{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:30:12Z","timestamp":1759602612537,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.pnpbp.2019.109642","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T11:21:55Z","timestamp":1556882515000},"page":"109642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry"],"prefix":"10.1016","volume":"94","author":[{"given":"Bruna S.","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata B.","family":"Cupertino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline B.","family":"Schuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djenifer B.","family":"Kappel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno","family":"Sanvicente-Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cibele E.","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisia","family":"von Diemen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix H.P.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio H.","family":"Grevet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Grassi-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claiton H.D.","family":"Bau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego L.","family":"Rovaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pnpbp.2019.109642_bb0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/10673220490910844","article-title":"Neurobiologic processes in drug reward and addiction","volume":"12","author":"Adinoff","year":"2004","journal-title":"Harv. Rev. Psychiatry"},{"year":"1994","series-title":"Diagnostic and statistical manual of mental disorders (DSM-IV)","author":"American Psychiatric Association (APA)","key":"10.1016\/j.pnpbp.2019.109642_bb0010"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12402-010-0039-6","article-title":"Effects of methylphenidate: the cellular point of view","volume":"2","author":"Bartl","year":"2010","journal-title":"ADHD Atten. Deficit Hyperact. Disord."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0020","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB. Genome Research 2012, 22(9):1790-1797. PMID: 22955989","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"issue":"360","key":"10.1016\/j.pnpbp.2019.109642_bb0025","article-title":"Analysis of shared heritability in common disorders of the brain","volume":"80","author":"Brainstorm Consortium","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/srep31033","article-title":"A highly polymorphic copy number variant in the NSF gene is associated with cocaine dependence","volume":"6","author":"Cabana-Dom\u00ednguez","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0035","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/j.1360-0443.2011.03482.x","article-title":"Recent status scores for version 6 of the addiction severity index (ASI-6)","volume":"106","author":"Cacciola","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0040","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neulet.2006.01.001","article-title":"Regulation of genes involved in dopamine transporter modulation by acute cocaine in rat striatum","volume":"398","author":"Courtin","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0045","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00702-016-1514-9","article-title":"SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond","volume":"123","author":"Cupertino","year":"2016","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0050","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.euroneuro.2017.01.007","article-title":"Replicated association of Synaptotagmin (SYT1) with ADHD and its broader influence in externalizing behaviors","volume":"27","author":"Cupertino","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2017.90","article-title":"Exocytosis-related genes and response to methylphenidate treatment in adults with ADHD","volume":"23","author":"da Silva","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0060","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1521-0391.2013.12047.x","article-title":"Attention deficit hyperactivity disorder in cocaine-dependent adults: A psychiatric comorbidity analysis","volume":"22","author":"Daigre","year":"2013","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0065","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0169-328X(98)00042-4","article-title":"Acute administration of cocaine, but not amphetamine, increases the level of synaptotagmin IV mRNA in the dorsal striatum of rat","volume":"55","author":"Denovan-Wright","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0070","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/15622975.2010.551406","article-title":"Candidate pathway association study in cocaine dependence: the control of neurotransmitter release","volume":"13","author":"Fern\u00e0ndez-Castillo","year":"2012","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0075","article-title":"Structured clinical interview for DSM-IV-TR Axis I disorders, Research version, patient edition. (SCID-I\/P)","author":"First","year":"2002","journal-title":"Biometrics Res."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0080","article-title":"Relationships between substance abuse\/dependence and psychiatric disorders based on polygenic scores","author":"Gurriar\u00e1n","year":"2018","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2210-6-6","article-title":"Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs","volume":"6","author":"Han","year":"2006","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0090","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.biopsych.2010.06.017","article-title":"Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo","volume":"68","author":"Hannestad","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuropharm.2014.06.012","article-title":"Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine","volume":"87","author":"Heal","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0100","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1590\/S0104-42302004000200039","article-title":"Validation of the Brazilian version of alcohol, smoking and substance involvement screening test (ASSIST)","volume":"50","author":"Henrique","year":"2004","journal-title":"Rev. Assoc. Med. Bras."