{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:39:48Z","timestamp":1792784388534,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Laboratory of Immunology"},{"name":"FONDAP","award":["15090007"],"award-info":[{"award-number":["15090007"]}]},{"DOI":"10.13039\/501100005853","name":"University of Chile","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.pnpbp.2018.12.012","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T02:29:49Z","timestamp":1545791389000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways"],"prefix":"10.1016","volume":"92","author":[{"given":"Susana","family":"Paredes-Z\u00fa\u00f1iga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-018X","authenticated-orcid":false,"given":"Nils","family":"Trost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera F.","family":"De la Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Alcayaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-2152","authenticated-orcid":false,"given":"Miguel L.","family":"Allende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2018.12.012_bb0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnmol.2018.00017","article-title":"Cocaine effects on dopaminergic transmission depend on a balance between sigma-1 and sigma-2 receptor expression","volume":"11","author":"Aguinaga","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0010","series-title":"Phytosanitary Products","article-title":"Material safety data sheet of Bayleton 250 EC","year":"2008"},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/FBP.0b013e32830c3658","article-title":"Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodents","volume":"19","author":"Bouwknecht","year":"2008","journal-title":"Behav. Pharmacol."},{"issue":"11","key":"10.1016\/j.pnpbp.2018.12.012_bb0020","first-page":"120","article-title":"The OpenCV library","volume":"25","author":"Bradski","year":"2000","journal-title":"Dr. Dobb's J. Softw. Tools"},{"issue":"3","key":"10.1016\/j.pnpbp.2018.12.012_bb0025","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/neu.10292","article-title":"Serotonin patterns locomotor network activity in the developing zebrafish by modulating quiescent periods","volume":"57","author":"Brustein","year":"2003","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0030","series-title":"Zebrafish Neurobehavioral Protocols. Neuromethods","article-title":"Video-aided analysis of zebrafish locomotion and anxiety-related behavioral responses","volume":"Vol 5","author":"Cachat","year":"2011"},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0035","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/clen.200900038","article-title":"Pharmaceuticals, personal care products and endocrine disrupting agents in the environment-a review","volume":"37","author":"Caliman","year":"2009","journal-title":"CLEAN-Soil Air Water"},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0040","doi-asserted-by":"crossref","first-page":"40442","DOI":"10.1074\/jbc.M501969200","article-title":"Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms","volume":"280","author":"Cervinski","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ydbio.2012.07.030","article-title":"MANF regulates dopaminergic neuron development in larval zebrafish","volume":"370","author":"Chen","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0050","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1289\/ehp.93101378","article-title":"Developmental effects of endocrine-disrupting chemicals in wildlife and humans","volume":"101","author":"Colborn","year":"1993","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.pnpbp.2018.12.012_bb0055","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3390\/ijms18040710","article-title":"Triazole fungicides inhibit zebrafish hatching blocking the secretory function of hatching gland cells","volume":"18","author":"De la Paz","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.pnpbp.2018.12.012_bb0060","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.06.022","article-title":"Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish","volume":"205","author":"Egan","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0065","doi-asserted-by":"crossref","first-page":"10387","DOI":"10.1523\/JNEUROSCI.1978-09.2009","article-title":"Serotonergic modulation of locomotion in zebrafish: endogenous release and synaptic mechanisms","volume":"29","author":"Gabriel","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tox.2005.08.021","article-title":"Effects of triadimefon on extracellular dopamine, DOPAC, HVA and 5-HIAA in adult rat striatum","volume":"217","author":"Gagnaire","year":"2006","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.pnpbp.2018.12.012_bb0075","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/01926230601047824","article-title":"Transcriptional profiles in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil","volume":"34","author":"Hester","year":"2006","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0080","first-page":"771","article-title":"Behavioral and neurochemical effects of acute and repeated administration of triadimefon in the male rat","volume":"18","author":"Ikaiddi","year":"1997","journal-title":"Neurotoxicology"},{"issue":"4","key":"10.1016\/j.pnpbp.2018.12.012_bb0085","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.pbb.2012.12.010","article-title":"Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish","volume":"103","author":"Irons","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0090","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/es8009309","article-title":"Azole fungicides: occurrence and fate in wastewater and surface waters","volume":"42","author":"Kahle","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0095","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1089\/zeb.2010.0669","article-title":"A review of monoaminergic neuropsychopharmacology in zebrafish","volume":"7","author":"Maximino","year":"2010","journal-title":"Zebrafish"},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nprot.2009.225","article-title":"Scototaxis as anxiety-like behavior in fish","volume":"5","author":"Maximino","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/cne.20280","article-title":"Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish","volume":"480","author":"McLean","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S1092852914000613","article-title":"Modulating the serotonin system in the treatment of major depressive disorder","volume":"19","author":"Morrissette","year":"2014","journal-title":"CNS Spectr."