{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:28:31Z","timestamp":1789968511836,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571321"],"award-info":[{"award-number":["81571321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630031"],"award-info":[{"award-number":["81630031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401129"],"award-info":[{"award-number":["81401129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571312"],"award-info":[{"award-number":["81571312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Basic Research Program of China","award":["2015CB856401"],"award-info":[{"award-number":["2015CB856401"]}]},{"name":"Beijing Brain Project","award":["Z171100000117016"],"award-info":[{"award-number":["Z171100000117016"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.pnpbp.2018.10.016","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T17:14:30Z","timestamp":1540746870000},"page":"400-411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Chronic mild corticosterone exposure during adolescence enhances behaviors and upregulates neuroplasticity-related proteins in rat hippocampus"],"prefix":"10.1016","volume":"89","author":[{"given":"Jitao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun'ai","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmei","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2018.10.016_bb0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1037\/0735-7044.120.2.249","article-title":"Anxiogenic-like effect of chronic corticosterone in the light-dark emergence task in mice","volume":"120","author":"Ardayfio","year":"2006","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2017.00237","article-title":"Adolescent Corticosterone and TrkB pharmaco-manipulations sex-dependently impact instrumental reversal learning later in life","volume":"11","author":"Barfield","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pbio.2003000","article-title":"Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure","volume":"15","author":"Barfield","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0020","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/archpsyc.1990.01810140081011","article-title":"Sensorimotor gating and schizophrenia: Human and animal model studies","volume":"47","author":"Braff","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0025","doi-asserted-by":"crossref","first-page":"e537","DOI":"10.1038\/tp.2015.34","article-title":"Stress inoculation modeled in mice","volume":"5","author":"Brockhurst","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0030","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of anxiety\/Depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0035","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.psyneuen.2011.08.008","article-title":"Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression","volume":"37","author":"Donner","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0040","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A Neurotrophic Model for Stress-Related Mood Disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0045","first-page":"1","article-title":"Recapitulation and reversal of a persistent depression-like syndrome in rodents","author":"Gourley","year":"2009","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0050","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.biopsych.2008.06.016","article-title":"Acute Hippocampal Brain-Derived Neurotrophic factor Restores Motivational and Forced Swim Performance after Corticosterone","volume":"64","author":"Gourley","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0055","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.yhbeh.2012.09.012","article-title":"Effects of stressors in adolescence on learning and memory in rodent models","volume":"64","author":"Green","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.steroids.2008.11.009","article-title":"The challenge of continuous exogenous glucocorticoid administration in mice","volume":"74","author":"Herrmann","year":"2009","journal-title":"Steroids"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.48","article-title":"Stress and adolescent hippocampal neurogenesis: Diet and exercise as cognitive modulators","volume":"7","author":"Hueston","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0070","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.neuron.2013.10.025","article-title":"AMPARs and synaptic plasticity: the last 25 years","volume":"80","author":"Huganir","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.tips.2006.03.007","article-title":"Corticosteroid effects in the brain: U-shape it","volume":"27","author":"Jo\u00ebls","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0080","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/jmg.2005.032946","article-title":"Confirmation of CHD7 as a cause of CHARGE association identified by mapping a balanced chromosome translocation in affected monozygotic twins","volume":"43","author":"Johnson","year":"2006","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0085","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1210\/en.2009-1436","article-title":"Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse","volume":"151","author":"Karatsoreos","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0090","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.nlm.2011.07.002","article-title":"An analysis of rat prefrontal cortex in mediating executive function","volume":"96","author":"Kesner","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fpsyt.2015.00031","article-title":"Dysregulated hypothalamic-pituitary-adrenal axis function contributes to altered endocrine and neurobehavioral responses to acute stress","volume":"6","author":"Kinlein","year":"2015","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0100","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.nbd.2012.03.015","article-title":"Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice","volume":"46","author":"Klug","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0105","first-page":"675","article-title":"Stress hormones and AMPA plasticity and memory","volume":"11","author":"Krugers","year":"2010","journal-title":"Nat. Publ. Gr."