{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:54:33Z","timestamp":1792677273944,"version":"4.5.0"},"reference-count":363,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["R01-NS046566"],"award-info":[{"award-number":["R01-NS046566"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["P01 NS058484"],"award-info":[{"award-number":["P01 NS058484"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["R01 NS083405"],"award-info":[{"award-number":["R01 NS083405"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["R01 NS084847"],"award-info":[{"award-number":["R01 NS084847"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neurobiology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.pneurobio.2017.08.003","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T17:30:45Z","timestamp":1503768645000},"page":"15-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology"],"prefix":"10.1016","volume":"158","author":[{"given":"Jacqueline R.","family":"Kulbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pneurobio.2017.08.003_bib0005","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1523\/JNEUROSCI.5397-12.2013","article-title":"Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation","volume":"33","author":"Abisambra","year":"2013","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0010","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fneur.2015.00114","article-title":"The temporal pattern of changes in serum biomarker levels reveals complex and dynamically changing pathologies after exposure to a single low-Intensity blast in mice","volume":"6","author":"Ahmed","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0015","doi-asserted-by":"crossref","first-page":"151979","DOI":"10.1155\/2015\/151979","article-title":"Tau hyperphosphorylation and oxidative stress, a critical vicious circle in neurodegenerative tauopathies?","volume":"2015","author":"Alavi Naini","year":"2015","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0020","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nm0796-783","article-title":"Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules","volume":"2","author":"Alonso","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0025","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.1073\/pnas.121119298","article-title":"Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments\/straight filaments","volume":"98","author":"Alonso","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0030","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jalz.2015.12.014","article-title":"Molecular mechanism of prion-like tau-induced neurodegeneration","volume":"10","author":"Alonso","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0035","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3233\/JAD-2010-100120","article-title":"A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration","volume":"21","author":"Amadoro","year":"2010","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0040","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.nbd.2013.10.018","article-title":"AD-linked: toxic NH2 human tau affects the quality control of mitochondria in neurons","volume":"62","author":"Amadoro","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2013.07.047","article-title":"Distinct patterns of expression of traumatic brain injury biomarkers after blast exposure: role of compromised cell membrane integrity","volume":"552","author":"Arun","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0050","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2015.10.036","article-title":"Acute decrease in alkaline phosphatase after brain injury: a potential mechanism for tauopathy","volume":"609","author":"Arun","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0055","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0060","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.bbabio.2008.07.004","article-title":"A peptide containing residues 26\u201344 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator","volume":"1777","author":"Atlante","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0065","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1515\/BC.2006.169","article-title":"Protein oxidation and proteolysis","volume":"387","author":"Bader","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0070","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bbadis.2011.10.017","article-title":"Antioxidant therapies in traumatic brain and spinal cord injury","volume":"1822","author":"Bains","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/jnc.12118","article-title":"Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model","volume":"125","author":"Bains","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/JAD-2006-9204","article-title":"Mitochondrial alterations in Alzheimer's disease","volume":"9","author":"Baloyannis","year":"2006","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0085","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/ana.21168","article-title":"Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis","volume":"62","author":"Bayir","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0090","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/02699050500488207","article-title":"Serum S-100 B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury","volume":"20","author":"Bazarian","year":"2006","journal-title":"Brain Inj."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0095","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1523\/JNEUROSCI.2872-13.2014","article-title":"Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury","volume":"34","author":"Begum","year":"2014","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0100","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1021\/bi027348m","article-title":"Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment","volume":"42","author":"Berry","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2010.08.023","article-title":"Regulation of tau pathology by the microglial fractalkine receptor","volume":"68","author":"Bhaskar","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0115","doi-asserted-by":"crossref","first-page":"e0159442","DOI":"10.1371\/journal.pone.0159442","article-title":"Repeated closed head injury in mice results in sustained motor and memory deficits and chronic cellular changes","volume":"11","author":"Bolton Hall","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0120","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/NEN.0000000000000115","article-title":"Regional neurodegeneration and gliosis are amplified by mild traumatic brain injury repeated at 24-hour intervals","volume":"73","author":"Bolton","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0125","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.freeradbiomed.2004.05.034","article-title":"Mitochondrial superoxide: production biological effects, and activation of uncoupling proteins","volume":"37","author":"Brand","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0891-5849(00)00318-X","article-title":"Peroxynitrite formed by mitochondrial NO synthase promotes mitochondrial Ca2+ release","volume":"29","author":"Bringold","year":"2000","journal-title":"Free Radic. Biol. Med."},{"issue":"Pt 3","key":"10.1016\/j.pneurobio.2017.08.003_bib0135","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.expneurol.2015.03.020","article-title":"Astrocyte roles in traumatic brain injury","volume":"275","author":"Burda","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0140","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.bbalip.2010.02.005","article-title":"Involvements of the lipid peroxidation product HNE, in the pathogenesis and progression of Alzheimer's disease","volume":"1801","author":"Butterfield","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0145","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1523\/JNEUROSCI.18-18-07061.1998","article-title":"Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis","volume":"18","author":"Canu","year":"1998","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fnsys.2016.00047","article-title":"Traumatic brain injury and neuronal functionality changes in sensory cortex","volume":"10","author":"Carron","year":"2016","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0155","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0006-8993(95)00535-X","article-title":"Evidence for oxidative stress in Pick disease and corticobasal degeneration","volume":"696","author":"Castellani","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0160","article-title":"Phenelzine protects brain mitochondrial function in vitro and in vivo following traumatic brain injury by scavenging the reactive carbonyls 4-hydroxynonenal and acrolein leading to cortical histological neuroprotection","author":"Cebak","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0165","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1460-9568.2006.04986.x","article-title":"Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy","volume":"24","author":"Cente","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0170","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nbd.2012.05.021","article-title":"Constitutive secretion of tau protein by an unconventional mechanism","volume":"48","author":"Chai","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0175","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1523\/JNEUROSCI.1012-06.2006","article-title":"Mitochondrial trafficking to synapses in cultured primary cortical neurons","volume":"26","author":"Chang","year":"2006","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0180","first-page":"337","article-title":"Chronic neurodegenerative consequences of traumatic brain injury","volume":"32","author":"Chauhan","year":"2014","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0185","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1089\/neu.2010.1308","article-title":"Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons","volume":"27","author":"Chen","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0190","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3233\/JAD-2010-101155","article-title":"MAPT isoforms: differential transcriptional profiles related to 3R and 4R splice variants","volume":"22","author":"Chen","year":"2010","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0195","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2014.12.027","article-title":"Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease","volume":"76","author":"Chen","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0200","doi-asserted-by":"crossref","first-page":"e00045","DOI":"10.1042\/AN20100019","article-title":"Mitochondria and neuroplasticity","volume":"2","author":"Cheng","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0205","doi-asserted-by":"crossref","first-page":"e115765","DOI":"10.1371\/journal.pone.0115765","article-title":"Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice","volume":"9","author":"Cheng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0210","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40478-016-0382-8","article-title":"Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy","volume":"4","author":"Cherry","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0215","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fneur.2013.00122","article-title":"Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease","volume":"4","author":"Chesser","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0220","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/nbdi.2000.0335","article-title":"Proapoptotic