{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:08:03Z","timestamp":1771034883257,"version":"3.50.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry for Health & Welfare, Republic of Korea","award":["A101915"],"award-info":[{"award-number":["A101915"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.pnpbp.2013.04.018","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T21:06:24Z","timestamp":1367528784000},"page":"73-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Intracerebroventricular administration of ouabain, a Na\/K-ATPase inhibitor, activates mTOR signal pathways and protein translation in the rat frontal cortex"],"prefix":"10.1016","volume":"45","author":[{"given":"Se Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Sook","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Geun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyooseob","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Young","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Min","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2013.04.018_bb0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2796.2006.01745.x","article-title":"New roles for an old enzyme: Na, K-ATPase emerges as an interesting drug target","volume":"261","author":"Aperia","year":"2007","journal-title":"J Intern Med"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0015","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11064-005-2684-2","article-title":"Modulation of aspartate release by ascorbic acid and endobain E, an endogenous Na+, K+-ATPase inhibitor","volume":"30","author":"Bersier","year":"2005","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0020","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11064-007-9412-z","article-title":"The expression of NMDA receptor subunits in cerebral cortex and hippocampus is differentially increased by administration of endobain E, a Na+, K+-ATPase inhibitor","volume":"33","author":"Bersier","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0025","doi-asserted-by":"crossref","first-page":"14296","DOI":"10.1523\/JNEUROSCI.2890-11.2011","article-title":"Alterations of molecular and behavioral responses to cocaine by selective inhibition of Elk-1 phosphorylation","volume":"31","author":"Besnard","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0030","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/jcp.21049","article-title":"MEK\/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells","volume":"212","author":"Bessard","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0035","doi-asserted-by":"crossref","first-page":"8911","DOI":"10.1523\/JNEUROSCI.22-20-08911.2002","article-title":"Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation","volume":"22","author":"Brami-Cherrier","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0006-8993(92)90982-F","article-title":"Inhibition of alpha 2\/alpha 3 sodium pump isoforms potentiates glutamate neurotoxicity","volume":"591","author":"Brines","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pnpbp.2012.03.005","article-title":"Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain","volume":"38","author":"Bruning","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"Pt 2","key":"10.1016\/j.pnpbp.2013.04.018_bb0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj3020335","article-title":"Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat","volume":"302","author":"Burda","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0055","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.bbamcr.2008.08.011","article-title":"ERK and p38 pathways regulate amino acid signalling","volume":"1783","author":"Casas-Terradellas","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0060","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1074\/jbc.M003390200","article-title":"N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures","volume":"276","author":"Chandler","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0065","doi-asserted-by":"crossref","first-page":"25485","DOI":"10.1074\/jbc.M501707200","article-title":"Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase","volume":"280","author":"Chiang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0070","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0306-9877(93)90089-9","article-title":"Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar illness","volume":"41","author":"Christo","year":"1993","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0075","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1158\/0008-5472.CAN-08-3014","article-title":"TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2","volume":"69","author":"Copp","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0080","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/BF00966123","article-title":"Preparation of a cell-free extract from rat brain which can initiate protein synthesis in vitro","volume":"11","author":"Cosgrove","year":"1986","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0085","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuron.2008.10.055","article-title":"Translational control of long-lasting synaptic plasticity and memory","volume":"61","author":"Costa-Mattioli","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0090","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1046\/j.1471-4159.1995.64052097.x","article-title":"Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain","volume":"64","author":"Cousin","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphar.2012.00013","article-title":"An emerging role for the Mammalian target of rapamycin in \u201cpathological\u201d protein translation: relevance to cocaine addiction","volume":"3","author":"Dayas","year":"2012","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2011.08.044","article-title":"Signaling pathways underlying the rapid antidepressant actions of ketamine","volume":"62","author":"Duman","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0115","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0278-5846(95)00123-D","article-title":"An animal model for mania: preliminary results","volume":"19","author":"El-Mallakh","year":"1995","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0110","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1034\/j.1399-5618.2003.00053.x","article-title":"Intracerebroventricular administration of ouabain as a model of mania in rats","volume":"5","author":"El-Mallakh","year":"2003","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0105","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.pnpbp.2006.04.003","article-title":"Efficacy of olanzapine and haloperidol in an animal model of mania","volume":"30","author":"El-Mallakh","year":"2006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00964332","article-title":"A simple reproducible cell-free system for measuring brain protein synthesis","volume":"5","author":"Fando","year":"1980","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00702-009-0337-3","article-title":"Evaluation of brain creatine kinase activity in an animal model of mania induced by ouabain","volume":"117","author":"Freitas","year":"2010","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0130","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.biopsych.2005.12.021","article-title":"Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders","volume":"60","author":"Goldstein","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0135","doi-asserted-by":"crossref","first-page":"18802","DOI":"10.1074\/jbc.M512524200","article-title":"Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons","volume":"281","author":"Gong","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0140","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.pnpbp.2009.06.002","article-title":"Effect