{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:42:56Z","timestamp":1787308976945,"version":"build-2736575974"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Canadian Foundation for Innovation & Research Manitoba","award":["CFI:29533"],"award-info":[{"award-number":["CFI:29533"]}]},{"name":"Canadian Foundation for Innovation & Research Manitoba","award":["RM:2013-155"],"award-info":[{"award-number":["RM:2013-155"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.pnpbp.2015.08.004","type":"journal-article","created":{"date-parts":[[2015,8,9]],"date-time":"2015-08-09T08:30:19Z","timestamp":1439109019000},"page":"131-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway"],"prefix":"10.1016","volume":"64","author":[{"given":"Pouria","family":"Heydarpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Rahimian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gohar","family":"Fakhfouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Khoshkish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Fakhraei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Salehi-Sadaghiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-9719","authenticated-orcid":false,"given":"Jean-Eric","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2015.08.004_bb0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0010","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1053\/j.gastro.2010.06.063","article-title":"Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice","volume":"139","author":"Bercik","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0015","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/ajg.2010.140","article-title":"A prospective population-based study of triggers of symptomatic flares in IBD","volume":"105","author":"Bernstein","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/157015908785777238","article-title":"The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology","volume":"6","author":"Berthold-Losleben","year":"2008","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0025","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1136\/gut.2007.134817","article-title":"Predicting relapse in Crohn's disease: a biopsychosocial model","volume":"57","author":"Bitton","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0140-6736(93)91476-3","article-title":"Nitric oxide synthase activity in ulcerative colitis and Crohn's disease","volume":"342","author":"Boughton-Smith","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0040","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0045","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.neuint.2011.07.014","article-title":"Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets","volume":"59","author":"Butterworth","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0050","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrn2214","article-title":"Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity","volume":"8","author":"Calabrese","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.pnpbp.2015.08.004_bb0055","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/01.psy.0000162254.61556.d5","article-title":"Depression, the autonomic nervous system, and coronary heart disease","volume":"67","author":"Carney","year":"2005","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0060","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1046\/j.1471-4159.2003.01786.x","article-title":"Proteomic identification of nitrated proteins in Alzheimer's disease brain","volume":"85","author":"Castegna","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0065","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1183\/09031936.98.11061218","article-title":"Pulmonary fibrosis: cytokines in the balance","volume":"11","author":"Coker","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0304-3959(98)00137-7","article-title":"Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia","volume":"78","author":"Coutinho","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00054725-200305000-00006","article-title":"Nitric oxide in inflammatory bowel disease","volume":"9","author":"Cross","year":"2003","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0080","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/sj.bjp.0705077","article-title":"The cyclopentenone prostaglandin 15-deoxy-delta(12,14)-PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat","volume":"138","author":"Cuzzocrea","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0085","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1111\/j.1440-1746.2011.06719.x","article-title":"Chronic lithium administration ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats; potential role for adenosine triphosphate sensitive potassium channels","volume":"26","author":"Daneshmand","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.niox.2011.02.002","article-title":"Nitric oxide and major depression","volume":"24","author":"Dhir","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0095","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/(SICI)1096-9896(199812)186:4<416::AID-PATH201>3.0.CO;2-U","article-title":"Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease","volume":"186","author":"Dijkstra","year":"1998","journal-title":"J. Pathol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0100","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/00054725-200608000-00005","article-title":"Depression and inflammatory bowel disease: findings from two nationally representative Canadian surveys","volume":"12","author":"Fuller-Thomson","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.yfrne.2011.12.002","article-title":"Cytokines and brain excitability","volume":"33","author":"Galic","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2008.12.032","article-title":"A role for nitrergic system in the antidepressant-like effects of chronic lithium treatment in the mouse forced swimming test","volume":"200","author":"Ghasemi","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0115","doi-asserted-by":"crossref","first-page":"G560","DOI":"10.1152\/ajpgi.00098.2007","article-title":"Vagus nerve integrity and experimental colitis","volume":"293","author":"Ghia","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0120","first-page":"2209","article-title":"Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression","volume":"118","author":"Ghia","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0125","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1053\/j.gastro.2009.02.069","article-title":"Reactivation of inflammatory bowel disease in a mouse model of depression","volume":"136","author":"Ghia","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0130","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00005072-199804000-00006","article-title":"Protein nitration in Parkinson's disease","volume":"57","author":"Good","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0135","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/ibd.20873","article-title":"Depression and anxiety in inflammatory bowel disease: a review of comorbidity and management","volume":"15","author":"Graff","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0140","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2005.11.071","article-title":"Long-term expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus of the hypothalamus in response to an acute colonic inflammation","volume":"1071","author":"Greenwood-Van Meerveld","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0145","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1523\/JNEUROSCI.20-17-06714.2000","article-title":"Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice","volume":"20","author":"Guhring","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0150","doi-asserted-by":"crossref","first-page":"e1418","DOI":"10.1542\/peds.2007-0905","article-title":"Gender differences in presentation and course of disease in pediatric patients with Crohn disease","volume":"120","author":"Gupta","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-2999(99)00191-0","article-title":"Nitric oxide synthase inhibitors have antidepressant-like properties in mice: 1. Acute treatments are active in the forced swim test","volume":"372","author":"Harkin","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0160","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0028-3908(03)00030-3","article-title":"Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors","volume":"44","author":"Harkin","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.euroneuro.2003.08.010","article-title":"Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test","volume":"14","author":"Harkin","year":"2004","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0170","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fnbeh.2014.00386","article-title":"Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice","volume":"8","author":"Hassan","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.pnpbp.2015.08.004_bb0175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.yhbeh.2012.12.005","article-title":"Estradiol