{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:55:40Z","timestamp":1758477340376},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.pnpbp.2016.08.003","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T22:29:06Z","timestamp":1470781746000},"page":"183-188","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Mineralocorticoid receptor function in depressed patients and healthy individuals"],"prefix":"10.1016","volume":"71","author":[{"given":"Kim","family":"Hinkelmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Hellmann-Regen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Wingenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn K.","family":"Kuehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Mews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Heuser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Otte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2016.08.003_bb0005","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1530\/EJE-09-1076","article-title":"Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitary-adrenal axis in humans","volume":"162","author":"Berardelli","year":"2010","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12020-012-9750-8","article-title":"Role of mineralocorticoid receptors on the hypothalamus-pituitary-adrenal axis in humans","volume":"43","author":"Berardelli","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12974-016-0563-1","article-title":"Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the kynurenine pathway in the mouse hippocampus","volume":"13","author":"Brooks","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpsychires.2015.04.012","article-title":"Target-based biomarker selection \u2014 mineralocorticoid receptor-related biomarkers and treatment outcome in major depression","volume":"66-67","author":"Buttner","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0025","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.lfs.2016.03.022","article-title":"Does mineralocorticoid receptor play a vital role in the development of depressive disorder?","volume":"152","author":"Chen","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0030","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1038\/npp.2011.162","article-title":"A randomized trial on mineralocorticoid receptor blockade in men: effects on stress responses, selective attention, and memory","volume":"36","author":"Cornelisse","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0035","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12379","article-title":"STRESS and DEPRESSION a crucial role of the mineralocorticoid receptor","author":"de Kloet","year":"2016","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0045","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1210\/jc.2005-0105","article-title":"Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade","volume":"90","author":"Giordano","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0050","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.psyneuen.2015.02.013","article-title":"Glucocorticoid and mineralocorticoid receptor polymorphisms and recurrence of major depressive disorder","volume":"55","author":"Hardeveld","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0055","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.psyneuen.2012.08.007","article-title":"Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour","volume":"38","author":"Harris","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0060","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0197-4580(00)00145-7","article-title":"The role of mineralocorticoid receptors in the circadian activity of the human hypothalamus-pituitary-adrenal system: effect of age","volume":"21","author":"Heuser","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0065","first-page":"1","article-title":"Association between cortisol awakening response and memory function in major depression","author":"Hinkelmann","year":"2013","journal-title":"Psychol. Med."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tins.2007.10.005","article-title":"The coming out of the brain mineralocorticoid receptor","volume":"31","author":"Joels","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2013.07.015","article-title":"The interplay between rapid and slow corticosteroid actions in brain","author":"Joels","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0080","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1177\/0269881113499205","article-title":"The role of mineralocorticoid receptor function in treatment-resistant depression","volume":"27","author":"Juruena","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0085","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.psyneuen.2010.07.024","article-title":"Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: interaction with SSRIs","volume":"36","author":"Klok","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0090","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/10253890701821081","article-title":"Hypothalamic-pituitary-adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function","volume":"11","author":"Kolber","year":"2008","journal-title":"Stress"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0095","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.psyneuen.2012.05.006","article-title":"The mineralocorticoid receptor agonist, fludrocortisone, differentially inhibits pituitary-adrenal activity in humans with psychotic major depression","volume":"38","author":"Lembke","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0100","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0006-3223(97)00484-8","article-title":"A.E. Bennett research award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression","volume":"43","author":"Lopez","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0105","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1358\/dnp.2006.19.10.1068007","article-title":"The effects of antidepressants on the hypothalamic-pituitary-adrenal axis","volume":"19","author":"Mason","year":"2006","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0110","doi-asserted-by":"crossref","first-page":"B900","DOI":"10.1093\/gerona\/58.10.B900","article-title":"Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans","volume":"58","author":"Otte","year":"2003","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0115","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/sj.npp.1301217","article-title":"Blockade of the mineralocorticoid receptor in healthy men: effects on experimentally induced panic symptoms, stress hormones, and cognition","volume":"32","author":"Otte","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0120","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jpsychires.2009.10.006","article-title":"Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double-blind, placebo-controlled proof-of-concept study","volume":"44","author":"Otte","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0125","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/npp.2014.181","article-title":"Mineralocorticoid receptor stimulation improves cognitive function and decreases cortisol secretion in depressed patients and healthy individuals","volume":"40","author":"Otte","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/1359786806066063","article-title":"The glucocorticoid receptor: part of the solution or part of the problem?","volume":"20","author":"Pariante","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0135","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0306-4530(02)00108-7","article-title":"Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change","volume":"28","author":"Pruessner","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0140","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/npp.2012.254","article-title":"Blocking mineralocorticoid receptors impairs, blocking glucocorticoid receptors enhances memory retrieval in humans","volume":"38","author":"Rimmele","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0145","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1677\/jme.0.0310573","article-title":"Determinants of spironolactone binding specificity in the mineralocorticoid receptor","volume":"31","author":"Rogerson","year":"2003","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0150","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0922-4106(93)90072-H","article-title":"Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands","volume":"247","author":"Rupprecht","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0155","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1210\/jcem-47-3-691","article-title":"Oral progestational activity of spironolactone","volume":"47","author":"Schane","year":"1978","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0160","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.neubiorev.2011.07.002","article-title":"Stress effects on memory: an update and integration","volume":"36","author":"Schwabe","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"Suppl. 20","key":"10.1016\/j.pnpbp.2016.08.003_bb0165","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0170","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/PSY.0b013e31820ad12b","article-title":"Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research","volume":"73","author":"Stetler","year":"2011","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0175","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/npp.2014.271","article-title":"Blocking the mineralocorticoid receptor in humans prevents the stress-induced enhancement of centromedial amygdala connectivity with the dorsal striatum","volume":"40","author":"Vogel","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0180","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.tics.2015.12.003","article-title":"Cognitive adaptation under stress: a case for the mineralocorticoid receptor","volume":"20","author":"Vogel","year":"2016","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0185","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/YPG.0000000000000081","article-title":"Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias","volume":"25","author":"Vrijsen","year":"2015","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.pnpbp.2016.08.003_bb0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1001\/archpsyc.60.1.24","article-title":"Mineralocorticoid receptor function in major depression","volume":"60","author":"Young","year":"2003","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584616301191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584616301191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T09:55:21Z","timestamp":1536486921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584616301191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":38,"alternative-id":["S0278584616301191"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2016.08.003","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mineralocorticoid receptor function in depressed patients and healthy individuals","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2016.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}