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Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0735","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1093\/nar\/gni180","article-title":"Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level","volume":"33","author":"Fatemi","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0740","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0197-0186(02)00049-9","article-title":"Noradrenergic regulation of inflammatory gene expression in brain","volume":"41","author":"Feinstein","year":"2002","journal-title":"Neurochem. 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Med."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0755","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S1474-4422(14)70065-1","article-title":"Frontotemporal dementia and its subtypes: a genome-wide association study","volume":"13","author":"Ferrari","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0760","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2174\/1389557511313040002","article-title":"The vigilance promoting drug modafinil modulates serotonin transmission in the rat prefrontal cortex and dorsal raphe nucleus. Possible relevance for its postulated antidepressant activity","volume":"13","author":"Ferraro","year":"2013","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0765","first-page":"234","article-title":"Selegiline in the treatment of Alzheimer\u2019s disease: a long-term randomized placebo-controlled trial: Czech and Slovak Senile Dementia of Alzheimer Type Study Group","volume":"24","author":"Filip","year":"1999","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0770","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1111\/j.1471-4159.1990.tb05789.x","article-title":"Serotonin metabolism by monoamine oxidase in rat primary astrocyte cultures","volume":"55","author":"Fitzgerald","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0775","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12031-015-0536-3","article-title":"Interaction between brain histamine and serotonin, norepinephrine, and dopamine systems: in vivo microdialysis and electrophysiology study","volume":"56","author":"Flik","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0780","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0785","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.ne.10.030187.000435","article-title":"Extrathalamic modulation of cortical function","volume":"10","author":"Foote","year":"1987","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0790","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1124\/jpet.104.078402","volume":"313","author":"Fox","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0795","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1038\/npp.2012.40","article-title":"Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer\u2019s disease","volume":"37","author":"Francis","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0800","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1523\/JNEUROSCI.4261-13.2014","article-title":"Activity-dependent tau protein translocation to excitatory synaps is disrupted by exposure to A\u03b2 oligomers","volume":"34","author":"Frandemiche","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0805","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/cne.902100108","article-title":"Dopaminergic neurons in the human retina","volume":"210","author":"Frederick","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0810","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1212\/WNL.50.3.660","article-title":"l-deprenyl in Alzheimer\u2019s disease: cognitive and behavioral effects","volume":"50","author":"Freedman","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0815","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1074\/jbc.M808759200","article-title":"Propagation of tau misfolding from the outside to the inside of a cell","volume":"284","author":"Frost","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0820","doi-asserted-by":"crossref","first-page":"S538","DOI":"10.1016\/j.jalz.2010.05.1937","article-title":"RQ-00000009, a selective 5-HT4 receptor partial agonist, suppressed brain amyloid-b protein levels and improved memory and cognitive performances in rodents","volume":"6","author":"Fujiuchi","year":"2010","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0825","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/brain\/awg031","article-title":"Vaccination with A\u03b2 peptide induces autoimmune encephalomyelitis in C57\/BL6 mice","volume":"126","author":"Furlan","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0830","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainres.2012.01.062","article-title":"On the role of volume transmission and receptor\u2013receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons","volume":"1476","author":"Fuxe","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0835","first-page":"37","article-title":"Evidence for the existence of monoamine neurons in the central nervous system: V. Distribution of monoamine nerve terminals in the central nervous system","volume":"64","author":"Fuxe","year":"1965","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0840","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer\u2019s disease","volume":"41","author":"G\u00f3mez-Isla","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0845","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.neuropharm.2009.03.011","article-title":"JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition","volume":"56","author":"Galici","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0850","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/sj.npp.1300330","article-title":"Differential involvement of 5-HT(1B\/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer\u2019s disease","volume":"29","author":"Garcia-Alloza","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0855","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuropsychologia.2004.06.007","article-title":"Cholinergic\u2013serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer\u2019s disease","volume":"43","author":"Garcia-Alloza","year":"2005","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0860","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/cne.902790208","article-title":"Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-\u03b2-hydroxylase","volume":"279","author":"Gaspar","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0865","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/JGP.0b013e318187de18","article-title":"Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer\u2019s