{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:13:45Z","timestamp":1780330425992,"version":"3.54.1"},"reference-count":69,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.pnpbp.2012.06.011","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T14:29:30Z","timestamp":1340288970000},"page":"162-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Anesthesia, surgery, illness and Alzheimer's disease"],"prefix":"10.1016","volume":"47","author":[{"given":"Roderic G.","family":"Eckenhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof F.","family":"Laudansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2012.06.011_bb0005","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/ALN.0b013e3181bc9719","article-title":"Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness","volume":"111","author":"Avidan","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0140-6736(55)92689-1","article-title":"Adverse cerebral effects of anaesthesia on old people","volume":"269","author":"Bedford","year":"1955","journal-title":"Lancet"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2010.00035","article-title":"NSAIDs may protect against age-related brain atrophy","volume":"2","author":"Bendlin","year":"2010","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0020","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.neurobiolaging.2007.02.009","article-title":"Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics","volume":"29","author":"Bianchi","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0025","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/00207459408986029","article-title":"Early and midlife exposure to anesthesia and age of onset of Alzheimer's disease","volume":"77","author":"Bohnen","year":"1994","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0030","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1532-5415.1994.tb04952.x","article-title":"Alzheimer's disease and cumulative exposure to anesthesia: a case\u2013control study","volume":"42","author":"Bohnen","year":"1994","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0035","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.pnpbp.2010.07.027","article-title":"Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats","volume":"34","author":"Cao","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0040","first-page":"CD003591","article-title":"Non-steroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy","author":"Cardwell","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0045","doi-asserted-by":"crossref","first-page":"e1879","DOI":"10.1371\/journal.pone.0001879","article-title":"Anesthetics impact the resolution of inflammation","volume":"3","author":"Chiang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0050","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/bja\/ael270","article-title":"The effects of propofol on neutrophil function, lipid peroxidation and inflammatory response during elective coronary artery bypass grafting in patients with impaired ventricular function","volume":"97","author":"Corcoran","year":"2006","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11481-011-9313-4","article-title":"Cognitive and behavioral consequences of impaired immunoregulation in aging","volume":"7","author":"Corona","year":"2012","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0060","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1213\/ANE.0b013e3182160431","article-title":"Surgery and anesthesia: healing the body but harming the brain?","volume":"112","author":"Crosby","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0065","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1213\/01.ANE.0000052712.67573.12","article-title":"The memory effects of general anesthesia persist for weeks in young and aged rats","volume":"96","author":"Culley","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0070","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1213\/01.ANE.0000135408.14319.CC","article-title":"Impaired acquisition of spatial memory 2weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats","volume":"99","author":"Culley","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0075","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000542-200402000-00020","article-title":"Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats","volume":"100","author":"Culley","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0080","doi-asserted-by":"crossref","first-page":"9275","DOI":"10.1523\/JNEUROSCI.2614-05.2005","article-title":"Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration","volume":"25","author":"Cunningham","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0085","doi-asserted-by":"crossref","first-page":"176","DOI":"10.7326\/0003-4819-153-3-201008030-00260","article-title":"National Institutes of Health State-of-the-Science Conference statement: Preventing Alzheimer disease and cognitive decline","volume":"153","author":"Daviglus","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.wad.0000165511.52746.1f","article-title":"Association between dementia and infectious disease: evidence from a case\u2013control study","volume":"19","author":"Dunn","year":"2005","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0095","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/jama.2010.167","article-title":"Association between acute care and critical illness hospitalization and cognitive function in older adults","volume":"303","author":"Ehlenbach","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0100","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1213\/ANE.0b013e318215217e","article-title":"Postoperative cognitive dysfunction is independent of type of surgery and anesthetic","volume":"112","author":"Evered","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0105","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/jcan.2002.31057","article-title":"Glucocorticoid effects on the inflammatory and clinical responses to cardiac surgery","volume":"16","author":"Fillinger","year":"2002","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s100720200017","article-title":"A case\u2013control study on Alzheimer's disease and exposure to anesthesia","volume":"23","author":"Gasparini","year":"2002","journal-title":"Neurol