},{"issue":"5","key":"10.1016\/j.pnpbp.2018.12.012_bb0120","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1021\/ac902465v","article-title":"Electrochemical quantification of serotonin in the live embryonic zebrafish intestine","volume":"82","author":"Njagi","year":"2010","journal-title":"Anal. Chem."},{"issue":"39","key":"10.1016\/j.pnpbp.2018.12.012_bb0125","doi-asserted-by":"crossref","first-page":"13796","DOI":"10.1523\/JNEUROSCI.2892-11.2011","article-title":"Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome","volume":"31","author":"Norton","year":"2011","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.pnpbp.2018.12.012_bb0130","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.nbd.2010.05.010","article-title":"The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases","volume":"40","author":"Panula","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0135","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.neuro.2012.03.005","article-title":"Endosulfan exposure inhibits brain AChE activity and impairs swimming performance in adult zebrafish (Danio rerio)","volume":"33","author":"Pereira","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0140","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pbb.2003.08.003","article-title":"Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon","volume":"76","author":"Reeves","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"3\u20134","key":"10.1016\/j.pnpbp.2018.12.012_bb0145","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0361-9230(01)00696-7","article-title":"Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost","volume":"57","author":"Rink","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0150","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbr.2011.12.016","article-title":"Measuring thigmotaxis in larval zebrafish","volume":"228","author":"Schn\u00f6rr","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-0322-8_1","article-title":"Development of the dopamine systems in zebrafish","volume":"651","author":"Schweitzer","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0160","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbr.2015.05.061","article-title":"Chronic social isolation affects thigmotaxis and whole-brain serotonin levels in adult zebrafish","volume":"292","author":"Shams","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"46","key":"10.1016\/j.pnpbp.2018.12.012_bb0165","doi-asserted-by":"crossref","first-page":"15291","DOI":"10.1523\/JNEUROSCI.3050-15.2015","article-title":"Amperometric monitoring of sensory-evoked dopamine release in awake larval zebrafish","volume":"35","author":"Shang","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0170","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jneumeth.2006.11.015","article-title":"An automated tracking system for C. elegans locomotor behavior and circadian studies application","volume":"161","author":"Simonetta","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0175","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ncomms1171","article-title":"Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems","volume":"2","author":"Tay","year":"2011","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.pnpbp.2018.12.012_bb0180","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1152\/jn.90568.2008","article-title":"Endogenous dopamine suppresses initiation of swimming in prefeeding zebrafish larvae","volume":"100","author":"Thirumalai","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0185","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/taap.2000.8996","article-title":"Upregulation of tyrosine hydroxylase and downregulation of choline acetyltransferase in lead-exposed PC12 cells: the role of PKC activation","volume":"167","author":"Tian","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0190","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0041-008X(90)90043-T","article-title":"Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats","volume":"102","author":"Walker","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0195","first-page":"1","article-title":"The SCS\/ARS\/CES pesticide properties database for environmental decision-making","volume":"123","author":"Wauchope","year":"1992","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0200","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1523\/JNEUROSCI.22-01-00294.2002","article-title":"Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis","volume":"22","author":"West","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pnpbp.2018.12.012_bb0205","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Daniorerio)","author":"Westerfield","year":"2009"},{"issue":"11","key":"10.1016\/j.pnpbp.2018.12.012_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079406","article-title":"An optimized whole-body cortisol quantification method for assessing stress levels in larval zebrafish","volume":"8","author":"Yeh","year":"2013","journal-title":"PLoS One"}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584618306961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278584618306961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T19:46:19Z","timestamp":1759520779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278584618306961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":42,"alternative-id":["S0278584618306961"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2018.12.012","relation":{},"ISSN":["0278-5846"],"issn-type":[{"value":"0278-5846","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2018.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}