disease","volume":"17","author":"Gehrman","year":"2009","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0870","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.neurobiolaging.2008.05.018","article-title":"Memory loss caused by A\u03b2 protein is rescued by a \u03b23-adrenoceptor agonist","volume":"31","author":"Gibbs","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0875","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer\u2019s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0880","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0006-291X(84)91209-9","article-title":"Alzheimer\u2019s disease and Down\u2019s syndrome: sharing of a unique cerebrovascular amyloid fibril protein","volume":"122","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0885","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/1533317506295889","article-title":"The influence of \u03b2-blockers on delayed memory function in people with cognitive impairment","volume":"22","author":"Gliebus","year":"2007","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0890","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0895","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/383550a0","article-title":"Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans","volume":"383","author":"Goedert","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0900","first-page":"23","article-title":"Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer\u2019s disease, Down\u2019s syndrome and aging","volume":"24","author":"Goldgaber","year":"1987","journal-title":"J. Neural Trans."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0905","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1136\/jnnp.68.6.778","article-title":"Alzheimer\u2019s disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response","volume":"68","author":"Golomb","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0910","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1046\/j.1471-4159.1995.65020732.x","article-title":"Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer\u2019s disease brain","volume":"65","author":"Gong","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0915","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0079-6123(08)00928-X","article-title":"Serotonin\/dopamine interaction in memory formation","volume":"172","author":"Gonzalez-Burgos","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0920","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1152\/japplphysiol.00238.2010","article-title":"Epigenetic alterations in aging","volume":"109","author":"Gonzalo","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0925","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0278-5846(86)90014-X","article-title":"Multiple biochemical deficits in both gray and white matter of Alzheimer brains. Prog","volume":"10","author":"Gottfries","year":"1986","journal-title":"Neuropsychopharmacol. Biol. 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Neurobiol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0940","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00401-013-1080-2","article-title":"Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation","volume":"125","author":"Grinberg","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0945","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/1567205010666131212110148","article-title":"A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer\u2019s disease","volume":"11","author":"Grove","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0950","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neurobiolaging.2006.02.007","article-title":"Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer\u2019s disease","volume":"28","author":"Grudzien","year":"2007","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0955","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0960","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1471-4159.2006.03784.x","article-title":"Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo","volume":"97","author":"Guillozet-Bongaarts","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0965","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neuroscience.2011.07.012","article-title":"Epigenetic mechanisms of A\u03b2 production in anisomycin-treated SH-SY5Y cells","volume":"194","author":"Guo","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0970","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.febslet.2013.01.051","article-title":"Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau","volume":"587","author":"Guo","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0975","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1101\/lm.026070.112","article-title":"Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer\u2019s disease","volume":"19","author":"Guzman-Ramos","year":"2012","journal-title":"Learn. 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Bull."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib0995","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/gerona\/60.1.67","article-title":"Cross-sectional and longitudinal association between antihypertensive medications and cognitive impairment in an elderly population","volume":"60","author":"Hajjar","year":"2005","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1000","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4161\/pri.19912","article-title":"Is tau ready for admission to the prion club?","volume":"6","author":"Hall","year":"2012","journal-title":"Prion"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0361-9230(89)90092-0","article-title":"Serotonin-like immunoreactive cells and fibres in the rat ventromedial mesencephalic tegmentum","volume":"22","author":"Halliday","year":"1989","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/cne.902730303","article-title":"Distribution of monoamine-synthesizing neurons in the human medulla oblongata","volume":"273","author":"Halliday","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1015","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/BF00227741","article-title":"Brain stem serotonin-synthesizing neurons in Alzheimer\u2019s disease: a clinicopathological correlation","volume":"84","author":"Halliday","year":"1992","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1020","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.biopsych.2012.06.013","article-title":"Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP\/PS1 mice","volume":"73","author":"Hammerschmidt","year":"2013","journal-title":"Biol. 