{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:57:00Z","timestamp":1791644220027,"version":"4.3.4"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":355,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009945","name":"FUNAPE\/UFG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009945","id-type":"DOI","asserted-by":"crossref"}]},{"name":", PRPPG\/UFG"},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"PIBIC\/CNPq"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.pnpbp.2012.04.012","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T17:12:14Z","timestamp":1335028334000},"page":"276-284","source":"Crossref","is-referenced-by-count":112,"title":["The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, \u03b2-caryophyllene, in male mice"],"prefix":"10.1016","volume":"38","author":[{"given":"Pablinny Moreira","family":"Galdino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vin\u00edcius Mariano","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iziara Ferreira","family":"Florentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Campos","family":"Lino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Oluwagbamigbe","family":"Fajemiroye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Abdallah","family":"Chaibub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Realino","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thereza Christina Monteiro","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elson Alves","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2012.04.012_bb0360","first-page":"93","article-title":"Estudo multic\u00eantrico de morbidade psiqui\u00e1trica em \u00e1reas urbanas brasileiras (Bras\u00edlia, S\u00e3o Paulo, Porto Alegre)","volume":"14","author":"Almeida Filho","year":"1992","journal-title":"Revista ABP\u2212APAL"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0010","series-title":"Cerrado: Esp\u00e9cies Vegetais \u00fateis","author":"Almeida","year":"1998"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0091-3057(97)00457-7","article-title":"Effects of propranolol, buspirone, pCPA, reserpine, and chlordiazepoxide on open-field behavior","volume":"59","author":"Angrini","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0003-3472(73)80065-X","article-title":"Tests for emotionality in rats and mice: a review","volume":"21","author":"Archer","year":"1973","journal-title":"Anim Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0025","doi-asserted-by":"crossref","first-page":"11700","DOI":"10.1523\/JNEUROSCI.1636-07.2007","article-title":"Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex","volume":"27","author":"Bambico","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(01)00291-1","article-title":"Measuring normal and pathological anxiety-like behavior in mice: a review","volume":"125","author":"Belzung","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0035","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neubiorev.2005.04.017","article-title":"Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20years on","volume":"29","author":"Bertoglio","year":"2005","journal-title":"Neurosci Behav Rev"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0022-3565(25)38117-6","article-title":"Differential properties of pre- and postsynaptic 5- hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins","volume":"265","author":"Blier","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0045","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1472-8206.2007.00526.x","article-title":"Animal models of anxiety in mice","volume":"21","author":"Bourin","year":"2007","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0050","first-page":"25","article-title":"Screening farmacol\u00f3gico de ansiol\u00edticos: metodologia laboratorial e compara\u00e7\u00e3o entre diazepam e clorobenzepam","volume":"1","author":"Carlini","year":"1979","journal-title":"Rev Assoc Bras Psiquiatr"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0055","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1248\/bpb.25.1629","article-title":"Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L.","volume":"25","author":"Carvalho-Freitas","year":"2002","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0060","unstructured":"Celedonio, Nat\u00e1lia Rocha, 2008. Estudo do mecanismo de a\u00e7\u00e3o antinociceptivo e antiedematog\u00eanico do \u00f3leo essencial de Croton argyrophylloides e seus constituintes: alfa-pineno e trans-cariofileno. [Disserta\u00e7\u00e3o de Mestrado \u2014 Universidade Estadual do Cear\u00e1]. 141 p."},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0065","series-title":"Anais do VI Congresso de Pesquisa, Ensino e Extens\u00e3o","first-page":"1891","article-title":"An\u00e1lise da composi\u00e7\u00e3o qu\u00edmica do \u00f3leo essencial e avalia\u00e7\u00e3o da atividade antimicrobiana do \u00f3leo essencial e extrato etan\u00f3lico bruto de Spiranthera odoratissima A. St. Hil","author":"Chaibub","year":"2009"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0070","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.lfs.2006.11.009","article-title":"Quantitative structure\u2013activity relationship (QSAR) for neuroprotective activity of terpenoids","volume":"80","author":"Chang","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00404370","article-title":"Exploratory behavior in chronic disulfoton poisoning in mice","volume":"20","author":"Clark","year":"1971","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0080","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","article-title":"Exploratory behavior models of anxiety in mice","volume":"9","author":"Crawley","year":"1985","journal-title":"Neurosci Behav Rev"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0091-3057(80)90067-2","article-title":"Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines","volume":"13","author":"Crawley","year":"1980","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0090","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","article-title":"A note on a simple apparatus for detecting neurological deficit in rats and mice","volume":"46","author":"Dunham","year":"1957","journal-title":"J Am Pharm Assoc"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0095","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1590\/S1516-44462010005000026","article-title":"Plantas medicinais no tratamento do transtorno de ansiedade generalizada: uma revis\u00e3o dos estudos cl\u00ednicos controlados","volume":"32","author":"Faustino","year":"2010","journal-title":"Rev Bras Psiquiatr"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejphar.2007.04.059","article-title":"Anti-inflammatory