{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:24:44Z","timestamp":1781576684500,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81001653"],"award-info":[{"award-number":["81001653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81102423"],"award-info":[{"award-number":["81102423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81173036"],"award-info":[{"award-number":["81173036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.pnpbp.2013.04.010","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T05:49:22Z","timestamp":1366696162000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder"],"prefix":"10.1016","volume":"45","author":[{"given":"Zhi-Kun","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Zhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yue","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ri-Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2013.04.010_bb0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1254\/jphs.FP0070325","article-title":"Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test","volume":"104","author":"Ago","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0010","doi-asserted-by":"crossref","first-page":"11605","DOI":"10.1523\/JNEUROSCI.4173-05.2005","article-title":"Neurosteroid access to the GABAA receptor","volume":"25","author":"Akk","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2010.00158","article-title":"Automated assessment of Pavlovian conditioned freezing and shock reactivity in mice using the Video Freeze system","volume":"4","author":"Anagnostaras","year":"2010","journal-title":"Front Behav Neurosci"},{"issue":"10","key":"10.1016\/j.pnpbp.2013.04.010_bb0020","doi-asserted-by":"crossref","first-page":"e46921","DOI":"10.1371\/journal.pone.0046921","article-title":"Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life","volume":"7","author":"Bai","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0025","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0010-440X(03)00111-1","article-title":"Affective and anxiety comorbidity in post-traumatic stress disorder treatment trials of sertraline","volume":"5","author":"Brady","year":"2003","journal-title":"Compr Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0030","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/archpsyc.1991.01810270028003","article-title":"Traumatic events and posttraumatic stress disorder in a urban population of young adult","volume":"48","author":"Breslau","year":"1991","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0035","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0006-3223(02)01909-1","article-title":"The relevance of differential response to trauma in an animal model of posttraumatic stress disorder","volume":"53","author":"Cohen","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0040","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.psyneuen.2010.07.021","article-title":"Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: stimulation of in vitro neurosteroid production affecting GABAA receptor activity","volume":"36","author":"Costa","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0045","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/156802612799078720","article-title":"Translocator protein as a promising target for novel anxiolytics","volume":"12","author":"Costa","year":"2012","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0050","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1021\/jm8003224","article-title":"Anxiolytic-like effects of N, N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis","volume":"51","author":"Da Settimo","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.psychres.2008.07.019","article-title":"Lifetime manic\u2013hypomanic symptoms in post-traumatic stress disorder: relationship with the 18kDa mitochondrial translocator protein density","volume":"177","author":"Dell'Osso","year":"2010","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02688609","article-title":"Posttraumatic stress disorder: a sensitization reaction","volume":"32","author":"Dykman","year":"1997","journal-title":"Integr Physiol Behav Sci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03001163","article-title":"Conditional and unconditional components of postshock freezing","volume":"15","author":"Fanselow","year":"1980","journal-title":"Pavlov J Biol Sci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biopsych.2004.03.010","article-title":"Central type benzodiazepine receptors in Gulf War veterans with posttraumatic stress disorder","volume":"56","author":"Fujita","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0893-133X(95)00078-R","article-title":"Altered platelet peripheral type benzodiazepine receptor in posttraumatic stress disorder","volume":"14","author":"Gavish","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0080","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0306-4530(03)00085-4","article-title":"Exposure to retrieval cues improves retention performance and induces changes in ACTH and corticosterone release","volume":"29","author":"Gisquet-Verrier","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0085","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3758\/BF03196029","article-title":"Light stimulus change evokes an activity response in the rat","volume":"32","author":"Godsil","year":"2004","journal-title":"Learn Behav"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1520-6394(1998)7:3<105::AID-DA2>3.0.CO;2-A","article-title":"Simple phobia as a comorbid anxiety disorder","volume":"7","author":"Goisman","year":"1998","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0095","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0091-3057(02)00722-0","article-title":"Rapid anxiolytic activity of progesterone and pregnanolone in male rats","volume":"72","author":"Gomez","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0100","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.genhosppsych.2011.06.005","article-title":"Prevalence and features of panic disorder and comparison to posttraumatic stress disorder in VA primary care","volume":"33","author":"Gros","year":"2011","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0105","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/jts.20284","article-title":"Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery","volume":"20","author":"Hopper","year":"2007","journal-title":"J Trauma Stress"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0110","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature05324","article-title":"Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites","volume":"444","author":"Hosie","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0115","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/archpsyc.1995.03950240066012","article-title":"Post-traumatic stress disorder in the National Comorbidity Survey","volume":"52","author":"Kessler","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0120","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pbb.2007.12.006","article-title":"Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice","volume":"89","author":"Kita","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0125","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.bjp.0705681","article-title":"Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand","volume":"142","author":"Kita","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0130","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.pnpbp.2009.05.018","article-title":"Lack of tolerance to anxiolysis and withdrawal symptoms in mice repeatedly treated with AC-5216, a selective TSPO ligand","volume":"33","author":"Kita","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0135","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0165-6147(00)89058-6","article-title":"Neurosteroids and GABAA receptor function","volume":"16","author":"Lambert","year":"1995","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0140","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pbb.2006.08.015","article-title":"The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder","volume":"85","author":"Li","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0145","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/npp.2009.66","article-title":"Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus","volume":"34","author":"Li","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0150","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1523\/JNEUROSCI.5236-10.2011","article-title":"Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling","volume":"31","author":"Li","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0166-4328(97)00198-8","article-title":"Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour","volume":"94","author":"Liebsch","year":"1998","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1037\/0097-7403.16.2.137","article-title":"Role