of ouabain on sodium pump alpha-isoform expression in an animal model of mania","volume":"33","author":"Hamid","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0145","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.neubiorev.2007.04.001","article-title":"Mimicking human bipolar ion dysregulation models mania in rats","volume":"31","author":"Herman","year":"2007","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1385\/MN:34:3:205","article-title":"The growing role of mTOR in neuronal development and plasticity","volume":"34","author":"Jaworski","year":"2006","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0155","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.pnpbp.2011.05.010","article-title":"The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder","volume":"35","author":"Jernigan","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0160","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jpsychires.2009.11.002","article-title":"Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain","volume":"44","author":"Jornada","year":"2010","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuron.2004.09.013","article-title":"Translational regulatory mechanisms in persistent forms of synaptic plasticity","volume":"44","author":"Kelleher","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0175","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.pnpbp.2008.05.027","article-title":"Dose-dependent effect of intracerebroventricular injection of ouabain on the phosphorylation of the MEK1\/2-ERK1\/2-p90RSK pathway in the rat brain related to locomotor activity","volume":"32","author":"Kim","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0170","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1017\/S1461145709991192","article-title":"Effects of neonatal MK-801 treatment on p70S6K\u2013S6\/eIF4B signal pathways and protein translation in the frontal cortex of the developing rat brain","volume":"13","author":"Kim","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0180","doi-asserted-by":"crossref","first-page":"18144","DOI":"10.1073\/pnas.1108416108","article-title":"Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+, K+-ATPase alpha3 sodium pump","volume":"108","author":"Kirshenbaum","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0185","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1021\/bi00388a057","article-title":"Characterization of interaction between DNA and 4\u2032,6-diamidino-2-phenylindole by optical spectroscopy","volume":"26","author":"Kubista","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0190","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0006-291X(02)00238-3","article-title":"Molecular crosstalk between p70S6k and MAPK cell signaling pathways","volume":"293","author":"Lehman","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02815161","article-title":"Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression","volume":"31","author":"Li","year":"1997","journal-title":"Mol Chem Neuropathol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0195","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0205","doi-asserted-by":"crossref","first-page":"C1489","DOI":"10.1152\/ajpcell.00158.2007","article-title":"Association of PI3K\u2013Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes","volume":"293","author":"Liu","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0210","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.nbd.2011.12.037","article-title":"Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome","volume":"45","author":"Liu","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0215","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1520-6394(1997)5:2<53::AID-DA1>3.0.CO;2-6","article-title":"Meta-analysis of erythrocyte Na, K-ATPase activity in bipolar illness","volume":"5","author":"Looney","year":"1997","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1937-6448(08)00801-0","article-title":"Physiological roles of ribosomal protein S6: one of its kind","volume":"268","author":"Meyuhas","year":"2008","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0225","doi-asserted-by":"crossref","first-page":"42628","DOI":"10.1074\/jbc.M405173200","article-title":"In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids","volume":"279","author":"Mothe-Satney","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","article-title":"NeuN, a neuronal specific nuclear protein in vertebrates","volume":"116","author":"Mullen","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0235","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-3223(97)00343-0","article-title":"Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3)","volume":"44","author":"Mynett-Johnson","year":"1998","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0240","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/j.lfs.2007.03.013","article-title":"The digitalis-like steroid hormones: new mechanisms of action and biological significance","volume":"80","author":"Nesher","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0245","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1007\/s11064-010-0274-4","article-title":"Cardiac glycosides ouabain and digoxin interfere with the regulation of glutamate transporter GLAST in astrocytes cultured from neonatal rat brain","volume":"35","author":"Nguyen","year":"2010","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0250","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1749-6632.1999.tb11320.x","article-title":"Expression mechanisms underlying NMDA receptor-dependent long-term potentiation","volume":"868","author":"Nicoll","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1990.tb19087.x","article-title":"Translational dynamics. Interactions between the translational factors, tRNA and ribosomes during eukaryotic protein synthesis","volume":"191","author":"Nygard","year":"1990","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0260","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.molmed.2004.10.009","article-title":"Cooperative translational control of gene expression by Ras and Akt in cancer","volume":"10","author":"Parsa","year":"2004","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0265","series-title":"The rat brain in stereotactic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0270","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/MCB.24.8.3112-3124.2004","article-title":"S6K1(\u2212\/\u2212)\/S6K2(\u2212\/\u2212) mice exhibit perinatal lethality and rapamycin-sensitive 5\u2032-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway","volume":"24","author":"Pende","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0275","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1471-4159.2008.05632.x","article-title":"Cocaine regulates protein kinase B and glycogen synthase kinase-3 activity in selective regions of rat brain","volume":"107","author":"Perrine","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0280","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1074\/jbc.275.10.7416","article-title":"FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions","volume":"275","author":"Peterson","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0285","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BJ20070024","article-title":"Signalling