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0105","article-title":"Cocaine'omics: genome-wide and transcriptome-wide analyses provide biological insight into cocaine use and dependence","author":"Huggett","year":"2019","journal-title":"Addict. Biol."},{"issue":"34","key":"10.1016\/j.pnpbp.2019.109642_bb0110","first-page":"24","article-title":"Psychometric properties of the sixth version of the addiction severity index (ASI-6) in Brazil. Rev. bras. Psiquiatr. S\u00e3o Paulo","volume":"1999","author":"Kessler","year":"2012","journal-title":"Brazil"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0115","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s41588-018-0147-3","article-title":"Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals","volume":"50","author":"Lee","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41588-017-0013-8","article-title":"Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism","volume":"50","author":"Luciano","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0125","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10550490500528316","article-title":"The addiction severity index at 25: origins, contributions and transitions","volume":"15","author":"McLellan","year":"2006","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0130","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41588-018-0151-7","article-title":"Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways","volume":"50","author":"Nagel","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03242-8","article-title":"Item-level analyses reveal genetic heterogeneity in neuroticism","volume":"9","author":"Nagel","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0140","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.comppsych.2014.04.021","article-title":"Psychiatric and substance-use comorbidities associated with lifetime crack cocaine use in young adults in the general population","volume":"55","author":"Narvaez","year":"2014","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1151\/spp05314","article-title":"The neurobiology of cocaine addiction","volume":"3","author":"Nestler","year":"2005","journal-title":"Sci. Pract. Perspect."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0150","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0169-328X(02)00518-1","article-title":"Synaptotagmin I and IV are differentially regulated in the brain by the recreational drug 3,4-methylenedioxymethamphetamine (MDMA)","volume":"108","author":"Peng","year":"2002","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0155","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004572","article-title":"Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals","volume":"10","author":"Ruiz-Linares","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0165","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.euroneuro.2012.07.014","article-title":"Evaluation of common variants in 16 genes involved in the regulation of neurotransmitter release in ADHD","volume":"23","author":"S\u00e1nchez-Mora","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0170","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/02791072.2014.977501","article-title":"The prevalence of posttraumatic stress disorder symptoms among addiction treatment patients with cocaine use disorders","volume":"47","author":"Saunders","year":"2015","journal-title":"J. Psychoactive Drugs"},{"issue":"Suppl. 2","key":"10.1016\/j.pnpbp.2019.109642_bb0175","first-page":"22","article-title":"The Mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0180","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2013.10.022","article-title":"Neurotransmitter release: the last millisecond in the life of a synaptic vesicle","volume":"80","author":"S\u00fcdhof","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20020776","article-title":"Role of synaptotagmin in ca 2 +\u2212triggered exocytosis","volume":"366","author":"Tucker","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0190","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2011","journal-title":"Nucleic Acids Res."},{"year":"2003","series-title":"The Alcohol, Smoking and Substance the Alcohol, Smoking and Substance and Substance Involvement Screening Test (ASSIST): Guidelines for Use in Primary Care","author":"WHO ASSIST Working Group","key":"10.1016\/j.pnpbp.2019.109642_bb0195"},{"key":"10.1016\/j.pnpbp.2019.109642_bb0200","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.bpj.2014.07.041","article-title":"Synaptotagmin's role in neurotransmitter release likely involves ca 2+ \u2212induced conformational transition","volume":"107","author":"Wu","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.pnpbp.2019.109642_bb0205","doi-asserted-by":"crossref","first-page":"W600","DOI":"10.1093\/nar\/gkp290","article-title":"SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies","volume":"37","author":"Xu","year":"2009","journal-title":"Nucleic Acids Res."}],"container-title":["Progress in Neuro-Psychopharmacology and Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858461930137X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027858461930137X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T19:46:25Z","timestamp":1759520785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027858461930137X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":41,"alternative-id":["S027858461930137X"],"URL":"https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109642","relation":{},"ISSN":["0278-5846"],"issn-type":[{"type":"print","value":"0278-5846"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between SYT1-rs2251214 and cocaine use disorder further supports its role in psychiatry","name":"articletitle","label":"Article Title"},{"value":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109642"}}