{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:55:15Z","timestamp":1792803315504,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.pnpbp.2014.04.010","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:47:16Z","timestamp":1399250836000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"special_numbering":"C","title":["Methylation of BDNF in women with bulimic eating syndromes: Associations with childhood abuse and borderline personality disorder"],"prefix":"10.1016","volume":"54","author":[{"given":"Lea","family":"Thaler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Gauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Joober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Groleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosherrie","family":"de Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-3142","authenticated-orcid":false,"given":"Amirthagowri","family":"Ambalavanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Steiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2014.04.010_bb0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jts.2490080106","article-title":"The development of a clinician\u2010administered PTSD scale","volume":"8","author":"Blake","year":"1995","journal-title":"J Trauma Stress"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0010","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.neubiorev.2010.09.012","article-title":"Eating disorders, gene\u2013environment interactions and epigenetics","volume":"35","author":"Campbell","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.cellbio.24.110707.175235","article-title":"Communication between the synapse and the nucleus in neuronal development, plasticity, and disease","volume":"24","author":"Cohen","year":"2008","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0020","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1186\/gb-2012-13-6-r43","article-title":"Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood","volume":"13","author":"Davies","year":"2012","journal-title":"Genome Biol"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0025","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jpsychires.2010.01.011","article-title":"Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosa","volume":"44","author":"Ehrlich","year":"2010","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0030","series-title":"Binge eating: nature, assessment, and treatment","first-page":"317","article-title":"The eating disorder examination","author":"Fairburn","year":"1993"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1097-0029(19990515\/01)45:4\/5<233::AID-JEMT7>3.0.CO;2-Y","article-title":"Neurotrophin actions during the development of the peripheral nervous system","volume":"45","author":"Fari\u00f1as","year":"1999","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0040","series-title":"Disorders","article-title":"The Childhood Trauma Interview: reliability, validity, and relationship to personality disorders","author":"Fink","year":"1993"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0045","series-title":"User's guide for the Structured Clinical Interview for DSM-IV Axis I Disorders\u2014research version","author":"First","year":"1996"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0050","series-title":"Structured Clinical Interview for DSM-IV Axis-II personality disorders (SCID-II), (version 2.0)","author":"First","year":"1996"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0060","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/sj.mp.4001931","article-title":"Global DNA hypomethylation and DNA hypermethylation of the alpha synuclein promoter in females with anorexia nervosa","volume":"12","author":"Frieling","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0055","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1038\/sj.npp.1301662","article-title":"Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity","volume":"33","author":"Frieling","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0065","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/eat.20745","article-title":"Epigenetic dysregulation of dopaminergic genes in eating disorders","volume":"43","author":"Frieling","year":"2010","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0070","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.biopsych.2006.08.025","article-title":"Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case\u2013control studies confirm association to substance-related disorders, eating disorders, and schizophrenia","volume":"61","author":"Gratac\u00f2s","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0075","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jpsychires.2013.10.003","article-title":"Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: associations with borderline personality disorder and exposure to childhood abuse","volume":"48","author":"Groleau","year":"2014","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0080","doi-asserted-by":"crossref","first-page":"17184","DOI":"10.1074\/jbc.274.24.17184","article-title":"Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence","volume":"274","author":"Guo","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0085","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jad.2013.08.001","article-title":"BDNF promoter methylation and suicidal behavior in depressive patients","volume":"151","author":"Kang","year":"2013","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0090","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1001\/archgenpsychiatry.2010.9","article-title":"Increased BDNF promoter methylation in the Wernicke area of suicide subjects","volume":"67","author":"Keller","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0095","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/13811118.2010.524025","article-title":"The epigenetics of suicide: explaining the biological effects of early life environmental adversity","volume":"14","author":"Labonte","year":"2010","journal-title":"Arch Suicide Res"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0100","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1101\/gad.7.12b.2483","article-title":"Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors","volume":"7","author":"Li","year":"1993","journal-title":"Genes Dev"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0105","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1128\/MCB.20.23.8803-8814.2000","article-title":"Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain","volume":"20","author":"Mari\u00e9","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0110","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1101\/gad.4.11.1886","article-title":"Transcriptional activation and DNA binding by the erythroid