{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:39:11Z","timestamp":1790894351567,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.pnpbp.2011.03.002","type":"journal-article","created":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T10:26:01Z","timestamp":1299666361000},"page":"1068-1073","source":"Crossref","is-referenced-by-count":29,"title":["Critical period exists in the effects of isolation rearing on sensorimotor gating function but not locomotor activity in rat"],"prefix":"10.1016","volume":"35","author":[{"given":"Yia-Ping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Se","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2011.03.002_bb0005","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0006-3223(00)00968-9","article-title":"Delayed onset of enhanced MK-801-induced motor hyperactivity after neonatal lesions of the rat ventral hippocampus","volume":"49","author":"Al-Amin","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0010","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0031-9384(99)00082-7","article-title":"Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats","volume":"67","author":"Bakshi","year":"1999","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0015","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuroscience.2003.10.018","article-title":"Effects of early environment on field CA2 pyramidal neurons in the guinea-pig","volume":"123","author":"Bartesaghi","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0020","series-title":"Behavioral development","first-page":"296","article-title":"A critical reanalysis of the ontogeny and phylogeny of mammalian social and locomotor play: an ethological hornet's nest","author":"Bekoff","year":"1981"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/sj.npp.1300547","article-title":"Activation of D1, but not D2 receptors potentiates dizocilpine-mediated disruption of prepulse inhibition of the startle","volume":"30","author":"Bortolato","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0030","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1469-8986.1978.tb01390.x","article-title":"Prestimulus effects on human startle reflex in normals and schizophrenics","volume":"15","author":"Braff","year":"1978","journal-title":"Psychophysiology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s002130100786","article-title":"Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats","volume":"156","author":"Cilia","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0045","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00702-009-0243-8","article-title":"Neurotransmitters and prefrontal cortex\u2013limbic system interactions: implications for plasticity and psychiatric disorders","volume":"116","author":"Del Arco","year":"2009","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0050","doi-asserted-by":"crossref","first-page":"60803","DOI":"10.1155\/2007\/60803","article-title":"The temporal dynamics model of emotional memory processing: a synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories, and the Yerkes-Dodson law","volume":"2007","author":"Diamond","year":"2007","journal-title":"Neural Plast"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0055","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0091-3057(97)00534-0","article-title":"The disruption of prepulse inhibition by social isolation in the Wistar rat: how robust is the effect?","volume":"59","author":"Domeney","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0060","series-title":"Childhood and society","author":"Erikson","year":"1950"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0065","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0163-1047(90)90407-W","article-title":"The effects of pre- and postweaning rearing conditions on latent inhibition and partial reinforcement extinction effect in male rats","volume":"53","author":"Feldon","year":"1990","journal-title":"Behav Neural Biol"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0070","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0166-4328(82)90163-2","article-title":"Different reaction patterns in individually and socially reared rats during exposures to novel environments","volume":"4","author":"Gentsch","year":"1982","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0075","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0361-9230(90)90241-Q","article-title":"Startle response models of sensorimotor gating and habituation deficits in schizophrenia","volume":"25","author":"Geyer","year":"1990","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0006-3223(93)90180-L","article-title":"Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia","volume":"34","author":"Geyer","year":"1993","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s002130100811","article-title":"Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review","volume":"156","author":"Geyer","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0090","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1469-8986.1975.tb01284.x","article-title":"The more or less startling effects of weak prestimulation","volume":"12","author":"Graham","year":"1975","journal-title":"Psychophysiology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0095","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1615\/CritRevNeurobiol.v12.i1-2.50","article-title":"Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences","volume":"12","author":"Hall","year":"1998","journal-title":"Crit Rev Neurobiol"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0100","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0091-3057(02)00796-7","article-title":"The effects of isolation rearing on glutamate receptor NMDAR1A mRNA expression determined by in situ hybridization in Fawn hooded and Wistar rats","volume":"73","author":"Hall","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0105","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.pnpbp.2007.12.015","article-title":"Effects of repeated dizocilpine treatment on adult rat behavior after neonatal lesions of the entorhinal cortex","volume":"32","author":"Harich","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/neur.1995.0001","article-title":"On the neuropathology of schizophrenia and its dementia: neurodevelopmental, neurodegenerative, or