{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:31:57Z","timestamp":1771515117340,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673625"],"award-info":[{"award-number":["81673625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20151568"],"award-info":[{"award-number":["BK20151568"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140961"],"award-info":[{"award-number":["BK20140961"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","award":["13XZR06"],"award-info":[{"award-number":["13XZR06"]}],"id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.pnpbp.2016.09.008","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:16:59Z","timestamp":1475281019000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness"],"prefix":"10.1016","volume":"73","author":[{"given":"Ruyan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenda","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baomei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2016.09.008_bb0005","doi-asserted-by":"crossref","DOI":"10.1007\/s00213-016-4409-4","article-title":"Topiramate increases the rewarding properties of cocaine in young-adult mice limiting its clinical usefulness","author":"Arenas","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.35","article-title":"The role of glucocorticoid receptor-dependent activity in the amygdala central nucleus and reversibility of early-life stress programmed behavior","volume":"5","author":"Arnett","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.pnpbp.2016.09.008_bb0015","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00213-011-2169-8","article-title":"CD-1 and Balb\/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy","volume":"215","author":"Bechtholt-Gompf","year":"2011","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.pnpbp.2016.09.008_bb0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0031-9384(95)00013-9","article-title":"Link between emotional memory and anxiety states: a study by principal component analysis","volume":"58","author":"Beuzen","year":"1995","journal-title":"Physiol. Behav."},{"issue":"5","key":"10.1016\/j.pnpbp.2016.09.008_bb0025","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/mp.2014.80","article-title":"Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress","volume":"20","author":"Bohacek","year":"2015","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pnpbp.2016.09.008_bb0030","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.yhbeh.2006.04.008","article-title":"High post-partum levels of corticosterone given to dams influence postnatal hippocampal cell proliferation and behavior of offspring: a model of post-partum stress and possible depression","volume":"50","author":"Brummelte","year":"2006","journal-title":"Horm. Behav."},{"issue":"4","key":"10.1016\/j.pnpbp.2016.09.008_bb0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.physbeh.2003.10.001","article-title":"Emotional reactivity in mice may not be inherited but influenced by parents","volume":"80","author":"Calatayud","year":"2004","journal-title":"Physiol. Behav."},{"issue":"12","key":"10.1016\/j.pnpbp.2016.09.008_bb0040","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0006-3223(00)01084-2","article-title":"Variations in maternal care in infancy regulate the development of stress reactivity","volume":"48","author":"Caldji","year":"2000","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pnpbp.2016.09.008_bb0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1300\/J070v15n03_02","article-title":"History of child abuse and severity of adult depression: the mediating role of cognitive schema","volume":"15","author":"Cukor","year":"2006","journal-title":"J. Child Sex. Abus."},{"issue":"8","key":"10.1016\/j.pnpbp.2016.09.008_bb0050","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/archgenpsychiatry.2010.90","article-title":"A randomized add-on trial of an N-methyl-d-aspartate antagonist in treatment-resistant bipolar depression","volume":"67","author":"Diazgranados","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.pnpbp.2016.09.008_bb0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.yfrne.2006.02.001","article-title":"Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects","volume":"27","author":"Fenoglio","year":"2006","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2016.08.006","article-title":"Activation of basolateral amygdala in juvenile C57BL\/6J mice during social approach behavior","author":"Ferri","year":"2016","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.pnpbp.2016.09.008_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.infbeh.2009.10.005","article-title":"Postpartum depression effects on early interactions, parenting, and safety practices: a review","volume":"33","author":"Field","year":"2010","journal-title":"Infant Behav. Dev."},{"issue":"5","key":"10.1016\/j.pnpbp.2016.09.008_bb0070","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/01.AOG.0000183597.31630.db","article-title":"Perinatal depression - a systematic review of prevalence and incidence","volume":"106","author":"Gavin","year":"2005","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0075","first-page":"1","article-title":"Perinatal depression: prevalence, screening accuracy, and screening outcomes","volume":"119","author":"Gaynes","year":"2005","journal-title":"Evid. Rep. Technol. Assess. (Summ.)"},{"issue":"1","key":"10.1016\/j.pnpbp.2016.09.008_bb0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.clinpsy.3.022806.091401","article-title":"Depression in mothers","volume":"3","author":"Goodman","year":"2007","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.psyneuen.2015.07.393","article-title":"The effects of early life stress on neurobehavioral development in children and adolescents: Mediation by the HPA axis","volume":"61","author":"Gunnar","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.pnpbp.2016.09.008_bb0095","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1001\/archpsyc.60.3.253","article-title":"Severity, chronicity, and timing of maternal depression and risk for adolescent offspring diagnoses in a community sample","volume":"60","author":"Hammen","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"issue":"12","key":"10.1016\/j.pnpbp.2016.09.008_bb0100","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1001\/archpsyc.1990.01810240032006","article-title":"Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder","volume":"47","author":"Hammen","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"issue":"16","key":"10.1016\/j.pnpbp.2016.09.008_bb0105","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"issue":"7","key":"10.1016\/j.pnpbp.2016.09.008_bb0110","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.pnpbp.2011.05.010","article-title":"The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder","volume":"35","author":"Jernigan","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0115","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yebeh.2013.10.020","article-title":"Early-life stress and HPA axis trigger recurrent adulthood depression","volume":"38","author":"Juruena","year":"2014","journal-title":"Epilepsy Behav."