{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:16:17Z","timestamp":1790021777240,"version":"4.0.1"},"reference-count":106,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Astra-Zeneca Italia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.pnpbp.2010.10.025","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T08:40:50Z","timestamp":1288860050000},"page":"184-197","source":"Crossref","is-referenced-by-count":45,"title":["The acute and chronic effects of combined antipsychotic\u2013mood stabilizing treatment on the expression of cortical and striatal postsynaptic density genes"],"prefix":"10.1016","volume":"35","author":[{"given":"Carmine","family":"Tomasetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Dell'Aversano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Iasevoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Marmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"de Bartolomeis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2010.10.025_bb0005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.biopsych.2004.11.036","article-title":"Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum","volume":"57","author":"Alimohamad","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0010","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1471-4159.2007.04532.x","article-title":"Antipsychotic drugs reverse the AMPA receptor-stimulated release of 5-HT in the medial prefrontal cortex","volume":"102","author":"Amargos-Bosch","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1385-299X(03)00056-4","article-title":"Method for quantitative in situ hybridization histochemistry and image analysis applied for Homer1a gene expression in rat brain","volume":"11","author":"Ambesi-Impiombato","year":"2003","journal-title":"Brain Res Brain Res Protoc"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0020","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/syn.20385","article-title":"Differential expression of Homer 1 gene by acute and chronic administration of antipsychotics and dopamine transporter inhibitors in the rat forebrain","volume":"61","author":"Ambesi-Impiombato","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0025","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/35082096","article-title":"Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer","volume":"411","author":"Ango","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0530","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00213-009-1551-2","article-title":"Early effects of mood stabilizers on the .Akt\/GSK\u20133beta signaling pathway and on cell survival and proliferation","volume":"205","author":"Aubry","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.pharmtox.011008.145634","article-title":"Akt\/GSK3 signaling in the action of psychotropic drugs","volume":"49","author":"Beaulieu","year":"2009","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2004.06.050","article-title":"A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression","volume":"368","author":"Benedetti","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2004.11.022","article-title":"Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta \u221250T\/C SNP","volume":"376","author":"Benedetti","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0045","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/386284a0","article-title":"Homer: a protein that selectively binds metabotropic glutamate receptors","volume":"386","author":"Brakeman","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0050","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.biopsych.2004.12.002","article-title":"Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions","volume":"57","author":"Browning","year":"2005","journal-title":"Biol Psychiatry"},{"issue":"Suppl 5","key":"10.1016\/j.pnpbp.2010.10.025_bb0055","first-page":"26","article-title":"Clinical highlights in bipolar depression: focus on atypical antipsychotics","volume":"66","author":"Calabrese","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0060","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0169-328X(99)00125-4","article-title":"Lithium and valproate differentially regulate brain regional expression of phosphorylated CREB and c-Fos","volume":"70","author":"Chen","year":"1999","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0065","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/mp.2010.3","article-title":"Translational research in bipolar disorder: emerging insights from genetically based models","volume":"15","author":"Chen","year":"2010","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0070","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0028-3908(02)00091-6","article-title":"Induction of differential patterns of local cerebral glucose metabolism and immediate-early genes by acute clozapine and haloperidol","volume":"43","author":"Cochran","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0075","first-page":"51","article-title":"The Homer family and the signal transduction system at glutamatergic postsynaptic density: potential role in behavior and pharmacotherapy","volume":"37","author":"de Bartolomeis","year":"2003","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0169-328X(01)00327-8","article-title":"Acute administration of antipsychotics modulates Homer striatal gene expression differentially","volume":"98","author":"de Bartolomeis","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.brainresbull.2009.01.006","article-title":"Antipsychotic and antidepressant co-treatment: effects on transcripts of inducible postsynaptic density genes possibly implicated in behavioural disorders","volume":"79","author":"Dell'aversano","year":"2009","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00213-004-1880-0","article-title":"Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine","volume":"176","author":"Denys","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0095","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0306-4522(95)00357-6","article-title":"The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization","volume":"70","author":"Deutch","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0100","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1073\/pnas.0805493105","article-title":"Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation","volume":"105","author":"Dong","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-8993(90)91300-6","article-title":"Haloperidol induces Fos and related molecules in intrastriatal grafts derived from fetal striatal primordia","volume":"530","author":"Dragunow","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0110","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1523\/JNEUROSCI.23-19-07311.2003","article-title":"The role of the extracellular signal-regulated kinase signaling pathway in mood modulation","volume":"23","author":"Einat","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ng1296","article-title":"Convergent evidence for impaired AKT1\u2013GSK3beta signaling in