{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:50:45Z","timestamp":1779907845899,"version":"3.53.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.pnpbp.2008.03.015","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T13:21:26Z","timestamp":1207142486000},"page":"1434-1438","source":"Crossref","is-referenced-by-count":54,"title":["Effects of second generation antipsychotics on leptin and ghrelin"],"prefix":"10.1016","volume":"32","author":[{"given":"Ay\u015fen","family":"Esen-Danac\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Sarand\u00f6l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Taneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Yurtsever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"\u00d6zlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pnpbp.2008.03.015_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02778056","article-title":"Regulation of circulating leptin in humans","volume":"7","author":"Ahr\u00e9n","year":"1997","journal-title":"Endocrine"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib2","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","article-title":"Antipsychotic-induced weight gain: a comprehensive research synthesis","volume":"156","author":"Allison","year":"1999","journal-title":"Am J Psychiatr"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0920-9964(02)00305-5","article-title":"Weight gain, serum leptin and triglyceride levels in patients with schizophrenia on antipsychotic treatment with quetiapine, olanzapine and haloperidol","volume":"60","author":"Atmaca","year":"2003","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.mp.4000352","article-title":"Serum leptin levels increase rapidly after initiation of clozapine therapy","volume":"3","author":"Bromel","year":"1998","journal-title":"Mol Psychiatry"},{"issue":"11","key":"10.1016\/j.pnpbp.2008.03.015_bib5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.4088\/JCP.v62n1102","article-title":"Leptin concentrations are increased in subjects treated with clozapine or conventional antipsychotics","volume":"62","author":"H\u00e4gg","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/sj.npp.1300563","article-title":"Plasma leptin and adiposity during antipsychotic treatment of schizophrenia","volume":"30","author":"Haupt","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.pnpbp.2008.03.015_bib7","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1210\/jc.81.12.4406","article-title":"Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss","volume":"81","author":"Havel","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2165\/00023210-200216020-00001","article-title":"Atypical antipsychotic-induced diabetes mellitus: how strong is the evidence?","volume":"16","author":"Henderson","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1192\/bjp.179.1.59","article-title":"Effects of long-term treatment with antipsychotics on serum leptin levels","volume":"179","author":"Herran","year":"2001","journal-title":"Br J Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2008.03.015_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1467-789X.2006.00270.x","article-title":"The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review","volume":"8","author":"Klok","year":"2007","journal-title":"Obes Rev"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00406-002-0394-1","article-title":"Weight gain and glucose and lipid metabolism disturbances during antipsychotic medication: a review","volume":"252","author":"Koponen","year":"2002","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1176\/ajp.156.2.312","article-title":"Body weight and leptin plasma levels during treatment with antipsychotic drugs","volume":"156","author":"Kraus","year":"1999","journal-title":"Am J Psychiatry"},{"issue":"4","key":"10.1016\/j.pnpbp.2008.03.015_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000054641","article-title":"Low leptin levels but normal body mass indices in patients with depression or schizophrenia","volume":"73","author":"Kraus","year":"2001","journal-title":"Neuroendocrinology"},{"issue":"11","key":"10.1016\/j.pnpbp.2008.03.015_bib14","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","article-title":"Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects","volume":"1","author":"Maffei","year":"1995","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.pnpbp.2008.03.015_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s002130000639","article-title":"Insulin and leptin levels in patients with schizophrenia or related psychoses\u2014a comparison between different antipsychotic agents","volume":"154","author":"Melkersson","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"issue":"10","key":"10.1016\/j.pnpbp.2008.03.015_bib28","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4088\/JCP.v61n1006","article-title":"Elevated levels of insulin, leptin, and blood lipids in olanzapine-treated patients with schizophrenia or related psychoses","volume":"61","author":"Melkersson","year":"2000","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2008.03.015_bib16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.psyneuen.2004.05.008","article-title":"Olanzapine increases plasma ghrelin level in patients with schizophrenia","volume":"30","author":"Murashita","year":"2005","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.pnpbp.2008.03.015_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1440-1819.2007.01610.x","article-title":"Glucose and lipid metabolism of long-term risperidone monotherapy in patients with schizophrenia","volume":"61","author":"Murashita","year":"2007","journal-title":"Psychiatry Clin Neurosci"},{"issue":"6817","key":"10.1016\/j.pnpbp.2008.03.015_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.pnpbp.2008.03.015_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.diabres.2005.03.008","article-title":"Correlation of serum ghrelin levels with body mass index and carbohydrate metabolism in patients treated with atypical antipsychotics","volume":"68","author":"Palik","year":"2005","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib20","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1079\/BJN2003945","article-title":"Gastric leptin: a putative role in the short-term regulation of food intake","volume":"90","author":"Pico","year":"2003","journal-title":"Br J Nutr"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yfrne.2003.10.001","article-title":"Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance","volume":"24","author":"Sahu","year":"2003","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm0596-589","article-title":"Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans","volume":"2","author":"Schwartz","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib23","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/gut.47.2.178","article-title":"Leptin secretion and leptin receptor in the human stomach","volume":"47","author":"Sobhani","year":"2000","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.pnpbp.2008.03.015_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00213-003-1642-4","article-title":"Serum ghrelin concentrations in patients receiving olanzapine or risperidone","volume":"172","author":"Togo","year":"2004","journal-title":"Psychopharmacology (Berl.)"},{"issue":"6522","key":"10.1016\/j.pnpbp.2008.03.015_bib25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/374542a0","article-title":"Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors","volume":"374","author":"Tecott","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/diabetes.50.4.707","article-title":"Circulating ghrelin levels are decreased in human obesity","volume":"50","author":"Tschop","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.pnpbp.2008.03.015_bib27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1192\/bjp.184.1.58","article-title":"Effects of antipsychotics on fat deposition and changes in leptin and insulin levels. Magnetic resonance imaging study of previously untreated people with schizophrenia","volume":"184","author":"Zhang","year":"2004","journal-title":"Br J Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584608000924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584608000924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T11:48:55Z","timestamp":1684324135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584608000924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0278584608000924"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2008.03.015","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}