},{"issue":"6","key":"10.1016\/j.pnpbp.2016.09.008_bb0120","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.neuron.2009.08.008","article-title":"DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.pnpbp.2016.09.008_bb0125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression","volume":"224","author":"Koike","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"5994","key":"10.1016\/j.pnpbp.2016.09.008_bb0130","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0135","doi-asserted-by":"crossref","first-page":"16024","DOI":"10.1038\/srep16024","article-title":"Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice","volume":"5","author":"Liu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.125","article-title":"Adversity in childhood and depression: linked through SIRT1","volume":"5","author":"Lo Iacono","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.pnpbp.2016.09.008_bb0145","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/mrdd.10074","article-title":"Early life influences on life-long patterns of behavior and health","volume":"9","author":"McEwen","year":"2003","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0150","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1146\/annurev.neuro.24.1.1161","article-title":"Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations","volume":"24","author":"Meaney","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.pnpbp.2016.09.008_bb0155","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0006-3223(02)01827-9","article-title":"Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice","volume":"54","author":"Merali","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpsychires.2014.08.021","article-title":"Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress","volume":"59","author":"Myers","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.130","article-title":"Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment","volume":"3","author":"Oh","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"10","key":"10.1016\/j.pnpbp.2016.09.008_bb0170","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/mp.2013.144","article-title":"Serotonin 2C receptor antagonists induce fast-onset antidepressant effects","volume":"19","author":"Opal","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"5","key":"10.1016\/j.pnpbp.2016.09.008_bb0175","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm.3513","article-title":"REDD1 is essential for stress-induced synaptic loss and depressive behavior","volume":"20","author":"Ota","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0180","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuroscience.2015.01.048","article-title":"Effects of stress early in gestation on hippocampal neurogenesis and glucocorticoid receptor density in pregnant rats","volume":"290","author":"Pawluski","year":"2015","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.pnpbp.2016.09.008_bb0185","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"4","key":"10.1016\/j.pnpbp.2016.09.008_bb0190","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/jwh.2008.0953","article-title":"The prevalence of postpartum depression among women with substance use, an abuse history, or chronic illness: a systematic review","volume":"18","author":"Ross","year":"2009","journal-title":"Journal of Womens Health"},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0195","doi-asserted-by":"crossref","first-page":"13573","DOI":"10.1038\/srep13573","article-title":"Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice","volume":"5","author":"Tang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0200","first-page":"44","article-title":"Using animal models to disentangle the role of genetic, epigenetic, and environmental influences on behavioral outcomes associated with maternal anxiety and depression","volume":"2","author":"Tarantino","year":"2011","journal-title":"Front. Psych."},{"issue":"10","key":"10.1016\/j.pnpbp.2016.09.008_bb0205","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/archpsyc.1992.01820100039008","article-title":"The course of major depression in the offspring of depressed parents. Incidence, recurrence, and recovery","volume":"49","author":"Warner","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"issue":"9","key":"10.1016\/j.pnpbp.2016.09.008_bb0210","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1073\/pnas.0507526103","article-title":"Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood","volume":"103","author":"Weaver","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pnpbp.2016.09.008_bb0215","doi-asserted-by":"crossref","first-page":"35042","DOI":"10.1038\/srep35042","article-title":"Chronic stress prior to pregnancy potentiated long-lasting postpartum depression, regulated by Akt-mTOR signaling in the hippocampus","volume":"6","author":"Xia","year":"2016","journal-title":"Sci. Rep"},{"issue":"3","key":"10.1016\/j.pnpbp.2016.09.008_bb0220","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s002130050130","article-title":"The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors","volume":"128","author":"Zaharia","year":"1996","journal-title":"Psychopharmacology"},{"issue":"8","key":"10.1016\/j.pnpbp.2016.09.008_bb0225","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584616302391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584616302391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T06:33:11Z","timestamp":1589697191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584616302391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":45,"alternative-id":["S0278584616302391"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2016.09.008","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2016.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}