schizophrenia","volume":"36","author":"Emamian","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0120","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1152\/jn.00361.2002","article-title":"Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32","volume":"88","author":"Flores-Hernandez","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2005.01.004","article-title":"Treatment guidelines for bipolar disorder: a critical review","volume":"86","author":"Fountoulakis","year":"2005","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0130","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1471-4159.2005.03149.x","article-title":"Chronic fluoxetine administration inhibits extracellular signal-regulated kinase 1\/2 phosphorylation in rat brain","volume":"93","author":"Fumagalli","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbr.2009.11.029","article-title":"Quetiapine blocks cocaine-induced enhancement of brain stimulation reward","volume":"208","author":"Gallo","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2008.12.028","article-title":"Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration","volume":"452","author":"Ghasemzadeh","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2009.01.047","article-title":"Region specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration","volume":"1267","author":"Ghasemzadeh","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0150","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1176\/appi.ajp.161.9.1537","article-title":"Antidepressants for bipolar depression: a systematic review of randomized, controlled trials","volume":"161","author":"Gijsman","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0155","doi-asserted-by":"crossref","first-page":"8908","DOI":"10.1523\/JNEUROSCI.0932-05.2005","article-title":"A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome","volume":"25","author":"Giuffrida","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0160","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00213-006-0317-3","article-title":"Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex","volume":"185","author":"Gobbi","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0165","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/sj.npp.1300731","article-title":"Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs","volume":"30","author":"Gould","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jad.2007.01.024","article-title":"The cognitive and neurophysiological basis of emotion dysregulation in bipolar disorder","volume":"103","author":"Green","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0175","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1046\/j.1471-4159.2001.00495.x","article-title":"CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium","volume":"78","author":"Grimes","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tips.2008.10.010","article-title":"Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling","volume":"30","author":"Guidotti","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0185","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.5747-03.2004","article-title":"Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis","volume":"24","author":"Hao","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0190","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/00004714-199908000-00005","article-title":"Effects of carbamazepine and valproate on haloperidol plasma levels and on psychopathologic outcome in schizophrenic patients","volume":"19","author":"Hesslinger","year":"1999","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0195","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00213-005-0206-1","article-title":"Augmentation by citalopram of risperidone-induced monoamine release in rat prefrontal cortex","volume":"185","author":"Huang","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0200","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2006.04.081","article-title":"Effects of divalproex and atypical antipsychotic drugs on dopamine and acetylcholine efflux in rat hippocampus and prefrontal cortex","volume":"1099","author":"Huang","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0205","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.pnpbp.2009.02.009","article-title":"Dopamine receptor subtypes contribution to Homer1a induction: Insights into antipsychotic molecular action","volume":"33","author":"Iasevoli","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0210","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.psychres.2010.02.009","article-title":"Haloperidol induces higher Homer1a expression than risperidone, olanzapine and sulpiride in striatal sub-regions","volume":"117","author":"Iasevoli","year":"2010","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0215","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(99)00517-8","article-title":"Valproate and carbamazepine increase prefrontal dopamine release by 5-HT1A receptor activation","volume":"380","author":"Ichikawa","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0220","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0028-3908(97)00060-9","article-title":"Effect of 5-HT1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus","volume":"36","author":"Invernizzi","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0225","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejphar.2005.12.073","article-title":"Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor","volume":"534","author":"Izumi","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0230","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1471-4159.2007.04840.x","article-title":"Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation","volume":"103","author":"Jiao","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0235","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tibs.2003.12.004","article-title":"The glamour and gloom of glycogen synthase kinase-3","volume":"29","author":"Jope","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0240","doi-asserted-by":"crossref","first-page":"8560","DOI":"10.1523\/JNEUROSCI.1830-08.2008","article-title":"Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons","volume":"28","author":"Kammermeier","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0245","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-5793(04)00082-1","article-title":"The effects of clozapine on the GSK-3-mediated signaling pathway","volume":"560","author":"Kang","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0250","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/070674370004500302","article-title":"Are animal studies of antipsychotics appropriately dosed? Lessons from the bedside to the bench","volume":"45","author":"Kapur","year":"2000","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0255","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1124\/jpet.102.046987","article-title":"Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy","volume":"305","author":"Kapur","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0260","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.tins.2008.07.007","article-title":"Molecular neurobiology of bipolar disorder: a disease of \u2018mood-stabilizing