{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:45:27Z","timestamp":1793281527755,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.pnpbp.2013.07.024","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T22:46:01Z","timestamp":1376433961000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["Perceptual and cognitive effects of antipsychotics in first-episode schizophrenia: The potential impact of GABA concentration in the visual cortex"],"prefix":"10.1016","volume":"47","author":[{"given":"Oguz","family":"Kelemen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Benedek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"K\u00e9ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2013.07.024_bb0005","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1167\/iovs.04-0188","article-title":"Contrast sensitivity deficits in inferred magnocellular and parvocellular pathways in retinitis pigmentosa","volume":"45","author":"Alexander","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0010","first-page":"679","article-title":"A szenzoros g\u00e1tl\u00e1si folyamatok zavara szkizofr\u00e9ni\u00e1ban I. A magnocellul\u00e1ris p\u00e1lya szelekt\u00edv hiperaktivit\u00e1sa","volume":"13","author":"Antal","year":"1998","journal-title":"Psychiatr Hung"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0022-3956(96)00044-1","article-title":"The role of stress and dopamine-GABA interactions in the vulnerability for schizophrenia","volume":"31","author":"Benes","year":"1997","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0020","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0166-2236(90)90113-O","article-title":"Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients","volume":"13","author":"Bodis-Wollner","year":"1990","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/jnnp.52.3.341","article-title":"Visual contrast sensitivity in drug-induced Parkinsonism","volume":"52","author":"Bulens","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/oxfordjournals.schbul.a033402","article-title":"Structured interview for assessing perceptual anomalies (SIAPA)","volume":"25","author":"Bunney","year":"1999","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biopsych.2008.03.023","article-title":"Visual perception and its impairment in schizophrenia","volume":"64","author":"Butler","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0045","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/schbul\/sbr020","article-title":"Abnormal visual motion processing in schizophrenia: a review of research progress","volume":"37","author":"Chen","year":"2011","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0040","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1176\/appi.ajp.160.10.1795","article-title":"Effects of typical, atypical, and no antipsychotic drugs on visual contrast detection in schizophrenia","volume":"160","author":"Chen","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0050","series-title":"Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV)","author":"First","year":"1996"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0055","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/223578a0","article-title":"The Moire effect from random dots","volume":"223","author":"Glass","year":"1969","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0060","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1176\/ajp.156.12.1944","article-title":"Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia I: sensitivity, reliability, and validity","volume":"156","author":"Gold","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0065","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/schbul\/sbs010","article-title":"NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia","volume":"38","author":"Gonzalez-Burgos","year":"2012","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0070","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1098\/rspb.2012.1430","article-title":"Do different \u2018magnocellular tasks\u2019 probe the same neural substrate?","volume":"279","author":"Goodbourn","year":"2012","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0075","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.pnpbp.2010.08.007","article-title":"No alterations of brain GABA after 6months of treatment with atypical antipsychotic drugs in early-stage first-episode schizophrenia","volume":"34","author":"Goto","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0080","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1001\/archpsyc.1994.03950120017004","article-title":"Backward masking in schizophrenia and mania. II. Specifying the visual channels","volume":"51","author":"Green","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0085","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/eye.1990.127","article-title":"The influence of dopamine on spatial vision","volume":"4","author":"Harris","year":"1990","journal-title":"Eye"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0090","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev.clinpsy.032408.153502","article-title":"When doors of perception close: bottom-up models of disrupted cognition in schizophrenia","volume":"5","author":"Javitt","year":"2009","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0095","first-page":"303","article-title":"The use of RBANS test (repeatable battery for the assessment of neuropsychological status) in neurocognitive testing of patients suffering from schizophrenia and dementia","volume":"56","author":"Juh\u00e1sz","year":"2003","journal-title":"Ideggyogy Sz"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0100","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0105","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archgenpsychiatry.2011.1519","article-title":"Elevated prefrontal cortex \u03b3-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy","volume":"69","author":"Kegeles","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0125","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0952523807070253","article-title":"Visual contrast sensitivity alterations in inferred magnocellular pathways and anomalous perceptual experiences in people at high-risk for psychosis","volume":"24","author":"K\u00e9ri","year":"2007","journal-title":"Vis Neurosci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0135","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroscience.2012.01.005","article-title":"Why is vision impaired in fragile X premutation carriers? The role of fragile X mental retardation protein and potential FMR1 mRNA toxicity","volume":"206","author":"K\u00e9ri","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0110","first-page":"393","article-title":"A szenzoros g\u00e1tl\u00e1si folyamatok zavara szkizofr\u00e9ni\u00e1ban II. Kapcsolat a figyelemdeficittel","volume":"14","author":"K\u00e9ri","year":"1999","journal-title":"Psychiatr Hung"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1176\/appi.neuropsych.14.2.190","article-title":"Spatiotemporal visual processing in schizophrenia","volume":"14","author":"K\u00e9ri","year":"2002","journal-title":"J Neuropsychiatr Clin Neurosci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0120","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1017\/S0033291705005398","article-title":"Anomalous visual experiences, negative symptoms, perceptual organization and the magnocellular pathway in schizophrenia: a shared construct?","volume":"35","author":"K\u00e9ri","year":"2005","journal-title":"Psychol Med"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1176\/appi.ajp.2009.09050723","article-title":"Suppression of