effects of compounds alpha-humulene and (\u2212)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea","volume":"569","author":"Fernandes","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0091-3057(95)02175-2","article-title":"Recent developments in anxiety, stress, and depression","volume":"54","author":"File","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0110","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/WNR.0b013e3283232caa","article-title":"5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig","volume":"20","author":"Foong","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0115","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s11418-010-0429-2","article-title":"Biological effects of Ocimum gratissimum L. are due to synergic action among multiple compounds present in essential oil","volume":"64","author":"Galindo","year":"2010","journal-title":"J Nat Med"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000118837","article-title":"Use of buspirone in patients with generalised anxiety disorder and coexisting depressive symptoms: a meta-analysis of eight randomised controlled trials","volume":"25","author":"Gammans","year":"1992","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0125","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0803601105","article-title":"Beta-caryophyllene is a dietary cannabinoid","volume":"105","author":"Gertsch","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0130","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0014-827X(01)01092-8","article-title":"Local anaesthesic activity of \u03b2-caryophyllene","volume":"56","author":"Ghelardini","year":"2001","journal-title":"Farmaco"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0135","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2165\/00003495-198632020-00002","article-title":"Buspirone: a preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic","volume":"32","author":"Goa","year":"1986","journal-title":"Drugs"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jep.2005.12.014","article-title":"Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice","volume":"106","author":"Gonzalez-Trujano","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0150","series-title":"Biological psychiatry","first-page":"96","article-title":"Animal models of anxiety disorders","author":"Graeff","year":"2002"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0091-3057(95)02135-3","article-title":"Role of 5-HT in stress, anxiety, and depression","volume":"54","author":"Graeff","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0155","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.neuropharm.2011.02.016","article-title":"Modulation of the serotonin system by endocannabinoid signaling","volume":"61","author":"Haj-Dahmane","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0160","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2006.09.042","article-title":"Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone","volume":"553","author":"Harada","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0165","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuint.2010.08.011","article-title":"Activation of serotonin 1A receptors in ventrolateral orbital cortex depresses persistent nociception: a presynaptic inhibition mechanism","volume":"57","author":"Huo","year":"2010","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0170","series-title":"Neuropsychopharmacology: the fifth generation of progress","first-page":"981","article-title":"The economic burden of anxiety and stress disorders","author":"Kessler","year":"2002"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0175","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1360-0443.1991.tb01831.x","article-title":"Benzodiazepine problems","volume":"86","author":"Lader","year":"1991","journal-title":"Br J Addict"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejphar.2007.09.022","article-title":"The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neurons","volume":"578","author":"Lau","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0185","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1472-8206.2009.00800.x","article-title":"Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent \u03b2-caryophyllene on rat isolated ileum","volume":"24","author":"Leonhardt","year":"2010","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0190","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0091-3057(00)00419-6","article-title":"Differences in anxiety-related behavior and response to diazepam in BALB\/cByJ and C57BL\/6J strains of mice","volume":"67","author":"Lepicard","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0006-8993(00)02858-4","article-title":"Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression","volume":"882","author":"Lilly","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0200","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0365","series-title":"New natural products and plant drugs with pharmacological, biological or therapeutical activity","first-page":"24","article-title":"Pharmacological approaches to natural product, screening and evaluation","author":"Malone","year":"1977"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2011.00063","article-title":"Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects","volume":"5","author":"Marco","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0225","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/S0102-695X2003000300006","article-title":"Atividade analg\u00e9sica e\/ou antiinflamat\u00f3ria da fra\u00e7\u00e3o aquosa do extrato etan\u00f3lico das folhas da Spiranthera odoratissima A. St. Hillaire (manac\u00e1)","volume":"3","author":"Matos","year":"2003","journal-title":"Rev Bras Farmacognosia"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0220","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ptr.1301","article-title":"Analgesic and anti-inflammatory activity of the ethanolic extract from Spiranthera odoratissima A. St. Hillaire (manac\u00e1) roots","volume":"18","author":"Matos","year":"2004","journal-title":"Phytother Res"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0215","series-title":"Anais do XIX Simp\u00f3sio de Plantas Medicinais do Brasil, Salvador-BA","article-title":"Estudo das atividades no sistema nervoso central da fra\u00e7\u00e3o hex\u00e2nica do extrato etan\u00f3lico das folhas da Spiranthera