{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:01:35Z","timestamp":1788458495061,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["30900483"],"award-info":[{"award-number":["30900483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["61035006"],"award-info":[{"award-number":["61035006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u201c10th Five-year-plan\u201d of National Key Technologies R&D Program of China","award":["2004DA7210A21"],"award-info":[{"award-number":["2004DA7210A21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.pnpbp.2011.02.006","type":"journal-article","created":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T09:23:55Z","timestamp":1298193835000},"page":"1297-1302","source":"Crossref","is-referenced-by-count":114,"title":["Disrupted regional homogeneity in treatment-resistant depression: A resting-state fMRI study"],"prefix":"10.1016","volume":"35","author":[{"given":"Wen-bin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-rong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-lian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2011.02.006_bb0005","series-title":"DSM-IV: Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0010","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/sj.npp.1300725","article-title":"Antidepressant effect on connectivity of the mood-regulating circuit: an fMRI study","volume":"30","author":"Anand","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0015","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tics.2004.02.010","article-title":"Inhibition and the right inferior frontal cortex","volume":"8","author":"Aron","year":"2004","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0020","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0165-1781(93)90046-J","article-title":"Hypercortisolemia and hippocampal changes in depression","volume":"47","author":"Axelson","year":"1993","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-0327(97)00143-2","article-title":"Treatment resistant depression in the elderly: a review of its conceptualisation, management and relationship to organic brain disease","volume":"46","author":"Baldwin","year":"1997","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0030","series-title":"Cognitive Therapy and the Emotional Disorders","author":"Beck","year":"1976"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0035","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo planar MRI","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0040","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0006-3223(94)91213-0","article-title":"Frontal and parietal metabolic disturbances in unipolar depression","volume":"36","author":"Biver","year":"1994","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0045","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.biopsych.2007.03.016","article-title":"Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and (11C) DASB; comparison with bipolar disorder","volume":"62","author":"Cannon","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0050","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/01.wnr.0000224769.92454.5d","article-title":"Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study","volume":"17","author":"Cao","year":"2006","journal-title":"NeuroReport"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0055","first-page":"6469","article-title":"Neural correlates of value, risk, and risk aversion contributing to decision making under risk","volume":"26","author":"Christopoulos","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.biopsycho.2004.03.002","article-title":"Frontal EEG asymmetry as a moderator and mediator of emotion","volume":"67","author":"Coan","year":"2004","journal-title":"Biol Psychol"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1001\/archpsyc.1993.01820130009002","article-title":"Quantitative cerebral anatomy in depression, a controlled magnetic resonance imaging study","volume":"50","author":"Coffey","year":"1993","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0070","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.59.7.597","article-title":"The neural basis of mood congruent emotional processing biases in depression","volume":"59","author":"Elliott","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0075","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0006-3223(02)01670-0","article-title":"Is treatment-resistant depression a unique subtype of depression?","volume":"53","author":"Fagiolini","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0080","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/hbm.20414","article-title":"An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder","volume":"29","author":"Fitzgerald","year":"2008","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0085","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/archpsyc.61.9.877","article-title":"Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study","volume":"61","author":"Fu","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0090","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1176\/ajp.2007.164.4.599","article-title":"Neural responses to happy facial expressions in major depression following antidepressant treatment","volume":"164","author":"Fu","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pscychresns.2007.11.005","article-title":"A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression","volume":"163","author":"Furtado","year":"2008","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopsych.2006.09.020","article-title":"Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus","volume":"62","author":"Greicius","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0105","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br J Soc Clin Psychol"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0110","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0006-3223(94)00174-2","article-title":"Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression","volume":"37","author":"Hickie","year":"1995","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0925-4927(96)02969-1","article-title":"Quantitative regional cerebral flow measured by Tc-99M HMPAO SPECT in mood disorder","volume":"68","author":"Iidaka","year":"1997","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0125","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1523\/JNEUROSCI.17-11-04302.1997","article-title":"The fusiform face area: a module in human extrastriate cortex specialized for face perception","volume":"17","author":"Kanwisher","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0130","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.pnpbp.2007.12.009","article-title":"Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder","volume":"32","author":"Lee","year":"2008","journal-title":"Prog Neuro Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0135","first-page":"167","article-title":"Treatment-resistant depression","volume":"80","author":"Little","year":"2009","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01.wnr.0000195666.22714.35","article-title":"Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study","volume":"17","author":"Liu","year":"2006","journal-title":"NeuroReport"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.pscychresns.2010.03.004","article-title":"Decrease regional homogeneity in insula and cerebellum: a resting-state fMRI study in patients with major depression and subjects at high risk for major depression","volume":"182","author":"Liu","year":"2010","journal-title":"Psychiatry Res Neuroimaging"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0150","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/00005053-199912000-00001","article-title":"Neuropsychiatric effects of insular stroke","volume":"187","author":"Manes","year":"1999","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0155","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1176\/jnp.9.3.471","article-title":"Limbic\u2013cortical