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Sci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1035","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1040","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s11064-006-9221-9","article-title":"Does A\u03b2 42 have a function related to blood homeostasis?","volume":"32","author":"Hardy","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1045","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1471-4159.2009.06181.x","article-title":"The amyloid hypothesis for Alzheimer\u2019s disease: a critical reappraisal","volume":"110","author":"Hardy","year":"2009","journal-title":"J. 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A."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/JCP.0b013e318172b479","article-title":"Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge","volume":"28","author":"Herrmann","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00294466","article-title":"Motor neuron disease with neurofibrillary tangles in a non-Guamanian patient","volume":"90","author":"Hilton","year":"1995","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1075","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ana.22319","article-title":"Apomorphine treatment in Alzheimer mice promoting amyloid-b degradation","volume":"69","author":"Himeno","year":"2011","journal-title":"Ann. 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Bull."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jnen\/62.1.55","article-title":"Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer\u00e8s disease","volume":"62","author":"Hof","year":"2003","journal-title":"J. Neuropathol. Exp. 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A."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1120","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1126\/science.282.5395.1914","article-title":"Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17","volume":"282","author":"Hong","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1125","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/cne.902970202","article-title":"Distribution of two morphologically distinct subsets of serotoninergic axons in the cerebral cortex of the marmoset","volume":"297","author":"Hornung","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jchemneu.2003.10.002","article-title":"The human raphe nuclei and the serotonergic system","volume":"26","author":"Hornung","year":"2003","journal-title":"J. Chem. 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Neuropathol. Exp. 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Pathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1370","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2217\/epi.10.43","article-title":"Role of epigenetics in Alzheimer\u2019s and Parkinson\u2019s disease","volume":"2","author":"Kwok","year":"2010","journal-title":"Epigenomics"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1375","doi-asserted-by":"crossref","first-page":"862","DOI":"10.4161\/epi.6.7.16353","article-title":"A genomic point-of-view on environmental factors influencing the human brain methylome","volume":"6","author":"LaSalle","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1380","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1600-079X.2004.00121.x","article-title":"Dietary supplementation with melatonin reduces levels of amyloid \u03b2-peptides in the murine cerebral cortex","volume":"36","author":"Lahiri","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1385","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(03)02554-X","article-title":"Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease","volume":"974","author":"Lai","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1390","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2478\/s13380-012-0037-6","article-title":"Active DNA A\u03b242 vaccination as immunotherapy for Alzheimer\u2019s disease","volume":"3","author":"Lambracht-Washington","year":"2012","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1395","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2015.05.002","article-title":"The epigenetics of aging and neurodegeneration","volume":"131","author":"Lardenoije","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1400","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2005.09.040","article-title":"Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice","volume":"393","author":"Larson","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1405","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1523\/JNEUROSCI.4162-03.2004","article-title":"Phosphorylation of tau by fyn: implications for Alzheimer\u2019s disease","volume":"24","author":"Lee","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1410","first-page":"201","article-title":"Serotonergic modulation of neural activities in the entorhinal cortex: int","volume":"4","author":"Lei","year":"2012","journal-title":"J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1415","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1073\/pnas.79.20.6385","article-title":"Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons","volume":"79","author":"Levitt","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1420","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.2111584","article-title":"Mutation of the Alzheimer\u2019s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type","volume":"248","author":"Levy","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1425","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1430","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s12031-014-0460-y","article-title":"Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance","volume":"55","author":"Leyk","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1435","doi-asserted-by":"crossref","first-page":"171464","DOI":"10.4061\/2011\/171464","article-title":"A comparative study of five mouse models of Alzheimer\u2019s disease: cell cycle events reveal new insights into neurons at risk for death","volume":"2011","author":"Li","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1440","first-page":"365","article-title":"BF2. 649 [1-{3-[3-(4-chlorophenyl) propoxy] propyl} piperidine, hydrochloride], a nonimidazole inverse agonist\/antagonist at the human histamine H3 receptor: preclinical pharmacology","volume":"320","author":"Ligneau","year":"2007","journal-title":"J. Pharmacol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1445","first-page":"351","article-title":"The sleep-wake cycle and Alzheimer\u2019s disease: what do we know? Neurodegener","volume":"4","author":"Lim","year":"2014","journal-title":"Dis. Manag."