type 1","volume":"286","author":"Vogel","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0910","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1097\/00001756-199611250-00018","article-title":"Endoneurial injection of TNF-alpha produces neuroapthic pain behaviors","volume":"7","author":"Wagner","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0915","doi-asserted-by":"publisher","first-page":"3910","DOI":"10.1093\/hmg\/ddr310","article-title":"Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I","volume":"20","author":"Wang","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0920","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/nrd1251","article-title":"Glia: a novel drug discovery target for clinical pain","volume":"2","author":"Watkins","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0925","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1002\/pbc.24873","article-title":"Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study","volume":"61","author":"Weiss","year":"2014","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0930","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1093\/neuonc\/nou235","article-title":"Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study","volume":"17","author":"Weiss","year":"2015","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0935","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1200\/JCO.2005.03.8638","article-title":"Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas","volume":"24","author":"Widemann","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0940","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ccr.2007.12.027","article-title":"Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells","volume":"13","author":"Wu","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0945","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S0006-8993(02)03666-1","article-title":"Involvement of a spinal brain-derived neurotrophic factor\/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice","volume":"958","author":"Yajima","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0950","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/j.1471-4159.2005.03045.x","article-title":"Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in mice","volume":"93","author":"Yajima","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0955","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.cell.2008.08.041","article-title":"Nf1-dependent tumors require a microenvironment containing Nf1+\/\u2212 and c-kit-dependent bone marrow","volume":"135","author":"Yang","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0960","doi-asserted-by":"publisher","first-page":"11219","DOI":"10.1007\/s13277-014-2454-3","article-title":"A functional and protein\u2013protein interaction analysis of neuroepithelial cell transforming gene 1 in hepatocellular carcinoma","volume":"35","author":"Ye","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0965","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ccr.2011.02.017","article-title":"A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions","volume":"19","author":"Yi","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0970","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.18632\/oncotarget.747","article-title":"Identification and characterization of a novel chemotype MEK inhibitor able to alter the phosphorylation state of MEK1\/2","volume":"3","author":"Yoshida","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0975","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.bone.2011.03.760","article-title":"Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model","volume":"48","author":"Zhang","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0980","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1126\/science.1068452","article-title":"Neurofibromas in NF1: Schwann cell origin and role of tumor environment","volume":"296","author":"Zhu","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0985","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ccr.2005.07.004","article-title":"Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma","volume":"8","author":"Zhu","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0990","doi-asserted-by":"publisher","first-page":"5577","DOI":"10.1242\/dev.02162","article-title":"Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation","volume":"132","author":"Zhu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.pneurobio.2016.01.004_bib0995","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1101\/gad.862101","article-title":"Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain","volume":"15","author":"Zhu","year":"2001","journal-title":"Genes Dev."}],"container-title":["Progress in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301008215300496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301008215300496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T19:20:31Z","timestamp":1692213631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301008215300496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":195,"alternative-id":["S0301008215300496"],"URL":"https:\/\/doi.org\/10.1016\/j.pneurobio.2016.01.004","relation":{},"ISSN":["0301-0082"],"issn-type":[{"type":"print","value":"0301-0082"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurofibromatosis as a gateway to better treatment for a variety of malignancies","name":"articletitle","label":"Article Title"},{"value":"Progress in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pneurobio.2016.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}