{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:56:18Z","timestamp":1758970578033},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["52932"],"award-info":[{"award-number":["52932"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.pnpbp.2011.08.020","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T09:30:49Z","timestamp":1314955849000},"page":"78-84","source":"Crossref","is-referenced-by-count":5,"title":["Intra-lateral septal infusions of folic acid alone or combined with various antidepressant drugs produce antidepressant-like actions in male Wistar rats forced to swim"],"prefix":"10.1016","volume":"36","author":[{"given":"Miguel","family":"Molina-Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Patricia","family":"T\u00e9llez-Alc\u00e1ntara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge I.","family":"Olivera-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Teresa","family":"Jaramillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2011.08.020_bb0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jpsychores.2006.07.007","article-title":"Folic acid and the treatment of depression","volume":"61","author":"Abou-Saleh","year":"2006","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/10401230209147396","article-title":"Folinic acid (Leucovorin) as an adjunctive treatment for SSRI-refractory depression","volume":"14","author":"Alpert","year":"2002","journal-title":"Ann Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00176837","article-title":"Is the forced swimming test a suitable model for revealing antidepressant activity?","volume":"94","author":"Borsini","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0020","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuropharm.2007.10.016","article-title":"Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems","volume":"54","author":"Brocardo","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0025","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2008.08.033","article-title":"Antidepressant-like effect of folic acid: Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway","volume":"598","author":"Brocardo","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0030","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-2999(00)00491-X","article-title":"Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin","volume":"402","author":"Brotto","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0035","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1101\/lm.531407","article-title":"Dissociated roles for the lateral and medial septum in elemental and contextual fear conditioning","volume":"14","author":"Calandreau","year":"2007","journal-title":"Learn Mem"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-2999(88)90252-X","article-title":"8-Hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin-1A receptor agonist, reduces the immobility of rats in the forced swimming test by acting on the nucleus raphe dorsalis","volume":"158","author":"Cervo","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0045","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/01443610802196658","article-title":"Prenatal multivitamins containing folic acid do not decrease prevalence of depression among pregnant women","volume":"28","author":"Cho","year":"2008","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0050","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0031-9384(90)90298-I","article-title":"Chronic clomipramine increase firing rate in lateral septum nuclei of the rat","volume":"48","author":"Contreras","year":"1990","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0055","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000118959","article-title":"Clomipramine enhances the excitatory actions of dorsal raphe nucleus stimulation in lateral septal neurons in the rat","volume":"27","author":"Contreras","year":"1993","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0031-9384(99)00169-9","article-title":"Lateral septal neuronal firing rate increases during proestrus\u2013estrus in the rat","volume":"68","author":"Contreras","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pnpbp.2003.10.013","article-title":"Spontaneous firing rate of lateral septal neurons decreases after forced swimming test in Wistar rat","volume":"28","author":"Contreras","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0165-0327(00)00153-1","article-title":"Enhancement of the antidepressant action of fluoxetine by folic acid: a randomized, placebo controlled study","volume":"60","author":"Coppen","year":"2000","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","article-title":"Exploratory behavior models of anxiety in mice","volume":"9","author":"Crawley","year":"1985","journal-title":"Neurosci Biobehav"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0080","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.pnpbp.2008.09.006","article-title":"Interaction of zinc with antidepressants in the tail suspension test","volume":"32","author":"Cunha","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0085","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00075197-200411000-00011","article-title":"Folate and brain function in the elderly","volume":"7","author":"D'Anci","year":"2004","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0165-0327(95)00034-K","article-title":"Therapeutic efficacy of antidepressants in agitated anxious depression \u2014 a metaanalysis of moclobemide studies","volume":"35","author":"Delini-Stula","year":"1995","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0166-4328(96)00067-8","article-title":"Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth","volume":"73","author":"Detke","year":"1996","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0306-4522(93)90467-T","article-title":"Serotoninergic innervation of the mature and developing lateral septum of the rat: a light and electron microscopic immunocytochemical analysis","volume":"55","author":"Dinopoulos","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2005.08.012","article-title":"To combine or not to combine? A literature review of antidepressant combination therapy","volume":"89","author":"Dodd","year":"2005","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0115","first-page":"4","article-title":"Augmenting antidepressants with folate: a clinical perspective","volume":"10","author":"Fava","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0120","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/cne.902250207","article-title":"Distribution of enkephalin, substance P, tyrosine hydroxylase and 5-hydroxytryptamine immunoreactivity in the septal region of the rat","volume":"225","author":"Gall","year":"1984","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-2999(03)01789-8","article-title":"Antidepressant-like effect of Ro5-4864, a peripheral-type benzodiazepine receptor ligand, in forced swimming test","volume":"471","author":"Gavioli","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0130","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/jech.2006.050385","article-title":"Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity","volume":"61","author":"Gilbody","year":"2007","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(96)00146-5","article-title":"Modulation of cognitive processes by trans-synaptic activation of the basal forebrain","volume":"84","author":"Givens","year":"1997","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0140","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.physbeh.2007.02.006","article-title":"Urine from stressed rats increases immobility in receptor rats forced to swim: Role of 