{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:22:34Z","timestamp":1789694554973,"version":"4.0.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,4]],"date-time":"2015-01-04T00:00:00Z","timestamp":1420329600000},"content-version":"vor","delay-in-days":278,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004809","name":"FINEP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005667","name":"FAPESC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAPES\/PROCAD"},{"name":"N\u00facleo de Excel\u00eancia em Neuroci\u00eancias Aplicadas de Santa Catarina (NENASC)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.pnpbp.2013.12.012","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T14:00:24Z","timestamp":1387893624000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice"],"prefix":"10.1016","volume":"50","author":[{"given":"Andiara E.","family":"Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis E.B.","family":"Bettio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian B.","family":"Neis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan\u00fabia B.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila B.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia S.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2013.12.012_bb0005","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/00207450490430543","article-title":"The effect of chronic restraint stress on spatial learning and memory: relation to oxidant stress","volume":"114","author":"Abidin","year":"2004","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0015","doi-asserted-by":"crossref","first-page":"893","DOI":"10.33549\/physiolres.931284","article-title":"The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress","volume":"57","author":"Akpinar","year":"2008","journal-title":"Physiol. Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0020","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0889-1591(02)00011-9","article-title":"Further evidence for the depressive effects of cytokines: anhedonia and neurochemical changes","volume":"16","author":"Anisman","year":"2002","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0025","doi-asserted-by":"crossref","first-page":"C1411","DOI":"10.1152\/ajpcell.00529.2008","article-title":"The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis","volume":"296","author":"Arndt","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2008.09.029","article-title":"Restraint stress-induced oxidative damage and its amelioration with selenium","volume":"600","author":"Atif","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0040","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00726-009-0402-0","article-title":"Agmatine prevents the Ca2+-dependent induction of permeability transition in rat brain mitochondria","volume":"38","author":"Battaglia","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-0327(00)00199-3","article-title":"Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments","volume":"64","author":"Bilici","year":"2001","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0050","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0891-5849(99)00173-2","article-title":"Tissue-specific functions of individual glutathione peroxidases","volume":"27","author":"Brigelius-Floh\u00e9","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0055","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuropharm.2007.10.016","article-title":"Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems","volume":"54","author":"Brocardo","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0060","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.expneurol.2012.10.024","article-title":"Folic acid prevents depressive-like behavior and hippocampal antioxidant imbalance induced by restraint stress in mice","volume":"240","author":"Budni","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0065","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.neubiorev.2009.05.004","article-title":"Restraint stress in biobehavioral research: recent developments","volume":"7","author":"Buynitsky","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0070","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","article-title":"Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0075","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1471-4159.2010.07085.x","article-title":"Agmatine effects on mitochondrial membrane potential and NF kappaB activation protect against rotenone-induced cell damage in human neuronal-like SH-SY5Y cells","volume":"116","author":"Condello","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0080","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd1825","article-title":"The ascent of mouse: advances in modeling human depression and anxiety","volume":"4","author":"Cryan","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0035","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s11064-010-0240-1","article-title":"Clomipramine treatment and repeated restraint stress alter parameters of oxidative stress in brain regions of male rats","volume":"35","author":"de Balk","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0085","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0891-5849(92)90150-F","article-title":"Metabolism of oxygen radicals in peroxisomes and cellular implications","volume":"13","author":"Del R\u00edo","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1191\/0748233706th264oa","article-title":"The effect of sulfite and chronic restraint stress on brain lipid peroxidation and anti-oxidant enzyme activities","volume":"22","author":"Derin","year":"2006","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0095","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1515\/BC.2003.059","article-title":"Glutathione pathways in the brain","volume":"384","author":"Dringen","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0100","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2007.11.031","article-title":"Impact of an acute exposure to ethanol on the oxidative stress status in the hippocampus of prenatal restraint stress adolescent male rats","volume":"1191","author":"Enache","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0110","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1211\/jpp.57.11.0017","article-title":"Protective effects of Polygala paniculata extract against methylmercury-induced neurotoxicity in mice","volume":"57","author":"Farina","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0115","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF01487101","article-title":"Glutathione peroxidase: enzymology and biological aspects","volume":"49","author":"Floh\u00e9","year":"1971","journal-title":"Klin. Wochenschr."