effects of tau cleavage product generated by caspase-3","volume":"8","author":"Chung","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0225","article-title":"Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?","author":"Collins-Praino","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0230","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1471-4159.2007.04857.x","article-title":"Single molecule profiling of tau gene expression in Alzheimer's disease","volume":"103","author":"Conrad","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0235","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.nbd.2014.10.019","article-title":"Neuroinflammation and brain atrophy in former NFL players: an in vivo multimodal imaging pilot study","volume":"74","author":"Coughlin","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0240","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fneur.2015.00221","article-title":"The complexity of biomechanics causing primary blast-Induced traumatic brain injury: a review of potential mechanisms","volume":"6","author":"Courtney","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0245","first-page":"3186","article-title":"Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin","volume":"22","author":"Cuchillo-Ibanez","year":"2008","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0250","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1523\/JNEUROSCI.3861-05.2006","article-title":"Impaired glutamate transport in a mouse model of tau pathology in astrocytes","volume":"26","author":"Dabir","year":"2006","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0255","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/cdd.2013.138","article-title":"Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance","volume":"20","author":"Dalleau","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0260","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mcn.2015.03.007","article-title":"Post-traumatic neurodegeneration and chronic traumatic encephalopathy","volume":"66","author":"Daneshvar","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0265","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1523\/JNEUROSCI.0060-05.2005","article-title":"Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau","volume":"25","author":"Darios","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0270","doi-asserted-by":"crossref","first-page":"23802","DOI":"10.1074\/jbc.M500356200","article-title":"Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice","volume":"280","author":"David","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0275","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1046\/j.1471-4159.1997.68041590.x","article-title":"Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures","volume":"68","author":"Davis","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0280","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nature08890","article-title":"Caspase activation precedes and leads to tangles","volume":"464","author":"de Calignon","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0285","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2007.01.023","article-title":"Temporal relationship of peroxynitrite-induced oxidative damage: calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury","volume":"205","author":"Deng","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0290","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/jcbfm.2008.10","article-title":"Neuroprotective effects of tempol a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model","volume":"28","author":"Deng-Bryant","year":"2008","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0295","doi-asserted-by":"crossref","first-page":"e0159929","DOI":"10.1371\/journal.pone.0159929","article-title":"Altered blood biomarker profiles in athletes with a history of repetitive head impacts","volume":"11","author":"Di Battista","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0300","doi-asserted-by":"crossref","first-page":"21978","DOI":"10.1074\/jbc.M110.110940","article-title":"A caspase cleaved form of tau is preferentially degraded through the autophagy pathway","volume":"285","author":"Dolan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0305","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0006-8993(97)00899-8","article-title":"Relation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis: implications for stress-induced suppression of protein synthesis","volume":"775","author":"Doutheil","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0310","first-page":"4063","article-title":"Behavioral deficit oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice","volume":"25","author":"Dumont","year":"2011","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0315","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.143.3.777","article-title":"Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease","volume":"143","author":"Ebneth","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0320","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1523\/JNEUROSCI.1644-07.2007","article-title":"Annonacin a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons","volume":"27","author":"Escobar-Khondiker","year":"2007","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0325","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13311-014-0319-5","article-title":"Chronic neurodegeneration after traumatic brain injury: alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?","volume":"12","author":"Faden","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0330","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neulet.2010.03.037","article-title":"Acute hypoxia promote the phosphorylation of tau via ERK pathway","volume":"474","author":"Fang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0335","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1046\/j.1471-4159.2000.0750624.x","article-title":"The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis","volume":"75","author":"Fasulo","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0340","series-title":"Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002\u20132006","author":"Faul","year":"2010"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0345","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12031-011-9635-y","article-title":"Frontotemporal dementia: from Mendelian genetics towards genome wide association studies","volume":"45","author":"Ferrari","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0350","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2119\/molmed.2010.00220","article-title":"Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies","volume":"17","author":"Ferreira","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0355","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1750-3639.2001.tb00387.x","volume":"11","author":"Ferrer","year":"2001","journal-title":"Brain Pathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0360","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnsys.2016.00029","article-title":"Altered mitochondrial dynamics and TBI pathophysiology","volume":"10","author":"Fischer","year":"2016","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0365","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1089\/neu.2000.17.843","article-title":"Mitochondrial participation in ischemic and traumatic neural cell death","volume":"17","author":"Fiskum","year":"2000","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0370","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2013.05.027","article-title":"SOD2 in mitochondrial dysfunction and neurodegeneration","volume":"62","author":"Flynn","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0375","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s00018-015-1839-9","article-title":"Cellular factors modulating the mechanism of tau protein aggregation","volume":"72","author":"Fontaine","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0380","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1523\/JNEUROSCI.0081-05.2005","article-title":"Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration","volume":"25","author":"Forman","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0385","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1212\/01.WNL.0000063313.57292.00","article-title":"Amyloid beta 1\u201342 and tau in cerebrospinal fluid after severe traumatic brain injury","volume":"60","author":"Franz","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0390","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1074\/jbc.M808759200","article-title":"Propagation of tau misfolding from the outside to the inside of a cell","volume":"284","author":"Frost","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0395","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3233\/JAD-2010-100687","article-title":"LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3beta in vivo and in vitro","volume":"21","author":"Fu","year":"2010","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0400","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/neu.2005.22.83","article-title":"Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury","volume":"22","author":"Gabbita","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0405","doi-asserted-by":"crossref","first-page":"19296","DOI":"10.1074\/jbc.M601849200","article-title":"The peptidylprolyl cis\/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease","volume":"281","author":"Galas","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0410","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2665","article-title":"Mitochondrial membrane permeabilization in neuronal injury","volume":"10","author":"Galluzzi","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0415","doi-asserted-by":"crossref","first-page":"10032","DOI":"10.1073\/pnas.1630428100","article-title":"Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease","volume":"100","author":"Gamblin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2010.09.008","article-title":"Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment","volume":"32","author":"Garg","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0425","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fpsyt.2010.00136","article-title":"Anti-inflammatory impact of minocycline in a mouse model of tauopathy","volume":"1","author":"Garwood","year":"2010","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0430","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1089\/neu.2015.4262","article-title":"Tau oligomers derived from traumatic brain injury cause cognitive impairment and accelerate onset of pathology in htau mice","volume":"33","author":"Gerson","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0435","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1471-4159.2005.03641.x","article-title":"Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease","volume":"96","author":"Ginsberg","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0440","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.redox.2014.03.002","article-title":"Abeta and tau toxicities in Alzheimer's are linked via oxidative stress-induced p38 activation: protective role of vitamin