of fear in mediating shuttle escape learning deficit produced by inescapable shock","volume":"16","author":"Maier","year":"1990","journal-title":"J Exp Psychol Anim Behav Process"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0165","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0091-3057(94)90197-X","article-title":"Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze","volume":"48","author":"Melchior","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2005.07.005","article-title":"Posttraumatic stress disorder: a state-of-the-science review","volume":"40","author":"Nemeroff","year":"2006","journal-title":"J Psychiatr Res"},{"issue":"73","key":"10.1016\/j.pnpbp.2013.04.010_bb0175","article-title":"Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression","volume":"2","author":"Nin","year":"2011","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0180","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2826.2011.02166.x","article-title":"Translocator protein (18kDa) as a target for novel anxiolytics with a favourable side-effect profile","volume":"24","author":"Nothdurfter","year":"2011","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0185","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tips.2006.06.005","article-title":"Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function","volume":"27","author":"Papadopoulos","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0190","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0006-8993(99)01381-5","article-title":"Sulfated and unsulfated steroids modulate gamma-aminobutyric acid A receptor function through distinct sites","volume":"830","author":"Park-Chung","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0195","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1073\/pnas.0801853105","article-title":"Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: a model relevant for posttraumatic stress disorder","volume":"105","author":"Pibiri","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0200","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2826.2011.02234.x","article-title":"Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder","volume":"24","author":"Pinna","year":"2012","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0205","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1073\/pnas.0600329103","article-title":"Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation","volume":"103","author":"Pinna","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0210","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00213-005-0213-2","article-title":"Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake","volume":"186","author":"Pinna","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0215","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coph.2008.12.006","article-title":"SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake","volume":"9","author":"Pinna","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0220","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0006-3223(95)00088-7","article-title":"A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders","volume":"39","author":"Pynoos","year":"1996","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0225","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.biopsych.2006.03.026","article-title":"Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder","volume":"60","author":"Rasmusson","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0230","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.neubiorev.2005.04.010","article-title":"Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder","volume":"29","author":"Rau","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0235","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.brainres.2009.03.037","article-title":"Pharmacotherapy of PTSD: premises, principles, and priorities","volume":"1293","author":"Ravindran","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0240","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-1781(98)00030-4","article-title":"Acute and long-term behavioral correlates of underwater trauma\u2014potential relevance to stress and post-stress syndromes","volume":"79","author":"Richter-Levin","year":"1998","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0245","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1037\/0033-295X.105.2.325","article-title":"From normal fear to pathological anxiety","volume":"105","author":"Rosen","year":"1998","journal-title":"Psychol Rev"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0250","doi-asserted-by":"crossref","first-page":"11054","DOI":"10.1523\/JNEUROSCI.23-35-11054.2003","article-title":"The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli","volume":"23","author":"Rosenkranz","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0255","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1175055","article-title":"Translocator protein (18kD) as target for anxiolytics without benzodiazepine-like side effects","volume":"325","author":"Rupprecht","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0260","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nrd3295","article-title":"Translocator protein (18kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders","volume":"9","author":"Rupprecht","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0265","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jpsychires.2006.07.017","article-title":"A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear","volume":"41","author":"Siegmund","year":"2007","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0270","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF00432023","article-title":"The staircase test in mice: a simple and efficient procedure for primary screening of anxiolytic agents","volume":"84","author":"Simiand","year":"1984","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0275","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0166-4328(05)80066-X","article-title":"Sex-dependent effects of aversive stimulation on holeboard and elevated plus-maze behavior","volume":"43","author":"Steetnbergen","year":"1991","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0280","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00213-006-0545-6","article-title":"Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats","volume":"189","author":"Takahashi","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0285","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1124\/pr.109.002063","article-title":"Regulation of GABA(A) receptor subunit expression by pharmacological agents","volume":"62","author":"Uusi-Oukari","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0290","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.pnpbp.2009.07.031","article-title":"Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats","volume":"33","author":"Wang","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0295","first-page":"5","article-title":"Posttraumatic stress disorder: diagnostic and epidemiological perspectives","volume":"14","author":"Wittchen","year":"2009","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0300","article-title":"Antidepressant-like effects of 071031B, a novel serotonin and norepinephrine reuptake inhibitor","author":"Xue","year":"2012","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.04.010_bb0305","first-page":"623753","article-title":"Anxiolytic effects of flavonoids in animal models of post-traumatic stress disorder","volume":"2012","author":"Zhang","year":"2012"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613000766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613000766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T12:18:20Z","timestamp":1644841100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584613000766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":61,"alternative-id":["S0278584613000766"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.04.010","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}