factor GF-1\/NF-E1\/Eryf 1","volume":"4","author":"Martin","year":"1990","journal-title":"Genes Dev"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0115","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/PL00000920","article-title":"Neurotrophins and neuronal differentiation in the central nervous system","volume":"58","author":"McAllister","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0120","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1601-183X.2007.00301.x","article-title":"Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia","volume":"6","author":"Mercader","year":"2007","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0125","series-title":"Neurocircuitry of eating disorders","article-title":"Behavioral neurobiology of eating disorders","author":"Monteleone","year":"2011"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0130","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/01.psy.0000138119.12956.99","article-title":"Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity","volume":"66","author":"Monteleone","year":"2004","journal-title":"Psychosom Med"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2006.07.040","article-title":"The 196G\/A (val66-met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder","volume":"406","author":"Monteleone","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0140","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0006-3223(02)01746-8","article-title":"Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders","volume":"54","author":"Nakazato","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0145","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/85820","article-title":"Dominant-negative mutations of CEBPA, encoding CCAAT\/enhancer binding protein-alpha (C\/EBPalpha), in acute myeloid leukemia","volume":"27","author":"Pabst","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0150","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1038\/tp.2012.140","article-title":"Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene","volume":"3","author":"Perroud","year":"2013","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0155","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/MCO.0b013e3283546fd3","article-title":"Epigenetics and eating disorders","volume":"15","author":"Pjetri","year":"2012","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0160","series-title":"The diagnostic interview schedule, version IV","author":"Robins","year":"1995"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0170","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yhbeh.2010.05.005","article-title":"Epigenetic marking of the BDNF gene by early-life adverse experiences","volume":"59","author":"Roth","year":"2011","journal-title":"Horm Behav"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0165","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.biopsych.2008.11.028","article-title":"Lasting epigenetic influence of early-life adversity on the BDNF gene","volume":"65","author":"Roth","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0175","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jpsychires.2011.01.013","article-title":"Epigenetic modification of hippocampal BDNF DNA in adult rats in an animal model of post-traumatic stress disorder","volume":"45","author":"Roth","year":"2011","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0180","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00787-009-0085-9","article-title":"Eating disorders: the current status of molecular genetic research","volume":"19","author":"Scherag","year":"2010","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0185","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1128\/MCB.20.1.389-401.2000","article-title":"DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites","volume":"20","author":"Soldaini","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0190","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/070674370705200403","article-title":"Phenotypes, endophenotypes, and genotypes in bulimia spectrum eating disorders","volume":"52","author":"Steiger","year":"2007","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0215","first-page":"354","article-title":"The 5HTTLPR polymorphism, prior maltreatment and dramatic\u2013erratic personality manifestations in women with bulimic syndromes","volume":"32","author":"Steiger","year":"2007","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0220","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/eat.20711","article-title":"Trait-defined eating-disorder subtypes and history of childhood abuse","volume":"43","author":"Steiger","year":"2010","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0195","first-page":"125","article-title":"Neural circuits, neurotransmitters, and behavior behavioral neurobiology of eating disorders","author":"Steiger","year":"2011"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0210","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/eat.22113","article-title":"Methylation of the glucocorticoid receptor gene promoter in bulimic women: associations with borderline personality disorder, suicidality, and exposure to childhood abuse","volume":"46","author":"Steiger","year":"2013","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0205","series-title":"Oxford textbook of psychopathology","article-title":"Eating disorders","author":"Steiger","year":"2014"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.socscimed.2011.09.036","article-title":"How does the social environment \u2018get into the mind\u2019? Epigenetics at the intersection of social and psychiatric epidemiology","volume":"74","author":"Toyokawa","year":"2012","journal-title":"Soc Sci Med"},{"key":"10.1016\/j.pnpbp.2014.04.010_bb0230","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1176\/appi.ajp.158.4.547","article-title":"Personality profiles in eating disorders: rethinking the distinction between axis I and axis II","volume":"158","author":"Westen","year":"2001","journal-title":"Am J Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584614000888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584614000888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T09:38:23Z","timestamp":1716716303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584614000888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":45,"alternative-id":["S0278584614000888"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2014.04.010","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylation of BDNF in women with bulimic eating syndromes: Associations with childhood abuse and borderline personality disorder","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2014.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}