E","volume":"2","author":"Giraldo","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0445","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1002\/j.1460-2075.1990.tb07870.x","article-title":"Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization","volume":"9","author":"Goedert","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0450","first-page":"134ra160","article-title":"Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model","volume":"4","author":"Goldstein","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0455","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jnr.10525","article-title":"Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells","volume":"71","author":"Gomez-Ramos","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0460","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1016\/j.febslet.2006.07.078","article-title":"Extracellular tau is toxic to neuronal cells","volume":"580","author":"Gomez-Ramos","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0465","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.mcn.2007.12.010","article-title":"Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells","volume":"37","author":"Gomez-Ramos","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0470","first-page":"2502","article-title":"Accumulation of tau induced in neurites by microglial proinflammatory mediators","volume":"23","author":"Gorlovoy","year":"2009","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0475","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0006-8993(97)00384-3","article-title":"Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease","volume":"763","author":"Grynspan","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0480","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neurobiolaging.2004.09.019","article-title":"Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease","volume":"26","author":"Guillozet-Bongaarts","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0485","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00401-007-0209-6","article-title":"Phosphorylation and cleavage of tau in non-AD tauopathies","volume":"113","author":"Guillozet-Bongaarts","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0490","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1212\/WNL.54.6.1316","article-title":"Head injury and the risk of AD in the MIRAGE study","volume":"54","author":"Guo","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0495","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ajem.2008.12.025","article-title":"Validity of serum tau protein levels in pediatric patients with minor head trauma","volume":"28","author":"Guzel","year":"2010","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0500","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/089771504772695904","article-title":"Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury","volume":"21","author":"Hall","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0505","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/neu.2005.22.252","article-title":"Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury","volume":"22","author":"Hall","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0510","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nurt.2009.10.021","article-title":"Antioxidant therapies for traumatic brain injury","volume":"7","author":"Hall","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0515","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.expneurol.2012.08.024","article-title":"Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury","volume":"238","author":"Hall","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0520","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1471-4159.2009.05869.x","article-title":"Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathies","volume":"108","author":"Hanes","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0525","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2008.04.021","article-title":"Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition","volume":"45","author":"Hansson","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0530","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-5793(98)01217-4","article-title":"Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly","volume":"437","author":"Hasegawa","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0535","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1074\/jbc.M113.472746","article-title":"Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies","volume":"288","author":"Hawkins","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0540","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fnhum.2013.00222","article-title":"Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology","volume":"7","author":"Hazrati","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0545","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0896-6273(02)00789-4","article-title":"Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration","volume":"35","author":"Higuchi","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2017.03.015","article-title":"Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury","author":"Hill","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0555","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3233\/JAD-2011-111037","article-title":"Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis","volume":"28","author":"Ho","year":"2012","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0560","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/j.1471-4159.2005.03493.x","article-title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy","volume":"95","author":"Hoglinger","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0565","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/16501970510027321","article-title":"Summary of the WHO collaborating centre for neurotrauma task force on mild traumatic brain injury","volume":"37","author":"Holm","year":"2005","journal-title":"J. Rehabil. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0570","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0575","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.biocel.2012.04.023","article-title":"Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration","volume":"44","author":"Hoozemans","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0580","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2009.080814","article-title":"The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus","volume":"174","author":"Hoozemans","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0585","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0002-9440(10)63462-1","article-title":"Nitration of tau protein is linked to neurodegeneration in tauopathies","volume":"163","author":"Horiguchi","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0590","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1523\/JNEUROSCI.1988-04.2004","article-title":"Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease","volume":"24","author":"Horowitz","year":"2004","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0595","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/JAD-130182","article-title":"Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury","volume":"37","author":"Huber","year":"2013","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0600","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2004.06.011","article-title":"Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury","volume":"190","author":"Ikonomovic","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0605","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0610","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3020-14.2014","article-title":"Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury","volume":"34","author":"Iliff","year":"2014","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0615","doi-asserted-by":"crossref","first-page":"122","DOI":"10.14802\/jmd.15033","article-title":"Genetics of progressive supranuclear palsy","volume":"8","author":"Im","year":"2015","journal-title":"J. Mov. Disord."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0620","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00401-013-1219-1","article-title":"The novel MAPT mutation K298E: mechanisms of mutant tau toxicity: brain pathology and tau expression in induced fibroblast-derived neurons","volume":"127","author":"Iovino","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0625","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/jnen\/60.6.647","article-title":"Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration","volume":"60","author":"Ishizawa","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0630","doi-asserted-by":"crossref","first-page":"32066","DOI":"10.1074\/jbc.M805300200","article-title":"Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation","volume":"283","author":"Jeganathan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0635","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/0006-291X(89)91150-9","article-title":"Proteolysis of tau by calpain","volume":"163","author":"Johnson","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0640","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1750-3639.2011.00513.x","article-title":"Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans","volume":"22","author":"Johnson","year":"2012","journal-title":"Brain Pathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0645","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrneurol.2013.33","article-title":"The clinical spectrum of sport-related traumatic brain injury","volume":"9","author":"Jordan","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0650","first-page":"43","article-title":"Glial tau pathology in tauopathies: functional consequences","volume":"9","author":"Kahlson","year":"2015","journal-title":"J. Exp. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0655","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/neu.1997.14.121","article-title":"Mechanisms of calpain proteolysis following traumatic brain injury: implications for pathology and therapy: implications for pathology and therapy: a review and update","volume":"14","author":"Kampfl","year":"1997","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0660","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneumeth.2011.09.003","article-title":"A mouse model of human repetitive mild traumatic brain injury","volume":"203","author":"Kane","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0665","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/bph.13125","article-title":"The contribution of astrocytes and microglia to traumatic brain injury","volume":"173","author":"Karve","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0670","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ajem.2006.10.008","article-title":"The value of serum tau protein for the diagnosis of intracranial injury in minor head trauma","volume":"25","author":"Kavalci","year":"2007","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0675","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.bbabio.2015.05.015","article-title":"Mitochondrial DNA mutations in neurodegeneration","volume":"1847","author":"Keogh","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0680","doi-asserted-by":"crossref","first-page":"19440","DOI":"10.1074\/jbc.M112.346072","article-title":"Trans-cellular propagation of Tau aggregation by fibrillar species","volume":"287","author":"Kfoury","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0685","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fneur.2013.00199","article-title":"Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases","volume":"4","author":"Khatri","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0690","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-0035-1545080","article-title":"Chronic