the P50 evoked response and neuregulin 1-induced AKT phosphorylation in first-episode schizophrenia","volume":"167","author":"K\u00e9ri","year":"2010","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0140","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1037\/a0019610","article-title":"When doors of perception open: visual contrast sensitivity in never-medicated, first-episode schizophrenia","volume":"119","author":"Kiss","year":"2010","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0145","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/archpsyc.58.2.158","article-title":"Diagnosing schizophrenia in the initial prodromal phase","volume":"58","author":"Klosterk\u00f6tter","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0150","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0042-6989(03)00333-X","article-title":"Spatial frequency processing in inferred PC- and MC-pathways","volume":"43","author":"Leonova","year":"2003","journal-title":"Vision Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.psychres.2009.03.033","article-title":"Perceptual\/attentional anomalies in schizophrenia: a family study","volume":"176","author":"Mart\u00edn-Reyes","year":"2010","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0155","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1167\/iovs.05-1549","article-title":"Vernier acuity is normal in migraine, whereas global form and global motion perception are not","volume":"47","author":"McKendrick","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0165","first-page":"15","article-title":"Scale for assessing perceptual anomalies. Validation of a Spanish version of the SIAPA scale in a sample of Cuban schizophrenic patients","volume":"35","author":"Mendoza Qui\u00f1ones","year":"2007","journal-title":"Actas Esp Psiquiatr"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0170","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.ne.16.030193.002101","article-title":"How parallel are the primate visual pathways?","volume":"16","author":"Merigan","year":"1993","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0175","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J","article-title":"Simultaneous in vivo spectral editing and water suppression","volume":"11","author":"Mescher","year":"1998","journal-title":"NMR Biomed"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0180","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrn2619","article-title":"Parallel processing strategies of the primate visual system","volume":"10","author":"Nassi","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0185","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2010.05.016","article-title":"Elevated gamma-aminobutyric acid levels in chronic schizophrenia","volume":"68","author":"Ong\u00fcr","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0190","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1017\/S0033291700005092","article-title":"Perceptual changes in schizophrenia: a questionnaire survey","volume":"15","author":"Phillipson","year":"1985","journal-title":"Psychol Med"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/11.5.7","article-title":"Review: steady and pulsed pedestals, the how and why of post-receptoral pathway separation","volume":"11","author":"Pokorny","year":"2011","journal-title":"J Vis"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0195","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1364\/JOSAA.14.002477","article-title":"Psychophysical signatures associated with magnocellular and parvocellular pathway contrast gain","volume":"14","author":"Pokorny","year":"1997","journal-title":"J Opt Soc Am A Opt Image Sci Vis"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0205","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1076\/jcen.20.3.310.823","article-title":"The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity","volume":"20","author":"Randolph","year":"1998","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0210","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fnhum.2011.00127","article-title":"Broader visual orientation tuning in patients with schizophrenia","volume":"5","author":"Rokem","year":"2011","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0215","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1016\/j.visres.2007.07.016","article-title":"Contrast sensitivity and magnocellular functioning in schizophrenia","volume":"47","author":"Skottun","year":"2007","journal-title":"Vision Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0220","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/schbul\/sbq114","article-title":"On identifying magnocellular and parvocellular responses on the basis of contrast-response functions","volume":"37","author":"Skottun","year":"2011","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0225","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1037\/0021-843X.107.1.49","article-title":"Contrast sensitivity for stationary and drifting spatial frequency gratings in positive- and negative-symptom schizophrenia","volume":"107","author":"Slaghuis","year":"1998","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0230","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jpsychires.2011.12.005","article-title":"Hippocampal volume and the AKT signaling system in first-episode schizophrenia","volume":"46","author":"Szamosi","year":"2012","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0235","first-page":"414","article-title":"Proton magnetic resonance spectroscopy changes after antipsychotic treatment","volume":"20","author":"Szulc","year":"2013","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.schres.2009.11.011","article-title":"GABA concentration in schizophrenia patients and the effects of antipsychotic medication: a proton magnetic resonance spectroscopy study","volume":"117","author":"Tayoshi","year":"2010","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0245","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0042-6989(95)00016-X","article-title":"Adaptive psychophysical procedures","volume":"35","author":"Treutwein","year":"1995","journal-title":"Vision Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0250","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1017\/S146114570500516X","article-title":"A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia","volume":"8","author":"Woodward","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0255","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.schres.2006.08.021","article-title":"A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects","volume":"89","author":"Woodward","year":"2007","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pnpbp.2013.07.024_bb0260","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1523\/JNEUROSCI.6158-09.2010","article-title":"GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression","volume":"30","author":"Yoon","year":"2010","journal-title":"J Neurosci"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613001668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613001668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T13:26:07Z","timestamp":1715865967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584613001668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":52,"alternative-id":["S0278584613001668"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.07.024","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perceptual and cognitive effects of antipsychotics in first-episode schizophrenia: The potential impact of GABA concentration in the visual cortex","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}