{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:59:21Z","timestamp":1792799961347,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.pnpbp.2013.11.003","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T05:46:42Z","timestamp":1384494402000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Ketamine reverses stress-induced depression-like behavior and increased GABA levels in the anterior cingulate: An 11.7T 1H-MRS study in rats"],"prefix":"10.1016","volume":"51","author":[{"given":"Shane A.","family":"Perrine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Ghoddoussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Michaels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-5898","authenticated-orcid":false,"given":"Imran S.","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"McKelvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Galloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2013.11.003_bb0005","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S1516-44462009000300010","article-title":"Effect of acute administration of ketamine and imipramine on creatine kinase activity in the brain of rats","volume":"31","author":"Assis","year":"2009","journal-title":"Rev Bras Psiquiatr"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0020","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/187152707783220929","article-title":"Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment","volume":"6","author":"Banasr","year":"2007","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0025","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.biopsych.2008.06.008","article-title":"Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors","volume":"64","author":"Banasr","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/mp.2008.106","article-title":"Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole","volume":"15","author":"Banasr","year":"2010","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients","volume":"47","author":"Berman","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0035","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.biopsych.2006.08.048","article-title":"Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects","volume":"61","author":"Bhagwagar","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S1461145707007924","article-title":"Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients","volume":"11","author":"Bhagwagar","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archpsyc.58.6.545","article-title":"Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder","volume":"58","author":"Cotter","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0050","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2011.01.038","article-title":"Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat","volume":"220","author":"Cox","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0055","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.psyneuen.2009.10.001","article-title":"Serotonin 2 receptor modulation of hyperthermia, corticosterone, and hippocampal serotonin depletions following serial exposure to chronic stress and methamphetamine","volume":"35","author":"Doyle","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0060","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1017\/S1092852900013754","article-title":"The subgenual anterior cingulate cortex in mood disorders","volume":"13","author":"Drevets","year":"2008","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2011.08.044","article-title":"Signaling pathways underlying the rapid antidepressant actions of ketamine","volume":"62","author":"Duman","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0075","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1742-7843.2008.00210.x","article-title":"Chronic administration of ketamine elicits antidepressant-like effects in rats without affecting hippocampal brain-derived neurotrophic factor protein levels","volume":"103","author":"Garcia","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0080","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pnpbp.2007.07.027","article-title":"Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus","volume":"32","author":"Garcia","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0085","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.pnpbp.2009.01.004","article-title":"Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats","volume":"33","author":"Garcia","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biopsych.2009.02.027","article-title":"Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1","volume":"66","author":"Garcia-Garcia","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0090","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/0269881109104845","article-title":"NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test","volume":"24","author":"Ghasemi","year":"2010","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2009.11.013","article-title":"Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS","volume":"290","author":"Ghoddoussi","year":"2010","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0100","first-page":"33","article-title":"The role of glutamate on the action of antidepressants","volume":"11","author":"Hashimoto","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archpsyc.64.2.193","article-title":"Reduced prefrontal glutamate\/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy","volume":"64","author":"Hasler","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbr.2012.03.011","article-title":"Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7T","volume":"232","author":"Hemanth Kumar","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0115","doi-asserted-by":"crossref","first-page":"11496","DOI":"10.1523\/JNEUROSCI.2213-07.2007","article-title":"NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons","volume":"27","author":"Homayoun","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jneumeth.2007.05.022","article-title":"Variation of the choline signal intensity in the dorsolateral prefrontal cortex of rats exposed to the forced swimming test as detected by in vivo 1H MR spectroscopy","volume":"165","author":"Hong","year":"2007","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0125","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1259\/bjr\/25165760","article-title":"Specific hippocampal choline decrease in an animal model of depression","volume":"82","author":"Hong","year":"2009","journal-title":"Br J Radiol"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0130","series-title":"Guide for the care and use of laboratory animals","author":"Institute of Laboratory Animal Resources (U.S.)","year":"1996"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0135","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.neuroscience.2009.01.067","article-title":"Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: the role of corticosterone","volume":"159","author":"Johnson","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0140","first-page":"168","article-title":"Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative","volume":"6","author":"Kessler","year":"2007","journal-title":"World Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0145","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2010.05.052","article-title":"Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex","volume":"480","author":"Knox","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0150","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression","volume":"224","author":"Koike","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0155","first-page":"215","article-title":"Ketamine and the potential role for rapid-acting antidepressant medications","volume":"137","author":"Krystal","year":"2007","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0160","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1007\/s11064-008-9739-0","article-title":"Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy","volume":"33","author":"Li","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0165","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0170","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","article-title":"Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure","volume":"69","author":"Li","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0175","doi-asserted-by":"crossref","first-page":"e56053","DOI":"10.1371\/journal.pone.0056053","article-title":"Long-lasting antidepressant action of ketamine, but not glycogen synthase kinase-3 inhibitor SB216763, in the chronic mild stress model of mice","volume":"8","author":"Ma","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0180","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.4088\/JCP.08m04659","article-title":"Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist","volume":"70","author":"Machado-Vieira","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0185","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11920-007-0063-1","article-title":"The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects","volume":"9","author":"Maeng","year":"2007","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0190","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0195","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1590\/S1516-44462005000300016","article-title":"Glutamate