{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:10:00Z","timestamp":1790813400049,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","award":["311637"],"award-info":[{"award-number":["311637"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.pnpbp.2016.12.004","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T10:49:44Z","timestamp":1482490184000},"page":"16-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Time-dependent interacting effects of caffeine, diazepam, and ethanol on zebrafish behaviour"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-8250","authenticated-orcid":false,"given":"Steven","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niveen","family":"Fulcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Nowicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Facciol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gerlai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2016.12.004_bb0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cbpc.2015.08.009","article-title":"Acute exposure to waterborne psychoactive drugs attract zebrafish","volume":"179","author":"Abreu","year":"2016","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0010","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neuropharm.2015.10.020","article-title":"Caffeine stimulates locomotor activity in the mammalian spinal cord via adenosine A1 receptor-dopamine D1 receptor interaction and PKA-dependent mechanisms","volume":"101","author":"Acevedo","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0015","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1517\/17425255.2013.759209","article-title":"Understanding the pharmacokinetics of anxiolytic drugs","volume":"9","author":"Altamura","year":"2013","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0020","series-title":"Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: a register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality","author":"Askgaard","year":"2016"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pbb.2009.07.009","article-title":"Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety","volume":"94","author":"Bencan","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2014.07.008","article-title":"Effects of mixing alcohol with caffeinated beverages on subjective intoxication: a systematic review and meta-analysis","volume":"47","author":"Benson","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0035","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3945\/jn.113.189027","article-title":"Caffeine and alcohol intakes and overall nutrient adequacy are associated with longitudinal cognitive performance among U.S. adults","volume":"144","author":"Beydoun","year":"2014","journal-title":"J. Nutr."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0040","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.physbeh.2011.07.029","article-title":"Stimuli affecting zebrafish (Danio rerio) behaviour in the light\/dark preference test","volume":"104","author":"Blaser","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0045","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.gep.2008.11.006","article-title":"Identification of zebrafish A2 adenosine receptors and expression in developing embryos","volume":"9","author":"Boehmler","year":"2009","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbr.2016.06.052","article-title":"DBI\/ACBP loss-of-function does not affect anxiety-like behaviour but reduces anxiolytic responses to diazepam in mice","volume":"313","author":"Budry","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0060","article-title":"Exploring the neurochemical basis of alcohol addiction-related behaviours: translational research","volume":"6","author":"Budygin","year":"2015","journal-title":"Transl. Biomed."},{"issue":"2","key":"10.1016\/j.pnpbp.2016.12.004_bb0065","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbr.2009.12.004","article-title":"Modeling withdrawal syndrome in zebrafish","volume":"208","author":"Cachat","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0070","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/019262339502300202","article-title":"An introduction to drug disposition: the basic principles of absorption, distribution, metabolism, and excretion","volume":"23","author":"Cadwell","year":"1995","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0075","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1089\/zeb.2015.1147","article-title":"A simple method for immunohistochemical staining of zebrafish brain sections for c-fos protein expression","volume":"12","author":"Chatterjee","year":"2015","journal-title":"Zebrafish"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0080","doi-asserted-by":"crossref","first-page":"140216","DOI":"10.1098\/rsos.140216","article-title":"An investigation of the false discovery rate and the misinterpretation of p-values","volume":"1","author":"Colquhoun","year":"2014","journal-title":"R. Soc. Open Sci."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.06.022","article-title":"Understanding behavioural and physiological phenotypes of stress and anxiety in zebrafish","volume":"205","author":"Egan","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0090","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/sj.bjp.0703170","article-title":"The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors","volume":"129","author":"El Yacoubi","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s002130051056","article-title":"The effect of treatment regimen on the development of tolerance to the sedative and anxiolytic effects of diazepam","volume":"145","author":"Fernandes","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0100","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s00213-016-4212-2","article-title":"Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders","volume":"233","author":"Ferre","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0105","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0091-3057(00)00422-6","article-title":"Drinks