{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:54:04Z","timestamp":1791161644317,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":304,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico (CNPq)"},{"name":"Financiadora de Estudos e Projetos (FINEP)"},{"name":"Programa de Apoio aos N\u00facleos de Excel\u00eancia (PRONEX)"},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 pesquisa do Estado do Rio Grande do Sul (FAPERGS)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.pnpbp.2012.04.007","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T08:16:47Z","timestamp":1334650607000},"page":"31-39","source":"Crossref","is-referenced-by-count":25,"title":["Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice"],"prefix":"10.1016","volume":"39","author":[{"given":"Jardel Gomes","family":"Villarinho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselei","family":"Fachinetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francielle de Vargas","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela da Silva","family":"Sant'Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Andr\u00e9ia","family":"Dombrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio da","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela de Almeida","family":"Cabrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Ant\u00f4nio Pinto","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio Gauze","family":"Bonacorso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo","family":"Zanatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel Antonello","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2012.04.007_bb0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0003-3472(73)80065-X","article-title":"Tests for emotionality in rats and mice: a review","volume":"21","author":"Archer","year":"1973","journal-title":"Anim Behav"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0010","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1073\/pnas.85.13.4934","article-title":"cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties","volume":"85","author":"Bach","year":"1988","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0015","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/sj.npp.1300677","article-title":"Antidepressant-like effect of D(2\/3) receptor-, but not D(4) receptor-activation in the rat forced swim test","volume":"30","author":"Basso","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-3223(02)01643-8","article-title":"Is there a role for 5-HT1A agonists in the treatment of depression?","volume":"53","author":"Blier","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0030","first-page":"391","article-title":"Pharmacological profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A","volume":"248","author":"Burkard","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0290","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","article-title":"Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0040","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0045","first-page":"400","article-title":"Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A","volume":"248","author":"Da Prada","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0050","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1472-8206.2004.00287.x","article-title":"Dopamine, depression and antidepressants","volume":"18","author":"Dailly","year":"2004","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2007.05.004","article-title":"Involvement of dopamine (DA)\/serotonin (5-HT)\/sigma (sigma) receptor modulation in mediating the antidepressant action of ropinirole hydrochloride, a D2\/D3 dopamine receptor agonist","volume":"74","author":"Dhir","year":"2007","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0060","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.pnpbp.2007.08.042","article-title":"Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a, d] cycloheptane in mice evaluated in the tail suspension test","volume":"32","author":"Duarte","year":"2008","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0295","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","article-title":"A note on a simple apparatus for detecting neurological deficit in rats and mice","volume":"46","author":"Dunham","year":"1957","journal-title":"J Am Pharm Assoc"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/archpsyc.64.3.327","article-title":"The role of dopamine in the pathophysiology of depression","volume":"64","author":"Dunlop","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0075","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pnpbp.2003.11.018","article-title":"Central monoamines and their role in major depression","volume":"28","author":"Elhwuegi","year":"2004","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0080","first-page":"659","article-title":"A double-blind comparison of gepirone extended release, imipramine, and placebo in the treatment of outpatient major depression","volume":"32","author":"Feiger","year":"1996","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0085","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4088\/JCP.v64n0304","article-title":"Gepirone extended-release: new evidence for efficacy in the treatment of major depressive disorder","volume":"64","author":"Feiger","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0090","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0091-3057(02)00750-5","article-title":"Aminoacid and monoamine alterations in the cerebral cortex and hippocampus of mice submitted to ricinine-induced seizures","volume":"72","author":"Ferraz","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2004.05.045","article-title":"Alpha 2-adrenoceptors and 5-HT receptors mediate the antinociceptive effect of new pyrazolines, but not of dipyrone","volume":"496","author":"Godoy","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0149-7634(98)00024-4","article-title":"The elevated T-maze as an experimental model of anxiety","volume":"23","author":"Graeff","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0105","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s002130050282","article-title":"Behavioural profiles of the reversible monoamine-oxidase-A inhibitors befloxatone and moclobemide in an experimental model for screening anxiolytic and anti-panic drugs","volume":"131","author":"Griebel","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0110","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0028-3908(98)00077-X","article-title":"Behavioral effects of phenelzine in an experimental model for screening anxiolytic and anti-panic drugs: correlation with changes in monoamine-oxidase activity and monoamine levels","volume":"37","author":"Griebel","year":"1998","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0115","doi-asserted-by":"crossref","first-page":"10150","DOI":"10.1523\/JNEUROSCI.18-23-10150.1998","article-title":"Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors","volume":"18","author":"Haddjeri","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0120","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0165-1781(96)02879-X","article-title":"Plasma dopamine and norepinephrine correlations with psychomotor retardation, anxiety, and depression in non-psychotic depressed patients: a pilot study","volume":"64","author":"Hamner","year":"1996","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0125","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1021\/jm950595m","article-title":"Selective inhibitors of monoamine oxidase. 