{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:18:43Z","timestamp":1780093123274,"version":"3.54.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.pnpbp.2013.01.002","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T23:54:31Z","timestamp":1357775671000},"page":"217-221","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Brain-derived neurotrophic factor in generalized anxiety disorder: Results from a duloxetine clinical trial"],"prefix":"10.1016","volume":"43","author":[{"given":"Susan","family":"Ball","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B.","family":"Marangell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lipsius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2013.01.002_bb0115","series-title":"The Diagnostic and Statistical Manual for Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0010","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1017\/S1461145708009309","article-title":"A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression","volume":"11","author":"Brunoni","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0120","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.psyneuen.2010.07.013","article-title":"Determinants of serum brain-derived neurotrophic factor","volume":"36","author":"Bus","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0020","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1124\/mol.109.063081","article-title":"Long-term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms","volume":"77","author":"Calabrese","year":"2010","journal-title":"Mol Pharmacol"},{"issue":"12","key":"10.1016\/j.pnpbp.2013.01.002_bb0125","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0150","series-title":"ECDEU Assessment Manual for Psychopharmacology (DHEW Publication No. 76\u2013338)","first-page":"218","article-title":"The clinician global severity and impression scales","author":"Guy","year":"1979"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0035","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br J Med Psychol"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0040","doi-asserted-by":"crossref","first-page":"333","DOI":"10.31887\/DCNS.2009.11.3\/jhunsberger","article-title":"The neurotrophic and neuroprotective effects of psychotropic agents","volume":"11","author":"Hunsberger","year":"2009","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0045","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/archpsyc.1992.01820090044008","article-title":"Major depression and generalized anxiety disorder. Same genes, (partly) different environments?","volume":"49","author":"Kendler","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0135","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0055","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.pnpbp.2005.04.010","article-title":"Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy","volume":"29","author":"Kobayashi","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0140","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.drudis.2009.05.002","article-title":"Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia","volume":"14","author":"Krystal","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jad.2006.11.005","article-title":"Decreased BDNF levels in depressed patients","volume":"101","author":"Lee","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrn1726","article-title":"The yin and yang of neurotrophin action","volume":"6","author":"Lu","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0075","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10571-007-9254-x","article-title":"BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake","volume":"28","author":"Mannari","year":"2008","journal-title":"Cell Mol Neurobiol"},{"issue":"7","key":"10.1016\/j.pnpbp.2013.01.002_bb0145","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/15622975.2011.587892","article-title":"Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety","volume":"13","author":"Molendijk","year":"2012","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0085","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.biopsych.2008.05.005","article-title":"Serum brain-derived neurotrophic factor, depression and antidepressant medications: meta-analyses and implications","volume":"64","author":"Sen","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0090","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/da.1033","article-title":"Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH-A)","volume":"13","author":"Shear","year":"2001","journal-title":"Depress Anxiety"},{"issue":"Suppl. 3","key":"10.1016\/j.pnpbp.2013.01.002_bb0095","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00004850-199606003-00015","article-title":"The measurement of disability","volume":"11","author":"Sheehan","year":"1996","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0100","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.pnpbp.2011.06.013","article-title":"Serum BDNF levels before treatment predict SSRI response in depression","volume":"35","author":"Wolkowitz","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0105","first-page":"3260","article-title":"Duloxetine versus placebo in the treatment of patients with generalized anxiety disorder in China","volume":"124","author":"Wu","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.pnpbp.2013.01.002_bb0110","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613000043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613000043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T12:39:01Z","timestamp":1644064741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584613000043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":22,"alternative-id":["S0278584613000043"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.01.002","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}