Sci"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0115","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1096\/fj.05-3776fje","article-title":"Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system","volume":"19","author":"Godbout","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0120","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1126\/science.1190929","article-title":"Changing face of microglia","volume":"330","author":"Graeber","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0125","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1523\/JNEUROSCI.2797-06.2006","article-title":"Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease","volume":"26","author":"Green","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0130","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1212\/WNL.0b013e318225ae07","article-title":"Proinflammatory cytokines, sickness behavior, and Alzheimer disease","volume":"77","author":"Holmes","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0135","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1212\/WNL.0b013e3181b6bb95","article-title":"Systemic inflammation and disease progression in Alzheimer disease","volume":"73","author":"Holmes","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0140","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1378\/chest.130.3.869","article-title":"Long-term neurocognitive function after critical illness","volume":"130","author":"Hopkins","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0145","doi-asserted-by":"crossref","first-page":"S331","DOI":"10.1097\/CCM.0b013e3181b6ed58","article-title":"Sepsis-associated encephalopathy and its differential diagnosis","volume":"37","author":"Iacobone","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0150","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1001\/jama.2010.1553","article-title":"Long-term cognitive impairment and functional disability among survivors of severe sepsis","volume":"304","author":"Iwashyna","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0155","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0006-3495(00)76656-2","article-title":"A designed four-alpha-helix bundle that binds the volatile general anesthetic halothane with high affinity","volume":"78","author":"Johansson","year":"2000","journal-title":"Biophys J"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0160","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/00000542-200206000-00014","article-title":"Postoperative cognitive dysfunction in middle-aged patients","volume":"96","author":"Johnson","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0165","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1523\/JNEUROSCI.6389-11.2012","article-title":"Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice","volume":"32","author":"Jurgens","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0170","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1399-6576.2011.02461.x","article-title":"Influence of propofol and volatile anaesthetics on the inflammatory response in the ventilated lung","volume":"55","author":"Kalimeris","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0175","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/EJA.0b013e3283534f56","article-title":"Meloxicam improves object recognition memory and modulates glial activation after splenectomy in mice","volume":"29","author":"Kamer","year":"2012","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0180","doi-asserted-by":"crossref","first-page":"03","DOI":"10.1097\/ALN.0b013e318246ec0b","article-title":"Surgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment","volume":"116","author":"Kline","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0185","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1212\/01.WNL.0000171954.92119.c7","article-title":"Coronary artery bypass grafting is not a risk factor for dementia or Alzheimer disease","volume":"65","author":"Knopman","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0190","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3233\/JAD-2005-7408","article-title":"Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty","volume":"7","author":"Lee","year":"2005","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0195","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbr.2011.12.010","article-title":"Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats","volume":"228","author":"Lin","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0200","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1097\/ALN.0b013e3181d94de1","article-title":"Anesthetic sevoflurane causes neurotoxicity differently in neonatal naive and Alzheimer disease transgenic mice","volume":"112","author":"Lu","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0205","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/archneur.2008.65.7.nct70006","article-title":"Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib","volume":"65","author":"Martin","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0210","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(97)07382-0","article-title":"Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction","volume":"351","author":"Moller","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.anes.0000296071.19434.1e","article-title":"Predictors of cognitive dysfunction after major noncardiac surgery","volume":"108","author":"Monk","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0220","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jss.2006.04.015","article-title":"Role of steroid administration to reduce inflammation after thoracotomy in a rat surgical stress model","volume":"135","author":"Nakamura","year":"2006","journal-title":"J Surg Res"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0225","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJM200102083440601","article-title":"Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery","volume":"344","author":"Newman","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0230","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3233\/JAD-2010-100702","article-title":"et al Coronary artery bypass surgery provokes Alzheimer's disease-like changes in the cerebrospinal fluid","volume":"21","author":"Palotas","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0235","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nri2015","article-title":"Systemic