traumatic encephalopathy: a neurodegenerative consequence of repetitive traumatic brain injury","volume":"35","author":"Kiernan","year":"2015","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0695","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1089\/neu.2010.1635","article-title":"Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and piglet","volume":"28","author":"Kilbaugh","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0700","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.expneurol.2008.04.025","article-title":"Mechanically-induced membrane poration causes axonal beading and localized cytoskeletal damage","volume":"212","author":"Kilinc","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0705","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1089\/neu.2012.2699","article-title":"Neurochemical profile of dementia pugilistica","volume":"30","author":"Kokjohn","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0710","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature14658","article-title":"Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy","volume":"523","author":"Kondo","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0715","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/0896-6273(89)90077-9","article-title":"Developmentally regulated expression of specific tau sequences","volume":"2","author":"Kosik","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0720","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fneur.2014.00047","article-title":"Blast TBI models, neuropathology, and implications for seizure risk","volume":"5","author":"Kovacs","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0725","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnins.2011.00042","article-title":"The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study","volume":"5","author":"Kovesdi","year":"2011","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0730","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2010.11.015","article-title":"Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury","volume":"1370","author":"Krajewska","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0735","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.1074\/jbc.M609521200","article-title":"Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation","volume":"282","author":"Kuhla","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0740","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.expneurol.2015.05.004","article-title":"Current status of fluid biomarkers in mild traumatic brain injury","volume":"275","author":"Kulbe","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0745","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1089\/neu.2016.4628","article-title":"synaptic mitochondria sustain more damage than non-Synaptic mitochondria following traumatic brain injury and are protected by cyclosporine a","volume":"34","author":"Kulbe","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0750","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.neurobiolaging.2009.10.014","article-title":"Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration","volume":"32","author":"Kulic","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0755","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1089\/neu.2015.4268","article-title":"Microglial\/Macrophage polarization dynamics following traumatic brain injury","volume":"33","author":"Kumar","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0760","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jnr.21850","article-title":"The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity","volume":"87","author":"LaPointe","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0765","doi-asserted-by":"crossref","first-page":"35101","DOI":"10.1074\/jbc.M405471200","article-title":"Cysteine oxidation of tau and microtubule-associated protein-2 by peroxynitrite: modulation of microtubule assembly kinetics by the thioredoxin reductase system","volume":"279","author":"Landino","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0770","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00001199-200609000-00001","article-title":"The epidemiology and impact of traumatic brain injury: a brief overview","volume":"21","author":"Langlois","year":"2006","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0775","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1046\/j.1471-4159.2003.02141.x","article-title":"Increased expression and processing of caspase-12 after traumatic brain injury in rats","volume":"88","author":"Larner","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0780","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1750-1326-6-39","article-title":"Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice","volume":"6","author":"Lasagna-Reeves","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0785","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-385883-2.00004-7","article-title":"Tau and tauopathies","volume":"107","author":"Lee","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0790","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1742-2094-7-56","article-title":"LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice","volume":"7","author":"Lee","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0795","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2014.07.024","article-title":"Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis","volume":"36","author":"Lee","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0800","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1523\/JNEUROSCI.23-05-01605.2003","article-title":"Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0805","first-page":"4384","article-title":"IFN-gamma promotes tau phosphorylation without affecting mature tangles","volume":"29","author":"Li","year":"2015","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0810","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/01.WCB.0000040581.43808.03","article-title":"Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus","volume":"23","author":"Lifshitz","year":"2003","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0815","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jss.2008.12.022","article-title":"Tau proteins in serum predict outcome after severe traumatic brain injury","volume":"160","author":"Liliang","year":"2010","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0820","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3233\/JAD-140207","article-title":"Region-specific expression of tau amyloid-beta protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats","volume":"41","author":"Lin","year":"2014","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0825","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0006-8993(93)90349-R","article-title":"Phosphorylation: calpain proteolysis and tubulin binding of recombinant human tau isoforms","volume":"604","author":"Litersky","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0830","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s11910-004-0055-z","article-title":"Update on progressive supranuclear palsy","volume":"4","author":"Litvan","year":"2004","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0835","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.freeradbiomed.2004.11.005","article-title":"Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations","volume":"38","author":"Liu","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0840","doi-asserted-by":"crossref","first-page":"e00051","DOI":"10.1042\/AN20100012","article-title":"Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions","volume":"3","author":"Liu","year":"2011","journal-title":"ASN Neuro"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0845","doi-asserted-by":"crossref","first-page":"e31302","DOI":"10.1371\/journal.pone.0031302","article-title":"Trans-synaptic spread of tau pathology in vivo","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0850","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fncel.2014.00421","article-title":"Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms","volume":"8","author":"Logsdon","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0855","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0197-4580(00)00235-9","article-title":"Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures","volume":"22","author":"Lovell","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0860","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3233\/JAD-2004-6610","article-title":"Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3","volume":"6","author":"Lovell","year":"2004","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0865","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.trsl.2015.08.005","article-title":"Amelioration of nicotinamide adenine dinucleotide phosphate-oxidase mediated stress reduces cell death after blast-induced traumatic brain injury","volume":"166","author":"Lucke-Wold","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0870","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3171\/2015.3.JNS141802","article-title":"Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy","volume":"124","author":"Lucke-Wold","year":"2016","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0875","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fneur.2014.00012","article-title":"Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury","volume":"5","author":"Luo","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0880","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ajem.2007.10.029","article-title":"Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury","volume":"26","author":"Ma","year":"2008","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0885","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1474-4422(08)70164-9","article-title":"Moderate and severe traumatic brain injury in adults","volume":"7","author":"Maas","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0890","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1460-9568.2010.07345.x","article-title":"Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses","volume":"32","author":"MacAskill","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0895","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.1995.75.4.835","article-title":"Role of microtubule-associated proteins in the control of microtubule assembly","volume":"75","author":"Maccioni","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0900","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/brain\/awr286","article-title":"Tau elevations in the brain extracellular space correlate with reduced amyloid-beta levels and predict adverse clinical outcomes after severe traumatic brain injury","volume":"135","author":"Magnoni","year":"2012","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0905","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/hmg\/dds072","article-title":"Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0910","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.23858","article-title":"Clinical correlates in an experimental model of repetitive mild brain injury","volume":"74","author":"Mannix","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0915","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fnins.2015.00196","article-title":"Loss of tau rescues inflammation-mediated