reduces depressive-like behavior through inhibiting nitric oxide\/cyclic GMP pathway in ovariectomized mice","volume":"63","author":"Heydarpour","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0180","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.eurpsy.2008.03.013","article-title":"Depression, comorbidities and the TNF-alpha system","volume":"23","author":"Himmerich","year":"2008","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0185","doi-asserted-by":"crossref","first-page":"14981","DOI":"10.1074\/jbc.M500966200","article-title":"Inhibition of RICK\/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease","volume":"280","author":"Hollenbach","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0190","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1023\/A:1021904216312","article-title":"Anxiety and depression are related to autonomic nervous system function in women with irritable bowel syndrome","volume":"48","author":"Jarrett","year":"2003","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0195","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00213-006-0326-2","article-title":"Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects","volume":"185","author":"Joca","year":"2006","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0200","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0022-3565(24)29482-9","article-title":"Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine","volume":"298","author":"Kankuri","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0205","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbr.2005.06.031","article-title":"Effects of potassium channel inhibitors in the forced swimming test: possible involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway","volume":"165","author":"Kaster","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0210","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1023\/A:1018849405922","article-title":"Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease","volume":"42","author":"Kimura","year":"1997","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0215","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2567.2004.01984.x","article-title":"Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle","volume":"113","author":"Kolios","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0220","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2190\/PM.37.3.a","article-title":"Depressive and anxiety symptoms, dysfunctional attitudes and social aspects in irritable bowel syndrome and inflammatory bowel disease","volume":"37","author":"Kovacs","year":"2007","journal-title":"Int. J. Psychiatry Med."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0225","doi-asserted-by":"crossref","first-page":"G1203","DOI":"10.1152\/ajpgi.2001.281.5.G1203","article-title":"Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in rats","volume":"281","author":"Kresse","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0230","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1136\/jech.55.10.716","article-title":"Depression and anxiety in people with inflammatory bowel disease","volume":"55","author":"Kurina","year":"2001","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0235","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1471-4159.2004.02780.x","article-title":"Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS\/NO induction by lipopolysaccharide in neuron\/glia co-cultures","volume":"91","author":"Lee","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0240","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1572-0241.2000.02012.x","article-title":"Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission","volume":"95","author":"Levenstein","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0245","first-page":"G544","article-title":"Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis","volume":"274","author":"Mahler","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0250","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0304-3959(93)90028-N","article-title":"Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats","volume":"54","author":"Malmberg","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0255","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1023\/B:DDAS.0000020509.23162.cc","article-title":"Crohn's disease: a two-year prospective study of the association between psychological distress and disease activity","volume":"49","author":"Mardini","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0260","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/gut.2005.064261","article-title":"Psychological stress in IBD: new insights into pathogenic and therapeutic implications","volume":"54","author":"Mawdsley","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0265","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/gut.45.6.864","article-title":"Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice","volume":"45","author":"McCafferty","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0270","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0306-4522(94)90250-X","article-title":"The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat","volume":"60","author":"Meller","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0275","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0024-3205(01)01139-0","article-title":"N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats","volume":"69","author":"Menchen","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0280","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0140-6736(93)90211-X","article-title":"Increased nitric oxide synthesis in ulcerative colitis","volume":"341","author":"Middleton","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0285","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-3565(25)10238-3","article-title":"Amelioration of chronic ileitis by nitric oxide synthase inhibition","volume":"264","author":"Miller","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0290","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.PSY.0000106907.24881.F2","article-title":"Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study","volume":"66","author":"Mittermaier","year":"2004","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0295","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0300","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neuropharm.2011.09.004","article-title":"Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence","volume":"62","author":"Montezuma","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0305","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1476-5381.1991.tb12153.x","article-title":"l-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse","volume":"102","author":"Moore","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0310","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0016-5085(89)80079-4","article-title":"Hapten-induced model of chronic inflammation and ulceration in the rat colon","volume":"96","author":"Morris","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0315","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nrn752","article-title":"Innate immunity: the missing link in neuroprotection and neurodegeneration?","volume":"3","author":"Nguyen","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0320","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/hup.609","article-title":"Cytokines: abnormalities in major depression and implications for pharmacological treatment","volume":"19","author":"O'Brien","year":"2004","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0325","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1038\/sj.bjp.0702508","article-title":"Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia","volume":"126","author":"Osborne","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0330","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1476-5381.2011.01326.x","article-title":"Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y","volume":"163","author":"Painsipp","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0335","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.psyneuen.2009.10.004","article-title":"Psychological adjustment and autonomic disturbances in inflammatory bowel diseases and irritable bowel