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0120","doi-asserted-by":"crossref","DOI":"10.1046\/j.1525-1373.1999.d01-140.x","article-title":"Antioxidants, oxidative stress, and degenerative neurological disorders","volume":"222","author":"Floyd","year":"1999","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11064-004-9691-6","article-title":"Repeated restraint stress induces oxidative damage in rat hippocampus","volume":"30","author":"Fontella","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.psy.0000195780.37277.2a","article-title":"Increased serum levels of 8-hydroxy-2\u2032-deoxyguanosine in clinical depression","volume":"68","author":"Forlenza","year":"2006","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.pnpbp.2009.12.010","article-title":"Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system","volume":"34","author":"Freitas","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0145","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3109\/00207454.2012.693998","article-title":"Chronic immobilization in the malpar1knockout mice increases oxidative stress in the hippocampus","volume":"122","author":"Garc\u00eda-Fern\u00e1ndez","year":"2012","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0149-7634(94)90027-2","article-title":"Restraint stress in biomedical research: an update","volume":"18","author":"Glavin","year":"1994","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0155","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1056\/NEJM198808183190706","article-title":"Clinical and biochemical manifestations of depression: relation to the neurobiology of stress II","volume":"319","author":"Gold","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0140","first-page":"548","article-title":"Stress, aging, hypothalamic\u2013pituitary\u2013adrenal axis and reliability of antioxidant enzyme defence","volume":"21","author":"Goncharova","year":"2008","journal-title":"Adv. Gerontol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0160","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/BST0351147","article-title":"Biochemistry of oxidative stress","volume":"35","author":"Halliwell","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0165","series-title":"Free radicals in biology and medicine","author":"Halliwell","year":"1999"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0170","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/da.20571","article-title":"Chronic and acute stress and the prediction of major depression in women","volume":"26","author":"Hammen","year":"2009","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0175","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/978-1-4614-0653-2_21","article-title":"Oxidative stress in developmental brain disorders","volume":"724","author":"Hayashi","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0305","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/stem.5530120305","article-title":"Most free-radical injury is iron-related: it is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin","volume":"12","author":"Herbert","year":"1994","journal-title":"Stem Cells"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0310","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10072-011-0770-6","article-title":"A review on animal models for screening potential anti-stress agents","volume":"32","author":"Jaggi","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0315","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.psych.48.1.191","article-title":"The effects of stressful life events on depression","volume":"48","author":"Kessler","year":"1997","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0320","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1017\/S1121189X00000282","article-title":"Antidepressants and the placebo response","volume":"18","author":"Kirsch","year":"2009","journal-title":"Epidemiol. Psychiatr. Soc."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0325","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1096\/fj.00-0823hyp","article-title":"NAD(P)H, a directly operating antioxidant?","volume":"15","author":"Kirsch","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0330","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.clinbiochem.2009.06.006","article-title":"Antioxidative enzymes and increased oxidative stress in depressive women","volume":"42","author":"Kodydkov\u00e1","year":"2009","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0335","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.pnpbp.2011.03.021","article-title":"Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: a 24-week follow-up study","volume":"35","author":"Kotan","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0340","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/jmf.2006.0207","article-title":"Quercetin protects against acute immobilization stress-induced behaviors and biochemical alterations in mice","volume":"11","author":"Kumar","year":"2008","journal-title":"J. Med. Food"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0345","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2009.10.004","article-title":"Nitric oxide mechanism in protective effect of imipramine and venlafaxine against acute immobilization stress-induced behavioral and biochemical alteration in mice","volume":"467","author":"Kumar","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0350","first-page":"1131","article-title":"Possible role of NO modulators in protective effect of trazodone and citalopram (antidepressants) in acute immobilization stress in mice","volume":"48","author":"Kumar","year":"2010","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0355","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1159\/000350094","article-title":"Molecular mechanisms of depression: perspectives on new treatment strategies","volume":"31","author":"Lang","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0360","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1399-5618.2002.01144.x","article-title":"Stress and depression: possible links to neuron death in the hippocampus","volume":"4","author":"Lee","year":"2002","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0365","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","article-title":"Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression","volume":"36","author":"Leonard","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0370","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1212\/WNL.51.6.1562","article-title":"Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease","volume":"51","author":"Lovell","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0375","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0385","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","article-title":"The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression","volume":"24","author":"Maes","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0380","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10787-011-0111-7","article-title":"New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates-Nrf2 activators and GSK-3 inhibitors","volume":"20","author":"Maes","year":"2012","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0390","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1468-2850.1998.tb00151.x","article-title":"Life stressors as risk factors in depression","volume":"5","author":"Mazure","year":"1998","journal-title":"Clin. Psychol. Sci. Pract."