neurodegeneration","volume":"9","author":"Maphis","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0920","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/brain\/awv081","article-title":"Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain","volume":"138","author":"Maphis","year":"2015","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0925","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/neu.2010.1638","article-title":"Proceedings of the military mTBI diagnostics workshop, St. pete beach, august 2010","volume":"28","author":"Marion","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0930","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0197-4580(98)00009-8","article-title":"Four-hydroxynonenal a product of lipid peroxidation, is increased in the brain in Alzheimer's disease","volume":"19","author":"Markesbery","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0935","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.expneurol.2005.10.003","article-title":"Administration of the immunophilin ligand FK506 differentially attenuates neurofilament compaction and impaired axonal transport in injured axons following diffuse traumatic brain injury","volume":"197","author":"Marmarou","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0940","doi-asserted-by":"crossref","first-page":"e0117338","DOI":"10.1371\/journal.pone.0117338","article-title":"Chronic traumatic encephalopathy in contact sports: a systematic review of all reported pathological cases","volume":"10","author":"Maroon","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0945","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.arr.2012.06.008","article-title":"Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A","volume":"12","author":"Martin","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0950","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/NEN.0b013e31818e06f3","article-title":"Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage","volume":"67","author":"Martinez","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0955","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00702-007-0800-y","article-title":"Glycolitic enzymes are targets of oxidation in aged human frontal cortex and oxidative damage of these proteins is increased in progressive supranuclear palsy","volume":"115","author":"Martinez","year":"2008","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0960","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.brainres.2008.07.111","article-title":"Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death","volume":"1234","author":"Matthews-Roberson","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0965","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1097\/00001756-199707070-00036","article-title":"4-Hydroxynonenal a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau","volume":"8","author":"Mattson","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0970","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.expneurol.2007.09.025","article-title":"Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811: a non-immunosuppressive cyclosporin A analog","volume":"209","author":"Mbye","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0975","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/jcbfm.2008.93","article-title":"Comparative neuroprotective effects of cyclosporin A and NIM811 a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury","volume":"29","author":"Mbye","year":"2009","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0980","doi-asserted-by":"crossref","first-page":"287","DOI":"10.31887\/DCNS.2011.13.2\/tmcallister","article-title":"Neurobiological consequences of traumatic brain injury","volume":"13","author":"McAllister","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0985","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/bjsports-2013-092248","article-title":"What is the evidence for chronic concussion-related changes in retired athletes: behavioural, pathological and clinical outcomes?","volume":"47","author":"McCrory","year":"2013","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0990","doi-asserted-by":"crossref","first-page":"S242","DOI":"10.1016\/j.jalz.2014.04.003","article-title":"Military-related traumatic brain injury and neurodegeneration","volume":"10","author":"McKee","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib0995","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","article-title":"Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury","volume":"68","author":"McKee","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1000","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"McKee","year":"2013","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00401-013-1230-6","article-title":"The neuropathology of sport","volume":"127","author":"McKee","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-015-1515-z","article-title":"The first NINDS\/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy","volume":"131","author":"McKee","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1015","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/cne.21867","article-title":"Tau isoform regulation is region- and cell-specific in mouse brain","volume":"511","author":"McMillan","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fncel.2014.00113","article-title":"The role of extracellular Tau in the spreading of neurofibrillary pathology","volume":"8","author":"Medina","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1025","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1523\/JNEUROSCI.3029-15.2016","article-title":"Pathological tau promotes neuronal damage by impairing ribosomal function and decreasing protein synthesis","volume":"36","author":"Meier","year":"2016","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1030","doi-asserted-by":"crossref","first-page":"e536","DOI":"10.1371\/journal.pone.0000536","article-title":"Mitochondrial oxidative stress causes hyperphosphorylation of tau","volume":"2","author":"Melov","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1035","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.3390\/ijms15034671","article-title":"Tau protein modifications and interactions: their role in function and dysfunction","volume":"15","author":"Mietelska-Porowska","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1040","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1242\/jcs.01130","article-title":"Axonal mitochondrial transport and potential are correlated","volume":"117","author":"Miller","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2012.12.011","article-title":"Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo","volume":"57","author":"Miller","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1050","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1089\/neu.2013.3218","article-title":"Temporal and spatial dynamics of nrf2-antioxidant response elements mediated gene targets in cortex and hippocampus after controlled cortical impact traumatic brain injury in mice","volume":"31","author":"Miller","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1055","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1089\/neu.2013.2995","article-title":"Therapeutic targeting of the axonal and microvascular change associated with repetitive mild traumatic brain injury","volume":"30","author":"Miyauchi","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1060","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13195-014-0068-z","article-title":"Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome","volume":"6","author":"Montenigro","year":"2014","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1065","first-page":"89","article-title":"E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures","volume":"148","author":"Montine","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1070","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/00005072-199708000-00004","article-title":"4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease","volume":"56","author":"Montine","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.virusres.2014.12.031","article-title":"Prion-like features of misfolded Abeta and tau aggregates","volume":"207","author":"Morales","year":"2015","journal-title":"Virus Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1080","doi-asserted-by":"crossref","first-page":"34287","DOI":"10.1074\/jbc.M204973200","article-title":"An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12","volume":"277","author":"Morishima","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1085","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1083\/jcb.131.5.1315","article-title":"Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons","volume":"131","author":"Morris","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1090","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.neuron.2011.04.009","article-title":"The many faces of tau","volume":"70","author":"Morris","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ana.24064","article-title":"Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model","volume":"75","author":"Mouzon","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1100","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1080\/02699052.2016.1219058","article-title":"Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study","volume":"30","author":"Mufson","year":"2016","journal-title":"Brain Inj."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1471-4159.2006.04032.x","article-title":"Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease","volume":"99","author":"Muntane","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1471-4159.2010.06749.x","article-title":"Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals","volume":"114","author":"Mustafa","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1115","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1471-4159.2011.07228.x","article-title":"Pharmacological inhibition of lipid peroxidation attenuates calpain-mediated cytoskeletal degradation after traumatic brain injury","volume":"117","author":"Mustafa","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1125","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.cell.2012.02.016","article-title":"Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease","volume":"149","author":"Nakamura","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1750-1326-9-55","article-title":"Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury","volume":"9","author":"Namjoshi","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1135","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/oxfordjournals.aje.a009724","article-title":"Traumatic brain injury and time to onset of Alzheimer's disease: a population-based study","volume":"149","author":"Nemetz","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1140","doi-asserted-by":"crossref","first-page":"e33606","DOI":"10.1371\/journal.pone.0033606","article-title":"CSF-biomarkers in Olympic boxing: diagnosis and effects of repetitive head trauma","volume":"7","author":"Neselius","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1145","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/02699052.2012.750752","article-title":"Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma","volume":"27","author":"Neselius","year":"2013","journal-title":"Brain Inj."