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1450","first-page":"323","article-title":"Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer\u2019s disease, and apolipoprotein E-\u03b54\/4 genotype","volume":"84","author":"Liu","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1455","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1111\/j.1460-9568.2005.04391.x","article-title":"Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation","volume":"22","author":"Liu","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1460","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/hipo.20305","article-title":"Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice","volume":"17","author":"Liu","year":"2007","journal-title":"Hippocampus"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1465","doi-asserted-by":"crossref","first-page":"13805","DOI":"10.1523\/JNEUROSCI.4218-08.2008","article-title":"Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer\u2019s disease","volume":"28","author":"Liu","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1470","doi-asserted-by":"crossref","first-page":"e31302","DOI":"10.1371\/journal.pone.0031302","article-title":"Trans-synaptic spread of tau pathology in vivo","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1475","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2478\/s13380-014-0217-7","article-title":"Cerebral microbleeds: spatial distribution implications","volume":"5","author":"Loehrer","year":"2014","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1480","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nn.3792","article-title":"The epigenetic landscape of Alzheimer\u2019s disease","volume":"17","author":"Lord","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1485","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archneurpsyc.1934.02250040061004","article-title":"Familial organic psychosis (Alzheimer\u2019s type)","volume":"31","author":"Lowenberg","year":"1934","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1490","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nn.4048","article-title":"How amyloid, sleep and memory connect","volume":"18","author":"Lucey","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1495","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2478\/v10134-010-0009-8","article-title":"Brain tau isoform mRNA and protein correlation in PSP brain","volume":"1","author":"Luk","year":"2010","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1500","series-title":"Understanding Alzheimer\u2019s Disease","first-page":"89","article-title":"Phosphorylation of tau protein associated as a protective mechanism in the presence of toxic, C-terminally truncated tau in Alzheimer\u2019s disease","author":"Luna-Mu\u00f1oz","year":"2013"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1505","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer\u2019s disease","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1510","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1021\/jz501457f","article-title":"Structural insight into tau protein\u2019s paradox of intrinsically disordered behavior, self-acetylation activity, and aggregation","volume":"5","author":"Luo","year":"2014","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","article-title":"Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update","volume":"119","author":"Mackenzie","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1520","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/gps.2562","article-title":"SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study","volume":"26","author":"Maher-Edwards","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1525","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/cne.903140312","article-title":"Dual serotoninergic projections to forebrain in the rat: morphologically distinct 5-HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives","volume":"314","author":"Mamounas","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1530","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.pneurobio.2007.06.001","article-title":"Iron dysregulation in Alzheimer\u2019s disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents","volume":"82","author":"Mandel","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1535","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1750-3639.2007.00053.x","article-title":"Structural principles of tau and the paired helical filaments of Alzheimer\u2019s disease","volume":"17","author":"Mandelkow","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1540","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn.4035","article-title":"\u03b2-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation","volume":"18","author":"Mander","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1545","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00294649","article-title":"The distribution of Alzheimer\u2019s neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis","volume":"80","author":"Mandybur","year":"1990","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1550","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2990.1986.tb00053.x","article-title":"The topography of plaques and tangles in Down\u2019s syndrome patients of different ages","volume":"12","author":"Mann","year":"1986","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1555","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1560","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neurobiolaging.2010.03.023","article-title":"Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer\u2019s disease: a combined [11C]DASB and [18F]altanserin-PET study","volume":"33","author":"Marner","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1565","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF02251133","article-title":"Monoamines and related matabolite levels in the cerebrospinal fluid of patients with dementia of Alzheimer type","volume":"3","author":"Martignoni","year":"1991","journal-title":"Influence of treatment with L-deprenyl. J. Neural.Transm. Park. Dis. Dement. Sect."