syndrome","volume":"35","author":"Pellissier","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0340","doi-asserted-by":"crossref","first-page":"e105328","DOI":"10.1371\/journal.pone.0105328","article-title":"Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome","volume":"9","author":"Pellissier","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0345","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1742-2094-9-75","article-title":"Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress","volume":"9","author":"Peng","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0350","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3109\/00365529609010354","article-title":"A prospective study of the relationship between disease activity and psychologic distress in patients with inflammatory bowel disease","volume":"31","author":"Porcelli","year":"1996","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0355","doi-asserted-by":"crossref","first-page":"G803","DOI":"10.1152\/ajpgi.00135.2004","article-title":"Neuronal activity and CRF receptor gene transcription in the brains of rats with colitis","volume":"287","author":"Porcher","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0360","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0365","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/gut.36.5.718","article-title":"Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease","volume":"36","author":"Rachmilewitz","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0375","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ejphar.2010.09.044","article-title":"Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats","volume":"649","author":"Rahimian","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0370","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2011.03.053","article-title":"Tropisetron ameliorates ischemic brain injury in an embolic model of stroke","volume":"1392","author":"Rahimian","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0380","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/eci.12141","article-title":"Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats","volume":"43","author":"Rahimian","year":"2013","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0385","doi-asserted-by":"crossref","first-page":"17151","DOI":"10.1073\/pnas.0806682105","article-title":"Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation","volume":"105","author":"Riazi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0390","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eplepsyres.2009.09.004","article-title":"Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability","volume":"89","author":"Riazi","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0395","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.pbb.2012.09.022","article-title":"Inhibition of nitric oxide synthase accentuates endotoxin-induced sickness behavior in mice","volume":"103","author":"Ribeiro","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0400","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bbr.2011.06.011","article-title":"Antidepressant-like effect of pioglitazone in the forced swimming test in mice: the role of PPAR-gamma receptor and nitric oxide pathway","volume":"224","author":"Sadaghiani","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.pnpbp.2015.08.004_bb0405","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00213-012-2722-0","article-title":"NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice","volume":"223","author":"Salehi-Sadaghiani","year":"2012","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0410","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2004.11.003","article-title":"Cytokines and major depression","volume":"29","author":"Schiepers","year":"2005","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0415","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0016-5085(96)70055-0","article-title":"Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease","volume":"111","author":"Singer","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0420","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2005.10.004","article-title":"Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach","volume":"22","author":"Sultana","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0425","first-page":"2964","article-title":"Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation","volume":"25","author":"Tang","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0430","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.autneu.2006.11.005","article-title":"The autonomic nervous system and inflammatory bowel disease","volume":"133","author":"Taylor","year":"2007","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0435","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/01.mib.0000227817.54969.5e","article-title":"Critical appraisal of the current practice in murine TNBS-induced colitis","volume":"12","author":"te Velde","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0440","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neuroscience.2014.03.025","article-title":"Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice","volume":"268","author":"Tomaz","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0445","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway","volume":"117","author":"Tracey","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0450","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1038\/tp.2012.8","article-title":"Association of depressive disorders, depression characteristics and antidepressant medication with inflammation","volume":"2","author":"Vogelzangs","year":"2012","journal-title":"Transl. Psychiatr."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0455","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(02)00312-1","article-title":"Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice","volume":"140","author":"Volke","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0460","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0163-8343(96)00036-9","article-title":"The relationship of current psychiatric disorder to functional disability and distress in patients with inflammatory bowel disease","volume":"18","author":"Walker","year":"1996","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0465","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/j.1572-0241.2008.01980.x","article-title":"The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders","volume":"103","author":"Walker","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0470","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neulet.2007.12.041","article-title":"Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor","volume":"433","author":"Wang","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0475","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/ph3010273","article-title":"Nitric oxide synthase inhibitors as antidepressants","volume":"3","author":"Wegener","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0480","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s002210050302","article-title":"Changes in nitric oxide synthase isoforms in the spinal cord of rat following induction of chronic arthritis","volume":"118","author":"Wu","year":"1998","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0485","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.pbb.2014.07.015","article-title":"Antidepressant-like effects of salidroside on olfactory bulbectomy-induced pro-inflammatory cytokine production and hyperactivity of HPA axis in rats","volume":"124","author":"Yang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0490","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s002139900316","article-title":"Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats","volume":"149","author":"Yildiz","year":"2000","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0495","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-3565(24)29615-4","article-title":"Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production","volume":"297","author":"Yue","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pnpbp.2015.08.004_bb0500","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1155\/S0962935193000559","article-title":"Arachidonic acid metabolism in TNS-induced chronic and immunologic enteritis in rats, and the effect of 5-ASA","volume":"2","author":"Zijlstra","year":"1993","journal-title":"Mediat. Inflamm."}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584615300245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584615300245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T22:59:51Z","timestamp":1748559591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584615300245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":100,"alternative-id":["S0278584615300245"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2015.08.004","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2015.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}