2-heptanone","volume":"91","author":"Guti\u00e9rrez","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0014-2999(98)00838-3","article-title":"Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression","volume":"364","author":"Harkin","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00406-010-0124-z","article-title":"Patients' attitudes toward side effects of antidepressants: an Internet survey","volume":"261","author":"Kikuchi","year":"2011","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0149-7634(01)00002-1","article-title":"Corticosteroids in relation to fear, anxiety and psychopathology","volume":"25","author":"Korte","year":"2001","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0160","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0893-133X(99)00100-1","article-title":"Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test","volume":"22","author":"L\u00f3pez-Rubalcava","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0165","first-page":"15","article-title":"Septal neurons related with hippocampus increase their firing rate after long-term clomipramine","volume":"40","author":"Marv\u00e1n","year":"1992","journal-title":"Bol Estud M\u00e9d Biol M\u00e9x"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0170","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0278-5846(99)00057-3","article-title":"Stimulation of 5-HT1A receptors by systemic or medial septum injection induces anxiogenic-like effects and facilitates acquisition of a spatial discrimination task in mice","volume":"23","author":"Micheau","year":"1999","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0175","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0091-3057(01)00459-2","article-title":"Estrus variation in anticonflict effects of midazolam microinjected into septal nuclei in female Wistar rats","volume":"68","author":"Molina","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0180","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0278-5846(96)00137-6","article-title":"Raphe-septal neurons changes in sensitivity to desipramine following an early septal lesion in the rat","volume":"20","author":"Molina","year":"1996","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0185","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.pnpbp.2004.08.006","article-title":"Synergistic interaction between ketoconazole and several antidepressant drugs with allopregnanolone treatments in ovariectomized Wistar rats forced to swim","volume":"28","author":"Molina","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0190","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.pnpbp.2006.04.022","article-title":"Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats","volume":"30","author":"Molina","year":"2006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0195","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pnpbp.2007.09.004","article-title":"Antidepressant-like actions of minocycline combined with several glutamate antagonists","volume":"32","author":"Molina","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0200","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.peptides.2010.03.012","article-title":"Antidepressant-like or anxiolytic-like actions of topiramate alone or co-administered with intra-lateral septal infusions of neuropeptide Y in male Wistar rats","volume":"31","author":"Molina","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0205","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pnpbp.2010.08.022","article-title":"The folic acid combined with 17-\u03b2 estradiol produces antidepressant-like actions in ovariectomized rats forced to swim","volume":"35","author":"Molina","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0210","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.pbb.2009.06.015","article-title":"Olanzapine plus 17-\u03b2 estradiol produce antidepressant-like actions in rats forced to swim","volume":"93","author":"Molina","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0215","series-title":"Guide for the care and use of laboratory animals Washington","author":"National Institutes of Health","year":"1996"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145705005195","article-title":"The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine","volume":"8","author":"Papakostas","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0225","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/hup.614","article-title":"Folic acid: neurochemistry, metabolism and relationship to depression","volume":"19","author":"Paul","year":"2004","journal-title":"Hum Psychopharmacol Clin Exp"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0230","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1982"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0235","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(85)90856-X","article-title":"Quantitative autoradiographic mapping of serotonin receptors in rat brain. I. Serotonin-1 receptors","volume":"346","author":"Pazos","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0240","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0245","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000151527","article-title":"Effect of folic acid combined with fluoxetine in patients with major depression on plasma homcysteine and vitamin B12 and serotonin levels in lymphocytes","volume":"15","author":"Resler","year":"2008","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0250","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1192\/S0007125000193250","article-title":"Folate deficiency in depressive illness","volume":"117","author":"Reynolds","year":"1970","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0255","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-0173(97)00009-X","article-title":"Connections of the rat lateral septal complex","volume":"24","author":"Risold","year":"1997","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0260","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1017\/S1092852900015418","article-title":"Novel therapeutics for depression: l-methylfolate as a trimonoamine modulator and antidepressant-augmenting agent","volume":"12","author":"Stahl","year":"2007","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0265","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/cne.901860408","article-title":"The connections of the septal region in the rat","volume":"186","author":"Swanson","year":"1979","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0270","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0166-4328(02)00346-7","article-title":"Improvement of shuttle-box performance by anterodorsal medial septal lesions in rats","volume":"141","author":"Torras-Garcia","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0275","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0091-3057(88)90413-3","article-title":"Thigmotaxis as a test for anxiolytic activity in rats","volume":"31","author":"Treit","year":"1988","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2011.08.020_bb0280","first-page":"114","article-title":"S\u00edntesis de serotonina y presencia de hidroxilasa de tript\u00f3fano en linfocitos de pacientes con depresi\u00f3n mayor tratados con fluoxetina y \u00e1cido f\u00f3lico","volume":"27","author":"Urbina","year":"2008","journal-title":"Arch Venez Farmacol Ter"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611002673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584611002673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T17:32:35Z","timestamp":1560533555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584611002673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0278584611002673"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2011.08.020","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}