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1570","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuropharm.2012.07.015","article-title":"Dopamine D2-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer\u2019s disease patients","volume":"64","author":"Martorana","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1575","doi-asserted-by":"crossref","first-page":"e6617","DOI":"10.1371\/journal.pone.0006617","article-title":"Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer\u2019s disease","volume":"4","author":"Mastroeni","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1580","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.neurobiolaging.2008.12.005","article-title":"Epigenetic changes in Alzheimer\u2019s disease: decrements in DNA methylation","volume":"31","author":"Mastroeni","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1585","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1471-4159.2003.01654.x","article-title":"Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer\u2019s disease","volume":"85","author":"Matsubara","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1590","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS A\u03b2 in Alzheimer\u2019s disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1595","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1749-6632.2000.tb06366.x","article-title":"Apolipoprotein E genotype and cerebral amyloid angiopathy-related hemorrhage","volume":"903","author":"McCarron","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1600","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1605","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging \u2013 Alzheimer\u2019s Association work groups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1610","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1124\/jpet.107.120311","article-title":"GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer\u2019s disease brain and improves cognitive performance in preclinical models","volume":"321","author":"Medhurst","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1615","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1476-5381.2008.00075.x","article-title":"Characterization of histamine H3 receptors in Alzheimer\u2019s Disease brain and amyloid over-expressing TASTPM mice","volume":"157","author":"Medhurst","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1620","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000197896","article-title":"Frontotemporal dementia: therapeutic interventions","volume":"24","author":"Mendez","year":"2009","journal-title":"Front. Neurol. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1625","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6123(08)00912-6","article-title":"The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer\u2019s disease","volume":"172","author":"Michelsen","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1630","doi-asserted-by":"crossref","first-page":"373","DOI":"10.31887\/DCNS.2014.16.3\/mmillan","article-title":"The epigenetic dimension of Alzheimer\u2019s disease","volume":"16","author":"Millan","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1635","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nm.3951","article-title":"Critical roles of acetylation in tau-mediated neurodegeneration and cognitive deficits","volume":"21","author":"Min","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1640","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer\u2019s disease (CERAD): part II. standardization of the neuropathologic assessment of Alzheimer\u2019s disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1645","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0006-3223(97)00510-6","article-title":"Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer\u2019s type with disturbed sleep-waking","volume":"45","author":"Mishima","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1650","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1755-5949.2010.00161.x","article-title":"The role of dopamine in symptoms and treatment of apathy in Alzheimer\u2019s disease","volume":"17","author":"Mitchell","year":"2011","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1655","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2478\/v10134-010-0035-6","article-title":"Astrocyte expression of D2-like dopamine receptors in the prefrontal cortex","volume":"1","author":"Mladinov","year":"2010","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1660","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/hup.430","article-title":"The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET)","volume":"17","author":"Mochizuki","year":"2002","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1665","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","article-title":"Blood-brain barrier breakdown in the aging human hippocampus","volume":"85","author":"Montagne","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1670","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0167-4943(98)00129-0","article-title":"Polysomnographic study of the effect of melatonin on sleep in elderly patients with chronic primary insomnia","volume":"28","author":"Monti","year":"1999","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1675","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.smrv.2010.11.003","article-title":"Serotonin control of sleep-wake behavior","volume":"15","author":"Monti","year":"2011","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1680","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging \u2212 Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1685","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The clinical dementia rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1690","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/cne.902430110","article-title":"Noradrenergic and serotoninergic innervation of cortical, thalamic, and tectal visual structures in Old and New World monkeys","volume":"243","author":"Morrison","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1695","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1126\/science.278.5337.412","article-title":"Life and death of neurons in the aging brain","volume":"278","author":"Morrison","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1700","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3233\/JAD-2010-100381","article-title":"CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer\u2019s disease","volume":"22","author":"Motawaj","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1705","doi-asserted-by":"crossref","first-page":"992","DOI":"10.2174\/1567205011666141107130505","article-title":"Locus (coeruleus) minoris resistentiae in pathogenesis of Alzheimer\u2019s disease","volume":"11","author":"Mravec","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1710","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt231","article-title":"Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias","volume":"6","author":"Murray","year":"2014","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1715","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pnpbp.2013.02.002","article-title":"Genotype-independent decrease in plasma dopamine \u03b2-hydroxylase activity in Alzheimer's disease","volume":"44","author":"Mustapi\u0107","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. 