modulators as novel interventions for mood disorders","volume":"27","author":"Mathew","year":"2005","journal-title":"Rev Bras Psiquiatr"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0200","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/sj.npp.1301652","article-title":"Novel drugs and therapeutic targets for severe mood disorders","volume":"33","author":"Mathew","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.pnpbp.2013.11.003_bb0205","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.biopsych.2012.09.006","article-title":"The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine","volume":"73","author":"Monteggia","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0210","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ntt.2007.03.062","article-title":"Region-dependent alterations in glutamate and GABA measured by high-resolution magnetic resonance spectroscopy following acute binge inhalation of toluene in juvenile rats","volume":"29","author":"O'Leary-Moore","year":"2007","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0215","doi-asserted-by":"crossref","first-page":"13290","DOI":"10.1073\/pnas.95.22.13290","article-title":"Glial reduction in the subgenual prefrontal cortex in mood disorders","volume":"95","author":"Ongur","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0220","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0893-133X(95)00152-4","article-title":"Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress","volume":"14","author":"Ortiz","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0225","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0245","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neuropharm.2007.10.007","article-title":"Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat","volume":"54","author":"Perrine","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0235","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/nbm.1352","article-title":"Cardiac effects of MDMA on the metabolic profile determined with 1H-magnetic resonance spectroscopy in the rat","volume":"22","author":"Perrine","year":"2009","journal-title":"NMR Biomed"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0230","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuro.2010.08.005","article-title":"MDMA administration decreases serotonin but not N-acetylaspartate in the rat brain","volume":"31","author":"Perrine","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0240","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.drugalcdep.2010.11.001","article-title":"Binge toluene exposure alters glutamate, glutamine and GABA in the adolescent rat brain as measured by proton magnetic resonance spectroscopy","volume":"115","author":"Perrine","year":"2011","journal-title":"Drug Alcohol Depend"},{"issue":"12","key":"10.1016\/j.pnpbp.2013.11.003_bb0250","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.biopsych.2013.01.021","article-title":"Glutamate-based antidepressants: preclinical psychopharmacology","volume":"73","author":"Pilc","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0255","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00213-008-1158-z","article-title":"Lack of persistent effects of ketamine in rodent models of depression","volume":"198","author":"Popik","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0260","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.biopsych.2008.10.025","article-title":"Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder","volume":"65","author":"Price","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0265","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0270","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0006-3223(99)00041-4","article-title":"Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression","volume":"45","author":"Rajkowska","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0275","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.brainresbull.2009.03.010","article-title":"Acute administration of ketamine reverses the inhibition of mitochondrial respiratory chain induced by chronic mild stress","volume":"79","author":"Rezin","year":"2009","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0280","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1017\/S1461145711001593","article-title":"An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression","volume":"15","author":"Salvadore","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0295","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/archpsyc.56.11.1043","article-title":"Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy","volume":"56","author":"Sanacora","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0305","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1176\/appi.ajp.159.4.663","article-title":"Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors","volume":"159","author":"Sanacora","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0300","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1176\/appi.ajp.160.3.577","article-title":"Increased cortical GABA concentrations in depressed patients receiving ECT","volume":"160","author":"Sanacora","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0290","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archpsyc.61.7.705","article-title":"Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression","volume":"61","author":"Sanacora","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0285","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.biopsych.2005.07.015","article-title":"Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy","volume":"59","author":"Sanacora","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0310","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1097\/WNR.0b013e3282742153","article-title":"Elevated spectroscopic glutamate\/gamma-amino butyric acid in rats bred for learned helplessness","volume":"18","author":"Sartorius","year":"2007","journal-title":"Neuroreport"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0315","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tips.2009.09.002","article-title":"Glutamate-based antidepressants: 20years on","volume":"30","author":"Skolnick","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0320","first-page":"68","article-title":"Evaluation of ketamine HCl for anti-depressant activity","volume":"214","author":"Sofia","year":"1975","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0325","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pscychresns.2010.10.009","article-title":"The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS","volume":"191","author":"Valentine","year":"2011","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0330","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0335","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural\u2013neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0340","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0149-7634(05)80194-0","article-title":"Chronic mild stress-induced anhedonia: a realistic animal model of depression","volume":"16","author":"Willner","year":"1992","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0345","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.neuroscience.2005.06.067","article-title":"In vivo evidence for reduced cortical glutamate\u2013glutamine cycling in rats treated with the antidepressant\/antipanic drug phenelzine","volume":"135","author":"Yang","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2005.12.004","article-title":"Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis","volume":"147","author":"Yildiz-Yesiloglu","year":"2006","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0355","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0091-3057(01)00693-1","article-title":"Prolonged effect of an anesthetic dose of ketamine on behavioral despair","volume":"71","author":"Yilmaz","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2013.11.003_bb0360","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch Gen Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613002467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613002467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T15:20:17Z","timestamp":1539184817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584613002467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":72,"alternative-id":["S0278584613002467"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.11.003","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketamine reverses stress-induced depression-like behavior and increased GABA levels in the anterior cingulate: An 11.7T 1H-MRS study in rats","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}