both?","volume":"4","author":"Harrison","year":"1995","journal-title":"Neurodegeneration"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0091-3057(92)90635-S","article-title":"Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry","volume":"43","author":"Jones","year":"1992","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0120","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbr.2009.03.028","article-title":"Behavioral abnormality and pharmacologic response in social isolation-reared mice","volume":"202","author":"Koike","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0125","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0896-6273(00)00111-2","article-title":"Catching up on schizophrenia: natural history and neurobiology","volume":"28","author":"Lewis","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0130","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0006-8993(90)91089-Y","article-title":"Long-term effects of early social isolation in Macaca mulatta: changes in dopamine receptor function following apomorphine challenge","volume":"513","author":"Lewis","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1037\/0735-7044.122.1.107","article-title":"Auditory fear conditioning modulates prepulse inhibition in socially reared rats and isolation-reared rats","volume":"122","author":"Li","year":"2008","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0140","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.neubiorev.2009.02.001","article-title":"Top\u2013down modulation of prepulse inhibition of the startle reflex in humans and rats","volume":"33","author":"Li","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0145","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.yhbeh.2008.10.014","article-title":"Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses","volume":"55","author":"Lukkes","year":"2009","journal-title":"Horm Behav"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0150","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/hipo.20367","article-title":"A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats","volume":"18","author":"Manahan-Vaughan","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2010.05.067","article-title":"Peri-adolescence isolation rearing alters social behavior and nociception in rats","volume":"480","author":"Meng","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0160","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuint.2007.06.019","article-title":"Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment","volume":"51","author":"Mouri","year":"2007","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0165","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.biopsych.2007.10.006","article-title":"N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortex","volume":"63","author":"Pinault","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0170","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/dev.420220206","article-title":"Aggressive behaviors in adult rats deprived of playfighting experience as juveniles","volume":"22","author":"Potegal","year":"1989","journal-title":"Dev Psychobiol"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0031-9384(86)90129-0","article-title":"The effects of long-term isolation on physiology and behavior in male guinea pigs","volume":"38","author":"Sachser","year":"1986","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0185","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s002130100776","article-title":"Sensitization of prepulse inhibition deficits by repeated administration of dizocilpine","volume":"156","author":"Schulz","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0190","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.138.3544.949","article-title":"Critical periods in behavioral development","volume":"138","author":"Scott","year":"1962","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0195","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0200","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1016\/S0024-3205(02)01509-6","article-title":"Effects of isolation-rearing on intracranial self-stimulation reward of the lateral hypothalamus: baseline assessment and drug challenges","volume":"70","author":"Sundstrom","year":"2002","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0205","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s002130100799","article-title":"Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges","volume":"156","author":"Swerdlow","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0210","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00213-009-1527-2","article-title":"Long-term effects of neonatal MK-801 treatment on prepulse inhibition in young adult rats","volume":"206","author":"Uehara","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0215","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1046\/j.1440-1681.2003.03823.x","article-title":"Deficient prepulse inhibition of acoustic startle in Hooded\u2013Wistar rats compared with Sprague\u2013Dawley rats","volume":"30","author":"van den Buuse","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0220","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0166-4328(98)00129-6","article-title":"Is there a critical developmental \u2018window\u2019 for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response?","volume":"100","author":"Varty","year":"1999","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0225","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0140-6736(95)91386-6","article-title":"From neuropathology to neurodevelopment","volume":"346","author":"Weinberger","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/npp.1994.8","article-title":"Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition","volume":"10","author":"Wilkinson","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.03.002_bb0235","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.pnpbp.2009.06.016","article-title":"Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats","volume":"33","author":"Zhao","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611000820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611000820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T22:25:14Z","timestamp":1543875914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584611000820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0278584611000820"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2011.03.002","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}