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Lett."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1895","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0031-6997(24)01417-0","article-title":"Autoregulation of serotonin neurons: role in antidepressant drug action","volume":"51","author":"Pi\u00f1eyro","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1900","doi-asserted-by":"crossref","first-page":"e87014","DOI":"10.1371\/journal.pone.0087014","article-title":"Regulation of amyloid precursor protein processing by serotonin signaling","volume":"21","author":"Pimenova","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib1905","first-page":"51","article-title":"Biogenic amines in cerebrospinal fluid and plasma of patients with dementia of Alzheimer type","volume":"2","author":"Pinessi","year":"1987","journal-title":"Funct. 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Ther."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2095","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3390\/biom6010006","article-title":"Tau protein hyperphosphorylation and aggregation in Alzheimer\u2019s disease and other tauopathies, and possible neuroprotective strategies","volume":"6","author":"\u0160imi\u0107","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2100","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S1474-4422(02)00130-8","article-title":"Pathological tau proteins in argyrophilic grain disease","volume":"1","author":"\u0160imi\u0107","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2105","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2478\/s13380-013-0136-z","article-title":"Pathogenesis, modulation, and therapy of Alzheimer\u2019s disease: a perspective on roles of liver-X receptors","volume":"4","author":"\u0160tefulj","year":"2013","journal-title":"Transl. 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Disord."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2215","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.biopsych.2012.11.028","article-title":"Resting state functional connectivity in preclinical Alzheimer\u2019s disease","volume":"74","author":"Sheline","year":"2013","journal-title":"Biol. 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Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2240","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1439760","article-title":"Production of the Alzheimer A\u03b2 protein by normal proteolytic processing","volume":"258","author":"Shoji","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2245","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.1073\/pnas.1302212110","article-title":"Low levels of copper disrupt brain A\u03b2 homeostasis by altering its production and clearance","volume":"110","author":"Singh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2250","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2478\/s13380-014-0222-x","article-title":"Molecular drug targets and therapies for Alzheimer\u2019s disease","volume":"5","author":"Singh","year":"2014","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2255","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1021\/ja206279b","article-title":"Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins","volume":"133","author":"Sinha","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2260","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0197-4580(98)00086-4","article-title":"Decreased monoamine metabolites in frontotemporal dementia and Alzheimer\u2019s disease","volume":"19","author":"Sj\u00f6gren","year":"1998","journal-title":"Neuobiol. 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Alzheimers Dis."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2285","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ng1292-330","article-title":"Genetic evidence for a novel familial Alzheimer\u2019s disease locus on chromosome 14","volume":"2","author":"St George-Hyslop","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2290","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4161\/auto.23487","article-title":"Latrepirdine (Dimebon\u00ae), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model","volume":"9","author":"Steele","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2295","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fnagi.2015.00067","article-title":"Catecholamine-based treatment in Alzheimer\u2019s disease patients: expectations and delusions","volume":"7","author":"Stefani","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2300","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3940(80)90184-6","article-title":"Serotonergic and non-serotonergic projections from the nucleus raphe dorsalis to the caudate-putamen complex in the rat, studied by a combined immunofluorescence and fluorescent retrograde axonal labeling technique","volume":"19","author":"Steinbusch","year":"1980","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2305","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2010.05.013","article-title":"Characterization of the 3xTg-AD mouse model of Alzheimer\u2019s disease: part 1. 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Lett."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2330","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuron.2013.08.035","article-title":"ADAM10 missense mutations potentiate A\u03b2 accumulation by impairing prodomain chaperone function","volume":"80","author":"Suh","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2335","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2174\/156720512800492567","article-title":"Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer\u2019s disease","volume":"9","author":"Sun","year":"2012","journal-title":"Curr. 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Psychopharmacol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2350","series-title":"The Human Nervous System","first-page":"1001","article-title":"Raphe nuclei and serotonin containing systems","author":"T\u00f6rk","year":"1990"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2355","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.1990.tb16870.x","article-title":"Anatomy of the serotonergic system","volume":"600","author":"T\u00f6rk","year":"1990","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2360","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0387-7604(86)80055-9","article-title":"Distribution of serotonin-containing cell bodies in the brainstem of the human fetus determined with immunohistochemistry using antiserotonin serum","volume":"8","author":"Takahashi","year":"1986","journal-title":"Brain Dev."