like a fish: zebrafish (Danio rerio) as a behaviour genetic model to study alcohol effects","volume":"67","author":"Gerlai","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0110","doi-asserted-by":"crossref","first-page":"28986","DOI":"10.1038\/srep28986","article-title":"Environmental and pharmacological manipulations blunt the stress response of zebrafish in a similar manner","volume":"6","author":"Giacomini","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0115","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1520\/JFS2003058","article-title":"Coexistence and concentrations of ethanol and diazepam in post-mortem blood specimens: risk for enhanced toxicity?","volume":"48","author":"Holmgren","year":"2003","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0120","first-page":"1","article-title":"The problems of long-term treatment with benzodiazepines and related substances","volume":"112","author":"Janhsen","year":"2015","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pnpbp.2014.03.007","article-title":"Anxiety, hyperactivity and stereotypy in a zebrafish model of fragile X syndrome and autism spectrum disorder","volume":"55","author":"Kim","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0135","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/toxsci\/kfw156","article-title":"From the cover: zebrafish larvae are insensitive to stimulation by cocaine: importance of exposure route and toxicokinetics","volume":"154","author":"Kirla","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.pnpbp.2016.12.004_bb0140","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.eplepsyres.2014.10.002","article-title":"Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures","volume":"108","author":"Klein","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0145","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/j.1530-0277.2002.tb02627.x","article-title":"Alcohol and benzodiazepines in fatal poisonings","volume":"26","author":"Koski","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0150","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbr.2015.04.020","article-title":"Acute caffeine administration affects zebrafish response to a robotic stimulus","volume":"289","author":"Ladu","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.pnpbp.2016.12.004_bb0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/jcr.2013.0003","article-title":"The impact of caffeine on the behavioural effects of ethanol related to abuse and addiction: a review of animal studies","volume":"3","author":"L\u00f3pez-Cruz","year":"2013","journal-title":"J. Caffeine Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0160","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.physbeh.2007.08.013","article-title":"Anxiogenic effects of cocaine withdrawal in zebrafish","volume":"93","author":"L\u00f3pez-Patino","year":"2008","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.pnpbp.2016.12.004_bb0165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1037\/1064-1297.11.3.228","article-title":"Dissociative antagonistic effects of caffeine on alcohol-induced impairment of behavioural control","volume":"11","author":"Marczinski","year":"2003","journal-title":"Exp. Clin. Psychopharmacol."},{"issue":"9","key":"10.1016\/j.pnpbp.2016.12.004_bb0170","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1111\/acer.13152","article-title":"Desire to drink alcohol is enhanced with high caffeine energy drink mixers","volume":"40","author":"Marczinski","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.pnpbp.2016.12.004_bb0175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1742-7843.2011.00710.x","article-title":"Adenosine A1, but not A2, receptor blockade increases anxiety and arousal in zebrafish","volume":"109","author":"Maximino","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103943","article-title":"Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviours","volume":"9","author":"Maximino","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pnpbp.2016.12.004_bb0185","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-016-0122-3","article-title":"ZNStress: a high-throughput drug screening protocol for identification of compounds modulating neuronal stress in the transgenic mutant sod1G93R zebrafish model of amyotrophic lateral sclerosis","volume":"11","author":"McGown","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0190","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/19371918.2013.758987","article-title":"The impact of alcohol on society: a brief overview","volume":"28","author":"Moss","year":"2013","journal-title":"Soc. Work Public Health"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0195","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1124\/mol.114.093773","article-title":"Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research","volume":"86","author":"Naito","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0200","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pbb.2014.09.022","article-title":"Serotonin antagonists induce anxiolytic and anxiogenic-like behaviour in zebrafish in a receptor-subtype dependent manner","volume":"126","author":"Nowicki","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0205","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pbb.2015.09.008","article-title":"Inhibition of phosphorylated tyrosine hydroxylase attenuates ethanol-induced hyperactivity in adult zebrafish (Danio rerio)","volume":"138","author":"Nowicki","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0210","first-page":"761","article-title":"Interaction between ethanol and diazepam in mice: chronobiological aspects","volume":"60","author":"Pietrzak","year":"2005","journal-title":"Pharmazie"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0215","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pmedr.2016.06.019","article-title":"Energy drink use is associated with alcohol and substance use in eighth, tenth, and twelfth graders","volume":"4","author":"Polak","year":"2016","journal-title":"Prev. Med. Rep."