{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:34:39Z","timestamp":1768088079170,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.pnpbp.2009.04.010","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T04:27:39Z","timestamp":1240374459000},"page":"867-871","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia-a postmortem study"],"prefix":"10.1016","volume":"33","author":[{"given":"Kai","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2009.04.010_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0920-9964(03)00183-X","article-title":"Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia","volume":"67","author":"Abdolmaleky","year":"2004","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0893-133X(96)00053-X","article-title":"5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia","volume":"15","author":"Burnet","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(95)00241-A","article-title":"Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications","volume":"69","author":"Cassel","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1046\/j.1440-1681.2001.03401.x","article-title":"A predicted cortical serotonergic\/cholinergic\/GABAergic interface as a site of pathology in schizophrenia","volume":"28","author":"Dean","year":"2001","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0920-9964(96)00034-5","article-title":"Decreased frontal cortical serotonin2A receptors in schizophrenia","volume":"21","author":"Dean","year":"1996","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0149-2918(04)90066-5","article-title":"Aripiprazole: A comprehensive review of its pharmacology, clinical efficacy, and tolerability","volume":"26","author":"DeLeon","year":"2004","journal-title":"Clin Ther"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib7","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/jnr.20600","article-title":"Decreased density of muscarinic receptors in the superior temporal gyrusin schizophrenia","volume":"81","author":"Deng","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib8","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00221-005-0290-9","article-title":"Increased density of GABAA receptors in the superior temporal gyrus in schizophrenia","volume":"168","author":"Deng","year":"2006","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12264-007-0051-9","article-title":"No changes in densities of cannabinoid receptors in the superior temporal gyrus in schizophrenia","volume":"23","author":"Deng","year":"2007","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib10","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.neuroscience.2006.02.068","article-title":"Fatty acids differentially affect serotonin receptor and transporter binding in the rat brain","volume":"139","author":"du Bois","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib11","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/sj.npp.1301656","article-title":"Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients","volume":"33","author":"Erritzoe","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/cercor\/bhg107","article-title":"Neuroanatomy of \u201chearing voices\u201d: a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia","volume":"14","author":"Gaser","year":"2004","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0197-0186(94)90117-1","article-title":"Muscarinic M1 receptor mediated inhibition of GABA release from rat cerebral cortex","volume":"24","author":"Hashimoto","year":"1994","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bbr.2006.03.040","article-title":"Olanzapine differentially affects 5-HT2Aand2C receptor mRNA expression in the rat brain","volume":"171","author":"Huang","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00213-007-0921-x","article-title":"5-HT2A receptor density is decreased in the at-risk mental state","volume":"195","author":"Hurlemann","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00429-005-0036-2","article-title":"Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia","volume":"210","author":"Hurlemann","year":"2005","journal-title":"Anat Embryol"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0920-9964(03)00016-1","article-title":"Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity","volume":"64","author":"Juckel","year":"2003","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib18","series-title":"The Use of CNS Autopsy Tissue in Psychiatric Research: A Practical Guide","first-page":"19","article-title":"Psychiatric diagnosis after death: the problems of accurate diagnosis","author":"Keks","year":"1999"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib19","first-page":"173","article-title":"Morphology of the lateral superior temporal gyrus in neuroleptic nai;ve patients with schizophrenia: relationship to symptoms","volume":"60","author":"Kim","year":"2003","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib20","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbrc.2005.12.101","article-title":"Association study of serotonin 2A receptor (5-HT2A) gene with schizophrenia and suicidal behavior using systematic meta-analysis","volume":"340","author":"Li","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.biopsych.2003.09.017","article-title":"Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia","volume":"55","author":"Lopez-Figueroa","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neulet.2004.12.059","article-title":"5-HT2A and muscarinic receptors in schizophrenia: a postmortem study","volume":"379","author":"Matsumoto","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0306-4522(93)90241-7","article-title":"Immunocytochemical localization and description of neurons expressing serotonin2 receptors in the rat brain","volume":"54","author":"Morilak","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pharmthera.2003.11.002","article-title":"Hallucinogens","volume":"101","author":"Nichols","year":"2004","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ajmg.b.30197","article-title":"Evidence for a common biological basis of the Absorption trait, hallucinogen effects, and positive symptoms: epistasis between 5-HT2a and COMT polymorphisms","volume":"137","author":"Ott","year":"2005","journal-title":"Am J Med Genet B, Neuropsychiatr Genet: Off Publicat Int Soc of Psychiatr Genet"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0920-9964(99)00150-4","article-title":"Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia","volume":"44","author":"Pralong","year":"2000","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib27","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.pnpbp.2007.01.012","article-title":"Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia","volume":"31","author":"Saiz","year":"2007","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatr"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.schres.2004.02.007","article-title":"Hippocampal 5-hydroxytryptamine receptors: abnormalities in postmortem brain from schizophrenic subjects","volume":"71","author":"Scarr","year":"2004","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib29","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/0024-3205(95)00210-W","article-title":"The role of 5-HT2A receptors in antipsychotic activity","volume":"56","author":"Schmidt","year":"1995","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10561-008-9076-1","article-title":"An Australian Brain Bank: a critical investment with a high return!","volume":"9","author":"Sheedy","year":"2008","journal-title":"Cell Tissue Bank"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/378176a0","article-title":"A functional neuroanatomy of hallucination in schizophrenia","volume":"378","author":"Silbersweig","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/sj.mp.4000920","article-title":"RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia","volume":"6","author":"Sodhi","year":"2001","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0920-9964(98)00014-0","article-title":"No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET","volume":"31","author":"Trichard","year":"1998","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/00207450490430552","article-title":"Are the cognitive effects of atypical antipsychotics influenced by their affinity to 5HT-2A receptors?","volume":"114","author":"Tyson","year":"2004","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0301-0082(98)00092-6","article-title":"Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory","volume":"58","author":"Van der Zee","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib36","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/S0024-3205(03)00141-3","article-title":"5-HT2A and 5-HT2C receptors and their atypical regulation properties","volume":"72","author":"Van Oekelen","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/(SICI)1096-8628(19970221)74:1<21::AID-AJMG6>3.0.CO;2-Y","article-title":"No association between schizophrenia and the serotonin receptor 5HTR2a in an Italian population","volume":"74","author":"Verga","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pnpbp.2009.04.010_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-1781(00)00198-0","article-title":"A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia","volume":"99","author":"Verhoeff","year":"2000","journal-title":"Psychiatr Res"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584609001201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584609001201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T19:41:05Z","timestamp":1759520465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584609001201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0278584609001201"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2009.04.010","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia-a postmortem study","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2009.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}