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00401-005-1027-3","article-title":"Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology","volume":"110","author":"Newman","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1155","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/path.3969","article-title":"The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies","volume":"226","author":"Nijholt","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1160","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-160912","article-title":"Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases","author":"Nilson","year":"2016","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1165","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tins.2006.07.003","article-title":"Autophagy in neurodegenerative disease: friend, foe or turncoat?","volume":"29","author":"Nixon","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1170","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jnen\/59.5.393","article-title":"Lipoperoxidation is selectively involved in progressive supranuclear palsy","volume":"59","author":"Odetti","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1175","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/NEN.0b013e3182814cdf","article-title":"Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice","volume":"72","author":"Ojo","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"Pt 3","key":"10.1016\/j.pneurobio.2017.08.003_bib1180","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.expneurol.2015.06.003","article-title":"Repetitive head trauma, chronic traumatic encephalopathy and tau: challenges in translating from mice to men","volume":"275","author":"Ojo","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1185","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/jamaneurol.2015.1383","article-title":"Peripheral total tau in military personnel who sustain traumatic brain injuries during deployment","volume":"72","author":"Olivera","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1190","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1471-4159.2001.00090.x","article-title":"N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation","volume":"76","author":"Olivieri","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1195","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1227\/01.NEU.0000163407.92769.ED","article-title":"Chronic traumatic encephalopathy in a National Football League player","volume":"57","author":"Omalu","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1200","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1227\/01.NEU.0000245601.69451.27","article-title":"Chronic traumatic encephalopathy in a national football league player: part II","volume":"59","author":"Omalu","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1227\/NEU.0b013e318212bc7b","article-title":"Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes","volume":"69","author":"Omalu","year":"2011","journal-title":"Neurosurgery"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1210","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2011.9.FOCUS11178","article-title":"Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide","volume":"31","author":"Omalu","year":"2011","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1215","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1212\/01.wnl.0000242732.06714.0f","article-title":"Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury","volume":"67","author":"Ost","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1220","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1523\/JNEUROSCI.1125-05.2005","article-title":"The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration","volume":"25","author":"Park","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1225","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2006.09.012","article-title":"Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons","volume":"144","author":"Park","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1230","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0014-5793(00)02323-1","article-title":"Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal","volume":"486","author":"Perez","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3233\/JAD-2003-5405","article-title":"Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model","volume":"5","author":"Perez","year":"2003","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1240","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jnr.23513","article-title":"A rodent model of mild traumatic brain blast injury","volume":"93","author":"Perez-Polo","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1245","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/NEN.0b013e3181a1fc49","article-title":"Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau","volume":"68","author":"Perreault","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1250","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.freeradbiomed.2004.06.012","article-title":"Reactions of 4-hydroxynonenal with proteins and cellular targets","volume":"37","author":"Petersen","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1255","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4103\/2152-7806.147566","article-title":"The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy","volume":"5","author":"Petraglia","year":"2014","journal-title":"Surg. Neurol. Int."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1260","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0925-4439(00)00093-4","article-title":"Acrolein inhibits respiration in isolated brain mitochondria","volume":"1535","author":"Picklo","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1265","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1046\/j.1471-4159.1999.721617.x","article-title":"4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites","volume":"72","author":"Picklo","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1270","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-016-0292-9","article-title":"Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy","volume":"4","author":"Piras","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1275","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.55.8.1158","article-title":"Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias","volume":"55","author":"Plassman","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1280","doi-asserted-by":"crossref","first-page":"e36873","DOI":"10.1371\/journal.pone.0036873","article-title":"Hyperphosphorylation and cleavage at D421 enhance tau secretion","volume":"7","author":"Plouffe","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1285","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s12035-016-9787-4","article-title":"Analysis of the role of CX3CL1 (Fractalkine) and its receptor CX3CR1 in traumatic brain and spinal cord injury: insight into recent advances in actions of neurochemokine agents","volume":"54","author":"Poniatowski","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1290","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/embor.2013.15","article-title":"Physiological release of endogenous tau is stimulated by neuronal activity","volume":"14","author":"Pooler","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1295","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1074\/jbc.M115.700914","article-title":"Characterization of neuronal tau protein as a target of extracellular signal-regulated kinase","volume":"291","author":"Qi","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1300","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.4049\/jimmunol.1600873","article-title":"Stimulation of TLR4 attenuates Alzheimer's disease-related symptoms and pathology in tau-transgenic mice","volume":"197","author":"Qin","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1305","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yexcr.2004.01.002","article-title":"Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5\/p35 pathway","volume":"295","author":"Quintanilla","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1310","doi-asserted-by":"crossref","first-page":"18754","DOI":"10.1074\/jbc.M808908200","article-title":"Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease","volume":"284","author":"Quintanilla","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1315","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00401-015-1487-z","article-title":"PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia","volume":"130","author":"Radford","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1320","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0891-5849(02)01111-5","article-title":"Peroxynitrite reactions and formation in mitochondria","volume":"33","author":"Radi","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1325","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2119\/2007-00133.Ramalho","article-title":"Apoptosis in transgenic mice expressing the P301L mutated form of human tau","volume":"14","author":"Ramalho","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1330","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: microglial activation and traumatic brain injury","volume":"70","author":"Ramlackhansingh","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1335","doi-asserted-by":"crossref","first-page":"12241","DOI":"10.1523\/JNEUROSCI.4119-08.2008","article-title":"Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression","volume":"28","author":"Rao","year":"2008","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1340","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.brainres.2007.04.002","article-title":"Preferential neuroprotective effect of tacrolimus (FK506) on unmyelinated axons following traumatic brain injury","volume":"1154","author":"Reeves","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1345","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/jcbfm.2013.30","article-title":"\u2018Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation","volume":"33","author":"Ren","year":"2013","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1350","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1021\/bi047982v","article-title":"Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease","volume":"44","author":"Reynolds","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1355","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1021\/bi052142h","article-title":"Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms","volume":"45","author":"Reynolds","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1360","doi-asserted-by":"crossref","first-page":"20057","DOI":"10.1073\/pnas.0905529106","article-title":"Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice","volume":"106","author":"Rhein","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1365","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI200420640","article-title":"Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology","volume":"114","author":"Rissman","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1370","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1054\/ceca.1999.0076","article-title":"Mitochondria as biosensors of calcium microdomains","volume":"26","author":"Rizzuto","year":"1999","journal-title":"Cell Calc."