{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:16:56Z","timestamp":1783441016189,"version":"3.54.6"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.pnpbp.2007.02.005","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T12:21:47Z","timestamp":1171628507000},"page":"887-891","source":"Crossref","is-referenced-by-count":44,"title":["Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania"],"prefix":"10.1016","volume":"31","author":[{"given":"Cristiane","family":"Corr\u00eaa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziela","family":"Amboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Clemes","family":"Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio R.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio","family":"Kapczinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio L.","family":"Streck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2007.02.005_bib1","series-title":"Diagnostic and statistical manual of mental disorders","year":"1994"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1176\/appi.ajp.157.7.1108","article-title":"Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients","volume":"157","author":"Anand","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib3","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1073\/pnas.0307921101","article-title":"Lithium antagonizes dopamine dependent behaviors mediated by an AKT\/glycogen synthase kinase 3 signaling cascade","volume":"101","author":"Beaulieu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hup.665","article-title":"Lithium and valproate attenuate dextroamphetamine-induced changes in brain activation","volume":"20","author":"Bell","year":"2005","journal-title":"Hum Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMra035354","article-title":"Bipolar disorder","volume":"351","author":"Belmaker","year":"2004","journal-title":"N Eng J Med"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/FBP.0b013e32801416ed","article-title":"Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss","volume":"18","author":"Bersudsky","year":"2007","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib7","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0006-3223(02)01911-X","article-title":"Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging","volume":"53","author":"Bertolino","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/070674370204700203","article-title":"The neurobiology of bipolar disorder: focus on signal transduction pathways and the regulation of gene expression","volume":"47","author":"Bezchlibnyk","year":"2002","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1023\/A:1010955807739","article-title":"Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity","volume":"26","author":"Calabrese","year":"2001","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1034\/j.1399-5618.2002.01179.x","article-title":"Neuroprotective effects of lithium in cultured cells and animal models of diseases","volume":"4","author":"Chuang","year":"2002","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0896-6273(03)00195-8","article-title":"Finding the intracellular signaling pathways affected by mood disorder treatments","volume":"38","author":"Coyle","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2006.03.061","article-title":"Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine","volume":"1089","author":"Cunha-Oliveira","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib13","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1176\/appi.ajp.160.5.873","article-title":"Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder","volume":"160","author":"Deicken","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib14","series-title":"Contemporary issues in modeling psychopathology","first-page":"165","article-title":"Animal models of bipolar disorder: from a single episode to progressive cycling models","author":"Einat","year":"2000"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib15","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1523\/JNEUROSCI.23-19-07311.2003","article-title":"The role of the extracellular signal-regulated kinase signaling pathway in mood regulation","volume":"23","author":"Einat","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.lfs.2006.01.002","article-title":"Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania","volume":"79","author":"Frey","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1399-5618.2006.00318.x","article-title":"Increased oxidative stress after repeated amphetamine exposure: possible relevance as an animal model of mania","volume":"8","author":"Frey","year":"2006","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s11064-006-9070-6","article-title":"Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of mania","volume":"31","author":"Frey","year":"2006","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/107385802237176","article-title":"The Wnt signaling pathway in bipolar disorder","volume":"8","author":"Gould","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1034\/j.1399-5618.2002.01162.x","article-title":"Evaluation of neuroprotection by lithium and valproic acid against ouabain-induced cell damage","volume":"4","author":"Hennion","year":"2002","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1034\/j.1399-5618.2000.020305.x","article-title":"Mitochondrial dysfunction in bipolar disorder","volume":"2","author":"Kato","year":"2000","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archpsyc.61.3.300","article-title":"Molecular evidence for mitochondrial dysfunction in bipolar disorder","volume":"61","author":"Konradi","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib23","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1001\/jama.293.20.2528","article-title":"The increasing medical burden in bipolar disorder","volume":"293","author":"Kupfer","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejphar.2006.03.076","article-title":"Cytoprotection by lithium and valproate varies between cell types and cellular stresses","volume":"539","author":"Lai","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib25","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1006\/ebeh.2001.0254","article-title":"Effect of the new antiepileptic drug levetiracetam in an animal model of mania","volume":"2","author":"Lamberty","year":"2001","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3940(00)01559-7","article-title":"A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: caspase-3 dependency","volume":"294","author":"Li","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0327(00)00361-X","article-title":"Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?","volume":"69","author":"Li","year":"2002","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1385\/BTER:114:1:163","article-title":"Stimulation effect of lithium on the metabolic activity of liver tissue mitochondria measured by microcalorimetry","volume":"114","author":"Li","year":"2006","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pnpbp.2003.10.015","article-title":"Perspectives for the development of animal models of bipolar disorder","volume":"28","author":"Machado-Vieira","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1471-4159.2002.00939.x","article-title":"BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents","volume":"82","author":"Mai","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib32","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1038\/sj.mp.4001018","article-title":"PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers","volume":"7","author":"Manji","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib33","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0006-3223(00)00929-X","article-title":"Signaling: cellular insights into the pathophysiology of bipolar disorder","volume":"48","author":"Manji","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/87865","article-title":"The cellular neurobiology of depression","volume":"7","author":"Manji","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01660077","article-title":"Oxaloacetate metabolic crossroads in liver. Enzyme compartmentation and regulation of gluconeogenesis","volume":"3","author":"Marco","year":"1974","journal-title":"Mol Cell Biochem"},{"issue":"Suppl 1","key":"10.1016\/j.pnpbp.2007.02.005_bib36","article-title":"Long-term pharmacological treatment of bipolar disorders","volume":"28","author":"Rybakowski","year":"2007","journal-title":"Neuro Endocrinol Lett"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj1140597","article-title":"The kinetic properties of citrate synthase from rat liver mitochondria","volume":"114","author":"Shepherd","year":"1969","journal-title":"Biochem J"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0165-0327(93)90057-Q","article-title":"The comparative efficacy of carbamazepine low and high serum level and lithium carbonate in the prophylaxis of affective disorders","volume":"28","author":"Simhandl","year":"1993","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib39","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/sj.mp.4001711","article-title":"Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research","volume":"10","author":"Stork","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib40","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0006-3223(97)00454-X","article-title":"Progressive behavioral response to repeated d-amphetamine challenge: further evidence for sensitization in humans","volume":"44","author":"Strakowski","year":"1998","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib41","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0028-3908(87)90157-2","article-title":"Effects of chronic administration of dextroamphetamine on enzymes of energy metabolism in regions of the rat brain","volume":"26","author":"Valenzuela","year":"1987","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2007.02.005_bib42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1399-5618.2005.00219.x","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies","volume":"7","author":"Yatham","year":"2005","journal-title":"Bipolar Disord"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584607000644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584607000644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T20:55:11Z","timestamp":1628456111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584607000644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0278584607000644"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2007.02.005","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}