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0395","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00737-002-0161-3","article-title":"The interplay of stress, gender and cognitive style in depressive onset","volume":"6","author":"Mazure","year":"2003","journal-title":"Arch. Womens Ment. Health"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0400","first-page":"41","article-title":"A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder","volume":"34","author":"McKinnon","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0405","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1742-7843.2011.00691.x","article-title":"Early changes in oxidative stress markers in a rat model of acute stress: effect of L-carnitine on the striatum","volume":"109","author":"M\u00e9ndez-Cuesta","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0410","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF03033290","article-title":"Reactive oxygen species and reactive nitrogen species: relevance to cyto(neuro)toxic events and neurologic disorders. An overview","volume":"1","author":"Metodiewa","year":"2000","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0415","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1016\/S0021-9258(19)45155-7","article-title":"The purification and properties of superoxide dismutase from Neurospora crassa","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0420","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12031-012-9892-4","article-title":"Protective effects of ascorbic acid on behavior and oxidative status of restraint-stressed mice","volume":"49","author":"Moretti","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0425","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cpr.2012.02.002","article-title":"Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis","volume":"32","author":"Morris","year":"2012","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0180","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1016\/j.febslet.2012.09.025","article-title":"Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?","volume":"586","author":"Niki","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0185","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(97)01200-6","article-title":"Regional localization of agmatine in the rat brain: an immunocyto-chemical study","volume":"787","author":"Otake","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0195","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00004850-200403000-00006","article-title":"Antioxidant enzyme activities and oxidative stress in affective disorders","volume":"19","author":"Ozcan","year":"2004","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0200","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0149-7634(86)90017-5","article-title":"Restraint stress in biomedical research: a review","volume":"10","author":"Par\u00e9","year":"1986","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1471-4159.2010.07083.x","article-title":"Restraint stress increases neuroinflammation independently of amyloid \u03b2 levels in amyloid precursor protein\/PS1 transgenic mice","volume":"116","author":"Perez Nievas","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0210","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0193-953X(05)70006-X","article-title":"Psychoneuroendocrinology of depression: hypothalamic\u2013pituitary\u2013adrenal axis","volume":"21","author":"Plotsky","year":"1998","journal-title":"Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0215","first-page":"746","article-title":"Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine","volume":"58","author":"Poleszak","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0220","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0225","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0165-1838(98)00091-5","article-title":"Agmatine: an endogenous ligand at imidazoline receptors may be a novel neurotransmitter in brain","volume":"72","author":"Reis","year":"1998","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0230","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1749-6632.1999.tb09343.x","article-title":"Agmatine: an endogenous ligand at imidazoline receptors is a novel neurotransmitter","volume":"881","author":"Reis","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0235","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0165-6147(00)01460-7","article-title":"Is agmatine a novel neurotransmitter in brain?","volume":"21","author":"Reis","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0240","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-0773.1996.tb00259.x","article-title":"Effect of perinatal lead exposure on rat behaviour in open-field and two-way avoidance tasks","volume":"79","author":"Rodrigues","year":"1996","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0245","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbr.2013.07.009","article-title":"Antidepressant-like responses in the forced swimming test elicited by glutathione and redox modulation","volume":"253","author":"Rosa","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0250","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/hup.829","article-title":"Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative\u2013antioxidative systems","volume":"22","author":"Sarandol","year":"2007","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0255","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1046\/j.1471-4159.1997.69062421.x","article-title":"Uptake of agmatine into rat brain synaptosomes: possible role of cation channels","volume":"69","author":"Sastre","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0260","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1601-5215.2012.00675.x","article-title":"The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study","volume":"25","author":"Shopsin","year":"2013","journal-title":"Acta Neuropsych."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0265","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1139\/y82-200","article-title":"Chemical and biochemical aspects of superoxide radicals and related species of activated oxygen","volume":"60","author":"Singh","year":"1982","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0270","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.bi.53.070184.003533","article-title":"Polyamines","volume":"53","author":"Tabor","year":"1984","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0275","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","article-title":"Glutathione peroxidase","volume":"77","author":"Wendel","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0285","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2007.05.062","article-title":"Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats","volume":"572","author":"Zafir","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0280","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pnpbp.2008.11.010","article-title":"In vivo antioxidant status: a putative target of antidepressant action","volume":"33","author":"Zafir","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0290","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00001756-200203250-00005","article-title":"Agmatine produces antidepressant-like effects in two models of depression in mice","volume":"13","author":"Zomkowski","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0295","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.brainres.2004.07.041","article-title":"Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test","volume":"1023","author":"Zomkowski","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.pnpbp.2013.12.012_bb0300","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neulet.2005.02.026","article-title":"Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test","volume":"381","author":"Zomkowski","year":"2005","journal-title":"Neurosci. Lett."}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613002911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584613002911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T11:49:21Z","timestamp":1647776961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584613002911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":85,"alternative-id":["S0278584613002911"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.12.012","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2013.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}