3. Structure\u2013activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups","volume":"39","author":"Harfenist","year":"1996","journal-title":"J Med Chem"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0091-3057(99)00191-4","article-title":"Anxiolytic-like effects of antidepressants after acute administration in a four-plate test in mice","volume":"65","author":"Hasco\u00ebt","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0135","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-2999(02)02874-1","article-title":"Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine","volume":"459","author":"Holmes","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0140","doi-asserted-by":"crossref","first-page":"77S","DOI":"10.1097\/00004714-199006001-00014","article-title":"Gepirone in the treatment of major depression","volume":"10","author":"Jenkins","year":"1990","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0145","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/0006-2952(68)90066-X","article-title":"Some observations upon a new inhibitor of monoamine oxidase in brain tissue","volume":"17","author":"Johnston","year":"1968","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.neuroscience.2004.09.026","article-title":"Inhibition of methamphetamine-induced hyperlocomotion in mice by clorgyline, a monoamine oxidase-A inhibitor, through alteration of the 5-hydroxytriptamine turnover in the striatum","volume":"130","author":"Kitanaka","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0155","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s11064-006-9087-x","article-title":"Modification of morphine-induced hyperlocomotion and antinociception in mice by clorgyline, a monoamine oxidase-A inhibitor","volume":"31","author":"Kitanaka","year":"2006","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0160","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00213-009-1684-3","article-title":"Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine","volume":"207","author":"Liu","year":"2010","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0170","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/jcp.0b013e3181bb617","article-title":"Half a century of antidepressnat drugs \u2013 on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part I: Monoamine oxidase inhibitors","volume":"27","author":"L\u00f3pez-Mu\u00f1oz","year":"2007","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0175","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pnpbp.2006.11.004","article-title":"Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: evidence for the involvement of the monoaminergic system","volume":"31","author":"Machado","year":"2007","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0180","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0009-9120(85)80094-1","article-title":"A sensitive fluorometric assay for serum monoamine oxidase with kynuramine as substrate","volume":"18","author":"Matsumoto","year":"1985","journal-title":"Clin Biochem"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0185","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00004714-199410000-00011","article-title":"Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement","volume":"14","author":"McGrath","year":"1994","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0190","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/archpsyc.63.11.1209","article-title":"Elevated monoamine oxidase A levels in the brain","volume":"63","author":"Meyer","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0195","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ejphar.2004.07.038","article-title":"The role of monoamines in the actions of established and \u201cnovel\u201d antidepressant agents: a critical review","volume":"500","author":"Millan","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0200","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0091-3057(95)02019-5","article-title":"Effects of moclobemide on forced-swimming stress and brain monoamine levels in mice","volume":"53","author":"Miura","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0205","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pbb.2007.11.001","article-title":"Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice","volume":"89","author":"Naderi","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0210","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.mppsy.2007.04.005","article-title":"Antidepressants","volume":"6","author":"Nash","year":"2007","journal-title":"Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0215","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.euroneuro.2005.12.002","article-title":"Dopaminergic-based pharmacotherapies for depression","volume":"16","author":"Papakostas","year":"2006","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S1461145798001096","article-title":"The effect of nifedipine, Ca2+ antagonist, on activity of MAO inhibitors, N-acetylserotonin and melatonin in the mouse tail suspension test","volume":"1","author":"Prakhie","year":"1998","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0225","first-page":"124","article-title":"Monoamine oxidase inhibitors: a new generation","volume":"36","author":"Robinson","year":"2002","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0230","doi-asserted-by":"crossref","first-page":"67S","DOI":"10.1097\/00004714-199006001-00013","article-title":"Clinical effects of the 5-HT1A partial agonists in depression: a composite analysis of buspirone in the treatment of depression","volume":"10","author":"Robinson","year":"1990","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0235","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pbb.2005.08.003","article-title":"Antidepressant-like and antinociceptive-like actions of 4-(4\u2032-chlorophenyl)-6-(4?-methylphenyl)-2-hydrazinepyrimidine Mannich base in mice","volume":"82","author":"Rodrigues","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0240","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/archpsyc.1985.01790350055010","article-title":"Plasma norepinephrine level in affective disorders. Relationship to melancholia","volume":"42","author":"Roy","year":"1985","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0245","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bmcl.2008.03.001","article-title":"Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors","volume":"19","author":"Sant'Anna","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0250","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1016\/j.lfs.2003.06.007","article-title":"\u201cBroad spectrum\u201d antidepressants: is more better for the treatment of depression?","volume":"73","author":"Skolnick","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0255","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0260","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0278-5846(87)90002-9","article-title":"The automated Tail Suspension Test: a computerized device which differentiates psychotropic drugs","volume":"11","author":"Steru","year":"1987","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0265","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0893-133X(94)00058-8","article-title":"MAOIs in the contemporary treatment of depression","volume":"12","author":"Thase","year":"1995","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0270","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pnpbp.2011.11.005","article-title":"The potential antidepressant-like effect of imidazoline I(2) ligand 2-BFI in mice","volume":"37","author":"Tonello","year":"2012","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0275","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nrd1303","article-title":"From monoamines to genomic targets: a paradigm shift for drug discovery in depression","volume":"3","author":"Wong","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0280","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrn1883","article-title":"The therapeutic potential of monoamine oxidase inhibitors","volume":"7","author":"Youdim","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pnpbp.2012.04.007_bb0285","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.brainres.2004.07.041","article-title":"Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test","volume":"1023","author":"Zomkowski","year":"2004","journal-title":"Brain Res"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612000796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612000796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T11:24:28Z","timestamp":1561634668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584612000796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0278584612000796"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2012.04.007","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}