neurons\u2019?","volume":"31","author":"Kato","year":"2008","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0265","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molbrainres.2003.07.005","article-title":"Activation of ERK cascade promotes accumulation of Vesl-1S\/Homer-1a immunoreactivity at synapses","volume":"118","author":"Kato","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0270","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0896-6273(00)00111-2","article-title":"Catching up on schizophrenia: natural history and neurobiology","volume":"28","author":"Lewis","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0275","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/sj.npp.1300439","article-title":"In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain","volume":"29","author":"Li","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0280","doi-asserted-by":"crossref","first-page":"15551","DOI":"10.1523\/JNEUROSCI.3336-09.2009","article-title":"Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex","volume":"29","author":"Li","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0285","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-8993(02)02620-3","article-title":"5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner","volume":"947","author":"Liegeois","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0290","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.neuron.2006.10.011","article-title":"Modulation of D2R\u2013NR2B interactions in response to cocaine","volume":"52","author":"Liu","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0295","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2174\/138161210790361416","article-title":"Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex","volume":"16","author":"Lopez-Gil","year":"2010","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0300","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1517\/14656560802504490","article-title":"Beneficial acute antidepressant effects of aripiprazole as an adjunctive treatment or monotherapy in bipolar patients unresponsive to mood stabilizers: results from a 16-week open-label trial","volume":"9","author":"Mazza","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0305","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1073\/pnas.90.8.3447","article-title":"Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics","volume":"90","author":"Merchant","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0310","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/j.1471-4159.1990.tb01230.x","article-title":"Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study","volume":"54","author":"Moghaddam","year":"1990","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0315","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1399-5618.2007.00354.x","article-title":"Effects of mood stabilizers on the inhibition of adenylate cyclase via dopamine D(2)-like receptors","volume":"9","author":"Montezinho","year":"2007","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0320","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.schres.2008.07.005","article-title":"Amisulpride the \u2018atypical\u2019 atypical antipsychotic\u2014comparison to haloperidol, risperidone and clozapine","volume":"105","author":"Natesan","year":"2008","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0325","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/syn.10189","article-title":"Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex","volume":"48","author":"Ninan","year":"2003","journal-title":"Synapse"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0330","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1111\/j.1460-9568.2008.06155.x","article-title":"Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression","volume":"27","author":"Orsetti","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0335","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/FPC.0b013e32832ee573","article-title":"Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats","volume":"19","author":"Orsetti","year":"2009","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0340","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0345","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2004.09.053","article-title":"The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortex","volume":"504","author":"Pira","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0350","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/taap.2002.9463","article-title":"Differential gene expression in rats following subacute exposure to the anticonvulsant sodium valproate","volume":"183","author":"Plant","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0355","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0893-133X(02)00371-8","article-title":"Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of D-cycloserine","volume":"27","author":"Polese","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0360","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0006-2952(02)01135-8","article-title":"Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling","volume":"64","author":"Pouyssegur","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0365","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.1471-4159.2003.01851.x","article-title":"Opposite regulation by typical and atypical anti-psychotics of ERK1\/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum","volume":"86","author":"Pozzi","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0370","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0024-3205(00)00911-5","article-title":"Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds","volume":"68","author":"Richelson","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0375","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1038\/sj.npp.1301305","article-title":"Dopamine and serotonin receptor binding and antipsychotic efficacy","volume":"32","author":"Richtand","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0380","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0306-4522(92)90054-6","article-title":"Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine","volume":"46","author":"Robertson","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0385","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0022-3565(25)23800-9","article-title":"Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity","volume":"271","author":"Robertson","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0390","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.biopsych.2004.10.039","article-title":"Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine","volume":"57","author":"Roh","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0395","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuroscience.2009.07.056","article-title":"Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1\/2 signaling","volume":"163","author":"Sarantis","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0400","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1073\/pnas.98.1.301","article-title":"Dopamine