},{"issue":"Pt 1","key":"10.1016\/j.pneurobio.2017.08.003_bib1375","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1469-7793.2000.00037.x","article-title":"Mitochondria as all-round players of the calcium game","volume":"529","author":"Rizzuto","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1380","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1460-9568.2011.07764.x","article-title":"Lipopolysaccharide-induced tau phosphorylation and kinase activity\u2013modulation, but not mediation, by corticotropin-releasing factor receptors","volume":"34","author":"Roe","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1385","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fneur.2012.00115","article-title":"A model for mild traumatic brain injury that induces limited transient memory impairment and increased levels of axon related serum biomarkers","volume":"3","author":"Rostami","year":"2012","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1390","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/00005072-199607000-00010","article-title":"Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat","volume":"55","author":"Saatman","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1395","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1089\/neu.2015.4288","article-title":"Noncontact rotational head injury produces transient cognitive deficits but lasting neuropathological changes","volume":"33","author":"Sabbagh","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1400","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1089\/neu.2011.1957","article-title":"Frontal cortex neuropathology in dementia pugilistica","volume":"29","author":"Saing","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1405","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1073\/pnas.90.7.2628","article-title":"Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration","volume":"90","author":"Saito","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1410","doi-asserted-by":"crossref","first-page":"15075","DOI":"10.1038\/srep15075","article-title":"Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury","volume":"5","author":"Sajja","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1415","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1074\/jbc.M111.277061","article-title":"Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease","volume":"287","author":"Saman","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1420","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00401-016-1630-5","article-title":"Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration","volume":"132","author":"Sanchez-Mejias","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1425","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","author":"Santacruz","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1430","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.4161\/15548627.2014.981787","article-title":"Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury","volume":"10","author":"Sarkar","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1435","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2008.02.084","article-title":"Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L","volume":"1214","author":"Sasaki","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1440","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1046\/j.1471-4159.1997.68052092.x","article-title":"4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease","volume":"68","author":"Sayre","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1445","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s004010000330","article-title":"Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease","volume":"101","author":"Schmidt","year":"2001","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1450","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12035-012-8308-3","article-title":"A new link to mitochondrial impairment in tauopathies","volume":"46","author":"Schulz","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1455","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1001\/jamaneurol.2014.367","article-title":"Blood biomarkers for brain injury in concussed professional ice hockey players","volume":"71","author":"Shahim","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1460","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2014.3741","article-title":"Serum tau fragments predict return to play in concussed professional ice hockey players","author":"Shahim","year":"2016","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1465","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1523\/JNEUROSCI.5927-11.2012","article-title":"Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease","volume":"32","author":"Shahpasand","year":"2012","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1470","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrn3156","article-title":"Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration","volume":"13","author":"Sheng","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1475","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1006\/exnr.2000.7393","article-title":"Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo","volume":"163","author":"Sheng","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1480","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0197-0186(01)00041-9","article-title":"Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation","volume":"39","author":"Sheng","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1485","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1089\/neu.2014.3445","article-title":"Alterations in cholinergic pathways and therapeutic strategies targeting cholinergic system after traumatic brain injury","volume":"32","author":"Shin","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1490","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/brain\/awv053","article-title":"Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury","volume":"138","author":"Shultz","year":"2015","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1495","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.febslet.2011.11.022","article-title":"Proteostasis of tau: tau overexpression results in its secretion via membrane vesicles","volume":"586","author":"Simon","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1500","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1002\/jnr.21360","article-title":"Peroxynitrite-mediated oxidative damage to brain mitochondria: protective effects of peroxynitrite scavengers","volume":"85","author":"Singh","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1505","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/jcbfm.2012.211","article-title":"Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal","volume":"33","author":"Singh","year":"2013","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1510","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/089771501750291846","article-title":"The immunophilin ligand FK506 attenuates axonal injury in an impact-acceleration model of traumatic brain injury","volume":"18","author":"Singleton","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1515","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuint.2008.06.003","article-title":"The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons","volume":"53","author":"Sinjoanu","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1520","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1523\/JNEUROSCI.17-08-02653.1997","article-title":"Widespread peroxynitrite-mediated damage in Alzheimer's disease","volume":"17","author":"Smith","year":"1997","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1525","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/00005072-199909000-00008","article-title":"Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig","volume":"58","author":"Smith","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1530","doi-asserted-by":"crossref","first-page":"44701","DOI":"10.1074\/jbc.M206047200","article-title":"Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation","volume":"277","author":"Song","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1535","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1523\/JNEUROSCI.3072-08.2008","article-title":"In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons","volume":"28","author":"Spires-Jones","year":"2008","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1540","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s12031-011-9566-7","article-title":"Are tangles as toxic as they look?","volume":"45","author":"Spires-Jones","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1545","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1083\/jcb.200108057","article-title":"Tau blocks traffic of organelles neurofilaments, and APP vesicles in neurons and enhances oxidative stress","volume":"156","author":"Stamer","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1550","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1212\/WNL.0b013e3182a55f7f","article-title":"Clinical presentation of chronic traumatic encephalopathy","volume":"81","author":"Stern","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1555","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3233\/JAD-151028","article-title":"Preliminary study of plasma exosomal tau as a potential biomarker for chronic traumatic encephalopathy","volume":"51","author":"Stern","year":"2016","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1560","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200700412","article-title":"Acrolein: sources metabolism, and biomolecular interactions relevant to human health and disease","volume":"52","author":"Stevens","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1565","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1471-4159.2009.06316.x","article-title":"Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport","volume":"111","author":"Stoothoff","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1570","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00401-009-0556-6","article-title":"Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease","volume":"118","author":"Streit","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1575","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neulet.2009.11.010","article-title":"Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells","volume":"468","author":"Su","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1580","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jnr.20292","article-title":"Mitochondrial permeability transition in CNS trauma: cause or effect of neuronal cell death?","volume":"79","author":"Sullivan","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1585","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/neu.2010.1646","article-title":"Therapeutic window analysis of the neuroprotective effects of cyclosporine A after traumatic brain injury","volume":"28","author":"Sullivan","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1590","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.bbadis.2011.08.012","article-title":"Brain aging Alzheimer's disease, and mitochondria","volume":"1812","author":"Swerdlow","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1595","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1046\/j.1471-4159.2000.0751234.x","article-title":"In Alzheimer's disease heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification","volume":"75","author":"Takeda","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1600","doi-asserted-by":"crossref","first-page":"34389","DOI":"10.1074\/jbc.M114.611368","article-title":"Oligomer formation of tau protein hyperphosphorylated in cells","volume":"289","author":"Tepper","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1605","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1089\/neu.2005.22.42","article-title":"Lateral fluid percussion brain injury: a 15-year review and evaluation","volume":"22","author":"Thompson","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1610","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.expneurol.2006.04.013","article-title":"Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice","volume":"201","author":"Thompson","year":"2006","journal-title":"Exp. Neurol."