{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:49:34Z","timestamp":1780580974186,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.pnpbp.2008.09.016","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T09:23:41Z","timestamp":1222853021000},"page":"1978-1981","source":"Crossref","is-referenced-by-count":45,"title":["Time course of the changes in antipsychotic-induced hyperprolactinemia following the switch to aripiprazole"],"prefix":"10.1016","volume":"32","author":[{"given":"Mong-Liang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston W.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2008.09.016_bib1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1055\/s-2007-979503","article-title":"Effects of the antipsychotic drug sulpiride on reproductive hormones in healthy premenopausal women: relationship with body weight regulation","volume":"30","author":"Baptista","year":"1997","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0165-1781(81)90078-0","article-title":"Tolerance to the prolactin-elevating effect of neuroleptics.","volume":"5","author":"Brown","year":"1981","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1177\/0269881107078281","article-title":"Prevalence of hyperprolactinaemia in a naturalistic cohort of schizophrenia and bipolar outpatients during treatment with typical and atypical antipsychotics.","volume":"21","author":"Bushe","year":"2007","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/jcp.0b013e31815ac4e5","article-title":"Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives.","volume":"27","author":"Byerly","year":"2007","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00213-002-1344-3","article-title":"Switching patients to aripiprazole from other antipsychotic agents: a multicenter randomized study","volume":"166","author":"Casey","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.pnpbp.2007.11.007","article-title":"Aripiprazole resolves symptomatic hyperprolactinemia in a male schizophrenic patient.","volume":"32","author":"Chen","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1001\/archpsyc.1978.01770250110011","article-title":"Prolactin responses to neuroleptics in normal and schizophrenic subjects","volume":"35","author":"Gruen","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib8","unstructured":"Guy W. (1976). Clinical global impression. ECDEU Assessment Manual for Psychopharmacology, Revised. Rockville, MD, National Institute of Mental Health."},{"key":"10.1016\/j.pnpbp.2008.09.016_bib9","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.2165\/00003495-200464200-00003","article-title":"Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management.","volume":"64","author":"Haddad","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/026988110401800308","article-title":"Mechanism of action of aripiprazole predicts clinical efficacy and a favourable side-effect profile","volume":"18","author":"Hirose","year":"2004","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-2999(02)01532-7","article-title":"The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor.","volume":"441","author":"Jordan","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib12","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.v63n0903","article-title":"Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder","volume":"63","author":"Kane","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib13","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1124\/jpet.102.035303","article-title":"The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats.","volume":"302","author":"Kapur","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib14","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.pnpbp.2003.09.004","article-title":"Half a century of antipsychotics and still a central role for dopamine D2 receptors.","volume":"27","author":"Kapur","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib15","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0006-3223(01)01251-3","article-title":"Dopamine D2 receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient.","volume":"50","author":"Kapur","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00004714-199902000-00011","article-title":"Prolactin levels and adverse events in patients treated with risperidone.","volume":"19","author":"Kleinberg","year":"1999","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0022-3565(24)38019-X","article-title":"Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens.","volume":"288","author":"Kuroki","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1440-1681.1992.tb00511.x","article-title":"A study of serum prolactin levels in schizophrenia: comparison of males and females.","volume":"19","author":"Kuruvilla","year":"1992","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib20","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.4088\/JCP.v67n0821a","article-title":"Reversal of antipsychotic-induced hyperprolactinemia, weight gain, and dyslipidemia by aripiprazole: a case report.","volume":"67","author":"Lin","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0447.1987.tb10566.x","article-title":"The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients.","volume":"334","author":"Lingjaerde","year":"1987","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-9964(03)00050-1","article-title":"Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials","volume":"61","author":"Marder","year":"2003","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2165\/00002018-199614050-00003","article-title":"A risk\u2013benefit assessment of sulpiride in the treatment of schizophrenia.","volume":"14","author":"Mauri","year":"1996","journal-title":"Drug Saf"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archpsyc.1976.01770030003001","article-title":"The effect of neuroleptics on serum prolactin in schizophrenic patients.","volume":"33","author":"Meltzer","year":"1976","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/0269881107082901","article-title":"Change in sexual dysfunction with aripiprazole: a switching or add-on study.","volume":"22","author":"Mir","year":"2008","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib26","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.pnpbp.2004.06.020","article-title":"Aripiprazole: a new atypical antipsychotic with a different pharmacological mechanism.","volume":"28","author":"Naber","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib27","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1038\/sj.npp.1300983","article-title":"Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models.","volume":"31","author":"Natesan","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S1461145706007115","article-title":"Amisulpride-induced hyperprolactinaemia is not reversed by addition of aripiprazole.","volume":"10","author":"Paulzen","year":"2007","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2265.1976.tb01953.x","article-title":"Effect of acute and chronic neuroleptic therapy on serum prolactin levels in men and women of different age groups.","volume":"5","author":"Rivera","year":"1976","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib30","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/sj.npp.1300203","article-title":"Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology","volume":"28","author":"Shapiro","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib31","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1176\/appi.ajp.2007.06071075","article-title":"Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial","volume":"164","author":"Shim","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib32","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1176\/appi.ajp.162.8.1542-a","article-title":"Reversal of symptomatic hyperprolactinemia by aripiprazole.","volume":"162","author":"Wahl","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/0269881105056668","article-title":"Switching antipsychotics: an updated review with a focus on quetiapine.","volume":"20","author":"Weiden","year":"2006","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1192\/bjp.182.3.199","article-title":"Antipsychotic-induced hyperprolactinaemia in women: pathophysiology, severity and consequences. Selective literature review.","volume":"182","author":"Wieck","year":"2003","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2710.2007.00806.x","article-title":"Hyperprolactinemia and amenorrhea associated with olanzapine normalized after addition of aripiprazole.","volume":"32","author":"Wolf","year":"2007","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.pnpbp.2008.09.016_bib36","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1001\/jama.284.23.3043","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.","volume":"284","author":"World Medical Association","year":"2000","journal-title":"JAMA"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858460800300X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858460800300X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T09:57:35Z","timestamp":1738403855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027858460800300X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S027858460800300X"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2008.09.016","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}