D1\/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons","volume":"98","author":"Seamans","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0405","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/070674370204700106","article-title":"Atypical antipsychotics: mechanism of action","volume":"47","author":"Seeman","year":"2002","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0410","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.mp.4000336","article-title":"Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors","volume":"3","author":"Seeman","year":"1998","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0415","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1044-7431(03)00037-X","article-title":"Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons","volume":"22","author":"Shiraishi","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0420","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/gb-2007-8-2-206","article-title":"The Homer family proteins","volume":"8","author":"Shiraishi-Yamaguchi","year":"2007","journal-title":"Genome Biol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0425","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1523\/JNEUROSCI.13-12-05066.1993","article-title":"Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum","volume":"13","author":"Steiner","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2001.00054.x","article-title":"The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory","volume":"76","author":"Sweatt","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0435","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1601-183X.2005.00120.x","article-title":"Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia","volume":"4","author":"Szumlinski","year":"2005","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0440","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.conb.2006.05.002","article-title":"Homer proteins: implications for neuropsychiatric disorders","volume":"16","author":"Szumlinski","year":"2006","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0445","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1073\/pnas.0505900103","article-title":"Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family","volume":"103","author":"Tappe","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0450","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroscience.2007.08.022","article-title":"Homer splice variants modulation within cortico-subcortical regions by dopamine D2 antagonists, a partial agonist, and an indirect agonist: implication for glutamatergic postsynaptic density in antipsychotics action","volume":"150","author":"Tomasetti","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0455","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0896-6273(00)80589-9","article-title":"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors","volume":"21","author":"Tu","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0460","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0896-6273(00)80810-7","article-title":"Coupling of mGluR\/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins","volume":"23","author":"Tu","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0465","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0893-133X(01)00261-5","article-title":"Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects","volume":"25","author":"Wadenberg","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/MN:29:1:01","article-title":"Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity","volume":"29","author":"Wang","year":"2004","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0475","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00702-006-0544-0","article-title":"Changes in region- and cell type-specific expression patterns of neutral amino acid transporter 1 (ASCT-1) in the anterior cingulate cortex and hippocampus in schizophrenia, bipolar disorder and major depression","volume":"114","author":"Weis","year":"2007","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0480","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1017\/S1092852900020307","article-title":"Extended release quetiapine fumarate monotherapy for major depressive disorder: results of a double-blind, randomized, placebo-controlled study","volume":"14","author":"Weisler","year":"2009","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0485","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1046\/j.1460-9568.2003.02525.x","article-title":"Topography of cocaine-induced gene regulation in the rat striatum: relationship to cortical inputs and role of behavioural context","volume":"17","author":"Willuhn","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0490","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2174\/187152706777950693","article-title":"Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade","volume":"5","author":"Wood","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0495","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0896-6273(00)80588-7","article-title":"Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins","volume":"21","author":"Xiao","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0500","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00213-009-1601-9","article-title":"Effects of quetiapine on monoamine, GABA, and glutamate release in rat prefrontal cortex","volume":"206","author":"Yamamura","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0505","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2003.12.059","article-title":"Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol","volume":"1011","author":"Yanahashi","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0510","doi-asserted-by":"crossref","first-page":"10846","DOI":"10.1523\/JNEUROSCI.2496-04.2004","article-title":"A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons","volume":"24","author":"Yang","year":"2004","journal-title":"J Neurosci"},{"issue":"Suppl 5","key":"10.1016\/j.pnpbp.2010.10.025_bb0515","first-page":"40","article-title":"Atypical antipsychotics in bipolar depression: potential mechanisms of action","volume":"66","author":"Yatham","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0520","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jad.2009.10.017","article-title":"Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia","volume":"124","author":"Yuan","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2010.10.025_bb0525","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0893-133X(00)00119-6","article-title":"Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex","volume":"23","author":"Zhang","year":"2000","journal-title":"Neuropsychopharmacology"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584610004112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584610004112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T15:52:10Z","timestamp":1740671530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584610004112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":106,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0278584610004112"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2010.10.025","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}