},{"issue":"Pt 14","key":"10.1016\/j.pneurobio.2017.08.003_bib1615","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1242\/jcs.112.14.2355","article-title":"Tau regulates the attachment\/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles","volume":"112","author":"Trinczek","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1620","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nn0905-1136","article-title":"Pathological tau: a loss of normal function or a gain in toxicity?","volume":"8","author":"Trojanowski","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1625","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0006-8993(93)90918-D","article-title":"In vitro polymerization of oxidized tau into filaments","volume":"613","author":"Troncoso","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1630","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3940(98)00348-6","article-title":"m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains","volume":"248","author":"Tsuji","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1635","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fneur.2015.00222","article-title":"The quest to model chronic traumatic encephalopathy: a multiple model and injury paradigm experience","volume":"6","author":"Turner","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1640","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.expneurol.2007.06.018","article-title":"Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans","volume":"208","author":"Uryu","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1645","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1089\/neu.2009.1172","article-title":"Lipid peroxidation-derived reactive aldehydes directly and differentially impair spinal cord and brain mitochondrial function","volume":"27","author":"Vaishnav","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1650","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0002-9440(10)63342-1","article-title":"Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease","volume":"165","author":"Veeranna","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1655","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nurt.2008.10.036","article-title":"Multifunctional drugs for head injury","volume":"6","author":"Vink","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1660","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jns.2014.11.011","article-title":"Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease","volume":"348","author":"Wang","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1665","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/jcbfm.2013.146","article-title":"Microglia\/macrophage polarization dynamics in white matter after traumatic brain injury","volume":"33","author":"Wang","year":"2013","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1670","doi-asserted-by":"crossref","first-page":"e76057","DOI":"10.1371\/journal.pone.0076057","article-title":"Expression of Tau40 induces activation of cultured rat microglial cells","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1675","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3892\/etm.2016.3017","article-title":"Serum tau protein as a potential biomarker in the assessment of traumatic brain injury","volume":"11","author":"Wang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1680","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0166-2236(99)01479-4","article-title":"Calpain and caspase: can you tell the difference?","volume":"23","author":"Wang","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1685","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1089\/neu.2012.2383","article-title":"MT5-MMP ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury","volume":"29","author":"Warren","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1690","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphar.2012.00060","article-title":"Altered calcium signaling following traumatic brain injury","volume":"3","author":"Weber","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1695","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1097\/00004647-200109000-00006","article-title":"Proteolysis of oxidized proteins after oxygen-glucose deprivation in rat cortical neurons is mediated by the proteasome","volume":"21","author":"Weih","year":"2001","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1700","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1126\/science.1062382","article-title":"Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles","volume":"293","author":"Wittmann","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1705","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1074\/jbc.M112.394528","article-title":"Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons","volume":"288","author":"Wu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1710","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/neu.1997.14.23","article-title":"Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury","volume":"14","author":"Xiong","year":"1997","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1715","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrn3407","article-title":"Animal models of traumatic brain injury","volume":"14","author":"Xiong","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1720","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.expneurol.2015.08.014","article-title":"Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury","volume":"273","author":"Xu","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1725","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1432-1033.1995.009_1.x","article-title":"Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments","volume":"233","author":"Yang","year":"1995","journal-title":"Eur. J. Biochem.\/FEBS"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1730","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1038\/srep11178","article-title":"Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model","volume":"5","author":"Yang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1735","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/ane.12644","article-title":"Involvement of tau phosphorylation in traumatic brain injury patients","volume":"135","author":"Yang","year":"2017","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1740","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1471-4159.2007.04970.x","article-title":"Alterations of cerebral cortex and hippocampal proteasome subunit expression and function in a traumatic brain injury rat model","volume":"104","author":"Yao","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1745","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1523\/JNEUROSCI.23-33-10662.2003","article-title":"Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes","volume":"23","author":"Yoshiyama","year":"2003","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1750","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1089\/neu.2005.22.1134","article-title":"Enhanced neurofibrillary tangle formation cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model","volume":"22","author":"Yoshiyama","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1755","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1760","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3233\/JAD-2010-100681","article-title":"Anti-inflammatory action of donepezil ameliorates tau pathology synaptic loss, and neurodegeneration in a tauopathy mouse model","volume":"22","author":"Yoshiyama","year":"2010","journal-title":"J. Alzheimer's Dis. JAD"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1765","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2011.08.017","article-title":"Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model","volume":"45","author":"Yoshiyama","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1770","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1089\/neu.2012.2449","article-title":"Lithium reduces BACE1 overexpression beta amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury","volume":"29","author":"Yu","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1775","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.freeradbiomed.2004.03.007","article-title":"Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1","volume":"36","author":"Zambrano","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1780","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1471-4159.1999.0720741.x","article-title":"Quantification of axonal damage in traumatic brain injury: affinity purification and characterization of cerebrospinal fluid tau proteins","volume":"72","author":"Zemlan","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1785","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0006-8993(02)02920-7","article-title":"C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome","volume":"947","author":"Zemlan","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1790","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1001\/archneur.63.9.1277","article-title":"Neurochemical aftermath of amateur boxing","volume":"63","author":"Zetterberg","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1795","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.febslet.2005.03.041","article-title":"Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity","volume":"579","author":"Zhang","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1800","first-page":"1431","article-title":"Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms","volume":"20","author":"Zhang","year":"2006","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1805","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/jcbfm.2014.216","article-title":"Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury","volume":"35","author":"Zhang","year":"2015","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1810","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00401-009-0499-y","article-title":"Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies","volume":"118","author":"Zilka","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.pneurobio.2017.08.003_bib1815","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jneuroim.2009.01.013","article-title":"Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy","volume":"209","author":"Zilka","year":"2009","journal-title":"J. Neuroimmunol."}],"container-title":["Progress in Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301008217300473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301008217300473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:34:29Z","timestamp":1750822469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301008217300473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":363,"alternative-id":["S0301008217300473"],"URL":"https:\/\/doi.org\/10.1016\/j.pneurobio.2017.08.003","relation":{},"ISSN":["0301-0082"],"issn-type":[{"value":"0301-0082","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology","name":"articletitle","label":"Article Title"},{"value":"Progress in Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pneurobio.2017.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}