{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:37:06Z","timestamp":1791023826582,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.pnpbp.2012.11.015","type":"journal-article","created":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T06:59:29Z","timestamp":1354949969000},"page":"40-48","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats"],"prefix":"10.1016","volume":"43","author":[{"given":"Erika","family":"Abrial","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Etievant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"B\u00e9try","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Scarna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Haddjeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lamb\u00e1s-Se\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2012.11.015_bb0005","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12035-011-8210-4","article-title":"A role for the PKC signaling system in the pathophysiology and treatment of mood disorders: involvement of a functional imbalance?","volume":"44","author":"Abrial","year":"2011","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopsych.2005.06.036","article-title":"Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments","volume":"59","author":"Alfonso","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0015","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.bmcl.2010.02.024","article-title":"Endoxifen is a new potent inhibitor of PKC: a potential therapeutic agent for bipolar disorder","volume":"20","author":"Ali","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0020","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jad.2010.08.015","article-title":"Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania","volume":"129","author":"Amrollahi","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0030","unstructured":"Arnsten A, Birnbaum S, 2005. Chelerythrine, analogs thereof and their use in the treatment of bipolar disorder and other cognitive disorders. Patent WO\/2005\/030143, issued April 7, 2005."},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0035","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2202-10-132","article-title":"Anti-depressant and anxiolytic like behaviors in PKCI\/HINT1 knockout mice associated with elevated plasma corticosterone level","volume":"10","author":"Barbier","year":"2009","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0040","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.bbagen.2010.01.006","article-title":"Influence of different estrogens on neuroplasticity and cognition in the hippocampus","volume":"1800","author":"Barha","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0045","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.npp.1300911","article-title":"Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases","volume":"31","author":"Basta-Kaim","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0050","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archpsyc.57.1.95","article-title":"A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania","volume":"57","author":"Bebchuk","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0006-3223(98)00138-3","article-title":"A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives","volume":"44","author":"Benes","year":"1998","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0060","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1126\/science.1100021","article-title":"Protein kinase C overactivity impairs prefrontal cortical regulation of working memory","volume":"306","author":"Birnbaum","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0065","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neubiorev.2005.04.017","article-title":"Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on","volume":"29","author":"Carobrez","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","article-title":"Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression","volume":"213","author":"Drevets","year":"2008","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0075","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/sj.npp.1300605","article-title":"Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: role in LH behavior","volume":"30","author":"Dwivedi","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0080","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.biopsych.2005.11.004","article-title":"Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder","volume":"59","author":"Einat","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0085","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1358\/dnp.2003.16.7.829357","article-title":"Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice","volume":"16","author":"Einat","year":"2003","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000106054","article-title":"Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder","volume":"55","author":"Einat","year":"2007","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0100","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s11064-006-9070-6","article-title":"Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of mania","volume":"31","author":"Frey","year":"2006","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0105","first-page":"326","article-title":"Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania","volume":"31","author":"Frey","year":"2006","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0110","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0006-3223(93)90006-Y","article-title":"Altered platelet protein kinase C activity in bipolar affective disorder, manic episode","volume":"33","author":"Friedman","year":"1993","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0115","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuropharm.2011.01.037","article-title":"Antidepressant phenotype by inhibiting the phospholipase C\u03b2(1)\u2013protein kinase C\u03b3 pathway in the forced swim test","volume":"60","author":"Galeotti","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0125","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1046\/j.1460-9568.2003.02694.x","article-title":"Protein kinase C and ERK involvement in dendritic spine plasticity in cultured rodent hippocampal neurons","volume":"17","author":"Goldin","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0130","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1440-1681.2007.04610.x","article-title":"Regulators of adult neurogenesis in the healthy and diseased brain","volume":"34","author":"Grote","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0135","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jpsychires.2004.10.007","article-title":"Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients","volume":"39","author":"Hahn","year":"2005","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0140","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1503\/jpn.110143","article-title":"Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis","volume":"37","author":"Hajek","year":"2012","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0145","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0006-291X(90)91544-3","article-title":"Chelerythrine is a potent and specific inhibitor of protein kinase C","volume":"172","author":"Herbert","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0150","doi-asserted-by":"crossref","first-page":"16659","DOI":"10.1073\/pnas.0407643101","article-title":"Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells","volume":"101","author":"Hsieh","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0155","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0924-977X(96)00396-3","article-title":"Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatments","volume":"7","author":"Jensen","year":"1997","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/FBP.0b013e32834f9e4e","article-title":"Behavioral differences in black Swiss mice from separate colonies: implications for modeling domains of mania","volume":"23","author":"Juetten","year":"2012","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0165","doi-asserted-by":"crossref","first-page":"e25158","DOI":"10.1371\/journal.pone.0025158","article-title":"A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse","volume":"6","author":"Kataoka","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0170","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0175","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3940(00)01376-8","article-title":"Inhibition