odoratissima","author":"Matos","year":"2006"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0230","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA","volume":"346","author":"Matsuda","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0235","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2009.09.055","article-title":"Monoaminergic neurotransmission contributes to cannabinoid-induced activation of the hypothalamic\u2013pituitary\u2013adrenal axis","volume":"624","author":"McLaughlin","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0240","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/sj.bjp.0707270","article-title":"Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw","volume":"151","author":"Medeiros","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0245","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jep.2004.03.039","article-title":"Anxiolytic-like actions of leaves of Casimiroa edulis (Rutaceae) in male Wistar rats","volume":"93","author":"Molina-Hern\u00e1ndez","year":"2004","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0250","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1248\/bpb.32.520","article-title":"Clastogenicity of beta-caryophyllene in mouse","volume":"32","author":"Molina-Jasso","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0255","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jep.2004.10.028","article-title":"Central nervous system activity of the hydroalcoholic extract of Casimiroa edulis in rats and mice","volume":"97","author":"Mora","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0260","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.neuropharm.2009.07.017","article-title":"Functional CB2 type cannabinoid receptors at CNS synapses","volume":"57","author":"Morgan","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0265","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0270","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0091-3057(88)90463-7","article-title":"Proconvulsant and anxiogenic effects of n-butyl-\u03b2-carboline-3-carboxilate on endogenous benzodiazepine binding inhibitor from brain","volume":"30","author":"Novas","year":"1988","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0275","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1196\/annals.1369.052","article-title":"Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain","volume":"1074","author":"Onaivi","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0280","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jep.2006.09.032","article-title":"Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea","volume":"110","author":"Passos","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0285","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0290","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0295","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/sj.bjp.0702723","article-title":"The recombinant 5-HT1A receptor: G protein coupling and signaling pathways","volume":"127","author":"Raymond","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0300","series-title":"Ethology and psychopharmacology","first-page":"9","article-title":"The elevated plus-maze: pharmacology, methodology and ethology","author":"Rodgers","year":"1994"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0305","series-title":"Horto Medicinal do Cerrado","author":"Salles","year":"1997"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0310","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.pbb.2004.07.013","article-title":"Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt","volume":"79","author":"Savi\u0107","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0315","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/00223980.1946.9917283","article-title":"A simple electronic device for the measurement of gross bodily activity of small animals","volume":"21","author":"Siegel","year":"1946","journal-title":"J Psychol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0320","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0091-3057(00)00200-8","article-title":"Effects of buspirone, diazepam, and zolpidem on open field behavior, and brain [3H]muscimol binding after buspirone pretreatment","volume":"66","author":"Siemiatkowski","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0325","series-title":"Plantas do cerrado","author":"Silva","year":"1998"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0330","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1590\/S0102-695X2008000400023","article-title":"Plantas medicinais e seus constituintes bioativos: Uma revis\u00e3o da bioatividade e potenciais benef\u00edcios nos dist\u00farbios da ansiedade em modelos animais","volume":"18","author":"Sousa","year":"2008","journal-title":"Rev Bras Farmacognosia"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0335","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijat.2006.09.006","article-title":"Natural killer cell activity and lymphocyte activation: investigating the effects of a selection of essential oils and components in vitro","volume":"16","author":"Standen","year":"2006","journal-title":"Int J Aromather"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0340","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0028-3908(92)90053-R","article-title":"The comparison of benzodiazepine derivates and serotonergic agonists and antagonists in two animal models of anxiety","volume":"31","author":"Stefanski","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0345","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-2999(98)00223-4","article-title":"Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and\/or anxiolytic state in mice","volume":"350","author":"Takeda","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0350","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1055\/s-2006-957942","article-title":"Gastric cytoprotectio of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene","volume":"5","author":"Tambe","year":"1996","journal-title":"Planta Med"},{"key":"10.1016\/j.pnpbp.2012.04.012_bb0355","first-page":"23","article-title":"Estudo sobre o com\u00e9rcio informal de plantas medicinais em Goi\u00e2nia e cidades vizinhas","volume":"3","author":"Tresvenzol","year":"2006","journal-title":"Rev Eletr\u00f4nica da Farm\u00e1cia"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858461200084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858461200084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:56:16Z","timestamp":1742968576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027858461200084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S027858461200084X"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2012.04.012","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}