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2010.10.074","article-title":"Persisting cognitive deficits induced by low-dose, subchronic treatment with MK-801 in adolescent rats","volume":"652","author":"Li","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pbb.2013.04.008","article-title":"Enhanced interaction among ErbB4, PSD-95 and NMDAR by chronic MK-801 treatment is associated with behavioral abnormalities","volume":"108","author":"Li","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"25","key":"10.1016\/j.pnpbp.2018.10.016_bb0120","article-title":"Differential behavioral and neurobiological effects of Chronic Corticosterone treatment in adolescent and adult rats","volume":"10","author":"Li","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0125","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.celrep.2017.10.006","article-title":"Suppressed Calbindin Levels in Hippocampal Excitatory Neurons Mediate Stress-Induced memory loss","volume":"21","author":"Li","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0130","series-title":"Nectins and Nectin-like Molecules in Development and Disease, 1st Ed, Current Topics in Developmental Biology","author":"Mandai","year":"2015"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroscience.2012.08.063","article-title":"From the stressed adolescent to the anxious and depressed adult: Investigations in rodent models","volume":"249","author":"McCormick","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0140","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1073\/pnas.0705615105","article-title":"Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy","volume":"105","author":"Mitra","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0145","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.npp.1301574","article-title":"Stress, depression, and neuroplasticity: a convergence of mechanisms","volume":"33","author":"Pittenger","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0155","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biopsych.2011.05.036","article-title":"Site-specific genetic manipulation of amygdala corticotropin-releasing factor reveals its imperative role in mediating behavioral response to challenge","volume":"71","author":"Regev","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0160","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/10253890.2011.572207","article-title":"Unpredictable chronic stress in juvenile or adult rats has opposite effects, respectively, promoting and impairing resilience","volume":"15","author":"Ricon","year":"2012","journal-title":"Stress"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0165","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/0963721413475445","article-title":"The Teenage Brain: the stress Response and the Adolescent Brain","volume":"22","author":"Romeo","year":"2013","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tins.2011.01.006","article-title":"Glucocorticoids act on glutamatergic pathways to affect memory processes","volume":"34","author":"Sandi","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0175","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nn.4109","article-title":"Stress and the brain: Individual variability and the inverted-U","volume":"18","author":"Sapolsky","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0180","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1038\/tp.2013.7","article-title":"A role for synaptic plasticity in the adolescent development of executive function","volume":"3","author":"Selemon","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0185","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.psyneuen.2017.10.001","article-title":"Neuroendocrine stress reactivity of male C57BL\/6N mice following chronic oral corticosterone exposure during adulthood or adolescence","volume":"86","author":"Shahanoor","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0190","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0195","doi-asserted-by":"crossref","first-page":"35964","DOI":"10.1074\/jbc.M112.363358","article-title":"Afadin is required for maintenance of dendritic structure and excitatory tone","volume":"287","author":"Srivastava","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2010.03.005","article-title":"Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: Relevance to depression","author":"Sterner","year":"2010","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0205","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/npp.2012.11","article-title":"Chronic corticosterone exposure during adolescence reduces impulsive action but increases impulsive choice and sensitivity to yohimbine in male Sprague-dawley rats","volume":"37","author":"Torregrossa","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0210","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1471-4159.2008.05642.x","article-title":"Age-dependent effects of chronic stress on brain plasticity and depressive behavior","volume":"107","author":"Toth","year":"2008","journal-title":"J. Neurochem."},{"issue":"4995","key":"10.1016\/j.pnpbp.2018.10.016_bb0215","article-title":"Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations","volume":"5","author":"van der Kooij","year":"2014","journal-title":"Nat. Commun."},{"issue":"26","key":"10.1016\/j.pnpbp.2018.10.016_bb0220","article-title":"Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression","volume":"7","author":"Veenit","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0225","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: Procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0230","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/nn.3395","article-title":"Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss","volume":"16","author":"Wang","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.196","article-title":"Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory","volume":"7","author":"Wang","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0240","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: Consistency and behavioural- neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.pnpbp.2018.10.016_bb0245","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jad.2010.11.005","article-title":"Chronic corticosterone administration from adolescence through early adulthood attenuates depression-like behaviors in mice","volume":"131","author":"Xu","year":"2011","journal-title":"J. Affect. Disord."}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584618304585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584618304585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T07:47:07Z","timestamp":1544428027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584618304585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":49,"alternative-id":["S0278584618304585"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2018.10.016","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic mild corticosterone exposure during adolescence enhances behaviors and upregulates neuroplasticity-related proteins in rat hippocampus","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2018.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}