{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:28:16Z","timestamp":1765758496539,"version":"3.40.5"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research, New Delhi","doi-asserted-by":"crossref","award":["GIA\/37\/DHR-2014"],"award-info":[{"award-number":["GIA\/37\/DHR-2014"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Indian Council for Medical Research, Government of India","award":["GIA\/37\/2014-DHR"],"award-info":[{"award-number":["GIA\/37\/2014-DHR"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.pnpbp.2018.01.016","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T10:21:38Z","timestamp":1517480498000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"PA","title":["Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems"],"prefix":"10.1016","volume":"84","author":[{"given":"Tanusree","family":"Saha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahasweta","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-6304","authenticated-orcid":false,"given":"Anirban","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swagata","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Rajamma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-7522","authenticated-orcid":false,"given":"Kanchan","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2018.01.016_bb0005","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1753-4887.1997.tb06468.x","article-title":"Nutrition and depression: the role of folate","volume":"55","author":"Alpert","year":"1997","journal-title":"Nutr. Rev."},{"year":"2000","series-title":"Diagnostic and Statistical Manual for Mental Disorders-IV-text revised (DSM-IV-TR)","author":"American Psychiatric Association","key":"10.1016\/j.pnpbp.2018.01.016_bb0010"},{"year":"2013","series-title":"Diagnostic and Statistical Manual for Mental Disorders-V (DSM-V)","author":"American Psychiatric Association","key":"10.1016\/j.pnpbp.2018.01.016_bb0015"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0020","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1007\/s11033-013-2563-x","article-title":"Betaine-homocysteinemethyltransferase742G>A polymorphism and risk of Down syndrome offspring in a Brazilian population","volume":"40","author":"Amorim","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ymgme.2007.02.004","article-title":"Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption","volume":"91","author":"Ananth","year":"2007","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.pbb.2011.01.020","article-title":"Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit\/hyperactivity disorder and related disorders","volume":"99","author":"Arnsten","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0035","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0140-6736(05)66915-2","article-title":"Attention-deficit hyperactivity disorder","volume":"366","author":"Biederman","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0040","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ajmg.a.20234","article-title":"Methionine synthase (MTR) 2756 (A\u2192G) polymorphism, double heterozygosity methionine synthase 2756 AG\/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome","volume":"121","author":"Bosco","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0045","series-title":"Folate in Health and Disease","first-page":"435","article-title":"Folate and neuropsychiatry","author":"Bottiglieri","year":"1995"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0050","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1289\/ehp.9166","article-title":"Neural tube defects and folate pathway genes: family-based association tests of gene\u2013gene and gene\u2013environment interactions","volume":"114","author":"Boyles","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0055","doi-asserted-by":"crossref","first-page":"e89609","DOI":"10.1371\/journal.pone.0089609","article-title":"Genetic variant in MTRR, but not MTR, is associated with risk of congenital heart disease: an integrated meta-analysis","volume":"9","author":"Cai","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0060","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1258\/jrsm.95.3.159","article-title":"Homocysteine in health and disease","volume":"95","author":"Carmel","year":"2002","journal-title":"J. R. Soc. Med."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0065","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1021\/bi049821x","article-title":"Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis","volume":"43","author":"Castro","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0070","first-page":"116","article-title":"At least its natural: herbs and dietary supplements in ADHD","volume":"17","author":"Chan","year":"2000","journal-title":"Contemp. Pediatr."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0075","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/A:1022602400621","article-title":"The Revised Conners' Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. J","volume":"26","author":"Conners","year":"1998","journal-title":"Abnormal Child Psychol."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0080","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1093\/jn\/132.8.2393S","article-title":"Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring","volume":"132","author":"Cooney","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0085","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1469-7610.2006.01671.x","article-title":"The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis","volume":"47","author":"Dickstein","year":"2006","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/gepi.10252","article-title":"Pedigree disequilibrium tests for multilocus haplotypes","volume":"25","author":"Dudbridge","year":"2003","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000119108","article-title":"Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data","volume":"66","author":"Dudbridge","year":"2008","journal-title":"Hum. Hered."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1179\/1476830511Y.0000000016","article-title":"Importance of gene variants and co-factors of folate metabolic pathway in the etiology of idiopathic intellectual disability","volume":"14","author":"Dutta","year":"2011","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0105","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejogrb.2005.07.028","article-title":"Abnormal folate metabolism in mothers with down syndrome offspring: review of the literature","volume":"124","author":"Eskes","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0110","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11920-014-0497-1","article-title":"Biomarkers in the diagnosis of ADHD-promising directions","volume":"16","author":"Faraone","year":"2014","journal-title":"Curr. Psychiatr. Rep."