infections and inflammation affect chronic neurodegeneration","volume":"7","author":"Perry","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0240","doi-asserted-by":"crossref","first-page":"12798","DOI":"10.1523\/JNEUROSCI.4101-08.2008","article-title":"Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo","volume":"28","author":"Planel","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0245","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.exger.2008.06.004","article-title":"Neuroinflammation and cognitive function in aged mice following minor surgery","volume":"43","author":"Rosczyk","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0250","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0163-8343(01)00123-2","article-title":"The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: Results of an exploratory study","volume":"23","author":"Rothenhausler","year":"2001","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0255","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in health and disease","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0260","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1056\/NEJMra1100109","article-title":"Cognitive and neurologic outcomes after coronary-artery bypass surgery","volume":"366","author":"Selnes","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0265","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/SLA.0b013e3182261118","article-title":"Preoperative glucocorticoid use in major abdominal surgery: systematic review and meta-analysis of randomized trials","volume":"254","author":"Srinivasa","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0270","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopsych.2010.06.012","article-title":"A meta-analysis of cytokines in Alzheimer's disease","volume":"68","author":"Swardfager","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0275","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/ALN.0b013e31822e9306","article-title":"Human Alzheimer and inflammation biomarkers after anesthesia and surgery","volume":"115","author":"Tang","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0280","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jalz.2010.10.003","article-title":"Anesthesia in presymptomatic Alzheimer Disease: a 3xTgAD study","volume":"7","author":"Tang","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0285","unstructured":"Tang JX, Mardini F, Janik LS, Garrity ST, Li RQ, Bachlani G, et al. Modulation of murine Alzheimer pathogenesis and behavior by surgery. Ann Surg in press."},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0290","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/ana.22664","article-title":"Resolving postoperative neuroinflammation and cognitive decline","volume":"70","author":"Terrando","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0295","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.1073\/pnas.1014557107","article-title":"Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline","volume":"107","author":"Terrando","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0300","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neurobiolaging.2009.03.006","article-title":"Anti-inflammatory drugs reduce age-related decreases in brain volume in cognitively normal older adults","volume":"32","author":"Walther","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0305","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00000542-200703000-00007","article-title":"Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus","volume":"106","author":"Wan","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0310","doi-asserted-by":"crossref","first-page":"e16648","DOI":"10.1371\/journal.pone.0016648","article-title":"Propofol directly increases tau phosphorylation","volume":"6","author":"Whittington","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0315","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1001\/jama.1995.03530010058035","article-title":"Cognitive effects after epidural vs general anesthesia in older adults. A randomized trial","volume":"274","author":"Williams-Russo","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0320","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s11908-007-0059-3","article-title":"Long-term outcomes from sepsis","volume":"9","author":"Yende","year":"2007","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0325","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/ALN.0b013e3181e89a77","article-title":"Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1","volume":"113","author":"Yuki","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0330","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1096\/fj.08-113324","article-title":"The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity","volume":"22","author":"Yuki","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0335","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/bjs.6744","article-title":"Randomized clinical trial of the effect of glucocorticoids on peritoneal inflammation and postoperative recovery after colectomy","volume":"96","author":"Zargar-Shoshtari","year":"2009","journal-title":"Br J Surg"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0340","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ana.23536","article-title":"Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory","volume":"71","author":"Zhang","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pnpbp.2012.06.011_bb0345","doi-asserted-by":"crossref","first-page":"e27019","DOI":"10.1371\/journal.pone.0027019","article-title":"Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Abeta oligomerization","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612001467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612001467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T01:55:38Z","timestamp":1642557338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584612001467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":69,"alternative-id":["S0278584612001467"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2012.06.011","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anesthesia, surgery, illness and Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2012.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}