{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:55:34Z","timestamp":1789692934963,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":259,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["472446\/2012-6"],"award-info":[{"award-number":["472446\/2012-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.pnpbp.2014.10.017","type":"journal-article","created":{"date-parts":[[2014,12,6]],"date-time":"2014-12-06T17:18:30Z","timestamp":1417886310000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Influence of enrichment on behavioral and neurogenic effects of antidepressants in Wistar rats submitted to repeated forced swim test"],"prefix":"10.1016","volume":"58","author":[{"given":"Fernanda","family":"Possamai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Walber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C.","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Souza","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cilene","family":"Lino de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.pnpbp.2014.10.017_bb0005","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/npp.2013.342","article-title":"Innovative drugs to treat depression: did animal models fail to be predictive or did clinical trials fail to detect effects?","volume":"39","author":"Belzung","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"6103","key":"10.1016\/j.pnpbp.2014.10.017_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.1222940","article-title":"Are we getting closer to valid translational models for major depression?","volume":"338","author":"Berton","year":"2012","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.pnpbp.2014.10.017_bb0015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hipo.22103","article-title":"Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner","volume":"23","author":"Birch","year":"2013","journal-title":"Hippocampus"},{"issue":"2","key":"10.1016\/j.pnpbp.2014.10.017_bb0020","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/sj.npp.1300820","article-title":"Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls","volume":"31","author":"Bj\u00f8rnebekk","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/j.pnpbp.2014.10.017_bb0025","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1017\/S1461145708008912","article-title":"Housing conditions modulate escitalopram effects on antidepressive-like behaviour and brain neurochemistry","volume":"11","author":"Bj\u00f8rnebekk","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00442247","article-title":"Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation","volume":"97","author":"Borsini","year":"1989","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2007.11.004","article-title":"Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum","volume":"89","author":"Brenes","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbr.2005.12.001","article-title":"Factor analysis of forced swimming test, sucrose preference test and open field test on enriched, social and isolated reared rats","volume":"169","author":"Brenes-Saenz","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.compbiomed.2011.12.002","article-title":"Ethowatcher: validation of a tool for behavioral and video-tracking analysis in laboratory animals","volume":"42","author":"Crispim-Junior","year":"2012","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00213-005-0093-5","article-title":"Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment","volume":"182","author":"Cryan","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"1\u20132","key":"10.1016\/j.pnpbp.2014.10.017_bb0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2006.05.048","article-title":"Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress","volume":"404","author":"Cui","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0166-4328(00)00220-5","article-title":"Influence of single or repeated experience of rats with forced swimming on behavioural and physiological responses to the stressor","volume":"114","author":"Dal-Zotto","year":"2000","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0070","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0065","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1037\/1064-1297.5.2.107","article-title":"Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression","volume":"5","author":"Detke","year":"1997","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0075","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.pbb.2008.09.008","article-title":"Stressors can affect immobility time and response to imipramine in the rat forced swim test","volume":"91","author":"Guti\u00e9rrez-Garc\u00eda","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"10.1016\/j.pnpbp.2014.10.017_bb0080","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.npp.1300924","article-title":"Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner","volume":"31","author":"Keilhoff","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"4\u20135","key":"10.1016\/j.pnpbp.2014.10.017_bb0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0031-9384(00)00213-4","article-title":"Varying responses to the rat forced-swim test under diurnal and nocturnal conditions","volume":"69","author":"Kelliher","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0090","first-page":"271","article-title":"Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats","volume":"4","author":"Kitamura","year":"2004","journal-title":"Acta Med Okayama"},{"issue":"5","key":"10.1016\/j.pnpbp.2014.10.017_bb0095","doi-asserted-by":"crossref","first-page":"e97603","DOI":"10.1371\/journal.pone.0097603","article-title":"Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats","volume":"9","author":"Klomp","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbr.2004.09.004","article-title":"Structure of the rat behaviour in the forced swimming test","volume":"158","author":"Lino-de-Oliveira","year":"2005","journal-title":"Behav Brain Res"},{"issue":"6\u20137","key":"10.1016\/j.pnpbp.2014.10.017_bb0105","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0110","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0115","first-page":"94","article-title":"Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats","volume":"117","author":"Marcussen","year":"2008","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0120","doi-asserted-by":"crossref","first-page":"e210","DOI":"10.1038\/tp.2012.141","article-title":"Sustained remission from depressive-like behavior depends on hippocampal neurogenesis","volume":"3","author":"Mateus-Pinheiro","year":"2013","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0125","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jneumeth.2010.12.015","article-title":"Repeated rat-forced swim test: reducing the number of animals to evaluate gradual effects of antidepressants","volume":"195","author":"Mezadri","year":"2011","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0130","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1982"},{"issue":"4","key":"10.1016\/j.pnpbp.2014.10.017_bb0135","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.neuroscience.2008.10.035","article-title":"Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat","volume":"158","author":"Pinnock","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0140","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioral despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0145","first-page":"38","article-title":"The importance of reporting housing and husbandry in rat research","volume":"5","author":"Prager","year":"2011","journal-title":"Behav Neurosci"},{"issue":"5634","key":"10.1016\/j.pnpbp.2014.10.017_bb0150","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.pnpbp.2014.10.017_bb0155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2009.12.052","article-title":"Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats","volume":"470","author":"Schiavon","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0170","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbr.2011.04.002","article-title":"The impact of environmental enrichment in laboratory rats\u2014behavioural and neurochemical aspects","volume":"222","author":"Simpson","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0165","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbr.2012.06.015","article-title":"The effects isolated and enriched housing conditions on baseline and drug-induced behavioural responses en the male rat","volume":"234","author":"Simpson","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0160","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.pnpbp.2012.02.008","article-title":"Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat","volume":"37","author":"Simpson","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.pnpbp.2014.10.017_bb0175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00441-013-1612-z","article-title":"Hippocampal neurogenesis: a biomarker for depression or antidepressant effects? Methodological considerations and perspectives for future research","volume":"354","author":"Tanti","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbr.2014.05.033","article-title":"Forced swim and chronic variable stress reduced hippocampal cell survival in OVX female rats","volume":"270","author":"Vega-Rivera","year":"2014","journal-title":"Behav Brain Res"},{"issue":"3","key":"10.1016\/j.pnpbp.2014.10.017_bb0185","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.physbeh.2009.11.002","article-title":"Circadian phase and sex effects on depressive\/anxiety-like behaviors and HPA axis responses to acute stress","volume":"99","author":"Verma","year":"2010","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pnpbp.2014.10.017_bb0190","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2008.09.001","article-title":"Frequency of climbing behavior as a predictor of altered motor activity in rat forced swimming test","volume":"445","author":"Vieira","year":"2008","journal-title":"Neurosci Lett"},{"issue":"12","key":"10.1016\/j.pnpbp.2014.10.017_bb0195","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.3727\/096368912X655181","article-title":"Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats","volume":"21","author":"Zhang","year":"2012","journal-title":"Cell Transplant"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584614002371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584614002371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T02:03:06Z","timestamp":1566093786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584614002371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":39,"alternative-id":["S0278584614002371"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2014.10.017","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of enrichment on behavioral and neurogenic effects of antidepressants in Wistar rats submitted to repeated forced swim test","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2014.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}