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/mutage\/geq052","article-title":"Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells","volume":"26","author":"Fenech","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0120","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ymgme.2010.10.010","article-title":"Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation","volume":"102","author":"Feng","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0125","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0003-9861(72)90451-1","article-title":"Methionine metabolism in mammals: kinetic study of betaine-homocysteine methyltransferase","volume":"153","author":"Finkelstein","year":"1972","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0130","series-title":"Rethinking ADHD: From Brain to Culture","first-page":"21","article-title":"ADHD: what do we really know?","author":"Furman","year":"2009"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0135","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/gerona\/59.12.1323","article-title":"Increases in homocysteine are related to worsening of Stroop scores in healthy elderly persons: a prospective follow-up study","volume":"59","author":"Garcia","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"6","key":"10.1016\/j.pnpbp.2018.01.016_bb0140","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s12263-014-0435-1","article-title":"Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine","volume":"9","author":"Garc\u00eda-Minguill\u00e1n","year":"2014","journal-title":"Genes Nutr."},{"year":"2009","series-title":"Brain and Behavior: An Introduction to Biological Psychology","author":"Garrett","key":"10.1016\/j.pnpbp.2018.01.016_bb0145"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00439-009-0694-x","article-title":"Candidate gene studies of ADHD: a meta-analytic review","volume":"126","author":"Gizer","year":"2009","journal-title":"Hum. Genet."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0155","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0304-3940(03)00468-3","article-title":"Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans","volume":"6","author":"Gueant-Rodriguez","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0160","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/bioinformatics\/btf869","article-title":"Multifactor dimensionality reduction software for detecting gene\u2013gene and gene\u2013environment interactions","volume":"19","author":"Hahn","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(98)11058-9","article-title":"Homocysteine and vascular disease","volume":"354","author":"Hankey","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0170","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/mgme.2000.3078","article-title":"Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans","volume":"71","author":"Heil","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0175","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.3390\/ijerph10094352","article-title":"Neural tube defects, folic acid and methylation","volume":"10","author":"Imbard","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0180","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/BJ20131568","article-title":"Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism","volume":"461","author":"Jadavji","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.04.067","article-title":"MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring","volume":"300","author":"Jadavji","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0190","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/gps.3899","article-title":"Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression","volume":"28","author":"Jamerson","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"issue":"24","key":"10.1016\/j.pnpbp.2018.01.016_bb0195","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1002\/cncr.25301","article-title":"Genetic variants in one-carbon metabolism related genes contribute to NSCLC prognosis in a Chinese population","volume":"116","author":"Jin","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0200","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13256-015-0735-0","article-title":"Micronutrient treatment for children with emotional and behavioral dysregulation: a case series","volume":"9","author":"Kaplan","year":"2015","journal-title":"J. Med. Case Rep."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0205","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/nu8020068","article-title":"B vitamins and the brain: mechanisms, dose and efficacy\u2014a review","volume":"8","author":"Kennedy","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0210","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cpr.2006.01.005","article-title":"Brain development and ADHD","volume":"26","author":"Kraina","year":"2006","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0215","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1192\/bjpo.bp.116.003491","article-title":"Vitamin levels in adults with ADHD","volume":"2","author":"Landaas","year":"2016","journal-title":"Br. J. Psych. Open"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0220","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2143\/AC.61.1.2005140","article-title":"Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation torisk of coronary artery disease","volume":"61","author":"Laraqui","year":"2006","journal-title":"Acta Cardiol."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0225","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.95.6.3059","article-title":"Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria","volume":"95","author":"Leclerc","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0230","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1056\/NEJM198806303182604","article-title":"Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis","volume":"318","author":"Lindenbaum","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0235","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/j.gastro.2008.10.016","article-title":"Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations","volume":"136","author":"Linhart","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004514","article-title":"Folic acid with or without vitamin B12 for cognition and dementia","volume":"4","author":"Malouf","year":"2003","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.pnpbp.2018.01.016_bb0245","first-page":"216","article-title":"The methylation, neurotransmitter, and antioxidant connections between folate and depression","volume":"13","author":"Miller","year":"2008","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0250","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0255","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00439-011-1117-3","article-title":"Folate and vitamin B12-related genes and risk for omphalocele","volume":"131","author":"Mills","year":"2012","journal-title":"Hum. Genet."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0260","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jtbi.2005.11.036","article-title":"A flexible computational framework for detecting, characterizing, and interpretingstatistical patterns of epistasis in genetic studies of human disease susceptibility","volume":"241","author":"Moore","year":"2006","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0265","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ajmg.a.20115","article-title":"Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida","volume":"119","author":"Morin","year":"2003","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0270","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1046\/j.1469-1809.1998.6250379.x","article-title":"Susceptibility to spina bifida; an association study of five candidate genes","volume":"62","author":"Morrison","year":"1998","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0275","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/jmg.2009.070029","article-title":"Associations of folate and choline metabolism gene polymorphisms with orofacial clefts","volume":"47","author":"Mostowska","year":"2010","journal-title":"J. Med. Genet."