{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:53:30Z","timestamp":1772351610205,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Health and Labor Science Research Grant","award":["H21-KOKORO-WAKATE-20"],"award-info":[{"award-number":["H21-KOKORO-WAKATE-20"]}]},{"name":"Health and Labor Science Research Grant","award":["H21-KOKORO-001"],"award-info":[{"award-number":["H21-KOKORO-001"]}]},{"name":"CREST of JST"},{"name":"Grant-in-Aid for Scientific Research","award":["22591269"],"award-info":[{"award-number":["22591269"]}]},{"name":"Intramural Research Grant for Neurological and Psychiatric Disorders of\u3000NCNP"},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mitsubishi Pharma Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.pnpbp.2011.05.004","type":"journal-article","created":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T12:31:19Z","timestamp":1305894679000},"page":"1738-1743","source":"Crossref","is-referenced-by-count":17,"title":["Expression of Ca2+-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients"],"prefix":"10.1016","volume":"35","author":[{"given":"Kotaro","family":"Hattori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Teraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunimasa","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kunugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2011.05.004_bb0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.mp.4001637","article-title":"BDNF in schizophrenia, depression and corresponding animal models","volume":"10","author":"Angelucci","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nn.2447","article-title":"Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes","volume":"13","author":"Belforte","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra073096","article-title":"Major depressive disorder","volume":"358","author":"Belmaker","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0020","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.bcp.2005.02.015","article-title":"Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)","volume":"69","author":"Binda","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0025","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1074\/jbc.M805328200","article-title":"Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake","volume":"284","author":"Brunk","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0074-7742(06)78011-4","article-title":"Involvement of neuropeptide systems in schizophrenia: human studies","volume":"78","author":"Caceda","year":"2007","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0035","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ajmg.b.30151","article-title":"Serotonin receptor 2C (HTR2C) and schizophrenia: examination of possible medication and genetic influences on expression levels","volume":"134B","author":"Castensson","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0040","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-3223(01)01083-6","article-title":"Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication","volume":"50","author":"Chen","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0045","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0050","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jpsychires.2009.03.008","article-title":"Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains","volume":"43","author":"Dunham","year":"2009","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0920-9964(00)00084-0","article-title":"Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses","volume":"52","author":"Durany","year":"2001","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0060","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1172\/JCI38620","article-title":"Comment on \u201cAutistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients\u201d","volume":"119","author":"Eran","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0065","doi-asserted-by":"crossref","unstructured":"Girgenti, M. J., Nisenbaum, L. K., Bymaster, F., Terwilliger, R., Duman, R. S., Newton, S. S., Antipsychotic-induced gene regulation in multiple brain regions. J Neurochem 113, 175\u2013187.","DOI":"10.1111\/j.1471-4159.2010.06585.x"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0070","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1523\/JNEUROSCI.4035-04.2005","article-title":"Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia","volume":"25","author":"Hashimoto","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/archgenpsychiatry.2008.514","article-title":"Elevated striatal dopamine function linked to prodromal signs of schizophrenia","volume":"66","author":"Howes","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0080","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0278-5846(03)00112-X","article-title":"Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains","volume":"27","author":"Iritani","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0085","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0090","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1523\/JNEUROSCI.5672-07.2008","article-title":"CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles","volume":"28","author":"Liu","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0095","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/schbul\/sbp010","article-title":"Presynaptic regulation of dopamine transmission in schizophrenia","volume":"37","author":"Lyon","year":"2011","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0100","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nn1971","article-title":"New insights into BDNF function in depression and anxiety","volume":"10","author":"Martinowich","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0105","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00702-005-0425-y","article-title":"Microarray analysis reveals distinct gene expression patterns in the mouse cortex following chronic neuroleptic and stimulant treatment: implications for body weight changes","volume":"113","author":"Mehler-Wex","year":"2006","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0110","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2009.06.009","article-title":"In vivo imaging of synaptic function in the central nervous system: II. Mental and affective disorders","volume":"204","author":"Nikolaus","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0115","series-title":"M.I.N.I. Mini international neuropsychiatric interview","year":"2005"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0120","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/cne.20947","article-title":"Differential distributions of the Ca2+-dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain","volume":"495","author":"Sadakata","year":"2006","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0125","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.2528-03.2004","article-title":"The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival","volume":"24","author":"Sadakata","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0130","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1523\/JNEUROSCI.2279-06.2007","article-title":"Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release","volume":"27","author":"Sadakata","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0135","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1172\/JCI29031","article-title":"Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients","volume":"117","author":"Sadakata","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0140","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00441-006-0268-3","article-title":"Neuropeptides as synaptic transmitters","volume":"326","author":"Salio","year":"2006","journal-title":"Cell Tissue Res"},{"issue":"Suppl. 20","key":"10.1016\/j.pnpbp.2011.05.004_bb0145","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0150","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0091-3057(96)00169-4","article-title":"Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)","volume":"56","author":"Siuciak","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0155","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.mp.4000718","article-title":"Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients","volume":"5","author":"Takahashi","year":"2000","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0160","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/MN:34:2:109","article-title":"Molecular profiling of antipsychotic drug function: convergent mechanisms in the pathology and treatment of psychiatric disorders","volume":"34","author":"Thomas","year":"2006","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0165","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0920-9964(99)00192-9","article-title":"The stanley foundation brain collection and neuropathology consortium","volume":"44","author":"Torrey","year":"2000","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2011.05.004_bb0170","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/sj.mp.4001308","article-title":"Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia","volume":"8","author":"Weickert","year":"2003","journal-title":"Mol Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611001564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611001564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T14:57:22Z","timestamp":1543762642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584611001564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0278584611001564"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2011.05.004","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}