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(In press)."},{"key":"10.1016\/j.pnpbp.2019.03.016_bb0445","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00213-011-2570-3","article-title":"Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases","volume":"219","author":"Moreno","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2019.03.016_bb0450","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/npp.2009.224","article-title":"Impulsivity characterization in the Roman high- and low-avoidance rat strains: behavioral and neurochemical differences","volume":"35","author":"Moreno","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pnpbp.2019.03.016_bb0455","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00213-011-2575-y","article-title":"Poor inhibitory control and neurochemical differences in high compulsive drinker rats selected by schedule-induced polydipsia","volume":"219","author":"Moreno","year":"2012","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pnpbp.2019.03.016_bb1015","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00213-014-3699-7","article-title":"Activation of serotonin 5-HT2A receptors inhibits high compulsive drinking on schedule-induced polydipsia","volume":"232","author":"Navarro","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"10.1016\/j.pnpbp.2019.03.016_bb0460","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/schbul\/sbw141","article-title":"Behavioral biomarkers of schizophrenia in high drinker rats: a potential Endophenotype of compulsive neuropsychiatric disorders","volume":"43","author":"Navarro","year":"2017","journal-title":"Schizophr. 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