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0220","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2011.11.041","article-title":"On the edge: pharmacological evidence for anxiety-related behaviour in zebrafish","volume":"228","author":"Richendrfer","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0230","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioural profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"Rihel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0235","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.neuropharm.2012.05.009","article-title":"Behavioural effects of taurine pretreatment in zebrafish acutely exposed to ethanol","volume":"63","author":"Rosemberg","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0240","first-page":"387","article-title":"Locomotor activity pattern induced by diazepam in control and caffeine-treated mice","volume":"47","author":"Sansone","year":"1995","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0245","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pbb.2016.01.013","article-title":"Irish coffee: effects of alcohol and caffeine on object discrimination in zebrafish","volume":"143","author":"Santos","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0250","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1097\/01.ALC.0000148105.79934.14","article-title":"Motor impairing effects of ethanol and diazepam in rats selectively bred for high and low ethanol consumption in a limited-access paradigm","volume":"28","author":"Shram","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0255","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pbb.2015.01.016","article-title":"Anxiogenic-like effects of chronic nicotine exposure in zebrafish","volume":"139","author":"Stewart","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0260","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbr.2013.05.065","article-title":"Time-course of behavioural changes induced by ethanol in zebrafish (Danio rerio)","volume":"252","author":"Tran","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0265","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbr.2014.02.034","article-title":"An integrative analysis of ethanol tolerance and withdrawal in zebrafish (Danio rerio)","volume":"276","author":"Tran","year":"2015","journal-title":"Behav. Brian Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0270","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1007\/s00213-015-4030-y","article-title":"Differential effects of acute administration of SCH-23390, a D1 receptor antagonist, and of ethanol on swimming activity, anxiety-related responses, and neurochemistry of zebrafish","volume":"232","author":"Tran","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0275","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pnpbp.2015.08.009","article-title":"Neurochemical factors underlying individual differences in locomotor activity and anxiety-like behavioural responses in zebrafish","volume":"65","author":"Tran","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0280","doi-asserted-by":"crossref","first-page":"383","DOI":"10.17796\/jcpd.36.4.t1j3625831144371","article-title":"Sedative effects of oral midazolam, intravenous midazolam, and oral diazepam","volume":"36","author":"Tyagi","year":"2012","journal-title":"J. Clin. Pediatr. Dent."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0285","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1242\/jcs.140194","article-title":"In vivo cell biology in zebrafish - providing insights into vertebrate development and disease","volume":"127","author":"Vacaru","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0290","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0140525X00077797","article-title":"Insensitivity of the analysis of variance of heredity-environment interaction","volume":"13","author":"Wahlsten","year":"1990","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0295","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbr.2009.12.023","article-title":"Analyzing habituation responses to novelty in zebrafish (Danio rerio)","volume":"208","author":"Wong","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0300","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neulet.2013.12.049","article-title":"Ethanol attenuates sensory stimulus-evoked responses in cerebellar granule cells via activation of GABA(A) receptors in vivo in mice","volume":"561","author":"Wu","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0305","first-page":"355","article-title":"Conscious sedation with diazepam and midazolam for dental patient: priority to diazepam","volume":"62","author":"Zanette","year":"2013","journal-title":"Minerva Stomatol."},{"issue":"1","key":"10.1016\/j.pnpbp.2016.12.004_bb0310","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1124\/jpet.116.232231","article-title":"Ethanol tolerance affects endogenous adenosine signaling in mouse hippocampus","volume":"358","author":"Zhang","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pnpbp.2016.12.004_bb0315","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuropharm.2014.05.044","article-title":"Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation","volume":"87","author":"Zhou","year":"2014","journal-title":"Neuropharmacology"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584616302925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584616302925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T12:50:16Z","timestamp":1536151816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584616302925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":60,"alternative-id":["S0278584616302925"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2016.12.004","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time-dependent interacting effects of caffeine, diazepam, and ethanol on zebrafish behaviour","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2016.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}