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2365","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1358\/mf.2005.27.3.890872","article-title":"Actions of tacrine and galanthamine on histamine-N-methyltransferase","volume":"27","author":"Taraschenko","year":"2005","journal-title":"Methods Find. Exp. Clin. 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Metab."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2465","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/archneur.1985.04060110040013","article-title":"Serotoninergic system in dementia of the Alzheimer type: abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid","volume":"42","author":"Volicer","year":"1985","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2470","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1176\/appi.ajp.158.5.704","article-title":"Sundowning and circadian rhythms in Alzheimer\u2019s disease","volume":"158","author":"Volicer","year":"2001","journal-title":"Am. J. 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Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2485","series-title":"Chemoarchitecture and Anatomy","first-page":"1","article-title":"The cerebellum","author":"Voogd","year":"1996"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2490","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1515\/tnsci-2015-0013","article-title":"Perception of emotions in mild cognitive impairment and Alzheimer\u2019s dementia: does intensity matter?","volume":"6","author":"Waanders-Oude Elferink","year":"2015","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2495","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A\u03b2 oligomers \u2013 a decade of discovery","volume":"101","author":"Walsh","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2500","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2505","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. 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Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2525","first-page":"1242","article-title":"Cerebrospinal fluid A\u03b21-42, phosphorylated tau181, and resting-state functional connectivity","volume":"70","author":"Wang","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2530","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","article-title":"A protein factor essential for microtubule assembly","volume":"72","author":"Weingarten","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2535","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2174\/138945012799499794","article-title":"Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer\u2019s disease treatment","volume":"13","author":"Weinreb","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2540","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/00005072-199810000-00001","article-title":"Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis","volume":"57","author":"Weller","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2545","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02736773","article-title":"Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer\u2019s disease patient","volume":"6","author":"West","year":"1995","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2550","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0079-6123(08)64131-X","article-title":"Descending noradrenergic projections and their spinal terminations","volume":"57","author":"Westlund","year":"1982","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2555","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1445-5994.2006.01153.x","article-title":"Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau","volume":"36","author":"Williams","year":"2006","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2560","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10735-007-9106-5","article-title":"Endosomal location of dopamine receptors in neuronal cell cytoplasm","volume":"38","author":"Wolstencroft","year":"2007","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2565","doi-asserted-by":"crossref","first-page":"8729","DOI":"10.1073\/pnas.82.24.8729","article-title":"Neuritic plaques and cerebrovascular amyloid in Alzheimer\u2019s disease are antigentically related","volume":"82","author":"Wong","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2570","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.celrep.2013.10.018","article-title":"The presenilin-1 \u0394E9 mutation results in reduced \u03b3-secretase activity, but not total loss of PS1 function, in isogenic human stem cells","volume":"5","author":"Woodruff","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2575","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1210\/jc.2003-030833","article-title":"Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages","volume":"88","author":"Wu","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2580","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/217953a0","article-title":"Formation of melatonin and 5-hydroxyindole acetic acid from 14C-tryptophan by rat pineal glands in organ culture","volume":"217","author":"Wurtman","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2585","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1440-1789.2003.00522.x","article-title":"Senile dementia of the neurofibrillary tangle type (tangle-only dementia): neuropathological criteria and clinical guidelines for diagnosis","volume":"23","author":"Yamada","year":"2003","journal-title":"Neuropathology"},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2590","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fnins.2015.00219","article-title":"Dopamine in socioecological and evolutionary perspectives: implications for psychiatric disorders","volume":"9","author":"Yamaguchi","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2595","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF00687815","article-title":"Nucleus raphe dorsalis in parkinsonism-dementia complex of Guam","volume":"67","author":"Yamamoto","year":"1985","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2600","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s004010051116","article-title":"Variant Gerstmann-Str\u00e4ussler syndrome with the P105L prion gene mutation: an unusual case with nigral degeneration and widespread neurofibrillary tangles","volume":"98","author":"Yamazaki","year":"1999","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2016.04.001_bib2605","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s004010000293","article-title":"Frontotemporal dementia: evidence for impairment of ascending serotoninergic but not noradrenergic innervation. 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