{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:48:41Z","timestamp":1760298521058},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.pnpbp.2012.04.016","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T12:02:20Z","timestamp":1336737740000},"page":"47-51","source":"Crossref","is-referenced-by-count":12,"title":["Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients"],"prefix":"10.1016","volume":"39","author":[{"given":"Lucio","family":"Tremolizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo C.","family":"DiFrancesco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Rodriguez-Menendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Galimberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ruffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Ferrarese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2012.04.016_bb0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2165\/00003088-199120020-00003","article-title":"Clinical pharmacology of valpromide","volume":"20","author":"Bialer","year":"1991","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0010","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1016\/j.lfs.2005.01.003","article-title":"Carbamazepine is an inhibitor of histone deacetylases","volume":"76","author":"Beutler","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/med.20027","article-title":"Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies","volume":"25","author":"Blaheta","year":"2005","journal-title":"Med Res Rev"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.clml.2012.01.005","article-title":"Epigenetic therapy with hydralazine and magnesium valproate reverses imatinib resistance in patients with chronic myeloid leukemia","volume":"12","author":"Cervera","year":"2012","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","author":"Chateauvieux","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0030","first-page":"1491","article-title":"Upregulation of NKG2D ligands and enhanced natural killer cell cytotoxicity by hydralazine and valproate","volume":"39","author":"Ch\u00e1vez-Blanco","year":"2011","journal-title":"Int J Oncol"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0035","doi-asserted-by":"crossref","first-page":"27586","DOI":"10.1074\/jbc.M303740200","article-title":"Valproate induces replication-independent active DNA demethylation","volume":"278","author":"Detich","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0040","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4161\/epi.5.8.13053","article-title":"Valproate induces DNA demethylation in nuclear extracts from adult mouse brain","volume":"5","author":"Dong","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0045","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1124\/dmd.105.008078","volume":"34","author":"Eikel","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0050","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.0013-9580.2004.00104.x","article-title":"The activity of antiepileptic drugs as histone deacetylase inhibitors","volume":"45","author":"Eyal","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb1000","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.imbio.2011.11.010","article-title":"Impact of valproic acid on dendritic cells function","volume":"217","author":"Frikeche","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0055","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0060","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neuropharm.2010.10.021","article-title":"Epigenetic GABAergic targets in schizophrenia and bipolar disorder","volume":"60","author":"Guidotti","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0065","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2174\/138945010790711923","article-title":"Valproic acid in the complex therapy of malignant tumors","volume":"11","author":"Hrebackova","year":"2010","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0070","doi-asserted-by":"crossref","first-page":"8422","DOI":"10.1523\/JNEUROSCI.22-19-08422.2002","article-title":"Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus","volume":"22","author":"Huang","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.eplepsyres.2008.04.019","article-title":"Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases?","volume":"81","author":"Hoffmann","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0080","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000327604","article-title":"Cytogenetic effects of valproic acid and ziprasidone in human lymphocyte cultures","volume":"64","author":"Karapidaki","year":"2011","journal-title":"Neuropsychobiology"},{"issue":"Suppl. 4","key":"10.1016\/j.pnpbp.2012.04.016_bb0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1528-1167.2011.03145.x","article-title":"The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis?","volume":"52","author":"Kobow","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0090","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2165\/00023210-200216100-00003","article-title":"Basic pharmacology of valproate: a review after 35years of clinical use for the treatment of epilepsy","volume":"16","author":"L\u00f6scher","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1874467210902010095","article-title":"Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection","volume":"2","author":"Monti","year":"2009","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0100","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.tips.2009.07.002","article-title":"Sodium valproate: an old drug with new roles","volume":"30","author":"Nalivaeva","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0105","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/npp.2009.188","article-title":"Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes","volume":"35","author":"Perisic","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2165\/00023210-200216100-00004","article-title":"Pharmacological and therapeutic properties of valproate: a summary after 35years of clinical experience","volume":"16","author":"Perucca","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0115","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0120","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1006\/bbrc.1999.1187","article-title":"A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands","volume":"262","author":"Pogribny","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb1005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0920-1211(97)00095-8","article-title":"Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid","volume":"30","author":"Radatz","year":"1998","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.schres.2006.07.015","article-title":"Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population","volume":"88","author":"Sharma","year":"2006","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/brain\/awh363","article-title":"Cancer risk in people with epilepsy: the role of antiepileptic drugs","volume":"128","author":"Singh","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0135","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00280-007-0519-3","article-title":"Plasma and cerebrospinal fluid pharmacokinetics of valproic acid after oral administration in non-human primates","volume":"61","author":"Stapleton","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0140","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1073\/pnas.262658999","article-title":"An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability","volume":"99","author":"Tremolizzo","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0145","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biopsych.2004.11.046","article-title":"Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice","volume":"57","author":"Tremolizzo","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0150","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00109-008-0388-1","article-title":"Multiple therapeutic effects of valproic acid in spinal muscular atrophy model mice","volume":"86","author":"Tsai","year":"2008","journal-title":"J Mol Med"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/02688697.2011.638996","article-title":"Effect of valproic acid on the outcome of glioblastoma multiforme","volume":"26","author":"Tsai","year":"2012","journal-title":"Br J Neurosurg."},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0160","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2010.08.001","article-title":"Epigenetic modifications in valproic acid-induced teratogenesis","volume":"248","author":"Tung","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0165","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1212\/WNL.0b013e31822f02e1","article-title":"Prolonged survival with valproic acid use in the EORTC\/NCIC temozolomide trial for glioblastoma","volume":"77","author":"Weller","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.pnpbp.2012.04.016_bb0170","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pbb.2009.08.001","article-title":"Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease","volume":"94","author":"Zadori","year":"2009","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612000887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612000887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T15:37:18Z","timestamp":1561736238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584612000887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0278584612000887"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2012.04.016","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}