dysregulation: a proposed model of depression","volume":"9","author":"Mayberg","year":"1997","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0160","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1052-5149(03)00104-7","article-title":"Positron emission tomography imaging in depression: a neural systems perspective","volume":"13","author":"Mayberg","year":"2003","journal-title":"Neuroimaging Clin N Am"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1017\/S0033291799001567","article-title":"Quantitative MRI of the hippocampus and amygdale in severe depression","volume":"30","author":"Mervaala","year":"2000","journal-title":"Psychol Med"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00001756-200302100-00003","article-title":"Neural response to pleasant stimuli in anhedonia: an fMRI study","volume":"14","author":"Mitterschiffthaler","year":"2003","journal-title":"NeuroReport"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0175","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1097\/01.yic.0000199455.39552.1c","article-title":"Why do we need new and better antidepressants?","volume":"21","author":"Montgomery","year":"2006","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0180","first-page":"39","article-title":"Treatment-resistant depression: definition and treatment approaches","volume":"51","author":"Nierenberg","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0185","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1093\/brain\/124.9.1708","article-title":"Pathological laughter and crying: a link to the cerebellum","volume":"124","author":"Parvizi","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0190","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1017\/S0033291701004305","article-title":"Treatment resistant depression and axis I co-morbidity","volume":"31","author":"Petersen","year":"2001","journal-title":"Psychol Med"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0195","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0006-3223(96)00335-6","article-title":"A quantitative magnetic resonance imaging study of cerebral and cerebellar grey matter volume in primary unipolar major depression: relationship to treatment response and clinical severity","volume":"42","author":"Pillay","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0290","doi-asserted-by":"crossref","unstructured":"Radua J, Phillips ML, Russell T, Lawrence N, Marshall N, Kalidindi S, El-Hage W, McDonald C, Giampietro V, Brammer MJ, David AS, Surguladze SA. Neural response to specific components of fearful faces in healthy and schizophrenic adults. NeuroImage 2010;49:939\u201346.","DOI":"10.1016\/j.neuroimage.2009.08.030"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0200","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1176\/ajp.154.7.918","article-title":"Neuroanatomical correlates of externally and internally generated human emotion","volume":"154","author":"Reiman","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0205","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/brain\/121.4.561","article-title":"The cerebellar cognitive affective syndrome","volume":"121","author":"Schmahmann","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0210","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1192\/bjp.172.6.527","article-title":"Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression, controlled magnetic resonance imaging study","volume":"172","author":"Shah","year":"1998","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0215","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1192\/bjp.180.5.434","article-title":"Chronic, treatment-resistant depression and right fronto-striatal atrophy","volume":"180","author":"Shah","year":"2002","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0220","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0006-3223(03)00347-0","article-title":"Neuroimaging studies of mood disorder effects on the brain","volume":"54","author":"Sheline","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0225","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1017\/S003329179800693X","article-title":"Is subcortical disease associated with a poor response to antidepressants? Neurological, neuropsychological and neuroradiological findings in late-life depression","volume":"28","author":"Simpson","year":"1998","journal-title":"Psychol Med"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0230","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0022-3956(97)00016-2","article-title":"The functional neuroanatomy of mood disorders","volume":"31","author":"Soares","year":"1997","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0235","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00124509-200103000-00009","article-title":"Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression","volume":"17","author":"Steffens","year":"2001","journal-title":"J ECT"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0240","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.biopsych.2004.10.028","article-title":"A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder","volume":"57","author":"Surguladze","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0245","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neulet.2006.02.022","article-title":"Altered resting-state functional connectivity patterns of anterior cingulated cortex in adolescents with attention deficit hyperactivity disorder","volume":"400","author":"Tian","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0250","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1586\/ern.09.137","article-title":"Therapy-resistant depression","volume":"10","author":"Tom","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0255","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/nimg.1997.0313","article-title":"Functional clustering: identifying strongly interactive brain regions in neuroimaging data","volume":"7","author":"Tononi","year":"1998","journal-title":"Neuroimage"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0260","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jad.2006.11.017","article-title":"Increased left prefrontal activation in patients with unipolar depression: an event-related, parametric performance controlled fMRI study","volume":"101","author":"Walter","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0265","series-title":"Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI","author":"Wu","year":"2010"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0270","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jad.2008.10.013","article-title":"Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study","volume":"115","author":"Yao","year":"2009","journal-title":"J Affect Disorders"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0275","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jad.2008.02.016","article-title":"Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study","volume":"111","author":"Yuan","year":"2008","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0280","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","article-title":"Regional homogeneity approach to fMRI data analysis","volume":"22","author":"Zang","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.pnpbp.2011.02.006_bb0285","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neulet.2007.02.081","article-title":"Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI","volume":"417","author":"Zhou","year":"2007","journal-title":"Neurosci Lett"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611000601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611000601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T17:42:47Z","timestamp":1560015767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584611000601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0278584611000601"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2011.02.006","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}