of brain protein kinase C attenuates immobilization stress-induced plasma corticosterone levels in mice","volume":"291","author":"Kim","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0180","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/j.1471-4159.2006.04316.x","article-title":"GAP-43 regulates NCAM-180-mediated neurite outgrowth","volume":"100","author":"Korshunova","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0185","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.psyneuen.2005.11.001","article-title":"A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder","volume":"31","author":"Kulkarni","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0190","series-title":"Global burden of disease and risk factors","author":"Lopez","year":"2006"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0195","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/sj.npp.1300234","article-title":"Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment","volume":"28","author":"Malberg","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0200","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0006-3223(99)00235-8","article-title":"Ziskind\u2013Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness","volume":"46","author":"Manji","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1471-4159.2006.03710.x","article-title":"Decreased calcium\/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice","volume":"97","author":"Moriguchi","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0210","doi-asserted-by":"crossref","first-page":"34514","DOI":"10.1074\/jbc.M109.016683","article-title":"Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activators","volume":"284","author":"Nelson","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0215","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/10253890802506383","article-title":"Different effect of chronic stress on learning and memory in BALB\/c and C57BL\/6 inbred mice: involvement of hippocampal NO production and PKC activity","volume":"12","author":"Palumbo","year":"2009","journal-title":"Stress"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0220","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0225","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0230","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0235","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1034\/j.1399-5618.2002.01149.x","article-title":"Cell pathology in bipolar disorder","volume":"4","author":"Rajkowska","year":"2002","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0240","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0278-5846(97)00013-4","article-title":"Protein kinase C in synaptic plasticity: changes in the in situ phosphorylation state of identified pre- and postsynaptic substrates","volume":"21","author":"Ramakers","year":"1997","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0245","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.2741\/3385","article-title":"Protein kinase C isoforms: multi-functional regulators of cell life and death","volume":"14","author":"Reyland","year":"2009","journal-title":"Front Biosci"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0250","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0090-9556(25)07102-8","article-title":"Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient","volume":"19","author":"Robinson","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0255","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0006-2952(95)00186-4","article-title":"Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues","volume":"50","author":"Rowlands","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0260","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/j.pnpbp.2008.09.023","article-title":"The antimanic-like effect of tamoxifen: behavioural comparison with other PKC-inhibiting and antiestrogenic drugs","volume":"32","author":"Sabioni","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0270","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.4088\/JCP.09r05259gre","article-title":"The neurobiology of the switch process in bipolar disorder: a review","volume":"71","author":"Salvadore","year":"2010","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0275","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1460-9568.2011.07614.x","article-title":"Neurogenesis and affective disorders","volume":"33","author":"Samuels","year":"2011","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0280","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0285","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0074-7742(06)77005-2","article-title":"Neurogenesis and neuroenhancement in the pathophysiology and treatment of bipolar disorder","volume":"77","author":"Schloesser","year":"2007","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0290","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/156720212799297056","article-title":"Protein kinase C and oxidative stress in an animal model of mania","volume":"9","author":"Steckert","year":"2012","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0295","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2005.02.028","article-title":"Dual effects of bryostatin-1 on spatial memory and depression","volume":"512","author":"Sun","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0300","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s002130000396","article-title":"Pharmacological demonstration of the differential involvement of protein kinase C isoforms in short- and long-term memory formation and retrieval of one-trial avoidance in rats","volume":"150","author":"Vianna","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0305","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0006-3223(03)00527-4","article-title":"Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness","volume":"54","author":"Vollmayr","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0310","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/FBP.0b013e3283423d6b","article-title":"Tail suspension test does not detect antidepressant-like properties of atypical antipsychotics","volume":"22","author":"Weso\u0142owska","year":"2010","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0315","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.brainres.2007.01.024","article-title":"Prenatal restraint stress impairs learning and memory and hippocampal PKCbeta1 expression and translocation in offspring rats","volume":"1141","author":"Wu","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0320","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/archgenpsychiatry.2007.43","article-title":"Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen","volume":"65","author":"Yildiz","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0325","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neuropharm.2008.09.019","article-title":"Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation","volume":"56","author":"Yu","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0330","first-page":"569","article-title":"Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder. C.N.S","volume":"23","author":"Zarate","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0335","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1399-5618.2007.00530.x","article-title":"Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study","volume":"9","author":"Zarate","year":"2007","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2012.11.015_bb0340","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<494::AID-IJC26>3.0.CO;2-L","article-title":"Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells","volume":"81","author":"Zeidman","year":"1999","journal-title":"Int J Cancer"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612002977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584612002977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:19:56Z","timestamp":1745410796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584612002977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":66,"alternative-id":["S0278584612002977"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2012.11.015","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}