},{"issue":"1","key":"10.1016\/j.pnpbp.2018.01.016_bb0280","first-page":"46","article-title":"Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders","volume":"19","author":"Mousain-Bosc","year":"2006","journal-title":"Magnes. Res."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0285","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/ana.20645","article-title":"Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study","volume":"58","author":"Nurk","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0290","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.3390\/nu5093481","article-title":"The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway","volume":"5","author":"Obeid","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0295","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymgme.2005.02.003","article-title":"Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association","volume":"85","author":"O'Leary","year":"2005","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0300","doi-asserted-by":"crossref","first-page":"35558","DOI":"10.1074\/jbc.M103707200","article-title":"Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation","volume":"276","author":"Olteanu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0305","doi-asserted-by":"crossref","first-page":"13378","DOI":"10.1021\/bi020536s","article-title":"Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase","volume":"41","author":"Olteanu","year":"2002","journal-title":"Biochemistry"},{"year":"2010","series-title":"l-Methylfolate Treatment for Psychiatric or Neurologic Disorders","author":"Quillin","key":"10.1016\/j.pnpbp.2018.01.016_bb0310"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0315","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/3-540-27310-7_6","article-title":"DNA methylation in epigenetic control of gene expression","volume":"38","author":"Razin","year":"2005","journal-title":"Prog. Mol. Sub Cell Biol."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0320","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1007\/s11064-014-1393-0","article-title":"A pilot study on the contribution of folate gene variants in the cognitive function of ADHD probands","volume":"39","author":"Saha","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0325","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/jhg.2017.23","article-title":"Components of the folate metabolic pathway and ADHD core traits: an exploration in eastern Indian Probands","volume":"62","author":"Saha","year":"2017","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0330","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/EDE.0b013e31821d0e30","article-title":"Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism","volume":"22","author":"Schmidt","year":"2011","journal-title":"Epidemiology"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0335","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1753-4887.2008.00107.x","article-title":"Nutritional and dietary influences on attention deficit hyperactivity disorder","volume":"66","author":"Sinn","year":"2008","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0340","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/01.DBP.0000267558.88457.a5","article-title":"Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD","volume":"28","author":"Sinn","year":"2007","journal-title":"J. Dev. Behav. Pediatr."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0345","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1371\/journal.pone.0007845","article-title":"Periconceptional maternal folic acid use of 400 microgram per day is related to increased methylation of the IGF2 gene in the very young child","volume":"4","author":"Steegers-Theunissen","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0350","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/abbi.1997.0246","article-title":"Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene","volume":"345","author":"Sunden","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0355","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0360","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00109-006-0093-x","article-title":"The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida","volume":"84","author":"Van der Linden","year":"2006","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0365","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/0253-7176.96155","article-title":"Attention-deficit\/hyperactivity disorder in children: clinical profile and co-morbidity","volume":"34","author":"Venkatesh","year":"2012","journal-title":"Ind. J. Psychol. Med."},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0370","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/mp.2016.85","article-title":"Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study","volume":"22","author":"Walton","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0375","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1590\/0103-6440201300394","article-title":"Genetic variants in folate and cobalamin metabolism-related genes in nonsyndromic cleft lip and\/or palate","volume":"26","author":"Waltrick-Zambuzzi","year":"2015","journal-title":"Braz. Dent. J."},{"issue":"2","key":"10.1016\/j.pnpbp.2018.01.016_bb0380","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1631\/jzus.B0710599","article-title":"Polymorphisms in genes involved in folate metabolism as maternal risk factors for down syndrome in China","volume":"9","author":"Wang","year":"2008","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0385","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ajmg.1320340320","article-title":"Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity","volume":"34","author":"Watkins","year":"1989","journal-title":"Am. J. Med. Genet."},{"year":"2008","series-title":"A Guide to Nutrigenomic Testing. Genetic Profiling Systems","author":"Yasko","key":"10.1016\/j.pnpbp.2018.01.016_bb0390"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0395","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1089\/gtmb.2011.0257","article-title":"BHMT G742A and MTHFD1G1958A polymorphisms and down syndrome risk in the Brazilian population","volume":"16","author":"Zampieri","year":"2012","journal-title":"Genet. Test Mol. Biomarkers"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0400","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1155\/2012\/693864","article-title":"Maternal risk for down syndrome is modulated by genes involved in folate metabolism","volume":"32","author":"Zampieri","year":"2012","journal-title":"Dis. Markers"},{"key":"10.1016\/j.pnpbp.2018.01.016_bb0405","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.4238\/2011.October.25.7","article-title":"A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population","volume":"10","author":"Zeng","year":"2011","journal-title":"Genet. Mol. Res."}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584617307613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584617307613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T10:02:25Z","timestamp":1535104945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584617307613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":81,"alternative-id":["S0278584617307613"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2018.01.016","relation":{},"ISSN":["0278-5846"],"issn-type":[{"type":"print","value":"0278-5846"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2018.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}