to translation: how signal transduction pathways control the protein synthetic machinery","volume":"403","author":"Proud","year":"2007","journal-title":"Biochem J"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0290","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0014-5793(97)00323-2","article-title":"The modular phosphorylation and activation of p70s6k","volume":"410","author":"Pullen","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0295","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/sj.emboj.7600193","article-title":"Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases","volume":"23","author":"Raught","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0300","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neuint.2009.05.003","article-title":"Animal model of mania induced by ouabain: evidence of oxidative stress in submitochondrial particles of the rat brain","volume":"55","author":"Riegel","year":"2009","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0305","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijdevneu.2010.02.002","article-title":"Intracerebroventricular ouabain administration induces oxidative stress in the rat brain","volume":"28","author":"Riegel","year":"2010","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0310","doi-asserted-by":"crossref","first-page":"30914","DOI":"10.1074\/jbc.M100157200","article-title":"Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F","volume":"276","author":"Rogers","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0315","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0006-3223(97)00440-X","article-title":"Alpha 2 isoform of the Na, K-adenosine triphosphatase is reduced in temporal cortex of bipolar individuals","volume":"44","author":"Rose","year":"1998","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0320","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1523\/JNEUROSCI.1081-09.2009","article-title":"Glutamate transporter coupling to Na, K-ATPase","volume":"29","author":"Rose","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0325","doi-asserted-by":"crossref","first-page":"14056","DOI":"10.1074\/jbc.M700906200","article-title":"RAS\/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation","volume":"282","author":"Roux","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0330","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1038\/sj.onc.1209098","article-title":"The Akt of translational control","volume":"24","author":"Ruggero","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0335","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0031-9384(97)00457-5","article-title":"Persistent hyperactivity following a single intracerebroventricular dose of ouabain","volume":"63","author":"Ruktanonchai","year":"1998","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0340","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tibs.2006.04.003","article-title":"Ribosomal protein S6 phosphorylation: from protein synthesis to cell size","volume":"31","author":"Ruvinsky","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0345","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1101\/gad.351605","article-title":"Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis","volume":"19","author":"Ruvinsky","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0350","first-page":"3504","article-title":"A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells","volume":"60","author":"Sekulic","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0355","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-5793(99)00922-9","article-title":"Short-term block of Na+\/K+-ATPase in neuro-glial cell cultures of cerebellum induces glutamate dependent damage of granule cells","volume":"456","author":"Stelmashook","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0360","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1046\/j.1471-4159.2002.01031.x","article-title":"Activity-dependent NMDA receptor-mediated activation of protein kinase B\/Akt in cortical neuronal cultures","volume":"82","author":"Sutton","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0365","doi-asserted-by":"crossref","first-page":"14921","DOI":"10.1074\/jbc.M808355200","article-title":"Changes in sodium pump expression dictate the effects of ouabain on cell growth","volume":"284","author":"Tian","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0370","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1515\/JBCPP.2000.11.4.375","article-title":"The mood cycle hypothesis: possible involvement of steroid hormones in mood regulation by means of Na+, K+-ATPase inhibition","volume":"11","author":"Traub","year":"2000","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0375","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1111\/j.1460-9568.2004.03278.x","article-title":"Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain","volume":"19","author":"Valjent","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0380","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1128\/MCB.23.5.1546-1557.2003","article-title":"The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation","volume":"23","author":"Wang","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0385","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroscience.2010.10.041","article-title":"Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization","volume":"172","author":"Wu","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0390","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mi.3.3.157","article-title":"Na+\u2013K+-ATPase-mediated signal transduction: from protein interaction to cellular function","volume":"3","author":"Xie","year":"2003","journal-title":"Mol Interv"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0395","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.pnpbp.2010.04.010","article-title":"Activation of Akt signaling in rat brain by intracerebroventricular injection of ouabain: a rat model for mania","volume":"34","author":"Yu","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0400","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.neuint.2011.08.011","article-title":"Intracerebroventricular administration of ouabain, a Na\/K-ATPase inhibitor, activates tyrosine hydroxylase through extracellular signal-regulated kinase in rat striatum","volume":"59","author":"Yu","year":"2011","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pnpbp.2013.04.018_bb0405","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1472-8206.2011.00947.x","article-title":"Na(+)\/K(+)-ATPase inhibition upregulates NMDA-evoked currents in rat hippocampal CA1 pyramidal neurons","volume":"26","author":"Zhang","year":"2012","journal-title":"Fundam Clin Pharmacol"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613000845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613000845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T21:38:58Z","timestamp":1644961138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584613000845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":81,"alternative-id":["S0278584613000845"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.04.018","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracerebroventricular administration of ouabain, a Na\/K-ATPase inhibitor, activates mTOR signal pathways and protein translation in the rat frontal cortex","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}